CN106975006A - A kind of to cough, throat, respiratory tract are uncomfortable, composition and preparation method of the flu with preventive and therapeutic action - Google Patents
A kind of to cough, throat, respiratory tract are uncomfortable, composition and preparation method of the flu with preventive and therapeutic action Download PDFInfo
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses one kind to cough, throat, respiratory tract are uncomfortable, and composition of the flu with preventive and therapeutic action is prepared from by following bulk drugs by weight percentage：Rosebud 8 50%, honeysuckle 5 45%, lily 5 40%, balloonflower root 5 40%.The invention also discloses to cough, throat, respiratory tract are uncomfortable, and the preparation method of composition of the flu with preventive and therapeutic action, the composition can be made into fragrant tea, tablet composition, particulate composition, oral liquid, beverage.The present invention makes fragrant tea have the sweet and refreshing characteristic of natural aromatic using rosebud, honeysuckle and lily；Preparation technology is simple, and the fragrant tea of obtained health care is in good taste, has been sufficiently reserved nutrition and the functional component of raw material, has drunk for a long time with good health-care effect.Clinical test shows that the composition of the present invention can effectively treat cough caused by haze and pungent, and throat and respiratory tract are uncomfortable.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly to a kind of to cough, throat, respiratory tract are uncomfortable, flu have prevention and
The composition and preparation method of therapeutic action.
Background technology
With the industrialized development of China, protection of the GDP growth ignorance to environment is blindly pursued in some areas, causes me
State most parts of the north, or even southern some areas haze are serious.
2016 since winter has set in, and multiple large area, long-time heavily contaminated weather have occurred for the multiple areas in the whole nation.Especially go
Since December in year, occur 5 a wide range of heavy air pollution courses so far.
Especially since the 29 days December in 2016, influenceed by adverse weather situation, China occurs continuing severe on a large scale
Air pollution weather.This time heavy air pollution process has been not only limited to Jing-jin-ji region and surrounding area, and northeast, Shaanxi, Sichuan are even
The urban in Guangdong also reaches severe and above pollution, especially the ground contamination outstanding problem such as Xi'an.To the wheel heavily contaminated mistake
Journey terminates, and lasting air serious pollution and continuous early warning total duration most long historical record are created in the ground such as Beijing.
Air PM2.5 pollutions cause 25.7 ten thousand people's excess in national 31 provincial capitals or municipality directly under the Central Government dead, excess death
Rate is averagely close to 1 ‰.And in the dead case of excess, it is lung cancer to have quite a few.International cancer research institution in 2015
(IARC) carcinogenic substance is regarded as in atmosphere pollution, Atmospheric particulates, i.e. PM2.5 are a kind of human carcinogens of confirmation.Haze
The influence of weather so that more children suffer from Bronchopneumonia.
Therefore, thus concern lung health it is very urgent！
At present also by the compound preparation constituted using Chinese medicine, such as tonifying lung ball, LIFEI PIAN, Yangyinqingfei Pill, Tongxuanlifei
Ball, lung-clearing anti-inflammatory ball, lung-clearing anti-inflammatory ball etc., these Chinese patent drugs are relieving cough and asthma in invigorating the lung and benefiting vital QI, treatment pulmonary infection, anti-inflammatory, town
Cough, eliminating the phlegm, preferable curative effect is all used in terms of flush end, but these are all medicines.The improvement of haze is one long-term and very long
Process, only by using medicine far can not meet people to lung health protect demand.
Therefore, it is possible to prevent lung's discomfort, resolving sputum, cough-relieving, the research for the Chinese medicine and health food relievingd asthma imperative.
The vanilla therapy carried out using vanilla, is by drinking the mode such as vanilla tea and champignon condiment, to delay body
The aging of body and method that is uncomfortable and absorbing polyphenoils.If custom replaces the coffee often drunk, milk tea etc. with vanilla tea, also
Obstinate chronic disease can be treated.
The characteristics of vanilla tea is that human psychological can be made to loosen, alleviate stress, while can prevent the discomfort of body, control
Treat disease, the immunocompetence for improving human body itself etc..In the modern society of excess load, people are paid much attention to from body ＆ mind
Two aspects carry out bodily protection, therefore vanilla therapy causes the extensive concern of people.
The content of the invention
To solve the above problems, the present invention provides a kind of to cough, throat, respiratory tract are uncomfortable, and flu is with prevention and controls
The composition and preparation method for the treatment of effect, clearing heat and detoxicating, Yin nourishing and lung moistening, to haze and pungent (particle in such as air)
Caused cough, throat and respiratory tract are uncomfortable, the symptom such as flu, with preventive and therapeutic action.
The present invention is realized using following technical scheme：
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：
Rosebud 8-50%, honeysuckle 5-45%, lily 5-40%, balloonflower root 5-40%.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, is crushed respectively, granularity is 0.5-2.0cm3, mixing,
Packed with non-woven fabrics.
The method can keep rosebud, honeysuckle and the sweet characteristic of lily fragrance, and nutrition and health care composition can be most
The reservation of limits.Hot water bubble drink remains the distinctive color and luster of rose, honeysuckle and fragrance, nutrition and health care composition after restoring
It is released completely.Be conducive to hot water bubble drink after non-woven fabrics packaging.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
Rosebud, honeysuckle, lily and the balloonflower root of recipe quantity are weighed, is mixed, ultramicro grinding, below 25 μm of granularity；Plus
Enter mixture weight 10-80% ethanol as wetting agent and prepare particle, the granular size of the particulate composition for 2000 μm-
150μm。
Ultramicro grinding, enable the nutrition and health care composition in raw material discharge to greatest extent from plant tissue and
It is retained.Hot water Instant Drinks remain rose and the distinctive color and luster of honeysuckle and fragrance after restoring, and nutrition and health care composition is complete
It is released.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, is mixed, ultramicro grinding, mixing, ultramicro grinding, grain
Less than 25 μm of degree；Capsule is processed into using mixing, granulation, filling step.
Ultramicro grinding, enable the nutrition and health care composition in raw material discharge to greatest extent from plant tissue and
It is retained.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is carried with microwave method
Take, extraction power is 200W-1000W, extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, and merge filter
Liquid, filtrate concentration, dry, crushing, obtains extract powder.
B, using this extract powder as active component, addition prepares tablet and often uses auxiliary material, and using mixing, granulation, tableting step adds
Work piece agent composition.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is carried with microwave method
Take, extraction power is 200W-1000W, extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, and merge filter
Liquid, filtrate concentration, dry, crushing, obtains extract powder.
B, using this extract powder as active component, using 50%-95% 0.1-5 parts of ethanol as wetting agent, using mixing,
Granulation step is processed into particulate composition, and the granular size of the particulate composition is 2000 μm -150 μm.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is carried with microwave method
Take, extraction power is 200W-1000W, extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, and merge filter
Liquid, filtrate concentration, dry, crushing, obtains extract powder.
B, using this extract powder as active component, using 0.1-5 parts of starch as auxiliary material, utilize mixing, granulation, filling step
It is processed into capsule.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is carried with microwave method
Take, extraction power is 200W-1000W, extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, and merge filter
Liquid, filtrate concentration, dry, crushing, obtains extract powder.
B, using this extract powder as active component, using 0.1-5 parts of starch as auxiliary material, utilize mixing, press strip, pill, choosing
Ball, drying, polishing step are processed into pill.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, plus 4-12 times is measured water refluxing extraction 1-3 times, is collected
Volatile oil；Filtering, merges extract solution twice, is processed into using concentration, centrifugation, constant volume plus the step such as volatile oil, seasoning, filling
Oral liquid.
Above-mentioned to cough, throat, respiratory tract are uncomfortable, the preparation method of composition of the flu with preventive and therapeutic action,
Methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, plus 4-12 times is measured water refluxing extraction 1-3 times, is collected
Volatile oil；Filtering, merges extract solution twice, and beverage is processed into using centrifugation, constant volume plus the step such as volatile oil, seasoning, filling.
Theory of the invention according to motherland's medicine and pharmacology, with reference to modern medicine newest research results, in ancient times on the basis of medication,
Through verifying repeatedly, rosebud 8-50%, honeysuckle 5-45% are screened, lily 5-40%, balloonflower root 5-40% is raw material, passes through one
Fixed technique is prepared from.With the clear facilitaing lung gas of honeysuckle, pharynx-clearing throat-benefiting is monarch drug in a prescription, rose regulating the flow of vital energy Xie Yu, resuscitation with aromatics, balloonflower root
Pharynx-clearing throat-benefiting, is altogether ministerial drug, and lily moistening lung and nourishing throat is adjutant, full side have it is clearing heat and detoxicating, the effect of Yin nourishing and lung moistening.To haze and
Cough caused by pungent (particle in such as air), throat and respiratory tract are uncomfortable, the symptom such as flu, with preventing and control
Treatment is acted on.
By substantial amounts of experiment and exploration, the present invention is optimized to each component and its content, makes it to clearing heat and detoxicating, foster
Cloudy moistening lung, to being coughed caused by haze and pungent (particle in such as air), throat and respiratory tract are uncomfortable, easily cause
The symptoms such as flu, with preventive and therapeutic action, specific formula is following (by weight)：Rosebud 8-50%, honeysuckle 5-
45%, lily 5-40%, balloonflower root 5-40%.The present invention caused by haze and pungent (particle in such as air) to coughing
Cough, throat and respiratory tract are uncomfortable, the symptom such as flu, with preventive and therapeutic action.
The present invention caused by haze and pungent (particle in such as air) to coughing, and throat and respiratory tract are uncomfortable,
Easily cause the symptoms such as flu, with preventive and therapeutic action, particularly have preferable curative effect, energy to haze and pungent
Effectively pre- haze and pungent stimulate caused cough, throat and respiratory tract uncomfortable, the symptom such as flu, the present invention
Component use integration of drinking and medicinal herbs thing for raw material, without any toxicity and side effects, can be used for a long time.
The present invention combines traditional Chinese medicine theory and modern scientific theory formula, and fragrant tea is prepared using advanced technology of preparing
And composite preparation, it is of the invention to be had the advantage that compared with existing formula and technology：
1. make fragrant tea that there is the sweet and refreshing characteristic of natural aromatic using rosebud, honeysuckle and lily.
2. preparation technology is simple, the fragrant tea of obtained health care is in good taste, has been sufficiently reserved nutrition and the functional component of raw material,
Drink for a long time with good health-care effect.
3. the present composition also uses ultramicro grinding and granulation technique, enable nutrition and health care composition in raw material most
Limits are discharged and are retained from plant tissue.
4. the composition of the present invention is also extracted using the technique of Microwave Extraction, extraction efficiency and preparation speed are carried significantly
Height, and destruction of the process to ingredient in raw material is reduced, remain nutrition and the functional component of raw material.
5. the fragrant tea and composition component of the present invention are medicine-food two-purpose thing, have no toxic side effect, can be with long-term taking.
6. clinical test shows that the composition of the present invention can effectively prevent and treat haze and pungent and stimulate and be drawn
Cough, throat and the respiratory tract risen is uncomfortable, the symptom such as flu.
Embodiment
Embodiment 1
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：Rosebud 8%, honeysuckle 45%, lily 30%, balloonflower root 17%.
The composition is fragrant tea.
The preparation method of the fragrant tea, comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are taken, is crushed respectively, granularity is 0.5-2.0cm3, mix, use
Non-woven fabrics is packed.Clearing heat and detoxicating, Yin nourishing and lung moistening is made, effectively prevention and treatment haze and pungent stimulates caused pharynx
The uncomfortable fragrant tea of larynx.
Embodiment 2
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：Rosebud 30%, honeysuckle 30%, lily 20%, balloonflower root 20%.
The composition is fragrant tea.
The preparation method of the fragrant tea is ibid.
Embodiment 3
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：Rosebud 45%, honeysuckle 45%, lily 5%, balloonflower root 5%.
The composition is fragrant tea
The preparation method of the fragrant tea is ibid.
Embodiment 4
The component and content embodiment 1 of fragrant tea；
The processing method of the fragrant tea comprises the following steps：
The 4 taste medicinal material of recipe quantity is taken, is mixed, ultramicro grinding, below 25 μm of granularity.Add mixture weight 10-
80% ethanol prepares particle as wetting agent, and the granular size of the particulate composition is 2000 μm -150 μm.
Embodiment 5
The component and content embodiment 1 of fragrant tea；
The processing method of the fragrant tea comprises the following steps：
The 4 taste medicinal material of recipe quantity is taken, is mixed, ultramicro grinding, below 25 μm of granularity.Add mixture weight 10-
80% ethanol prepares particle as wetting agent, and the granular size of the particulate composition is 2000 μm -150 μm, using mixing,
Granulation, filling step are processed into capsule.
Embodiment 6
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：Rosebud 20%, honeysuckle 20%, lily 30%, balloonflower root 30%.
The processing method of the composition comprises the following steps：
The 4 taste medicinal material of recipe quantity, plus 6 times of amount water are taken, are extracted with microwave method, extraction power is 200W, is extracted
Time is 5 minutes, and filtering, the dregs of a decoction are extracted 1 time again, is filtered, merging filtrate, and filtrate concentrates, dries, crushed, and obtains extract powder.With this
Extract powder is active component, and addition prepares tablet and often uses auxiliary material, and tablet composition is processed into using mixing, granulation, tableting step.
Embodiment 7
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：Rosebud 35%, honeysuckle 35%, lily 15%, balloonflower root 15%.
The processing method of the composition comprises the following steps：
The 4 taste medicinal material of recipe quantity, plus 6 times of amount water are taken, are extracted with microwave method, extraction power is 200W, is extracted
Time is 5 minutes, and filtering, the dregs of a decoction are extracted 1 time again, is filtered, merging filtrate, and filtrate concentrates, dries, crushed, and obtains extract powder.With this
Extract powder is active component, and using 95% 0.1 part of ethanol as wetting agent, particle group is processed into using mixing, granulation step
Compound, the granular size of the particulate composition is 2000 μm.
Embodiment 8
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：Rosebud 40%, honeysuckle 40%, lily 10%, balloonflower root 10%.
The processing method of the composition comprises the following steps：
The 4 taste medicinal material of recipe quantity is taken, plus 8 times are measured water refluxing extraction 2 times, collect volatile oil；Filtering, merging is carried twice
Liquid is taken, oral liquid is processed into using the step such as concentration, centrifugation, constant volume, addition volatile oil, seasoning, filling.
Embodiment 9
A kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, by weight percentage
Than being prepared from by following bulk drugs：Rosebud 10%, honeysuckle 10%, lily 40%, balloonflower root 40%.
The processing method of the composition comprises the following steps：
The 4 taste medicinal material of recipe quantity is taken, plus 8 times are measured water refluxing extraction 2 times, collect volatile oil；Filtering, merging is carried twice
Liquid is taken, beverage is processed into using the step such as concentration, centrifugation, constant volume, addition volatile oil, seasoning, filling.
Test example 1
The fragrant tea of the present invention and the phlegm-dispelling functions of tablet.
This example by a kind of clearing heat and detoxicating, Yin nourishing and lung moistening prepared by above-described embodiment, effectively prevention and treatment haze and
Cough caused by pungent (particle in such as air), throat and the uncomfortable fragrant tea of respiratory tract and composition tablet enter
Row zoopery and clinical observation on the therapeutic effect, to clearing heat and detoxicating, Yin nourishing and lung moistening of the invention, effectively prevention and treatment haze and excitant
Coughed caused by material (particle in such as air), throat and the uncomfortable fragrant tea of respiratory tract, to prevention and treatment haze and thorn
Swash and coughed caused by property material (particle in such as air), throat and respiratory tract discomfort effect are specifically described.
Zoopery：
Prevent and treat caused by haze and pungent (particle in such as air) and cough described in this example, throat and exhale
Inhale the uncomfortable fragrant tea in road：Using the fragrant tea of above-mentioned formula, rosebud 3g, honeysuckle 3g, lily 6g, balloonflower root 6g are with 80 DEG C
Hot water 100ml soaks 30 minutes, pours out soak, 80ml hot-water soaks 2 times again of fragrant tea 15 minutes every time, pour out soak,
Merge 3 soaks, 18ml (per 1ml medicinal extract equivalent to crude drug in whole 1g) is concentrated under reduced pressure on a rotary evaporator as fragrant tea
Tested material.Dosage is 5 times, 10 times and 20 times of day for human beings usage amount.
Prevent and treat caused by haze and pungent (particle in such as air) and cough described in this example, throat and exhale
Inhale the uncomfortable composition tablet in road：The composition tablet processed using above-mentioned formula and technique, was crushed 40 mesh sieves, and took 18g to add
Water 18ml, ultrasonic dissolution (per 1ml decoctions equivalent to crude drug in whole 1g) is used as tablet tested material.
The experimental animal that this example is used is cleaning grade Kunming mouse.
Test method：Experiment uses the phenol red method of mouse.Mouse is divided into 8 groups, and every group 10, ♀ ♂ half and half are grouped into:(1) it is raw
Manage salt solution group：With the physiological saline gastric infusion 0.1ml.10g with administration group same volume-1, it is continuous three days, latter in last dose
Hour is tested.(2) this fragrant tea tested material is divided into three dosage groups, and tablet tested material is divided into three dosage groups, continuous to fill
Stomach is administered 3 days, is tested in last dose one hour after.(3) ammonium chloride group (0.5g/kg body weight).Before being tested, prohibit
Food can't help water 12 hours, and gastric infusion is once.Saline control group, tested material group 30 minutes and ammonium chloride after last dose
30 minutes after group single administration, only, 30 minutes de- cervical vertebras put to death mouse to the phenol red solution 0.5ml/ of intraperitoneal injection 0.5% after injection,
Face upward position to be fixed on surgical plate, cut off neck center skin, separate tracheae, peel off tracheae surrounding tissue, cut under thyroid cartilage
To one section of tracheae of tracheae bifurcation, it is put into the test tube for filling 2ml physiological saline, then Jia 1~2 drop 1mol/L NaOH solutions,
After placing 2 hours, UV, visible light spectrophotometer is used, OD values are surveyed at wavelength 546nm, each group difference is compared with control group
Conspicuousness.Phenol red excretion increment rate is calculated by following equation.
Phenol red excretion increment rate (%)=(N-N0)/N0× 100%
N0：The phenol red excretion average N of physiological saline group：The phenol red excretion average of administration group
Result of the test：Tested material, ammonium chloride group are compared the phenol red equal significance of excretion difference with physiological saline group, because
This tested material has phlegm-dispelling functions (being shown in Table 1).
The phlegm-dispelling functions (n=10) of the tested material of table 1
Note：Compared with physiological saline group*P ＜ 0.05**P ＜ 0.01
Clinical observation on the therapeutic effect
The fragrant tea cough-relieving of the present invention, phlegm-dispelling functions clinical observation on the therapeutic effect
1st, diagnostic criteria：
1.1 clinically to cough, cough up phlegm as cardinal symptom；Exclude with cough, Other diseases (such as lung knot for symptom of coughing up phlegm
Core, pneumoconiosis, pulmonary abscess, heart disease, cardiac insufficiency, chronic naso-pharynageal disease etc.)
1.2 pure：With coughing, 2 symptoms of coughing up phlegm.
The division of 1.3 severity extents
1.3.1 cough
Slightly (+)：Daytime, interruption cough, did not influenceed normal life and work.
Moderate (++)：Symptom is between slight between severe.
Severe (+++)：Round the clock cough frequently or paroxysmal cough, influence rest and sleep.
1.3.2 cough up phlegm：
Few (+)：Cough up phlegm 10~50ml round the clock, or night and early morning cough up phlegm 5~25ml.
In (++)：Cough up phlegm 51~100ml round the clock, or night and early morning cough up phlegm 26~50ml.
Many (+++)：Cough up phlegm more than 100ml round the clock, or night and early morning cough up phlegm more than 50ml.
2nd, case standard is tested
2.1 include case standard：Clinically to cough, cough up phlegm as cardinal symptom；Exclude with cough, symptom of coughing up phlegm its
Its disease (such as pulmonary tuberculosis, pneumoconiosis, pulmonary abscess, heart disease, cardiac insufficiency, chronic naso-pharynageal disease etc.)
2.2 Excluded cases standards：(including inadaptation or rejecting standard)
2.2.1 confirm that the chronic cough caused by the factors such as tuberculosis, fungi, tumour, irritative gas allergy is breathed heavily on inspection
Cease patient.
2.2.2 the concurrent serious cardiac insufficiency person of chronic bronchitis.
2.2.3 the severe primary disease such as angiocarpy, kidney, liver and hemopoietic system, mental patient are associated with.
2.2.4 gestation or women breast-feeding their children, those who are allergic to this drug.
2.2.5 it is all not meet inclusive criteria, not by regulation medication, it is impossible to judge curative effect or can not observe etc. affect the treatment or
Security judgement person.
3rd, curative effect determinate standard
3.1 individual event symptom Outcome measures
Clinic control：Cough, phlegm syndrome shape disappears substantially.
It is effective：Cough, phlegm syndrome shape is clearly better (+++ →+).
Effectively：Cough, phlegm syndrome shape take a turn for the better (+++ → ++, or ++ →+).
It is invalid：Cough, phlegm syndrome shape is without change, or mitigate not obvious and exacerbation of symptoms person.
4th, experimental method
93 patients are selected according to experiment case standard, are divided according to severity extent, in slight, moderate and severe group
Middle selection 30% respectively takes jizhi syrup as a control group, bag/time of fragrant tea 1 of other clothes for patients present invention, 3 times/day,
Continuously take 5 days, observe the symptoms.
5th, observational technique and observation result
Observing time was fixed tentatively as 7 days, daily the change of record symptom.2 are the results are shown in Table, it is of the invention as can be seen from Table 4
Fragrant tea, with cough-suppressing phlegm-dispelling functions, its total effective rate is up to more than 80%.
Table 2, fragrant tea and jizhi syrup cough-relieving, the clinical observation of eliminating the phlegm are contrasted
Finally it should be noted that：The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention,
Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used
To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic.
Within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., should be included in the present invention's
Within protection domain.
Claims (10)
1. a kind of to cough, throat, respiratory tract are uncomfortable, composition of the flu with preventive and therapeutic action, it is characterised in that press
Percentage by weight is prepared from by following bulk drugs：
Rosebud 8-50%, honeysuckle 5-45%, lily 5-40%, balloonflower root 5-40%.
2. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, is crushed respectively, granularity is 0.5-2.0cm3, mixing, with nothing
Spin cloth packaging.
3. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
Rosebud, honeysuckle, lily and the balloonflower root of recipe quantity are weighed, is mixed, ultramicro grinding, below 25 μm of granularity；Add mixed
Polymer weight 10-80% ethanol prepares particle as wetting agent, and the granular size of the particulate composition is 2000 μm of -150 μ
m。
4. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, is mixed, ultramicro grinding, below 25 μm of granularity；Using mixed
Close, pelletize, filling step is processed into capsule.
5. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is extracted, carried with microwave method
It is 200W-1000W to take power, and extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, merging filtrate, filtrate
Concentration, dry, crushing, obtain extract powder；
B, using this extract powder as active component, addition prepares tablet and often uses auxiliary material, and using mixing, granulation, tableting step is processed into
Tablet composition.
6. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is extracted, carried with microwave method
It is 200W-1000W to take power, and extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, merging filtrate, filtrate
Concentration, dry, crushing, obtain extract powder；
B, using this extract powder as active component, using 50%-95% 0.1-5 parts of ethanol as wetting agent, utilize mixing, granulation
Step is processed into particulate composition, and the granular size of the particulate composition is 2000 μm -150 μm.
7. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is extracted, carried with microwave method
It is 200W-1000W to take power, and extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, merging filtrate, filtrate
Concentration, dry, crushing, obtain extract powder；
B, using this extract powder as active component, using 0.1-5 parts of starch as auxiliary material, utilize mixing, granulation, the processing of filling step
Into capsule.
8. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
A, the rosebud for weighing recipe quantity, honeysuckle, lily, balloonflower root, plus 4-12 times measured water, is extracted, carried with microwave method
It is 200W-1000W to take power, and extraction time is 5-30 minutes, and filtering, the dregs of a decoction are extracted 1-3 times again, are filtered, merging filtrate, filtrate
Concentration, dry, crushing, obtain extract powder；
B, using this extract powder as active component, using 0.1-5 parts of starch as auxiliary material, using mixing, press strip, pill, select ball, baking
Dry, polishing step is processed into pill.
9. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, plus 4-12 times is measured water refluxing extraction 1-3 times, collects volatilization
Oil；Filtering, merges extract solution twice, is processed into orally using concentration, centrifugation, constant volume plus the step such as volatile oil, seasoning, filling
Liquid.
10. described in a kind of claim 1 to cough, throat, respiratory tract are uncomfortable, combination of the flu with preventive and therapeutic action
The preparation method of thing, it is characterised in that methods described comprises the following steps：
Rosebud, honeysuckle, lily, the balloonflower root of recipe quantity are weighed, plus 4-12 times is measured water refluxing extraction 1-3 times, collects volatilization
Oil；Filtering, merges extract solution twice, and beverage is processed into using centrifugation, constant volume plus the step such as volatile oil, seasoning, filling.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107343930A (en) * | 2017-08-27 | 2017-11-14 | 夏季 | A kind of medicine for treating aphonia and preparation method thereof |
| CN108743809A (en) * | 2018-06-21 | 2018-11-06 | 云南德彩堂生物医药科技有限公司 | A kind of pharynx-clearing throat-benefiting composition and the preparation method and application thereof |
| CN109673789A (en) * | 2017-10-19 | 2019-04-26 | 任月朗 | A kind of anti-haze tea of relieving sore-throat clearing lung-heat |
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| CN1814031A (en) * | 2005-11-29 | 2006-08-09 | 封士兰 | Cough-relieving, sputum-eliminating medicine sucking preparation and preparing method |
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| CN1814031A (en) * | 2005-11-29 | 2006-08-09 | 封士兰 | Cough-relieving, sputum-eliminating medicine sucking preparation and preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107343930A (en) * | 2017-08-27 | 2017-11-14 | 夏季 | A kind of medicine for treating aphonia and preparation method thereof |
| CN109673789A (en) * | 2017-10-19 | 2019-04-26 | 任月朗 | A kind of anti-haze tea of relieving sore-throat clearing lung-heat |
| CN108743809A (en) * | 2018-06-21 | 2018-11-06 | 云南德彩堂生物医药科技有限公司 | A kind of pharynx-clearing throat-benefiting composition and the preparation method and application thereof |
| CN108743809B (en) * | 2018-06-21 | 2020-12-04 | 云南德彩堂生物医药科技有限公司 | Throat clearing composition and preparation method and application thereof |
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Application publication date: 20170725 |