CN106974924A - Isocardiospermin-5-p-hydroxybenzoate的制备及其在制备治疗类风湿关节炎药物中的应用 - Google Patents
Isocardiospermin-5-p-hydroxybenzoate的制备及其在制备治疗类风湿关节炎药物中的应用 Download PDFInfo
- Publication number
- CN106974924A CN106974924A CN201610028261.3A CN201610028261A CN106974924A CN 106974924 A CN106974924 A CN 106974924A CN 201610028261 A CN201610028261 A CN 201610028261A CN 106974924 A CN106974924 A CN 106974924A
- Authority
- CN
- China
- Prior art keywords
- isocardiospermin
- hydroxybenzoate
- preparation
- methanol
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 206010039073 rheumatoid arthritis Diseases 0.000 title claims abstract description 12
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- 150000001875 compounds Chemical class 0.000 claims abstract description 19
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 27
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- 238000000605 extraction Methods 0.000 claims description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 238000010521 absorption reaction Methods 0.000 claims description 6
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 241001092389 Sorbaria Species 0.000 claims description 4
- WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
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- 239000002250 absorbent Substances 0.000 claims description 2
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- 150000001298 alcohols Chemical class 0.000 claims 1
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- OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 18
- 239000000243 solution Substances 0.000 description 10
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- XILIYVSXLSWUAI-UHFFFAOYSA-N 2-(diethylamino)ethyl n'-phenylcarbamimidothioate;dihydrobromide Chemical compound Br.Br.CCN(CC)CCSC(N)=NC1=CC=CC=C1 XILIYVSXLSWUAI-UHFFFAOYSA-N 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
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- 241000196324 Embryophyta Species 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
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- 241000700157 Rattus norvegicus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610028261.3A CN106974924B (zh) | 2016-01-16 | 2016-01-16 | Isocardiospermin-5-p-hydroxybenzoate的制备及其在制备治疗类风湿关节炎药物中的应用 |
Applications Claiming Priority (1)
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CN201610028261.3A CN106974924B (zh) | 2016-01-16 | 2016-01-16 | Isocardiospermin-5-p-hydroxybenzoate的制备及其在制备治疗类风湿关节炎药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN106974924A true CN106974924A (zh) | 2017-07-25 |
CN106974924B CN106974924B (zh) | 2020-08-18 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080160059A1 (en) * | 2006-11-08 | 2008-07-03 | Quimica Agronomica De Mexico | Antibiotic/antimycotic preparation and use in plants |
CN101773577A (zh) * | 2010-01-29 | 2010-07-14 | 刘志民 | 用于治疗风湿、关节炎、老年性退行性关节病的关东茶浴包 |
KR20110074194A (ko) * | 2009-12-24 | 2011-06-30 | 주식회사 코스메카코리아 | 쉬땅나무 추출물을 포함하는 피부미백용 화장료 조성물 |
CN103301288A (zh) * | 2013-06-12 | 2013-09-18 | 邬存娟 | 一种治疗痛风性关节炎的中药组合物 |
CN104547494A (zh) * | 2015-02-09 | 2015-04-29 | 王秋霞 | 治疗甲亢的中药组合物药酒及制备工艺 |
-
2016
- 2016-01-16 CN CN201610028261.3A patent/CN106974924B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080160059A1 (en) * | 2006-11-08 | 2008-07-03 | Quimica Agronomica De Mexico | Antibiotic/antimycotic preparation and use in plants |
KR20110074194A (ko) * | 2009-12-24 | 2011-06-30 | 주식회사 코스메카코리아 | 쉬땅나무 추출물을 포함하는 피부미백용 화장료 조성물 |
CN101773577A (zh) * | 2010-01-29 | 2010-07-14 | 刘志民 | 用于治疗风湿、关节炎、老年性退行性关节病的关东茶浴包 |
CN103301288A (zh) * | 2013-06-12 | 2013-09-18 | 邬存娟 | 一种治疗痛风性关节炎的中药组合物 |
CN104547494A (zh) * | 2015-02-09 | 2015-04-29 | 王秋霞 | 治疗甲亢的中药组合物药酒及制备工艺 |
Non-Patent Citations (9)
Title |
---|
ADOLF NAHRSTEDT ET AL.: "Leucine-derived cyanogenic glucosides in the rosaceae—spiraeoideae", 《PBYTOCHEMISTRY》 * |
ADOLF NAHRSTEDT: "A new cyanogenic glycoside from Sorbaria arborea (Rosaceae)", 《NATURFORSCH》 * |
GUI-WU QU ET AL.: "Leucine-derived cyanoglucosides from the aerial parts of Sorbaria sorbifolia (L.) A. Braun", 《FITOTERAPIA》 * |
KIM DK ET AL.: "A new cyanogenic glycoside from Sorbaria sorbifolia var. stellipila.", 《CHEM.PHARM.BULL.》 * |
吉林省中医中药研究所 等: "《长白山植物药志》", 30 June 1982, 吉林人民出版社 * |
崔福德主编: "《药剂学》", 31 August 2011, 人民卫生出版社 * |
张家佳: "白鹃梅化学成分", 《中国中药杂志》 * |
李孝栋等: "东北珍珠梅化学成分的研究", 《中国中药杂志》 * |
鲁文雪等: "珍珠梅中γ-羟基腈苷Sutherlandin-5-cis-p-coumarate的抗炎、镇痛活性研究", 《中国现代中药》 * |
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