CN106974898A - A kind of anxious branch Neulized inhalation pharmaceutical solutions and preparation method thereof - Google Patents
A kind of anxious branch Neulized inhalation pharmaceutical solutions and preparation method thereof Download PDFInfo
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention relates to a kind of anxious branch Neulized inhalation pharmaceutical solutions, belong to galenic pharmacy field.A kind of Neulized inhalation pharmaceutical solutions of anxious branch, including (1) anxious branch active ingredient；(2) isotonic agent and solvent, can also include buffer solution.Pharmaceutical solutions prepared by the present invention compensate for the blank on domestic market, can prevent due to a lack of the special preparation medicine of Inhalation in Treating.Convenient using process and pharmaceutical solutions prepared by the present invention is to aim at Neulized inhalation to be designed with patient, is supported the use with atomizer, compared with jizhi syrup, method of administration is different, and dosage is reduced, and security is improved.
Description
Technical field
The present invention relates to a kind of anxious branch Neulized inhalation pharmaceutical solutions and preparation method thereof, belong to galenic pharmacy field.
Background technology
Cough, phlegm, breathe heavily, inflammation is that the common master of ALRI levies.ALRI has acute and chronic
Point, acute infection is mainly acute tracheobronchitis, caused by being virus or the pathogenic infection such as bacterium
Bronchial mucosa inflammation, category common disease, frequently-occurring disease are especially common with children and old age, often secondary to above exhaling
Inhale after road infection, be also often the Early manifestation of pneumonia, it is clinical to have bronchus point to cough with (or not companion)
Secretions are characterized.Chronic bronchitis is common complaint among the elderly, and its cardinal symptom is prolonged
Repeated coughing, expectoration and with asthma, in ARI, symptom is aggravated rapidly, and amount of expectoration increases,
Viscosity increases or is yellow purulence, occasionally has blood-stained sputum, here it is AECB.
Jizhi syrup has effects that clearing heat and eliminating phlegm, facilitaing lung cough-relieving；Modern medicine confirms that this product has stronger
Anti-inflammation and antivirus action, treat bronchitis in terms of, can infection control again can kobadrin.
But be administered orally and work slowly, consumption is big, and toxic side effect is larger, therefore urgently develops a kind of safer
Formulation, is allowed medicament to be directly entered respiratory tract, dosage is small, rapid-action, reduces adverse reaction, and raising is faced
Bed drug safety.
The content of the invention
The present invention solves the technical problem of provide it is a kind of safely, effectively, the atomization of the anxious branch of good quality
Suction pharmaceutical solutions；Present invention also offers the preparation method of said preparation.
The present invention is achieved by the following technical solutions：
A kind of anxious branch Neulized inhalation pharmaceutical solutions, including：
(1) anxious branch active ingredient；
(2) isotonic agent and solvent；
Buffer solution can also be added.
Wherein, the mass ratio of active ingredient and isotonic agent is 1: 1-1: 5.
Active ingredient is prepared obtaining：
10-250 parts of cordate houttuynia, 10-250 parts of cymose buckwheat rhizome, 10-250 parts of Chinese holly, 5-150 parts of aster,
5-100 parts of the root of purple-flowered peucedanum, 5-100 parts of Fructus Aurantii, 5-60 parts of Chinese ephedra, 5-60 parts of radix glycyrrhizae；
Cordate houttuynia, Fructus Aurantii add water distillation, collect distillate；The Six-elements such as the dregs of a decoction and remaining cymose buckwheat rhizome are added water to cook
Secondary, filtration, merging filtrate is concentrated into right amount, merged with above-mentioned distillate, obtains the effective of the present invention
Composition.
Isotonic agent is in sodium chloride, potassium chloride, magnesium chloride, calcium chloride, glucose, xylitol, sorbierite
One kind.
Buffer solution be citric acid-sodium citrate, citrate-phosphate disodium hydrogen, potassium dihydrogen phosphate-disodium hydrogen phosphate,
One kind in citric acid-sodium hydroxide, citric acid-disodium hydrogen phosphate.
Appropriate flavouring can also be added in the present invention.
The pH value of aerosol inhalation solution is 3.0-8.5；Preferable ph is 4.0-7.0.
The consumption of aerosol inhalation solution is 0.01-1.0 times of jizhi syrup consumption；Preferable amount is jizhi syrup
0.05-0.8 times of consumption；More preferably consumption is 0.1-0.5 times of jizhi syrup consumption.
Anxious branch Neulized inhalation pharmaceutical solutions of the present invention can be used for treatment acute bronchitis, chronic
Bronchitis acute attack etc..
It is an advantage of the present invention to provide a kind of novel form better than jizhi syrup, said preparation is directly by respiratory tract
Suction, in localized clusters into higher concentration, and directly acts on the receptor or target acceptor of airway surface and sends out
The effect of waving, and can directly be absorbed from air flue mucous membrane and lung, the administering mode can directly pass effective component
Focus is delivered to, safely and effectively, bioavilability is high, can realize low dosage and fast and effectively treat, because
And have a clear superiority.
Pharmaceutical solutions prepared by the present invention compensate for the blank on domestic market, can prevent due to a lack of suction
Enter to treat special preparation medicine.And pharmaceutical solutions prepared by the present invention is to aim at Neulized inhalation to be set with patient
Meter, is supported the use with atomizer, convenient using process, compared with jizhi syrup, and method of administration is different, makes
Reduced with dosage, security is improved.
Beneficial effects of the present invention are further illustrated below by way of test example：
Acute bronchitis rat model 80 is prepared, Normal group, positive controls, medicine is randomly divided into
Thing group one, medicine group two, medicine group three, medicine group four, medicine group five, medicine group six, every group 10,
Wherein, Normal group gives normal saline gavage；Positive controls give jizhi syrup gavage；Medicine
Thing group one, two, three, four, five, six gives anxious branch aerosol inhalation solution respectively, and (consumption is respectively anxious branch sugar
0.01 times, 0.05 times, 0.1 times, 0.5 times, 0.8 times, 1.0 times of slurry), successive administration 3 days is seen
Examine after treatment, lung tissue and blood after the cure rate of each group, adverse reaction rate, and last dose
Peak concentration of drug in liquid.Specifically it see the table below：
Situation after the treatment of table each group
It can thus be seen that each medicine group has preferable therapeutic action to acute bronchitis rat, wherein
The therapeutic effect of medicine group is substantially better than positive controls, and does not have adverse reaction.
In summary, medicine group dosage is small, and adverse reaction is few, and medicine it is main lung be gathered into compared with
High concentration, is conducive to effective component to directly act on focus, and bioavilability is high, realizes low dosage and fast
Fast effective treatment, thus have a clear superiority.
Equally, the effect of medicine group treatment AECB is also significantly better than jizhi syrup.
The therapeutic effect of urgency branch aerosol inhalation solution of the invention is substantially better than jizhi syrup, has filled up the current country
The urgency of in the market props up the blank of special aerosol inhalation solution, and compared with jizhi syrup, dosage greatly reduces,
It is 0.01-1.0 times of jizhi syrup, preferably 0.05-0.8 times, more preferably 0.1-0.5 times, simultaneously
Method of administration is changed, the generation of adverse reaction is reduced, therefore, the present invention possesses creative and prominent reality
Matter feature and significant progress.
Embodiment
The consumption of material used in material used in the production process and preparation of following pharmaceutical preparation embodiment or preparation is not
It is limited to character express, the formulation method of all pharmaceutical compositions provided containing the present invention belongs to the present invention's
Protection domain.
Embodiment 1
(1) preparation of active ingredient：
10-250 parts of cordate houttuynia, 10-250 parts of cymose buckwheat rhizome, 10-250 parts of Chinese holly, 5-150 parts of aster,
5-100 parts of the root of purple-flowered peucedanum, 5-100 parts of Fructus Aurantii, 5-60 parts of Chinese ephedra, 5-60 parts of radix glycyrrhizae
Cordate houttuynia, Fructus Aurantii add water distillation, collect distillate；The Six-elements such as the dregs of a decoction and remaining cymose buckwheat rhizome are added water to cook
Secondary, filtration, merging filtrate is concentrated into right amount, merged with above-mentioned distillate, obtains the effective of the present invention
Composition.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Sodium and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to 0.4mol/L in right amount
Solution, stirring be slowly added into solution 3, regulation pH value to 5.0-7.0, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 2
(1) preparation of active ingredient：Be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Sodium, adds appropriate water for injection, is stirred to dissolve, obtains solution 2；Solution 1 and solution is 2-in-1 simultaneously, stirring
Uniformly, solution 3 is obtained；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to the molten of 0.4mol/L in right amount
Liquid, stirring is slowly added into solution 3, regulation pH value to 4.0-7.0, plus water for injection 1000ml, is filled
Dress, sealing, are produced.
Embodiment 3
(1) preparation of active ingredient：Be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Magnesium and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to 0.2mol/L in right amount
Solution, stirring be slowly added into solution 3, regulation pH value to 5.0-6.0, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 4
(1) preparation of active ingredient：Be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Calcium and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to 0.4mol/L in right amount
Solution, stirring be slowly added into solution 3, regulation pH value to 5.0-6.5, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 5
(1) preparation of active ingredient：Be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Sodium and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take sodium citrate appropriate, plus water for injection is configured to 0.4mol/L in right amount
Solution, stirring be slowly added into solution 3, regulation pH value to 6.0-7.0, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 6
(1) preparation of active ingredient：Be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take grape
Sugar and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to 0.4mol/L in right amount
Solution, stirring be slowly added into solution 3, regulation pH value to 4.5-5.5, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 7
(1) preparation of active ingredient：Be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take xylose
Alcohol and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take Sodium hydroxide q. s, plus appropriate water for injection to be configured to 0.1mol/L
Solution, stirring be slowly added into solution 3, regulation pH value to 3.0-5.0, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 8
(1) preparation of active ingredient：Preparation method be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Sodium and potassium dihydrogen phosphate, add appropriate water for injection, are stirred to dissolve, obtain solution 2；By solution 1 and solution
It is 2-in-1 simultaneously to stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured in right amount
0.4mol/L solution, stirring is slowly added into solution 3, regulation pH value to 7.5-8.5, plus injection
Water 1000ml, filling, sealing is produced.
Embodiment 9
(1) preparation of active ingredient：Preparation method be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take sorb
Alcohol and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to 0.2mol/L in right amount
Solution, stirring be slowly added into solution 3, regulation pH value to 5.0-6.0, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 10
(1) preparation of active ingredient：Preparation method be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Sodium and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to 0.2mol/L in right amount
Solution, stirring be slowly added into solution 3, regulation pH value to 5.0-6.5, plus water for injection 1000ml,
Filling, sealing, is produced.
Embodiment 11
(1) preparation of active ingredient：Preparation method be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Magnesium, adds appropriate water for injection, is stirred to dissolve, obtains solution 2；Solution 1 and solution is 2-in-1 simultaneously, stirring
Uniformly, solution 3 is obtained；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to the molten of 0.4mol/L in right amount
Liquid, stirring is slowly added into solution 3, regulation pH value to 6.5-8.5, plus water for injection 1000ml, is filled
Dress, sealing, are produced.
Embodiment 12
(1) preparation of active ingredient：Preparation method be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Sodium and citric acid, add appropriate water for injection, are stirred to dissolve, obtain solution 2；Solution 1 and solution is 2-in-1
And, stir, obtain solution 3；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to 0.4mo1/L in right amount
Solution, it is appropriate to add Aspartame, stirs, is slowly added into solution 3, regulation pH value to
4.0-7.0, plus water for injection 1000ml, filling, sealing, are produced.
Embodiment 13
(1) preparation of active ingredient：Preparation method be the same as Example 1.
(2) preparation of anxious branch Neulized inhalation solution：
Active ingredient is weighed by recipe quantity, appropriate water for injection is added, stirs, obtain solution 1；Take chlorination
Sodium, adds appropriate water for injection, is stirred to dissolve, obtains solution 2；Solution 1 and solution is 2-in-1 simultaneously, stirring
Uniformly, solution 3 is obtained；It is another to take disodium hydrogen phosphate appropriate, plus water for injection is configured to the molten of 0.4mol/L in right amount
Liquid, adds flavouring in right amount, stirs, be slowly added into solution 3, adjusts pH value to 4.0-7.0,
Plus water for injection 1000ml, filling, sealing, produce.
Claims (10)
1. a kind of anxious branch Neulized inhalation pharmaceutical solutions, it is characterised in that including (1) anxious branch active ingredient；
(2) isotonic agent and solvent；
Wherein, the mass ratio of active ingredient and isotonic agent is 1: 1-1: 5.
2. preparation according to claim 1, it is characterised in that active ingredient is prepared obtaining：
10-250 parts of cordate houttuynia, 10-250 parts of cymose buckwheat rhizome, 10-250 parts of Chinese holly, 5-150 parts of aster,
5-100 parts of the root of purple-flowered peucedanum, 5-100 parts of Fructus Aurantii, 5-60 parts of Chinese ephedra, 5-60 parts of radix glycyrrhizae
Eight taste medicines are weighed according to above-mentioned parts by weight, and cordate houttuynia, Fructus Aurantii add water distillation, collect distillate；The dregs of a decoction
Add water to cook secondary, filtration with the Six-element such as remaining Fagopyrum cymosum Meisn, merging filtrate, be concentrated into it is appropriate, with above-mentioned steaming
Distillate merges, and obtains the active ingredient of the present invention.
3. preparation according to claim 1, it is characterised in that described isotonic agent is sodium chloride, chlorine
Change one kind in potassium, magnesium chloride, calcium chloride, glucose, xylitol, sorbierite.
4. preparation according to claim 1, it is characterised in that also include buffer solution in said preparation.
5. preparation according to claim 4, it is characterised in that described buffer solution is citric acid-lemon
Lemon acid sodium, citrate-phosphate disodium hydrogen, potassium dihydrogen phosphate-disodium hydrogen phosphate, citric acid-sodium hydroxide, Chinese holly
One kind in rafter acid-disodium hydrogen phosphate.
6. preparation according to claim 1, it is characterised in that Neulized inhalation is with the pH value of solution
3.0-8.5。
7. preparation according to claim 7, it is characterised in that Neulized inhalation is with the pH value of solution
4.0-7.0。
8. preparation according to claim 1, it is characterised in that Neulized inhalation is anxious with the consumption of solution
0.01-1.0 times of branch syrup consumption.
9. preparation according to claim 8, it is characterised in that Neulized inhalation is anxious with the consumption of solution
0.05-0.8 times of branch syrup consumption.
10. preparation according to claim 9, it is characterised in that Neulized inhalation is with the consumption of solution
0.1-0.5 times of jizhi syrup consumption.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104567672A (en) * | 2014-12-25 | 2015-04-29 | 北京无线电计量测试研究所 | Large compact range scanning frame system and method for adjusting space geometric quantity of scanning frame system |
| CN109745364A (en) * | 2017-11-03 | 2019-05-14 | 北京盈科瑞创新药物研究有限公司 | A kind of cymose buckwheat rhizome Neulized inhalation pharmaceutical solutions and preparation method thereof |
| CN109939089A (en) * | 2017-12-21 | 2019-06-28 | 盈科瑞（横琴）药物研究院有限公司 | A kind of peaceful pharmaceutical solutions of sucking lung and preparation method thereof |
| CN110090244A (en) * | 2018-01-30 | 2019-08-06 | 北京盈科瑞创新药物研究有限公司 | A kind of sucking cruelly red pharmaceutical solutions of a kind of reed mentioned in ancient books and preparation method thereof |
| CN110090262A (en) * | 2018-01-30 | 2019-08-06 | 北京盈科瑞创新药物研究有限公司 | A kind of Compound Loquat cough-relieving sucking pharmaceutical solutions and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104567672A (en) * | 2014-12-25 | 2015-04-29 | 北京无线电计量测试研究所 | Large compact range scanning frame system and method for adjusting space geometric quantity of scanning frame system |
| CN104567672B (en) * | 2014-12-25 | 2017-07-04 | 北京无线电计量测试研究所 | A kind of large-scale scanning frame for compact antenna test range system and the method for adjustment to the scanning support system space geometric sense |
| CN109745364A (en) * | 2017-11-03 | 2019-05-14 | 北京盈科瑞创新药物研究有限公司 | A kind of cymose buckwheat rhizome Neulized inhalation pharmaceutical solutions and preparation method thereof |
| CN109939089A (en) * | 2017-12-21 | 2019-06-28 | 盈科瑞（横琴）药物研究院有限公司 | A kind of peaceful pharmaceutical solutions of sucking lung and preparation method thereof |
| CN110090244A (en) * | 2018-01-30 | 2019-08-06 | 北京盈科瑞创新药物研究有限公司 | A kind of sucking cruelly red pharmaceutical solutions of a kind of reed mentioned in ancient books and preparation method thereof |
| CN110090262A (en) * | 2018-01-30 | 2019-08-06 | 北京盈科瑞创新药物研究有限公司 | A kind of Compound Loquat cough-relieving sucking pharmaceutical solutions and preparation method thereof |
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