CN106860638A - Traditional Chinese medicinal aerosol and preparation method that a kind of cough-relieving apophlegmatic is relievingd asthma - Google Patents
Traditional Chinese medicinal aerosol and preparation method that a kind of cough-relieving apophlegmatic is relievingd asthma Download PDFInfo
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Abstract
Traditional Chinese medicinal aerosol and preparation method that cough-relieving apophlegmatic is relievingd asthma, described Traditional Chinese medicinal aerosol are made up of Chinese ephedra, semen armeniacae amarae, gypsum, honey-fried licorice root water extract and cosolvent, propellant, surfactant.Preparation method includes (1) Chinese ephedra, semen armeniacae amarae, gypsum, honey-fried licorice root, adds water to cook extraction twice, filtering, filtrate concentration, is condensed into powder processed after clear cream；(2) high score is asked to be well mixed with cosolvent, propellant, surfactant water extract, it is filling, propellant is pressed into, Traditional Chinese medicinal aerosol is obtained.The positive effect of the present invention is：Drug ingedient can be made to directly act on respiratory system focus, with targeting it is strong, tunica mucosa bronchiorum can be directly acted on, local drug concentration is high, while Neulized inhalation energy humidifying respiratory tract, is conducive to secretion to discharge, curative effect is high, it is easy to use the features such as.There is preferable therapeutic effect to diseases such as the infection of the upper respiratory tract, bronchitis and bronchial astehmas.Avoid oral stomach and intestine first pass effect, the adverse reaction of drug administration by injection.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of cough-relieving apophlegmatic of aerosol-type is relievingd asthma Chinese medicine.
Background technology
Cough, many phlegm, pant, the infection of the upper respiratory tract, bronchitis and bronchial astehma etc. be all a kind of clinically ratio
More typical illness, existing relieving cough and reducing sputum Chinese medicine is generally injection, tablet, capsule, oral liquid etc., Chinese patent CN
A kind of preparation methods of decoction containing ephedra, apricot kernel, gypsum, and licorice of 101480437B；The preparation method of the A Chinese ephedra and almond containing cough stopping sugar-pills of CN 103800478；
A kind of Chinese ephedra and almond containing cough stopping dripping pills of CN 1634476A and preparation method thereof, national drug standards WS-11363 (ZD-1363) -2002-
2012Z discloses Chinese ephedra and almond containing cough stopping tablet quality standard, mouth of the above with numb apricot, semen armeniacae amarae, gypsum and honey-fried licorice root as main component
Formulation, and exist that disintegration time is long, dissolution rate is low, absorption is poor after oral formulations are taken, liver sausage first pass effect and biology
The low problem of availability, does not reach preferable therapeutic effect.Traditional Chinese medicine adverse reaction is more, and security is poor, and preparation technology is multiple
It is miscellaneous, and administration inconvenience.
The content of the invention
The Traditional Chinese medicinal aerosol and preparation method relievingd asthma it is an object of the invention to provide a kind of cough-relieving apophlegmatic of convenient drug administration, use
In cough, many phlegm, pant, the infection of the upper respiratory tract, bronchitis and the disease treatment such as bronchial astehma, overcome existing treatment
Such disease medicament above shortcomings.
The Traditional Chinese medicinal aerosol that cough-relieving apophlegmatic of the invention is relievingd asthma, is made up of following percentage by weight raw material：Chinese ephedra, bitter apricot
The weight portion of extract 20~60 that benevolence, gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 10~30, propellant 30~50
Weight portion, the weight portion of surfactant 0~2.
The extract be 20~40 weight portion Chinese ephedras, 20~30 weight portion semen armeniacae amaraes, 40~80 weight portion gypsum, 10~
The extract that 30 weight portion honey-fried licorice roots are obtained through water extraction.
The aerosol is solution aerosol or suspension aerosol.
The cosolvent is water, ethanol, propane diols are combined in any proportion；The surfactant be oleic acid, sapn or
Tween；The propellant is hydrofluoroalkane or compressed air.
The preparation method of the Traditional Chinese medicinal aerosol that cough-relieving apophlegmatic of the invention is relievingd asthma, it is characterised in that comprise the following steps：
(1) 20~40 weight portion Chinese ephedras, 20~30 weight portion semen armeniacae amaraes, 40~80 weight portion gypsum, 10~30 weight are taken
Part honey-fried licorice root, is added water to cook twice, and 6~10 times of water of amount of quality of medicinal material are added for the first time, is decocted 1~2 hour, is added for the second time
The decocting of 6~8 times of amounts of quality of medicinal material is boiled 0.5~2 hour, collecting decoction, filtration, filtrate concentration, is concentrated into close at 60~80 DEG C
The clear cream for 1.05~1.2 is spent, or clear cream is spray-dried, be crushed to 1~10 μm of medicinal powder of particle diameter；
(2) extract obtained 20~60 weight portion of step (1), the weight portion of cosolvent 10~30, the weight of propellant 30~50 are taken
Amount part, the weight portion of surfactant 0~2 is well mixed, filling, is pressed into propellant, and Traditional Chinese medicinal aerosol is obtained.
The clear cream spray drying condition is 150~180 DEG C of EAT, 75~95 DEG C of leaving air temp, atomizing pressure 0.2
~0.6MPa, spray velocity is 1~10ml/s.
The positive effect of the present invention is：Drug ingedient can be made to directly act on respiratory system focus, coughed for treatment,
The diseases such as asthma, many phlegm, with targeting it is strong, curative effect is high, it is easy to use the features such as.Test of pesticide effectiveness result of study shows to above exhaling
Inhaling the diseases such as road infection, bronchitis and bronchial astehma has preferable therapeutic effect.The present invention is directly administered with respiratory tract, is kept away
Exempt from oral stomach and intestine first pass effect, it is ensured that the adverse reaction of drug administration by injection can be avoided while drug effect.Aerosol inhalation method due to
Tunica mucosa bronchiorum can be directly acted on, local drug concentration is high, while Neulized inhalation energy humidifying respiratory tract, is conducive to secretion to arrange
Go out, instant effect few with consumption, carry easy, the advantages of easy to use, clinic popularization and application.
Specific embodiment
Embodiment 1
The Chinese Medicines type aerosol that a kind of cough-relieving apophlegmatic is relievingd asthma, is made up of following percentage by weight raw material：Chinese ephedra, bitter apricot
The weight portion of extract 40 that benevolence, gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 20, the weight portion of propellant 40.
Preparation method is as follows：
30 weight portion Chinese ephedras, 20 weight portion semen armeniacae amaraes, 60 weight portion gypsum, 10 weight portion honey-fried licorice roots are taken, two are added water to cook
Secondary, 6 times of water of amount of addition quality of medicinal material, decoct 2 hours for the first time, add 6 times of decoctings measured of quality of medicinal material to boil 1 for the second time small
When, collecting decoction, filtration, filtrate concentration is concentrated into the clear cream that 80 DEG C of density is 1.15；Ethanol and propane diols are added, makes the third two
Alcohol: ethanol: water reaches 1: 4: 5, mixes, filling, press-in, HFA-227ea.
Embodiment 2
The Chinese Medicines type aerosol that a kind of cough-relieving apophlegmatic is relievingd asthma, is made up of following percentage by weight raw material：Chinese ephedra, bitter apricot
The weight portion of extract 60 that benevolence, gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 10, the weight portion of propellant 30.
Preparation method is as follows：
40 weight portion Chinese ephedras, 15 weight portion semen armeniacae amaraes, 50 weight portion gypsum, 20 weight portion honey-fried licorice roots are taken, two are added water to cook
Secondary, 10 times of water of amount of addition quality of medicinal material, decoct 1 hour for the first time, add 10 times of decoctings measured of quality of medicinal material to boil 1 for the second time small
When, collecting decoction, filtration, filtrate concentration is concentrated into the clear cream that 80 DEG C of density is 1.05, adds ethanol and propane diols, makes the third two
Alcohol: ethanol: water reaches 1: 3: 6, mixes, filling, is pressed into HFC-134a.
Embodiment 3
The Chinese Medicines type aerosol that a kind of cough-relieving apophlegmatic is relievingd asthma, is made up of following percentage by weight raw material：Chinese ephedra, bitter apricot
The weight portion of extract 20 that benevolence, gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 30, the weight portion of propellant 50.
Preparation method is as follows：
25 weight portion Chinese ephedras, 20 weight portion semen armeniacae amaraes, 80 weight portion gypsum, 20 weight portion honey-fried licorice roots are taken, two are added water to cook
Secondary, 8 times of water of amount of addition quality of medicinal material, decoct 2 hours for the first time, add 8 times of decoctings measured of quality of medicinal material to boil 1.5 for the second time small
When, collecting decoction, filtration, filtrate concentration is concentrated into the clear cream that 80 DEG C of density is 1.2, adds ethanol and propane diols, makes propane diols
: ethanol: water reaches 1: 2: 7, mix, it is filling, it is pressed into compressed air.
Embodiment 4
The Chinese medicine suspension aerosol that a kind of cough-relieving apophlegmatic is relievingd asthma, is made up of following percentage by weight raw material：Chinese ephedra, bitter apricot
The weight portion of extract 40 that benevolence, gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 18, the weight portion of surfactant 2 is thrown
Penetrate the weight portion of agent 40.
Preparation method is as follows：
30 weight portion Chinese ephedras, 20 weight portion semen armeniacae amaraes, 60 weight portion gypsum, 10 weight portion honey-fried licorice roots are taken, two are added water to cook
Secondary, 6 times of water of amount of addition quality of medicinal material, decoct 2 hours for the first time, add 6 times of decoctings measured of quality of medicinal material to boil 1 for the second time small
When, collecting decoction, filtration, filtrate concentration is concentrated into the clear cream that 80 DEG C of density is 1.15, and spray drying condition is EAT
150 DEG C, 75 DEG C of leaving air temp, atomizing pressure 0.3MPa, spray velocity is 5ml/s, is crushed to 5 μm of particle diameter, adds ethanol and third
Glycol, makes propane diols: ethanol: water reaches 1: 4: 5, and the weight portion of sapn 2 is mixed, filling, press-in, HFC-134a.
Embodiment 5
The Chinese medicine suspension aerosol that a kind of cough-relieving apophlegmatic is relievingd asthma, is made up of following percentage by weight raw material：Chinese ephedra, bitter apricot
The weight portion of extract 59 that benevolence, gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 10, the weight portion of surfactant 1 is thrown
Penetrate the weight portion of agent 30.
Preparation method is as follows：
40 weight portion Chinese ephedras, 15 weight portion semen armeniacae amaraes, 50 weight portion gypsum, 20 weight portion honey-fried licorice roots are taken, two are added water to cook
Secondary, 10 times of water of amount of addition quality of medicinal material, decoct 1 hour for the first time, add 10 times of decoctings measured of quality of medicinal material to boil 1 for the second time small
When, collecting decoction, filtration, filtrate concentration is concentrated into the clear cream that 80 DEG C of density is 1.05, and spray drying condition is EAT
160 DEG C, 80 DEG C of leaving air temp, atomizing pressure 0.4MPa, spray velocity is 6ml/s, is crushed to 8 μm of particle diameter, adds ethanol and third
Glycol, makes propane diols: ethanol: water reaches 1: 3: 6, and the weight portion of oleic acid 1 is mixed, filling, is pressed into HFC-134a.
Embodiment 6
The Chinese medicine suspension aerosol that a kind of cough-relieving apophlegmatic is relievingd asthma, is made up of following percentage by weight raw material：Chinese ephedra, bitter apricot
The weight portion of extract 20 that benevolence, gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 30, the weight portion of surfactant 2 is thrown
Penetrate the weight portion of agent 48.
Preparation method is as follows：
25 weight portion Chinese ephedras, 20 weight portion semen armeniacae amaraes, 80 weight portion gypsum, 20 weight portion honey-fried licorice roots are taken, two are added water to cook
Secondary, 8 times of water of amount of addition quality of medicinal material, decoct 2 hours for the first time, add 8 times of decoctings measured of quality of medicinal material to boil 1.5 for the second time small
When, collecting decoction, filtration, filtrate concentration is concentrated into the clear cream that 80 DEG C of density is 1.2, and spray drying condition is EAT 170
DEG C, 85 DEG C of leaving air temp, atomizing pressure 0.5MPa, spray velocity is 8ml/s, is crushed to 4 μm of particle diameter, adds ethanol and the third two
Alcohol, makes propane diols: ethanol: water reaches 1: 2: 7, and the weight portion of tween 2 is mixed, filling, is pressed into HFC-134a.Pharmacodynamic study
1 experiment material：
1.1 test drugs：Medicine of the present invention is prepared according to the method for embodiment 1；Chinese ephedra and almond containing cough stopping piece：The limited duty of Fusong County Chinese medicine
Ren companies；Hydrochloric acid matches sieve oxazoline nasal spray：Hubei Grand Everyday Bright Eyes Pharmaceutical Co., Ltd.,；Jizhi syrup：Taiji Group weight
Celebrating Fuling Pharmaceutical Factory Co., Ltd；Budinad fog preparation：Lunan Beite Pharmaceutical Co., Ltd..
1.2 strains：Pneumococcus
1.3 culture mediums：Blood agar basal medium, GAM broth bouillons.
2 experimental animals
Wistar rats 130,180-220g, male and female half and half are bought in the zoopery of Bethune medical college of Jilin University
Center；ICR mouse 70,18-22g, male and female half and half are bought in Bethune medical college of Jilin University animal experimental center.
3 instruments：
Inverted microscope CDS-1 types：Chongqing optical instrument factory；Clean bench SW-CJ-IF types：Su Jing groups Suzhou peace
Safe air technique Co., Ltd；Precision electronic balance ESJ60-4：Longteng Electronic Weighing Instrument Co., Ltd., Shenyang.Steam sterilizing
Device (YXQ-LS-50SII types, Shanghai medical apparatus and instruments factory of Bo Xun Industrial Co., Ltd.s), hot air sterilizer (GR-246 types, Shanghai
Medical apparatus and instruments factory of Bo Xun Industrial Co., Ltd.s)；ELIASA (SMP-500-18272-LSI0 types, Manufactured in China
Designed in California USA)；
4 experimental techniques
4.1 pairs of influences of the infection of the upper respiratory tract
4.1.1 animal packet and modeling
70 ICR mouse are divided into 7 groups at random, respectively blank control group, model control group, positive controls and fiber crops
Apricot cough stopping tablet group, high, medium and low dosage group of the invention, every group 10.The pneumonia obtained to culture with 0.9% physiological saline of sterilizing
It is 1.2 × 10 that coccus is deployed into concentration9CFU/mL bacterium solutions.75% ethanol disinfection mouse external nares, oral cavity and head, treat that ethanol is waved
After dry, ether light anesthesia state dorsal position collunarium, blank control group mouse 0.9% physiological saline collunarium of sterilizing, remaining is each
Group bacterium solution collunarium modeling, per the μ l of mouse 20.
4.1.2 it is administered
Since the modeling same day, it is administered in the following manner：Positive controls (hydrochloric acid match sieve oxazoline nasal spray) are per mouse
10 μ l, twice a day, continuous two days；The high, medium and low dosage group of the present invention (14.6,8.8,2.9g crude drugs/kg), spray delivery, often
Mouse 10 μ l, continuous two days；Chinese ephedra and almond containing cough stopping piece (2.9g crude drugs/kg) gastric infusion, twice a day, continuous two days.Respectively at administration
1,4,7,14 days de- cervical vertebras put to death each group mouse totally 7 after twice and after the completion of administration.
4.1.3 Immunoglobulin culture
Ethanol disinfection external nares, oral cavity and head are first used before sacrifice, mouse is put to death after ethanol is volatilized, to sterilize
0.9% physiological saline does pharynx nasalis lavation, every time 50 μ l, and lavation is twice.Take the μ l of irrigating solution 5 to coat on agar plate, be placed in
Clump count is counted after 48h is cultivated in 37 DEG C of insulating boxs and with CFU/ mouse statistics.
4.1.4 result
Compare with model group, after being administered twice, pneumococcus clump count substantially subtracts high dose group of the present invention within the 1st, 4,7 days
Few (P<0.05)；After being administered twice, pneumococcus clump count significantly reduces (P to middle dose group within the 1st, 4,7 days<0.05)；Low dose
After being administered twice, pneumococcus clump count significantly reduces (P to amount group within the 1st day<0.05) after, Chinese ephedra and almond containing cough stopping piece group is administered twice,
Clump count reduces (P within 1st day<0.05).It is shown in Table 3
The resistance to streptococcus pneumonia colony counting (Mean ± SD.n=10) of the Chinese ephedra and almond containing cough stopping spray of table 3
Compare with blank group,#P<0.05；Compare with model group,*P<0.05.
4.2 pairs of effects of rat acute bronchitis
4.2.1 modeling method
60 rats beyond blank control group (n=10) are placed in the smoke-box of special 80cm × 80cm × 40cm,
Add sawdust face 10g with 20 cigarettes every time, mixing sootiness 30min, continues 15 by 2 times/day every time.Blank control group is then placed in
Raised in normal smokeless environment.
4.2.2 packet and administration
Rat model 60 is taken at the 15th day, 6 groups, every group 10 are randomly divided into.Group sets and is respectively：Model control group
(8.1g gives birth to for (distilled water), jizhi syrup group (20ml/kg), Chinese ephedra and almond containing cough stopping piece group (2.0g crude drugs/kg), high dose group of the present invention
Medicine/kg), middle dose group (4.0g crude drugs/kg), low dose group (2.0g crude drugs/kg), active compound group gastric infusion, jizhi syrup group
Volume gastric infusion is administered by 20ml/kg, remaining each group rat takes aerosol drug delivery mode, 1 times/day, continuous 5 days.
4.2.3 Indexs measure
1h after last dose, femoral artery takes blood, and 2500rpm room temperatures are centrifuged 20 minutes, separate serum, are surveyed using Elisa methods
Fixed each index.To rat blood serum IL-6, the influence of IL-8, TNF- ɑ, NF-kB, sICAM-1
4.2.4 result
From table 5,6, compare with blank control group, model control group can significantly raise IL-6 in rat blood serum, IL-8,
The content of TNF- ɑ, NF-kB, sICAM-1；Compare with model control group, positive controls, high, medium and low dosage group of the invention are equal
The content of IL-6, IL-8, TNF- ɑ, NF-kB, sICAM-1 can be reduced.
Table 5 is to rat blood serum IL-6, the influence of IL-8
Compare with blank group,#P<0.05；Compare with model group,*P<0.05
Influence of the table 6 to rat blood serum TNF- ɑ, NF-kB, sICAM-1
Compare with blank group,#P<0.05,##P<0.01,###P<0.001；Compare with model group,*P<0.05,**P<
0.01,***P<0.001
4.3 pairs of influences of bronchial astehma
4.3.1 packet and modeling
Healthy male Wistar rat 70, is divided into Normal group, asthmatic model group, positive controls (cloth at random
Desonide aerosol) and Chinese ephedra and almond containing cough stopping piece group (2.0g crude drugs/kg), high, medium and low dosage group of the invention (8.1,4.05,2.0g lifes
Medicine/kg), every group 10.In addition to blank group, remaining rat equal intraperitoneal injection aluminium hydroxide 200mg's and egg protein 100mg
1mL mixed liquor sensitization, two weeks after give egg protein ultrasonic atomizatio and excite, once a day；Administration group rat before exciting every time
30min, gives positive drug and Chinese ephedra and almond containing cough stopping aerosol, Chinese ephedra and almond containing cough stopping piece, continuous 2 weeks respectively；Control rats intraperitoneal injection and
Neulized inhalation physiological saline.Each group rat was put to death in the 14th day after administration, and detects corresponding index.
4.3.2 bronchoalveolar lavage fluid of rats (BALF) is obtained with 9% chloraldurate with 3ml/kg intraperitoneal injection of anesthesia
Rat, ligatures right principal bronchus and does transverse incision in rat trachea bottom first behind opening thoracic cavity, through otch injection 4mL sterilizing lifes
Resorption obtains BALF after the left lung 15s of reason saline lavage.The BALF centrifugations that will be obtained, with the resuspended addition blood count of physiological saline
Device, counted for total White WBC, eosinophil number (EOS) is calculated according to various types of cells percentage under the microscope.
4.3.3 tracheal wall and wall side lung tissue EOS infiltration density take each group rat middle lobe of right lung and are organized in paraformaldehyde
It is dehydrated after fixation, embedded, is cut into slices, row HE dyeing, the infiltration of lung tissue EOS by 400 times of light Microscopic observation bronchial walls and its wall
Situation；Randomly select 10 visuals field and count EOS, take the average value in each visual field as typical value.
4.3.4IL-5 its supernatant is taken after determining BALF centrifugations, IL-5 levels is determined with ELISA, in strict accordance with kit
Specification is carried out.
4.3.5 result
4.3.5.1 after ordinary circumstance modeling, asthma group rat occur obvious irritated, short of breath, abdominal muscle quickly twitch,
The asthma attack symptoms such as cough, present invention group rat attack degree substantially mitigates compared with asthma group, and control rats are without obvious asthma
Breaking-out symptom.4.3.5.2BALF middle WBC and EOS quantity, IL-5 levels, IL-5 levels and WBC and EOS numbers in administration group BALF
Amount is less than asthma group, and is higher than Normal group.It is shown in Table 7.
4.3.5.3 tracheal wall and wall side lung tissue EOS wettabilities control group, asthma group, Chinese ephedra and almond containing cough stopping piece group and the present invention
The wettability of high, medium and low dosage group rat trachea wall and wall side lung tissue EOS be respectively under 400 times of light microscopics each visual field (7 ±
2), (29 ± 6), (22 ± 3), (16 ± 2), (19 ± 4), (21 ± 4) individual cell, statistically significant (the P ＜ of comparing difference
0.05), administration group is less than asthma group.
WBC and EOS quantity, IL-5 levels in the BALF of table 7
Compare with blank group,#P<0.05,##P<0.01,###P<0.001；Compare with model group,*P<0.05,**P<
0.01,***P<0.001
5. conclusion
It is above-mentioned test result indicate that, the infection of the upper respiratory tract mouse that causes to pneumococcus of the present invention has substantially treatment to make
With, to rat acute bronchitis and bronchial astehma have good therapeutic effect, can effectively reduce inflammatory factor level, and effect
Fruit is substantially better than Chinese ephedra and almond containing cough stopping piece group.
Claims (2)
1. the Traditional Chinese medicinal aerosol that cough-relieving apophlegmatic is relievingd asthma, it is characterized in that：It is made up of following percentage by weight raw material：Chinese ephedra, semen armeniacae amarae,
The weight portion of extract 20~60 that gypsum, honey-fried licorice root water extraction are obtained, the weight portion of cosolvent 10~30, the weight of propellant 30~50
Part, the weight portion of surfactant 0~2；
The extract is 20~40 weight portion Chinese ephedras, 20~30 weight portion semen armeniacae amaraes, 40~80 weight portion gypsum, 10~30 weights
The extract that amount part honey-fried licorice root is obtained through water extraction；
The aerosol is solution aerosol or suspension aerosol；
The cosolvent is water, ethanol, propane diols are combined in any proportion；The surfactant is oleic acid, sapn or tween；
The propellant is hydrofluoroalkane or compressed air.
2. the preparation method of the Traditional Chinese medicinal aerosol that a kind of cough-relieving apophlegmatic as claimed in claim 1 is relievingd asthma, it is characterised in that including
Following steps：
(1) 20~40 weight portion Chinese ephedras, 20~30 weight portion semen armeniacae amaraes, 40~80 weight portion gypsum, 10~30 weight portions are taken to process
Radix Glycyrrhizae, is added water to cook twice, and 6~10 times of water of amount of quality of medicinal material are added for the first time, is decocted 1~2 hour, and medicinal material is added for the second time
The decocting of 6~8 times of amounts of quality is boiled 0.5~2 hour, collecting decoction, filtration, filtrate concentration, and density is when being concentrated into 60~80 DEG C
1.05~1.2 clear cream, or clear cream is spray-dried, it is crushed to 1~10 μm of medicinal powder of particle diameter；
(2) extract obtained 20~60 weight portion of step (1) is taken, the weight portion of cosolvent 10~30, the weight portion of propellant 30~50,
The weight portion of surfactant 0~2 is well mixed, filling, is pressed into propellant, and Traditional Chinese medicinal aerosol is obtained；
The clear cream spray drying condition be 150~180 DEG C of EAT, 75~95 DEG C of leaving air temp, atomizing pressure 0.2~
0.6MPa, spray velocity is 1~10ml/s.
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| CN107773592A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of child cough and panting Neulized inhalation pharmaceutical solutions and preparation method thereof |
| CN110090262A (en) * | 2018-01-30 | 2019-08-06 | 北京盈科瑞创新药物研究有限公司 | A kind of Compound Loquat cough-relieving sucking pharmaceutical solutions and preparation method thereof |
| CN112587602A (en) * | 2020-12-23 | 2021-04-02 | 上海市第七人民医院(上海中医药大学附属第七人民医院) | Traditional Chinese medicine composition for relieving cough and reducing sputum, extract and preparation method and application thereof |
| CN117379484A (en) * | 2023-12-13 | 2024-01-12 | 内蒙古自治区农牧业科学院 | Cattle and sheep pneumonia aerosol and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107773592A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of child cough and panting Neulized inhalation pharmaceutical solutions and preparation method thereof |
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| CN117379484A (en) * | 2023-12-13 | 2024-01-12 | 内蒙古自治区农牧业科学院 | Cattle and sheep pneumonia aerosol and preparation method and application thereof |
| CN117379484B (en) * | 2023-12-13 | 2024-03-15 | 内蒙古自治区农牧业科学院 | Cattle and sheep pneumonia aerosol and preparation method and application thereof |
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