CN106974290A - A kind of health-preserving food for preventing and treating intractable oral cavity ulcer - Google Patents

A kind of health-preserving food for preventing and treating intractable oral cavity ulcer Download PDF

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Publication number
CN106974290A
CN106974290A CN201710363659.7A CN201710363659A CN106974290A CN 106974290 A CN106974290 A CN 106974290A CN 201710363659 A CN201710363659 A CN 201710363659A CN 106974290 A CN106974290 A CN 106974290A
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China
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health
clam worm
preserving food
spirulina
parts
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CN201710363659.7A
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Chinese (zh)
Inventor
许凌川
方志勇
方志林
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Fujian Sea Beauty Marine Biotechnology Co Ltd
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Fujian Sea Beauty Marine Biotechnology Co Ltd
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Priority to CN201710363659.7A priority Critical patent/CN106974290A/en
Publication of CN106974290A publication Critical patent/CN106974290A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/36—Freezing; Subsequent thawing; Cooling
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/40—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by drying or kilning; Subsequent reconstitution
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/40—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by drying or kilning; Subsequent reconstitution
    • A23L3/44—Freeze-drying
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/85—Food storage or conservation, e.g. cooling or drying

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  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides a kind of health-preserving food for preventing and treating intractable oral cavity ulcer.The health-preserving food is mainly prepared from by clam worm, chitosan, spirulina and auxiliary material, wherein clam worm is used as major ingredient, functionally complemented each other with the active component in chitosan and spirulina and Synergistic, efficiently treat intractable oral cavity ulcer so that the health-preserving food has, prevent its recurrent exerbation, the advantage treated both principal and secondary aspect of disease and had no toxic side effect.The perinereis aibihitensis Grube that the preferred perinereis aibihitensis Grube of clam worm of the present invention, especially Zhangzhou, Fujian Dongshan Island waters are obtained, above-mentioned clam worm is rich in amino acid, Zn such as glutamic acid2+Deng trace element, taurine, Lumbrokinase, fibrinolysin, active peptide and biosterin isoreactivity material and heavy metal free pollution, therefore, the health-preserving food being made up of above-mentioned clam worm, quality better, health care effect are also more protruded.

Description

A kind of health-preserving food for preventing and treating intractable oral cavity ulcer
Technical field
The present invention relates to health-preserving food field, eaten in particular to a kind of health for preventing and treating intractable oral cavity ulcer Product.
Background technology
Intractable oral cavity ulcer, also known as " Ah not stomatitis ", the traditional Chinese medical science is referred to as " aphtha ", is the table occurred on mucous membrane of mouth Fester, size can be from the grain of rice to soya bean size, rounded or ellipse, and ulcer surface is recessed, and surrounding is congested.Intractable oral cavity Ulcer have periodically, recurrent and localized character, lip, cheek, tongue source etc. are apt to occur in, especially to occur the most pain on tongue body Hardship, hurt like hell, it is difficult to feed and speak, it is not easy to fully recover.During morbidity, more with phenomenons such as constipation, halitosis.
The definite cause of disease of intractable oral cavity ulcer so far still can not be completely clear and definite, it is generally accepted that intractable oral cavity ulcer It is the result of many factors comprehensive function.Immune, h and E be probably intractable oral cavity ulcer morbidity " three because Element ", i.e. genetic background and appropriate environmental factor (including the neural constitution of spirit, Psychology and behavior state, life and work and social ring Border etc.) abnormal immune response can be triggered and intractable oral cavity ulcer feature lesions occur.Also it has been proposed that " bigeminy factor " By, i.e., extrinsic factor (virus and bacterium) and endogenous inducement (change of hormone, psychologic factors, nutritional deficiency, Systemic disease and immunologic function disorder) interact and cause a disease.
Existing intractable oral cavity ulcer medicine mainly has：Local antibacterial medicine such as Chlorhexidine Acetate Gargles, aureomycin Ointment, gentamicin pad pasting etc.；Topical corticosteroid such as hydrocortisone medicine film, beclomethasone gargle or spray etc.； Local analgesia agent such as benzydamine gargle or spray, local anesthetic gel etc.；Other local anti-inflammatory preparation such as nasmils stop Cough syrup, prostaglandin E2 glue etc.；Systemic administration such as prednisolone, miaow sulphur purine, levamisol, colchicine etc..
Although above medicine can produce different degrees of therapeutic effect to intractable oral cavity ulcer, take stopgap measures and do not control This, the state of an illness of patient easily occurs repeatedly, when it is good when bad, influence diet and daily life, bring very big puzzlement to patient.Meanwhile, on Medicine is stated there is also different degrees of adverse reaction and side effect, such as some medicines are irritant to mucous membrane of mouth, patient feels It is uncomfortable or be easily caused the overall constitution of people and decline.
Therefore, this area urgently propose one kind can treat both principal and secondary aspect of disease, avoid intractable oral cavity ulcer recurrent exerbation and simultaneously without The health-preserving food of side effect.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of health-preserving food for treating intractable oral cavity ulcer, the health-preserving food energy Enough effectively treatment intractable oral cavity ulcers, prevent from recurring and have no toxic side effect.
The second object of the present invention is a kind of method for preparing above-mentioned health-preserving food of offer, can be fast by this method Speed, easily prepare it is above-mentioned be used to treat the health-preserving food of intractable oral cavity ulcer, be easy to large-scale production.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of health-preserving food for treating intractable oral cavity ulcer, by weight, the health-preserving food are main by following original Material is prepared from：10~15 parts of 30~40 parts of clam worm, 10~15 parts of chitosan, 10~15 parts of spirulina and auxiliary material.
Clam worm, is commonly called as extra large centipede, extra large leech, extra large silkworm or marine borer, with high nutritive value and medical value.《Book on Chinese herbal medicine Detailed outline》Record the medicinal efficacy of " extra large silkworm "：Long term usage qi-restoratives is won, and makes us gloss, macrobiosis of making light of one's life by commiting suicide is not old.Modern scientific research discovery, Clam worm rich in sulphur guanidine derivative, deep-sea hydroxyl protoferriheme, arenicochrome, purine nucleotides, biosterin, active peptide, The medicinal ingredients such as taurine, Lumbrokinase, fibrinolysin and lysozyme, and Zn2+Deng trace element, immunogenic amino acid (glutamic acid And glycine), the nutriment such as essential amino acid and unsaturated fatty acid ester class.
Chitosan (chitosan), also referred to as chitosan, are the products of chitin (chitin) deacetylate, its is wide In the general shell for being present in the shellfish such as crab, shrimp, and the cell membrane of fungi such as mushroom.Chitosan is positively charged sun Ion animal food fiber, is the alkaline polysaccharide that nature is uniquely present again, with important physiological function, is referred to as 20 Centurial functional food.Chitosan is not only able to supplement the nutrient of needed by human body, moreover it is possible to the effectively life of regulation human body Reason activity, it is both domestic and external it is widely studied show, it has lipid-loweringing, hypoglycemic, immunological regulation, improves the work of functions of intestines and stomach and fat-reducing With.
Spirulina (Spirulina) is a kind of in glaucous many cells filamentous cyanobacteria, belongs to low aquatic organism, edible algae Class, containing abundant protein (60%~70%), vitamin (especially B12 and content beta-carotene are higher), polysaccharides, The multiple biological activities composition such as trace element, because it has higher nutrition and medicinal health care function, is caused extensively in recent years Research.Phycobniliprotein is a kind of wherein critically important active material, with anti-oxidant, anti-inflammatory, neuroprotection and liver protection function； The content of beta carotene accounts for 69.5% of carotenoid total content in spirulina in spirulina, with reduction cholesterol and reduction The characteristics of cancered risk；Polysaccharides have antiviral, antineoplastic effect, and can reduce the cancered probability of animal；γ- Leukotrienes has certain curative effect for reduction cholesterol.
The above-mentioned health-preserving food of the present invention is mainly made up of clam worm, chitosan, spirulina and auxiliary material.Although prior art is Open clam worm, chitosan and spirulina have certain health-care effect, but prior art above-mentioned raw materials list not on the books Solely or be applied in combination have effects that treatment intractable oral cavity ulcer.It has been found, unexpectedly, being combined by above-mentioned raw materials The health-preserving food of preparation can effectively treat intractable oral cavity ulcer, also, with the mode of general treatment intractable oral cavity ulcer Compare, the health-preserving food can effectively prevent intractable oral cavity ulcer recurrent exerbation.Due to for preparing above-mentioned health-preserving food Raw material be medicine-food two-purpose, property is gentle, therefore, the present invention be the health-preserving food also have human body will not be produced it is harmful Toxic side effect advantage.
In some embodiments, by weight, the health-preserving food is mainly prepared from the following materials：Clam worm 32 10~13 parts of~38 parts, 12~15 parts of chitosan, 11~14 parts of spirulina and auxiliary material.
In some embodiments, by weight, the health-preserving food is mainly prepared from the following materials：Clam worm 33 10~12 parts of~36 parts, 12~13 parts of chitosan, 13~14 parts of spirulina and auxiliary material.
In some embodiments, by weight, the health-preserving food is mainly prepared from the following materials：Clam worm 30 Part, 10 parts of chitosan, 10 parts of spirulina and 10 parts of auxiliary material.
In some embodiments, by weight, the health-preserving food is mainly prepared from the following materials：Clam worm 35 Part, 13 parts of chitosan, 13 parts of spirulina and 12 parts of auxiliary material.
In some embodiments, by weight, the health-preserving food is mainly prepared from the following materials：Clam worm 40 Part, 15 parts of chitosan, 15 parts of spirulina and 15 parts of auxiliary material.
The present invention is adjusted to the proportioning of each raw material in above-mentioned health-preserving food so that clam worm, chitosan and spirulina it Between proportioning it is more reasonable, each other functionally have mutually support, collaboration interaction effect, so as to further lift above-mentioned health Food treats the effect of intractable oral cavity ulcer.
In some embodiments, clam worm be selected from perinereis aibihitensis Grube, curved tooth enclose clam worm, only tooth enclose clam worm, Perinereis nuntia, Flat tooth encloses the one or more that clam worm, Neantes japonica, sharp foot are pierced in clam worm, alum clam worm and kiss clam worm entirely.
In some embodiments, the clam worm is perinereis aibihitensis Grube, it is preferable that the perinereis aibihitensis Grube is Zhangzhou, Fujian The perinereis aibihitensis Grube that Dongshan Island waters captures or cultivated.
The method of the invention is preferably using perinereis aibihitensis Grube as raw material, and perinereis aibihitensis Grube is raw for the Gu guarded on evolving Thing, rich in various nutriments and active material, its amino acid, trace element, sterol, taurine, Lumbrokinase, fibrinolysin and work The content of property peptide is all substantially better than other clam worms, therefore, food of the present invention can be lifted by raw material of perinereis aibihitensis Grube Health-preserving function.
It is highly preferred that the perinereis aibihitensis Grube that the method for the invention is cultivated or captured using Zhangzhou, Fujian Dongshan Island waters is original Material.Zhangzhou, Fujian Dongshan Island is located at north latitude 23 ° 33 ' -23 ° 47 ', 17 ' -117 ° of 35' of east longitude 117 °, belongs to typical subtropical zone sea Domain, by Fujian Guangdong littoral flow, Kuroshio warm current and Nanhai Warm Current etc., a variety of stream systems dominate, and the water quality in the waters is limpid, heavy metal free is dirty Dye or eutrophication, the content of dissolved oxygen are high.In the waters, cultivation or the Growth of Perinereis aibuhitensis state captured are good, vigor is high, Nutrition content is abundant, heavy metal free pollution.Therefore, the present invention preferably using the waters obtain perinereis aibihitensis Grube as raw material, The quality of health-preserving food of the present invention can be obviously improved.
In some embodiments, the spirulina is spirulina maxim or blunt top spirulina.
In some embodiments, one kind in starch, Icing Sugar, dextrin, lactose, microcrystalline cellulose of the auxiliary material or It is a variety of；Preferably, the auxiliary material is starch and dextrin；It is highly preferred that the starch is cornstarch, the dextrin is pasted for malt Essence；It is highly preferred that the cornstarch is non-transgenic cornstarch.
In some embodiments, the health-preserving food is tablet, pulvis, granule, pill or paste, it is preferable that institute Health-preserving food is stated for tablet.
The invention further relates to the preparation method of above-mentioned health-preserving food, it the described method comprises the following steps：By each original of crushing Material is mixed, and health-preserving food is made.
The above method of the present invention can be prepared quickly and conveniently for treating intractable oral cavity by simply mixing The above-mentioned health-preserving food of ulcer, is easy to large-scale production.
In some embodiments, methods described before mixing, is pre-processed to clam worm in the following manner：By clam worm It is placed on 3~6h of standing under -16~-12 DEG C of environment；Take out and dry afterwards；Clam worm after drying at 80~105 DEG C baking 3~ 6h；Then the good clam worm of baking is crushed.
The above method of the present invention in a low temperature of -16~-12 DEG C by handling and in the special side of 80~105 DEG C of bakings Formula is handled clam worm.Wherein low-temperature treatment can make clam worm in a dormant state, keep the freshness of clam worm, it is to avoid nutrition The loss of material, meanwhile, low temperature can also kill the bacterium being attached on clam worm；And high temperature baking actually shortening process so that Clam worm can directly eat, meanwhile, heating can further be sterilized and inactivate protease, it is to avoid active ingredient is dropped Solution.
In some embodiments, methods described before mixing, is pre-processed to spirulina in the following manner：Take and wash Net spirulina grinds to form pureed, and pureed spirulina is placed in into 9~12h of processing at -25~-15 DEG C；Afterwards, microwave freezing is passed through Drying prepares spirulina powder.
The step of above method of the present invention also includes pre-processing spirulina, the spirulina powder obtained by the step The content of middle active component (such as phycobniliprotein) is high, is acted on higher nutrition and health, while good fluidity, is easy to add Work is molded.
Compared with prior art, beneficial effects of the present invention are：
1), health-preserving food of the present invention, which has, efficiently treats intractable oral cavity ulcer, prevents its recurrent exerbation, and sample is simultaneous The advantage controlled and had no toxic side effect.
2), health-preserving food of the present invention is preferably with the bidentate of perinereis aibihitensis Grube, especially Zhangzhou, Fujian Dongshan Island waters Enclose clam worm to be prepared from as raw material, the clam worm is rich in biosterin, amino acid, Zn2+Deng trace element, active peptide, ox sulphur Acid, Lumbrokinase and fibrinolysin isoreactivity material, nutritious, active component content is high, heavy metal free pollution, can further carry Rise the quality of the health-preserving food.
3), preparation method of the present invention can simply and quickly be made above-mentioned and be used to treat intractable oral cavity ulcer Health-preserving food, is easy to large-scale production；Also, the method for the invention also carries out special processing to clam worm and spirulina so that The health-preserving food finally prepared has the advantages that safety and sanitation, active component are intact.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, be The conventional products that can be obtained by commercially available purchase.
Embodiment 1
The health-preserving food for treating intractable oral cavity ulcer is prepared in the following manner：
1st, clam worm is pre-processed：The clam worm of new 15~22cm of living body length is taken, 13 DEG C of constant temperature in seawater or salt solution is put into and stands 48h so that clam worm drains internal debris totally naturally；Clam worm after debris is drained totally, which is placed at -14 DEG C, stands 4h, makes Clam worm keeps resting state, while killing the bacterium being attached on clam worm；Clam worm is taken out, in 100,000 grades of dustless glass sunlight houses certainly So dry, make the water content as little as 6% of clam worm；The baking 4h at 98 DEG C of the clam worm after drying is taken, makes the water content of clam worm as little as 3%；The good clam worm of baking is cooled to after room temperature, clam worm is crushed to 200 mesh with water cooling flour mill.
2nd, spirulina is pre-processed：By the filter-cloth filtering gathering screw algae of 350 mesh, and cleaned repeatedly with water, be to pH value 7；Fresh spirulina is laid in culture dish by thickness for 4mm, pre-freeze 9h in refrigerator is placed in, pre-freezing temperature is -25 DEG C.Will The good spirulina of pre-freeze is put into microwave vacuum freeze-drying device, and it is 35Pa and microwave drying power to set drying chamber pressure 120W, dries 5h, and the water content to spirulina is less than 7%.
3rd, by weight, by clam worm powder, chitosan, spirulina, non-transgenic cornstarch and maltodextrin by 30 parts, 10 parts, 10 parts, 5 parts and 5 parts of ratio, constant temperature mixed at high speed, tabletted with tablet press machine afterwards at 40 DEG C.
Embodiment 2
The health-preserving food for treating intractable oral cavity ulcer is prepared in the following manner：
1st, clam worm is pre-processed：The clam worm of new 15~22cm of living body length is taken, 13 DEG C of constant temperature in seawater or salt solution is put into and stands 48h so that clam worm drains internal debris totally naturally；Clam worm after debris is drained totally, which is placed at -14 DEG C, stands 4h, makes Clam worm keeps resting state, while killing the bacterium being attached on clam worm；Clam worm is taken out, in 100,000 grades of dustless glass sunlight houses certainly So dry, make the water content as little as 6% of clam worm；The baking 4h at 98 DEG C of the clam worm after drying is taken, makes the water content of clam worm as little as 3%；The good clam worm of baking is cooled to after room temperature, clam worm is crushed to 200 mesh with water cooling flour mill.
2nd, spirulina is pre-processed：By the filter-cloth filtering gathering screw algae of 350 mesh, and cleaned repeatedly with water, be to pH value 7；Fresh spirulina is laid in culture dish by thickness for 4mm, pre-freeze 10h in refrigerator is placed in, pre-freezing temperature is -20 DEG C. The good spirulina of pre-freeze is put into microwave vacuum freeze-drying device, it is 35Pa and microwave drying power to set drying chamber pressure 120W, dries 5h, and the water content to spirulina is less than 7%.
4th, by weight, by clam worm powder, chitosan, spirulina, non-transgenic cornstarch and maltodextrin by 35 parts, 13 parts, 13 parts, 5 parts and 7 parts of ratio, constant temperature mixed at high speed, tabletted with tablet press machine afterwards at 40 DEG C.
Embodiment 3
The health-preserving food for treating intractable oral cavity ulcer is prepared in the following manner：
1st, clam worm is pre-processed：The clam worm of new 15~22cm of living body length is taken, 13 DEG C of constant temperature in seawater or salt solution is put into and stands 48h so that clam worm drains internal debris totally naturally；Clam worm after debris is drained totally, which is placed at -14 DEG C, stands 4h, makes Clam worm keeps resting state, while killing the bacterium being attached on clam worm；Clam worm is taken out, in 100,000 grades of dustless glass sunlight houses certainly So dry, make the water content as little as 6% of clam worm；The baking 4h at 98 DEG C of the clam worm after drying is taken, makes the water content of clam worm as little as 3%；The good clam worm of baking is cooled to after room temperature, clam worm is crushed to 200 mesh with water cooling flour mill.
2nd, spirulina is pre-processed：By the filter-cloth filtering gathering screw algae of 350 mesh, and cleaned repeatedly with water, be to pH value 7；Fresh spirulina is laid in culture dish by thickness for 4mm, pre-freeze 12h in refrigerator is placed in, pre-freezing temperature is -15 DEG C. The good spirulina of pre-freeze is put into microwave vacuum freeze-drying device, it is 35Pa and microwave drying power to set drying chamber pressure 120W, dries 5h, and the water content to spirulina is less than 7%.
3rd, by weight, by clam worm powder, chitosan, spirulina, non-transgenic cornstarch and maltodextrin by 40 parts, 15 parts, 15 parts, 7 parts and 8 parts of ratio, constant temperature mixed at high speed, tabletted with tablet press machine afterwards at 40 DEG C.
Comparative example 1
The health-preserving food for treating intractable oral cavity ulcer is prepared with reference to embodiment 2, is differed only in, pretreatment is husky The step of silkworm, is omitted, and clam worm is removed from the raw material for preparing health-preserving food.
Comparative example 2
The health-preserving food for treating intractable oral cavity ulcer is prepared with reference to embodiment 2, is differed only in, spiral shell will be pre-processed The step of rotation algae, is omitted, and spirulina is removed from the raw material for preparing health-preserving food.
Comparative example 3
Prepare the health-preserving food for treating intractable oral cavity ulcer with reference to embodiment 2, differ only in, by chitosan from Prepare in the raw material of health-preserving food and remove.
Comparative example 4
The health-preserving food for treating intractable oral cavity ulcer is prepared with reference to embodiment 2, is differed only in, by weight Meter, by clam worm powder, chitosan, spirulina, cornstarch and maltodextrin in 30 parts, 5 parts, 5 parts, 3 parts and 2 parts of ratio, Constant temperature mixed at high speed, tabletted with tablet press machine afterwards at 40 DEG C.
Comparative example 5
The health-preserving food for treating intractable oral cavity ulcer is prepared with reference to embodiment 2, is differed only in, by weight Meter, by clam worm powder, chitosan, spirulina, cornstarch and maltodextrin in 40 parts, 25 parts, 25 parts, 10 parts and 8 parts of ratio, Constant temperature mixed at high speed, tabletted with tablet press machine afterwards at 40 DEG C.
Experimental example 1
Detect the effect that health-preserving food prepared by embodiment 1~3 and comparative example 1~5 promotes intractable oral cavity ulcer to heal Really：
1st, 90 male rats are taken, body weight 180-220g, 10% chloral hydrate anesthesia, dosage is 0.40ml/100g, anesthesia Afterwards by the interior plastic dropper (internal diameter for having a 90% phenol cotton balls：3mm) lower end is flat on the cheek film at rats with left bicker about 1mm On, calcination 30 seconds is shown in the white infringement of about 3mm at this.
2nd, 90 rats are grouped at random after 24 hours, every group 10, point 9 groups, i.e. control group, experimental group 1~3 and contrast Group 1~5.Wherein control group does not make any processing, and experimental group 1~3 distinguishes health-preserving food prepared by feeding embodiment 1~3, daily Feeding 4 times, each feeding 50mg, fed continuous 4 days；Health-preserving food prepared by the difference feeding of contrast groups 1~5 comparative example 1~5, Daily feeding 4 times, each feeding 50mg, fed continuous 4 days.
3rd, next day observation ulcer area size (in terms of the diameter of ulcer) after feeding, is designated as 0 day, specific inspection feeding day first Survey result as shown in table 1.
It can be seen from data shown in table 1, the healing state of rat described in experimental group 1~3 will be substantially better than control group and right Than group 1~3, show that clam worm has certain curative effect to canker sore, but the compounding of clam worm, chitosan and spirulina three can show Write enhancing clam worm treat intractable oral cavity ulcer effect, three have have complementary functions, the effect of Synergistic.And by experimental group 1~3 with contrast groups 4~5 be compared understand, the weight ratio of clam worm, chitosan and spirulina is limited to 30~40：10~15: In the range of 10~15, the effect of health-preserving food treatment intractable oral cavity ulcer is more preferable.
Influence of the health-preserving food of table 1 to intractable oral cavity ulcer healing state
Experimental example 2
Recurrent stubbornness canker sore patient 90, clinical manifestation with the local red and swollen and center ulcer of mucous membrane of mouth, erosion, Based on pain, without other non-cancer lesions, no medication history, no serious systemic disease.Patient is randomly divided into 9 groups, be respectively pair According to group, experimental group 1~3, contrast groups 1~5, wherein control group are without any processing, experimental group 1~3 take respectively embodiment 1~ 3 health-preserving foods prepared, 3 times a day, each 200mg, continuously takes 5 days, and contrast groups 1~5 take the system of comparative example 1~5 respectively Standby health-preserving food, 3 times a day, each 200mg, continuously takes 5 days.The cure rate of health-preserving food is evaluated after 5 days, and counts 1 Whether intractable oral cavity ulcer recurs in individual month, and concrete outcome is referring to table 2.
The standard of curative effect evaluation：Ulcer heals substantially, and without pain symptom is to cure；Ulcer has pain symptom, i.e., without improvement Not cure.
It can be seen from data shown in table 2, the controlling when treating intractable oral cavity ulcer of health-preserving food described in embodiment 1~3 More the health-preserving food that rate is prepared apparently higher than comparative example 1~3, shows that the compounding between clam worm, chitosan and spirulina has association With the effect of synergy, while the health-preserving food including above-mentioned three kinds of raw materials can significantly improve the cure rate of intractable oral cavity ulcer And reduce intractable oral cavity ulcer recurrent exerbation.
And experimental group 1~3 and contrast groups 4~5 are compared and understood, the weight ratio limit of clam worm, chitosan and spirulina It is scheduled on 30~40：10~15:In the range of 10~15, the effect of health-preserving food treatment intractable oral cavity ulcer and reduction recurrence probability Fruit is more preferably.
Therapeutic effect of the health-preserving food of table 2 to recurrent intractable oral cavity ulcer
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent The present invention is described in detail with reference to foregoing embodiments for pipe, but it will be understood by those within the art that：Its The technical scheme described in foregoing embodiments can still be modified, or to which part or all technical characteristic Carry out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention skill The scope of art scheme.

Claims (10)

1. a kind of health-preserving food for preventing and treating intractable oral cavity ulcer, it is characterised in that by weight, the health-preserving food master It is prepared from the following materials：30~40 parts of clam worm, 10~15 parts of chitosan, 10~15 parts of spirulina and auxiliary material 10~15 Part.
2. health-preserving food according to claim 1, it is characterised in that by weight, the health-preserving food it is main by with Lower raw material is prepared from：12 parts of 35 parts of clam worm, 13 parts of chitosan, 13 parts of spirulina and auxiliary material.
3. health-preserving food according to claim 1, it is characterised in that the clam worm is selected from perinereis aibihitensis Grube, curved tooth and encloses sand Silkworm, only tooth enclose clam worm, Perinereis nuntia, flat tooth enclose clam worm, Neantes japonica, sharp foot pierce full clam worm, alum clam worm and kiss clam worm in One or more.
4. health-preserving food according to claim 3, it is characterised in that the clam worm is perinereis aibihitensis Grube, it is preferable that described Perinereis aibihitensis Grube is the perinereis aibihitensis Grube that Zhangzhou, Fujian Dongshan Island waters captures or cultivated.
5. health-preserving food according to claim 1, it is characterised in that the spirulina is spirulina maxim or blunt top spiral Algae.
6. health-preserving food according to claim 1, it is characterised in that the auxiliary material be selected from starch, Icing Sugar, dextrin, lactose, One or more in microcrystalline cellulose；Preferably, the auxiliary material is starch and dextrin；It is highly preferred that the starch is corn Starch, the dextrin is maltodextrin；It is highly preferred that the cornstarch is non-transgenic cornstarch.
7. health-preserving food according to claim 1, it is characterised in that health-preserving food is tablet, pulvis, granule, pill Or paste, it is preferable that the health-preserving food is tablet.
8. the preparation method of any one of claim 1~7 health-preserving food, it is characterised in that the described method comprises the following steps：Will Each raw material crushed is mixed, and health-preserving food is made.
9. method according to claim 8, it is characterised in that before mixing, is located in advance to clam worm in the following manner Reason：Clam worm is placed on 3~6h of standing under -16~-12 DEG C of environment；Take out and dry afterwards；Clam worm after drying is at 80~105 DEG C 3~6h of baking；Then the good clam worm of baking is crushed.
10. method according to claim 8, it is characterised in that before mixing, is carried out pre- to spirulina in the following manner Processing：Take clean spirulina to grind to form pureed, pureed spirulina is placed in 9~12h of processing at -25~-15 DEG C；Afterwards, lead to Cross microwave freeze-drying and spirulina powder is made.
CN201710363659.7A 2017-05-22 2017-05-22 A kind of health-preserving food for preventing and treating intractable oral cavity ulcer Pending CN106974290A (en)

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