CN106967600A - Chip carrier, chip fixing component and sample load apparatus - Google Patents

Abstract

The present invention discloses a kind of chip carrier, and it includes chip link and suction pipe.The chip link is used to place nucleic acid sequencing chip, and the nucleic acid sequencing chip is formed with liquid inlet and liquid outlet.Described suction pipe one end is connected with the chip link and connected with the liquid inlet, and the suction pipe other end is used to draw nucleic acid molecules sample and reagent.In addition, being used for invention additionally discloses a kind of by the chip fixing component of the chip carrier fixation nucleic acid sequencing chip and the sample load apparatus with the chip fixing component and the chip carrier.The chip carrier, the chip fixing component, the sample load apparatus have the advantages that simple to operate, efficient, precision is high and success rate is high, and can avoid manually operating and polluting the gene sequencer.

Description

Chip carrier, chip fixing component and sample load apparatus

Technical field

The present invention relates to gene sequencing technology, more particularly to a kind of chip carrier, chip fixing component and sample load apparatus.

Background technology

Before gene sequencing is carried out, nucleic acid molecules sample need to be loaded on to nucleic acid sequencing chip, then could be using gene sequencer to nucleic acid Nucleic acid molecules sample in sequence testing chip is sequenced.At present, if nucleic acid molecules sample is loaded onto into nucleic acid sequencing core in gene sequencer In piece, then have that complex operation, efficiency is low, precision is low and the low problem of success rate, however, can not be by craft by nucleic acid molecules sample Product are loaded onto in nucleic acid sequencing chip.

The content of the invention

It is contemplated that at least solving one of technical problem present in prior art.Therefore, a kind of chip carrier of present invention offer, chip are solid Determine component and sample load apparatus.

The chip carrier of embodiment of the present invention includes：

Chip link, the chip link is used to place nucleic acid sequencing chip, and the nucleic acid sequencing chip is formed with liquid inlet and goes out liquid Mouthful；And

Suction pipe, described suction pipe one end is connected with the chip link and connected with the liquid inlet, and the suction pipe other end is used to draw core Acid molecule sample and reagent.

In some embodiments, the chip link molds shaping using PC, PP or PEEK；

Optionally, the chip link is formed with the liquid-entering hole for connecting the liquid inlet and the suction pipe, the liquid inlet with it is described enter liquid Hole is docked, and the suction pipe is connected with the liquid-entering hole；

The chip link is formed with the fluid hole for connecting the liquid outlet, and the liquid outlet is docked with the fluid hole.

In some embodiments, the nucleic acid sequencing chip includes die bottom surface, the chip link include connection top of support and Link bottom surface,

The liquid inlet and/or the liquid outlet are formed at the die bottom surface, and the liquid-entering hole and/or the fluid hole run through the connection Top of support and the link bottom surface.

In some embodiments, the chip link includes being arranged on the sealing ring of the liquid-entering hole and/or the fluid hole, it is described enter Liquid mouthful and/or the liquid outlet are docked with the sealing ring, and the suction pipe is connected with the sealing ring；

Optionally, the sealing ring is using medical grade silica gel or rubber die sinking shaping.

In some embodiments, the connection top of support is formed with the accepting groove connected with the liquid-entering hole or the fluid hole,

The chip link includes the elastomeric pad for being contained in the accepting groove, and the elastomeric pad includes and the liquid-entering hole or described The sealing ring portion of fluid hole connection,

The liquid inlet or the liquid outlet are docked with the sealing ring portion, and the suction pipe is connected with the sealing ring portion；

Optionally, the elastomeric pad is using medical grade silica gel or rubber die sinking shaping.

In some embodiments, the liquid inlet includes multiple, and the liquid outlet also includes multiple, each liquid outlet and corresponding one The number of individual liquid inlet connection, the liquid-entering hole and the suction pipe is corresponding with the number of the liquid inlet, the number of the fluid hole and The number correspondence of the liquid outlet.

The chip fixing component of embodiment of the present invention includes：

Mounting seat, the mounting seat is used to place the chip carrier；And

Clamping jaw, the clamping jaw is rotated with the mounting seat and is connected, described for the nucleic acid sequencing chip to be fixed on by the chip carrier In mounting seat.

In some embodiments, the mounting seat includes being used to install the mounting surface of the chip carrier and positioned at the mounting surface opposite end First side and second side, the mounting seat include be formed at the first pin-jointed structure of the first side and positioned at the second side The first snap-in structure；

The clamping jaw includes the 3rd side corresponding with the first side and four side corresponding with the second side, the clamping jaw bag Include be formed at the 3rd side and with first pin-jointed structure coordinate the second pin-jointed structure and positioned at the four side and with it is described The second snap-in structure that first snap-in structure coordinates；

The clamping jaw is rotated with the mounting seat by the pivot joint of first pin-jointed structure and second pin-jointed structure and is connected, and passes through institute The cooperation for stating the first snap-in structure and second snap-in structure is fixed in the mounting seat；

Optionally, the mounting seat includes the positioning boss that is upwardly extended from the mounting surface, the nucleic acid sequencing chip be formed with it is described The first locating slot that positioning boss coordinates, the chip carrier is formed with the second locating slot coordinated with the positioning boss, and the chip carrier leads to The cooperation for crossing second locating slot and the positioning boss is positioned in the mounting seat, and the nucleic acid sequencing chip is fixed by described first The cooperation of position groove and the positioning boss is positioned on the chip carrier；

Optionally, the side of first locating slot is formed with the first oriented structure, and the side of second locating slot is formed with the second orientation Structure, the side of the positioning boss be formed with the 3rd oriented structure that coordinates with first oriented structure and with second oriented structure The 4th oriented structure coordinated, second oriented structure coordinates with the 4th oriented structure to be installed for limiting the chip carrier described Direction on seat, first oriented structure coordinates for limiting the nucleic acid sequencing chip in the mounting seat with the 3rd oriented structure On direction；

Optionally, the chip carrier includes hog frame, and the hog frame is used to fix the suction pipe, and the chip fixing component includes strengthening Stand, for fixing the hog frame to limit the bearing of trend of the suction pipe；

Optionally, the hog frame includes installation sheet and fixes fin；The installation sheet is rectangular, and includes installation sheet top surface, installation Piece bottom surface, leading flank and trailing flank, the installation sheet are formed through the sipper pore of the installation sheet top surface and the installation sheet bottom surface；Institute State the mounting hole that installation sheet is also formed with running through the leading flank and the trailing flank；

The fixing fin includes two, and outwards and forward extends from the two ends of the installation sheet width respectively；The fixing fin The card muscle extended outwardly including lateral surface and from the outside；

The reinforcement stand is formed with contiguous block and mounting blocks, and the contiguous block connects the mounting seat and the mounting blocks, the mounting blocks Positioned at mounting seat downside and the position of the correspondence suction pipe；

The mounting blocks are formed with the mounting groove for housing the installation sheet；The mounting groove is formed with groove bottom and hung down with the groove bottom It is direct-connected to connect and outside groove side；The mounting blocks are formed through the sipper pore and the assembly hole positioned at the groove side of the groove bottom； The side wall of the mounting groove has been inwardly formed projection；

The installation sheet is placed in the mounting groove, and the fixing fin engages with the side wall, and the card muscle engages with projection so that institute State hog frame and pre-fix or be fixed on the installation mounting；

The mounting hole, which is equipped with after fastener, to be fixed in the assembly hole.

The sample load apparatus of embodiment of the present invention includes：

Support platform；

The chip fixing component, the chip fixing component is arranged in the support platform；

Syringe pump, the syringe pump is connected with the nucleic acid sequencing chip, for providing negative pressure to the nucleic acid sequencing chip；

Motion platform, the motion platform is arranged in the support platform, and the kit is provided on the motion platform；And

Control device, the control device can be used for controlling the motion platform to move the kit so that the suction pipe and the kit Connection.

In some embodiments, the support platform includes substrate and support, and the support is arranged on the substrate；

The support includes four support columns being vertically arranged on the substrate and the supporting plate being arranged on the support column；

The chip fixing component is set on the bracket；

Optionally, the motion platform includes：

Mounting platform on the substrate is set；

It is movably arranged on the longitudinally-moving platform on the mounting platform；

Longitudinal driving device, for driving the longitudinally-moving platform to be vertically moved on the mounting platform；

It is movably arranged on the laterally movable platform on the longitudinally-moving platform；

The lateral driver device on the longitudinally-moving platform is arranged on, for driving the laterally movable platform in the longitudinally-moving platform Upper transverse shifting；

Optionally, the mounting platform includes underframe, upper frame and underframe mounting post connected vertically, and the mounting post can be with respect to institute State upper frame sliding；

The longitudinally-moving platform includes the portable plate being arranged in the mounting post and above the upper frame and is arranged on the activity Guide rail on plate, the guiding direction of the guide rail is extended in the longitudinal；

The longitudinal driving device includes the longitudinal motor being fixed on the upper frame and coupled with the longitudinal motor and living with the longitudinal direction The longitudinal drive shaft of moving platform connection；

The laterally movable platform includes the sliding block being slidably arranged on the guide rail and the kit bracket being arranged on the sliding block；

The lateral driver device include the cross motor that is arranged on the portable plate and coupled with the cross motor and with the transverse direction The horizontal power transmission shaft of movable platform connection；

Optionally, the sample load apparatus includes waste collecting device, the waste liquid for collecting the nucleic acid sequencing chip discharge, described useless Liquor collecting device is arranged in the sample load apparatus；

Optionally, the waste collecting device includes waste liquid storage tank, for storing the waste liquid；

Optionally, the waste collecting device includes monitoring modular, and the monitoring modular is used to detect whether waste liquid storage tank is filled with；

Optionally, the sample load apparatus include shell, the shell can be used for covering with protect the support platform, the syringe pump, The motion platform and the control device；

Optionally, the shell include front side board, with the left plate of the substantially vertical connection of the front side board, right plate and with the front side board, The left plate and right plate top plate connected vertically；The left plate is formed with thermovent, for being radiated for the sample load apparatus；

Optionally, the right plate correspondence waste liquid storage tank is formed in part with waste liquid door, is easy to open and takes out the waste liquid storage tank；

Optionally, the top plate is corresponding with the chip fixing component and the kit is formed in part with renovating, it is described renovate with it is described Top panel turns are connected, for stirring, to open the sample load apparatus, to be put into or change the kit or the nucleic acid sequencing chip, The shaft parallel renovated is in the front side board；

Optionally, the top plate portion correspondence chip fixing component and the kit are formed in part with transparent panel；

Optionally, the sample load apparatus also includes user interface, and the user interface is used to realize people with the sample load apparatus for user Machine is interacted；

Optionally, the user interface is touch display screen, and is arranged on the shell；

Optionally, the sample load apparatus also includes scanner, for scanning the bar code on the kit or the nucleic acid sequencing chip, To load the information of reagent and nucleic acid molecules sample in the kit；

Optionally, the scanner is set on the housing.

Chip carrier, chip fixing component and the sample load apparatus of embodiment of the present invention have simple to operate, efficient, precision high and success rate High advantage, and fully automatically can load on nucleic acid molecules sample in nucleic acid sequencing chip, it is to avoid artificial operation and pollution gene is surveyed Sequence instrument.

Brief description of the drawings

The above-mentioned and/or additional aspect and advantage of the present invention will be apparent and easily from description of the accompanying drawings below to embodiment is combined Understand, wherein：

Fig. 1 is the schematic perspective view of the sample load apparatus of embodiment of the present invention.

Fig. 2 is the schematic perspective view of another angle of the sample load apparatus of embodiment of the present invention.

Fig. 3 is the schematic perspective view of another angle of the sample load apparatus of embodiment of the present invention.

Fig. 4 is that the sample load apparatus of embodiment of the present invention opens the schematic perspective view for state of renovating.

Fig. 5 is the schematic perspective view inside the sample load apparatus of embodiment of the present invention.

Fig. 6 is the schematic perspective view of another angle inside the sample load apparatus of embodiment of the present invention.

Fig. 7 is the schematic perspective view of another angle inside the sample load apparatus of embodiment of the present invention.

Fig. 8 is the enlarged diagram of Fig. 5 VIII parts.

Fig. 9 is the schematic perspective view of the nucleic acid sequencing chip for embodiment of the present invention.

Figure 10 is the schematic perspective view of the chip carrier of embodiment of the present invention.

Figure 11 is the schematic perspective view of another angle of the chip carrier of embodiment of the present invention.

Figure 12 is the schematic perspective view of the chip carrier of another embodiment of the invention.

Figure 13 is the schematic perspective view of another angle of the chip carrier of another embodiment of the invention.

Figure 14 is the perspective exploded view of the chip carrier of another embodiment of the invention.

Figure 15 is the perspective exploded view of another angle of the chip carrier of another embodiment of the invention.

Figure 16 is the schematic perspective view of the chip fixing component of embodiment of the present invention, and its clamping jaw is in open mode.

Figure 17 is the schematic perspective view of another angle of the chip fixing component of embodiment of the present invention, and its clamping jaw is in open mode.

Figure 18 is the schematic perspective view of another angle of the chip fixing component of embodiment of the present invention, and its clamping jaw is in open mode.

Figure 19 is another schematic perspective view of the chip fixing component of embodiment of the present invention.

Figure 20 is the working condition schematic perspective view of the chip fixing component of embodiment of the present invention.

Figure 21 is the schematic perspective view of the motion platform of embodiment of the present invention.

Embodiment

Embodiments of the present invention are described below in detail, the example of the embodiment is shown in the drawings, wherein identical from beginning to end or class As label represent same or similar element or the element with same or like function.The embodiment described below with reference to accompanying drawing It is exemplary, is only used for explaining the present invention, and is not considered as limiting the invention.

Fig. 1-7 are referred to, the sample load apparatus 100 of embodiment of the present invention is used in kit 200 outside gene sequencer (not shown) Nucleic acid molecules sample (not shown) be automatically loaded into nucleic acid sequencing chip 300.

Gene sequencer is used for gene sequencing.

Gene sequencing/nucleic acid sequencing includes DNA sequencing and RNA is sequenced.

DNA sequencing (DNA sequencing, or translate DNA sequencing) refer to analyze specific DNA fragments base sequence, that is, gland it is fast The arrangement mode of purine (A), thymidine (T), cytimidine (C) and guanine (G).Similarly, RNA sequencings (RNA sequencing, or translate RNA sequencing) refer to the base sequence of analyzing specific RNA fragments, that is, adenine (A), guanine (G), cytimidine (C) and uracil (U) arrangement mode.

Sample load apparatus 100 can collectively form sample loading system (not shown) with kit 200 and nucleic acid sequencing chip 300.

Kit 200 is used to house the nucleic acid molecules sample needed for gene sequencing.

Also referring to Fig. 8, in some embodiments, kit 200 can be substantially rectangular, and is formed with accommodation space 210. Accommodation space 210 is used to house the reagent and nucleic acid molecules sample needed for gene sequencing.Kit 200 is also formed with and accommodation space 210 The liquid taking port 220 of connection.

In some embodiments, kit 200 could be formed with multiple accommodation spaces 210, with respectively house a variety of required reagents and Nucleic acid molecules sample.Kit 200 is formed with multiple liquid taking ports 220, and each liquid taking port 220 is connected with corresponding accommodation space 210.

Liquid taking port 220 can be in array arrangement.

Certainly, kit 200 is not limited to embodiments discussed above, demand can be regarded in other embodiments suitable using other Kit 200.

Also referring to Fig. 9, nucleic acid sequencing chip 300 is formed with liquid inlet 310.Liquid inlet 310 is used for nucleic acid sequencing chip 300 Reagent and nucleic acid molecules sample are inside passed through, nucleic acid molecules sample is carried in nucleic acid sequencing chip 300.

In some embodiments, nucleic acid sequencing chip 300 is also formed with being used to discharge waste liquid (such as used reagent and nucleic acid molecules sample Product) liquid outlet 320.

In some embodiments, nucleic acid sequencing chip 300 is substantially rectangular and includes die bottom surface 330, liquid inlet 310 and goes out liquid Mouth 320 is formed in die bottom surface 330.

In this way, facilitating liquid inlet 310 and liquid outlet 320 and external connection.Certainly, in other embodiments, liquid inlet 310 and go out Liquid mouthful 320 can also be arranged as required to the other positions in nucleic acid sequencing chip 300, however it is not limited to embodiments discussed above.

In some embodiments, the number of liquid inlet 310 and liquid outlet 320 is two (i.e. two passages), and is formed at die bottom surface 330 along the two ends of the length direction of nucleic acid sequencing chip 300.

Certainly, the number and position of liquid inlet 310 and liquid outlet 320 are not limited to embodiments discussed above, and can be as needed Set.For example in other some embodiments, the number of liquid inlet 310 and liquid outlet 320 is eight (i.e. eight passages).

In some embodiments, the bottom surface 330 of nucleic acid sequencing chip 300 is provided with the first locating slot 340.First locating slot 340 is used for Nucleic acid sequencing chip 300 is positioned on sample load apparatus 100, is accurately positioned with realizing, the success rate of loading is improved.

In some embodiments, the first locating slot 340 is rectangular through slot.Certainly, the structure of the first locating slot 340 is not limited to above-mentioned Embodiment, and change can be optionally made, or even in other embodiments, nucleic acid sequencing chip 300 can also be using others Mode is positioned on sample load apparatus 100, and saves the first locating slot 340.

In some embodiments, it is also formed with the first oriented structure 342 on the side of the first locating slot 340.First oriented structure 342 For limiting direction of the nucleic acid sequencing chip 300 on the sample load apparatus 100, in this way, can prevent from filling by mistake, improve loading into Power.

In some embodiments, the first oriented structure 342 can be the convex tendon extended sideways out or other conjunctions of the first locating slot 340 Suitable structure.

Certainly, the concrete structure of nucleic acid sequencing chip 300 is not limited to embodiments discussed above, and should be depending on real needs.

In some embodiments, sample load apparatus 100 includes chip carrier 110.

Also referring to Figure 10-11, in some embodiments, chip carrier 110 includes chip link 112 and suction pipe 114.Chip connects Connecing frame 112 is used to place nucleic acid sequencing chip 300.The one end of suction pipe 114 is connected with chip link 112 and connected with liquid inlet 310, The other end of suction pipe 114 is used to connect with kit 200.

In some embodiments, chip link 112 can use PC (makrolon), PP (polypropylene) or PEEK (polyether-ether-ketone) Shaping is molded etc. medical grade environment-friendly materials, to meet the quality requirement of gene sequencing.

In some embodiments, chip link 112 is formed with the liquid-entering hole 1122 of connection liquid inlet 310 and suction pipe 114.For example, Liquid inlet 310 is docked with liquid-entering hole 1122, and suction pipe 114 is also connected with liquid-entering hole 1122, so as to realize liquid inlet 310 and suction pipe 114 Between connection.

In this way, when changing nucleic acid sequencing chip 300, suction pipe 114 can keep being connected with liquid-entering hole 1122, and only need after replacing The liquid inlet 310 of nucleic acid sequencing chip 300 is docked with liquid-entering hole 1122.In other words, nucleic acid sequencing chip 300 is facilitated Assembling and replacing.

In the embodiment that nucleic acid sequencing chip 300 is formed with liquid outlet 320, chip link 112 can also be formed with for going out The fluid hole 1124 of the docking of liquid mouthful 320.Liquid outlet 320 discharges reagent and nucleic acid molecules sample by fluid hole 1124.

In some embodiments, fluid hole 1124 can be connected with discharging tube (not shown), it is possible to discharge reagent and core by discharging tube Acid molecule sample.

In these embodiments, equally there is the effect of the assembling for facilitating nucleic acid sequencing chip 300 and replacing.

In some embodiments, chip link 112 is substantially rectangular, and includes connection top of support 1126 and link bottom surface 1128. Liquid-entering hole 1122 and fluid hole 1124 are through connection top of support 1126 and link bottom surface 1128.

In this way, when installing, nucleic acid sequencing chip 300 is placed on after chip link 112 liquid inlet 310 with liquid outlet 320 respectively with entering Fluid apertures 1122 and the docking of fluid hole 1124 are so as to connect, and suction pipe 114 and discharging tube can respectively be inserted from the lower section of link bottom surface 1128 Enter liquid-entering hole 1122 and fluid hole 1124, so as to be connected with chip link 112.

In some embodiments, chip link 112 can also include the sealing ring being arranged in liquid-entering hole 1122 and fluid hole 1124 1121.Liquid inlet 310 is docked with liquid outlet 320 with sealing ring 1121, and suction pipe 114 and discharging tube are connected with sealing ring 1121.

It is tightly connected in this way, can be realized between liquid inlet 310 and liquid-entering hole 1122, between liquid outlet 320 and fluid hole 1124.Separately Outside, it can also realize and be tightly connected between suction pipe 114 and liquid-entering hole 1122 and fluid hole 1124.

Figure 12-15 are referred to, in some embodiments, chip carrier 110a includes chip link 112a and suction pipe 114.Chip is connected Frame 112a and chip link 112 are essentially identical.But, chip link 112a includes connection top of support 1126a, and in link Top surface 1126a is formed with the two accepting groove 1123a connected respectively with liquid-entering hole 1122a and fluid hole 1124a.Chip link 112a Two elastomeric pad 1121a can be included, two elastomeric pad 1121a are contained in above-mentioned two accepting groove 1123a respectively.Each bullet Property pad 1121a is formed with the sealing ring portion 1125a of connection corresponding with liquid-entering hole 1122a or fluid hole 1124a.Liquid inlet 310 and go out Liquid mouthfuls 320 is docked with sealing ring portion 1125a respectively, suction pipe 114 and discharging tube respectively with corresponding sealing ring portion 1125a connections.

It is tightly connected in this way, can be realized between liquid inlet 310 and liquid-entering hole 1122a and fluid hole 320 and fluid hole 1124a.In addition, It can also realize and be tightly connected between suction pipe 114 and liquid-entering hole 1122a, between discharging tube and fluid hole 1124a.

Sealing ring 1121 and elastomeric pad 1121a can be using medical grade silica gel or rubber die sinking shapings.

In some embodiments, the number of correspondence liquid inlet 310 and liquid outlet 320 is two, liquid-entering hole 1122 or liquid-entering hole 1122a, Suction pipe 114 and fluid hole 1124 or fluid hole 1124a number are also two, but should not necessarily be limited by embodiments discussed above, and are answered This is according to demand depending on (for example, concrete structure of nucleic acid sequencing chip 300).For example, in other some embodiments, liquid-entering hole 1122 or liquid-entering hole 1122a, suction pipe 114 and fluid hole 1124 or fluid hole 1124a number be eight.

In some embodiments, chip link 112 or chip link 112a can also be formed with the second locating slot 1127.Second Locating slot 1127 is used to chip link 112 or chip link 112a being positioned at sample load apparatus 100, is accurately positioned with realizing, Improve the success rate of loading.

In some embodiments, the second locating slot 1127 is rectangular through slot.Certainly, the structure of the second locating slot 1127 is not limited to Embodiment is stated, and can optionally make change.Even in other embodiments, chip link 112 or chip link 112a It can also be positioned at using other modes on sample load apparatus 100, and save the second locating slot 1127.

In some embodiments, it is also formed with the second oriented structure 1129 on the side of the second locating slot 1127.Second oriented structure 1129 For limiting the direction of chip link 112 or chip link 112a on sample load apparatus 100, in this way, can prevent from missing Dress, improves the success rate of loading.

Second oriented structure 1129 can be the convex tendon or other suitable structures extended sideways out.

Certainly, chip link 112 or chip link 112a concrete structure should not necessarily be limited by embodiments discussed above, and should Depending on real needs.

In some embodiments, suction pipe 114 can be made of PEEK.

The material of suction pipe 114 or other characteristics also should not necessarily be limited by embodiments discussed above, can be depending on real needs.

In some embodiments, chip carrier 110 or chip carrier 110a can also include hog frame 116.Hog frame 116 is used for fixed inhale Pipe 114, to limit the bearing of trend of suction pipe 114, furthermore such that suction pipe 114 will not excessive deformation or deviation when being acted on by external force Position.

In some embodiments, hog frame 116 includes installation sheet 1162 and fixes fin 1164.

In some embodiments, installation sheet 1162 can be substantially rectangular, and includes installation sheet top surface 11622, installation sheet bottom surface 11624th, leading flank 11626 and trailing flank 1168.Installation sheet 1162 is formed through installation sheet top surface 11622 and installation sheet bottom surface 11624 Sipper pore 11621.Sipper pore 11621 is used to wear for suction pipe 114, so that suction pipe 114 be fixed, and then limits suction pipe 114 Bearing of trend.Installation sheet 1162 is also formed with the mounting hole 11623 through leading flank 11626 and trailing flank 11628, mounting hole 11623 For being worn for fastener (not shown) so that installation sheet 1162 is fixed on into sample load apparatus 100.

In some embodiments, fixing fin 1164 includes two, and respectively the two ends of the width of self installation piece 1162 outwards and to Preceding extension.Fixing fin 1164 includes lateral surface 11642 and the card muscle 11644 extended outwardly from outside.Fix fin 1164 and card Muscle 11644 is used to engage with sample load apparatus 100, so that hog frame 116 be pre-fixed or fixed.

Certainly, the structure of hog frame 116 is not limited to embodiments discussed above, and can adopt as needed in other embodiments With other suitable structures.

In some embodiments, sample load apparatus 100 includes chip fixing component 120.

Figure 16-20 are referred to, chip fixing component 120 includes mounting seat 122 and clamping jaw 124.Mounting seat 122 is used for chip placement seat 110 or chip carrier 110a.Clamping jaw 124 and mounting seat 122 are rotated and are connected, for by nucleic acid sequencing chip 300 by chip carrier 110 or Chip carrier 110a is fixed in mounting seat 122.

In some embodiments, mounting seat 122 can with rectangular tabular, and including for chip seat 110 or chip carrier 110a Mounting surface 1222 and the positioning boss 1224 that raises up of self installation face 1222.

Mounting surface 1222 includes the first side 1226 and second side 1228 positioned at the length direction two ends of mounting seat 122.

Mounting seat 122 includes first for being located at the first pin-jointed structure 1221 of first side 1226 and being upwardly extended from second side 1228 Snap-in structure 1223.The axial direction of first pin-jointed structure 1221 is basically parallel to mounting surface 1222 and perpendicular to the length direction of mounting seat 122. First snap-in structure 1223 can include tongue that is upward and extending to remote first side 1226.

Positioning boss 1224 coordinates with the second locating slot 1127 and the first locating slot 340, for locating core bar 110 or chip carrier 110a And nucleic acid sequencing chip 300.Therefore, the form and dimension of positioning boss 1224 can be the second locating slot 1127 and the first locating slot 340 Complementary structure.

For example, in some embodiments, the shape of the second locating slot 1127 of correspondence and the first locating slot 340, positioning boss 1224 can With substantially rectangular.

In some embodiments, the side of positioning boss 1224 could be formed with the 3rd coordinated respectively with the first oriented structure 342 and determine The 4th oriented structure 12244 coordinated to structure 12242 and with the second oriented structure 1129.For example, correspondence the first oriented structure 342 and The shape of second oriented structure 1129, the 3rd oriented structure 12242 and the 4th oriented structure 12244 can be the grooves coordinated with convex tendon Etc. structure.

In some embodiments, positioning boss 1224 includes two, and be arranged in certainly first side 1226 and second side 1228 it Between.

In other words, chip fixing component 110 can fix two nucleic acid sequencing chips 300 simultaneously.The species of nucleic acid sequencing chip 300 And structure can be different, the chip carrier 110 or chip carrier 110a of use can also be different, for example, use chip carrier 110 and chip simultaneously Seat 110a.

Certainly, the structure and shape of mounting seat 122 can be not limited to embodiments discussed above, and can make suitable change according to demand More.

Clamping jaw 124 is used to nucleic acid sequencing chip 300 being pressed on mounting seat 122.

In some embodiments, clamping jaw 124 can be substantially rectangular framework.Clamping jaw 124 includes corresponding with first side 1226 The 3rd side 1242 and with the corresponding four side 1244 in second side 1228.

Clamping jaw 124 includes the second pin-jointed structure 1246 stretched out from the 3rd side 1242, and the axial direction of the second pin joint seat is basically parallel to The width of clamping jaw 124.Clamping jaw 124 is also formed with four side 1244 engages knot with the second of the cooperation of the first snap-in structure 1223 Structure 1248.

Clamping jaw 124 is rotated with mounting seat 122 by the pivot joint of the first pin-jointed structure 1221 and the second pin-jointed structure 1246 and is connected, and can be led to The cooperation for crossing the first snap-in structure 1223 and the second snap-in structure 1248 is fixed in mounting seat 122.

In some embodiments, the second snap-in structure 1248 is corresponding with the first snap-in structure 1223, can be socket.

Certainly, the structure of clamping jaw 124 is not limited to embodiments discussed above, and can be made pair depending on demand in other embodiments It should change.

In some embodiments, chip fixing component 120 also includes the reinforcement stand 126 being connected with mounting seat 122.Strengthen stand 126 For being installed for hog frame 116.

In some embodiments, strengthen stand 126 and be formed with contiguous block 1262 and mounting blocks 1264.Contiguous block 1262 connects mounting seat 122 and mounting blocks 1264, mounting blocks 1264 are located at the downside of mounting seat 122 and correspondence chip carrier 110 or chip carrier 110a are installed on installation The position of suction pipe 114 after seat 122.

In some embodiments, mounting blocks 1264 are formed with the mounting groove 12642 for housing installation sheet 1162.Mounting groove 12642 It is formed with groove bottom 12644 and vertical with groove bottom 12644 is connected and outside groove side 12646.Mounting blocks 1264 are formed through groove The sipper pore 12648 of bottom surface 12644 and the assembly hole 12641 positioned at groove side 12646.The side wall 12643 of mounting groove 12642 is inside It is formed with projection 12645.

Certainly, strengthen stand 126 and be not limited to present embodiment, and it is suitable using other in other embodiments can to regard demand Structure.

In use, chip carrier 110 or chip carrier 110a pass through the second locating slot 1127 and the second oriented structure 1129 and positioning boss 1224 Cooperation be placed in mounting seat 122, nucleic acid sequencing chip 300 passes through the first locating slot 340 and the first oriented structure 342 and positioning again The cooperation of boss 1224 is placed in mounting seat 122.

Therefore, in some embodiments, the height of positioning boss 1224 can be less than or equal to the second locating slot 1127 and the first positioning The depth sum of groove 340.So, it is ensured that clamping jaw 124 can be pressed on nucleic acid sequencing chip 300.

Then, hog frame 116 is installed on reinforcement stand 126, for example, installation sheet 1162 can be placed in mounting groove 12642, blocked Gu fin 1164 engages with side wall 12643, particularly card muscle 11644 engages with projection 12645 so that hog frame 116 pre-fix or It is fixed on installation mounting 126.Then, fastener can wear and is fixed on after mounting hole 11623 in assembly hole 12641, so that further Fixed hog frame 116 is on stand 126 is strengthened, and suction pipe 114 can be extended downwardly through sipper pore 12648.

Certainly, the structure of chip fixing component 120 is not limited to embodiments discussed above, and can regard in other embodiments needs Ask and make correspondence change.For example, in other embodiments,

Fig. 5-7 are referred to, in some embodiments, sample load apparatus 100 can also include support platform 130, syringe pump 140, fortune Moving platform 150 and control device 160.

Chip fixing component 120 is arranged in support platform 130.Nucleic acid sequencing chip 300 passes through chip carrier 110 or chip carrier 110a It is fixed on after being fixed in chip fixing component 120 in support platform 130.Syringe pump 140 is connected with nucleic acid sequencing chip 300, is used for Negative pressure is provided to nucleic acid sequencing chip 300.Motion platform 150 is arranged in support platform 130.Kit 200 is arranged on motion platform On 150.Control device 160 is used to control the mobile reagent box 200 of motion platform 150 so that suction pipe 114 is connected with kit 200.

The sample load apparatus 100 of embodiment of the present invention is under the control of control device 160, and motion platform 150 can automatically move reagent Box 200 is so that suction pipe 114 is connected with kit 200.On the other hand, under the suction function that syringe pump 140 is provided, kit 200 Interior reagent and nucleic acid molecules sample can automatically be passed through and load in nucleic acid sequencing chip 300, so as to realize oneself of nucleic acid molecules sample Dynamic loading.

In some embodiments, support platform 130 includes substrate 132 and support 134.Support 134 is arranged on substrate 132.Core Piece fixing component 120 is arranged on support 134.

In some embodiments, substrate 132 can be substantially rectangular.

Certainly, in other embodiments, substrate 132 can also use other suitable shapes, however it is not limited to embodiment party discussed above Formula.

In some embodiments, support 134 can be arranged on the right-rearward portion of substrate 132.Support 134 can be substantially vertical including four The support column 1342 being arranged on substrate 132 and the supporting plate 1344 being arranged on support column 1342.Chip fixing component 120 is arranged on In supporting plate 1344.

In this way, support 134 is simple in construction, moreover, other elements can also be set between support column 1342, space utilization is improved Rate so that sample load apparatus 100 is compacter.

Certainly, in other embodiments, the position of support 134 and structure can make suitable change as needed, however it is not limited to above The embodiment of discussion.

After chip fixing component 120 is arranged in supporting plate 1344, suction pipe 114 is set forward, and is extended downwardly.Fluid hole 1124 and Liquid outlet 320 is set backwards.

In some embodiments, syringe pump 140 can also be arranged on substrate 132, it is possible to be arranged on support 134 close to support 134 Rear.

In this way, syringe pump 140 is set close to liquid outlet 320, syringe pump 140 is facilitated to be connected with liquid outlet 320.

In some embodiments, syringe pump 140 can be connected by discharging tube with fluid hole 1124 and liquid outlet 320.

Certainly, syringe pump 140 can be not limited to embodiments discussed above, and can make suitable depending on demand in other embodiments Change.

In some embodiments, motion platform 150 can be arranged on substrate 132, and is arranged on the front lower place of support 134.

Figure 21 is referred to, in some embodiments, motion platform 150 includes mounting platform 152, longitudinally-moving platform 154, longitudinal direction Drive device 156, laterally movable platform 158 and lateral driver device 151.

Mounting platform 152 can be arranged on substrate 132 and including underframe 1522, with the mounting post 1524 connected vertically of underframe 1522 and Upper frame 1526.

Underframe 1522 can be substantially rectangular framework, and be arranged on the front lower place of support 1342.Mounting post 1524 includes four simultaneously It is arranged on four corners of underframe 1522.Upper frame 1526 can also be substantially rectangular framework, and four mounting posts 1524 are each passed through Four corners of upper frame 1526 and it can be slid with respect to upper frame about 1526.With reference to referring to Fig. 6, upper frame 1526 is actually by front and rear Two pieces of vertically disposed connecting plates are fixed on substrate 132, that is to say, that upper frame 1526 be relative to substrate 132 it is fixed, no It can relatively move, for the ease of signal, the schematic diagram in Figure 21 is concealed positioned at that block connecting plate above.

Certainly, the position of mounting platform 152 and structure are not limited to embodiments discussed above, and can other embodiment according to Need to make change.

Longitudinally-moving platform 154 can be movably arranged on mounting platform 152, for example, be slidably arranged in mounting post 1524 and positioned at top The top of frame 1526.In this way, longitudinally-moving platform 154 can be slided up and down.

For example, longitudinally-moving platform 154 can include the portable plate 1542 being connected with the upper end of mounting post 1524 and be arranged on portable plate 1542 On guide rail 1544.The guiding direction of guide rail 1544 is extended in the longitudinal.

Certainly, the position of longitudinally-moving platform 154 and structure are not limited to embodiments discussed above, and can be in other embodiment Make change as needed.

Longitudinal driving device 156 can be arranged on mounting platform 152, and for driving longitudinally-moving platform 154 to slide up and down.

For example, longitudinal driving device 156 can include being fixed on longitudinal motor 1562 on upper frame 1526 and with the coupling of longitudinal motor 1562 The longitudinal drive shaft 1564 for closing and being connected with longitudinally-moving platform 154.

In this way, longitudinal motor 1562 can drive longitudinal drive shaft 1564 to move up and down to drive longitudinally-moving platform 154 installing flat Longitudinal direction (up and down) is mobile on platform 152.Because mounting post 1524 is fixedly connected with portable plate 1542, therefore, moved down on portable plate 1542 When dynamic, four mounting posts 1524 are also moved up and down therewith, and the effect of this four mounting posts 1524 is portable plate 1542 can be made steady Motion.

Certainly, the position of longitudinal driving device 156 and structure are not limited to embodiments discussed above, and can be in other embodiment Make change as needed.

Laterally movable platform 158 can be movably arranged on longitudinally-moving platform 154, for example, be slidably arranged on guide rail 1544.In this way, Laterally movable platform 158 can slide back and forth along guide rail 1544.

For example, laterally movable platform 158 can include the sliding block 1582 being slidably arranged on guide rail 1544 and be arranged on sliding block 1582 Kit bracket 1584.Kit bracket 1584 is used for fixating reagent box 200 (referring to Fig. 7).

In some embodiments, kit bracket 1584 could be formed with the kit groove for accommodating and fixating reagent box 200 15842 (referring to Fig. 8).

Certainly, the position of laterally movable platform 158 and structure are not limited to embodiments discussed above, and can be in other embodiment Make change as needed.

Lateral driver device 151 can be arranged on longitudinally-moving platform 154, and for driving laterally movable platform 158 to slide.

For example, lateral driver device 151 can include being arranged on cross motor 1512 on portable plate 1542 and with cross motor 1512 Coupling and the horizontal power transmission shaft 1514 being connected with laterally movable platform 158.

In this way, cross motor 1512 can drive the elastic movement of horizontal power transmission shaft 1514 to drive laterally movable platform 158 laterally It is (front and rear) mobile.

Certainly, the position of lateral driver device 151 and structure are not limited to embodiments discussed above, and can be in other embodiment Make change as needed.

The position of whole motion platform 150 and structure are not limited to embodiments discussed above, and can be in other embodiment according to need Make change.

Fig. 5-7 are referred to, in some embodiments, control device 160 can include central processing unit 162, motion control device 164 and drive dynamic control device 166.

Central processing unit 162 is used to send control command according to user instruction or predetermined instruction.

Motion control device 164 is used to produce motion control commands according to control command.

Drive dynamic control device 166 is used to control the mobile reagent box 200 of motion platform 150 according to motion control commands, such as vertical by control Rotated to motor 1562 and cross motor 1512.

For example, needing connected sucking pipe 114 and target accommodation space 210 according to user instruction or predetermined instruction in central processing unit 162 When, motion control device 164 can determine motion control commands according to the position between suction pipe 114 and target accommodation space 210, then Drive dynamic control device 166 controls cross motor 1512 to cause the mobile reagent box 200 of motion platform 150 to inhale according to motion control commands Pipe 114 aligns with target accommodation space 210, then controls longitudinal motor 1562 that the mobile reagent box 200 of motion platform 150 is caused Suction pipe 114 enters target accommodation space 210 by liquid taking port 220.

In some embodiments, sample load apparatus 100 also includes power supply 170, and power supply 170 can use battery, and for center Processing unit 162, motion control device 164 and drive dynamic control device 166 are powered.Certainly, power supply 170 designated herein is more often Refer to the electrical equipment of transformer etc., voltage needed for sample load apparatus 100 is larger, generally by externally fed.

In some embodiments, power supply 170 can be substantially rectangular, it is possible to is arranged on the left back portion of substrate 132.Center processing Device 162 can be circuit board (being, for example, computer main board) and erect the leading edge for being arranged on substrate 132.Motion control device 164 can be with Circuit board, and erect be arranged on power supply 170 and be attached on support 1342, drive dynamic control device 162 can substantially it is rectangular simultaneously It is arranged on power supply 170.

So so that sample load apparatus 100 is compacter.

Certainly, in other embodiments, the composition of drive device 160, component kind, shape and position are not limited to discussed above Embodiment, and can be arranged as required to.

Power supply 170 also should not necessarily be limited by present embodiment, and can use other suitable power supplys in other embodiments.

In some embodiments, sample load apparatus 100 also includes waste collecting device 180, is passed through for collecting nucleic acid sequencing chip 300 The waste liquid (reagent and nucleic acid molecules sample for example tested) that liquid outlet 320 is discharged.

In some embodiments, waste collecting device 180 can be arranged on substrate 132, and is arranged at support 134 close to support 134 Right lateral side.

In this way, waste collecting device 180 is set close to liquid outlet 320, it is convenient to collect the reagent discharged via liquid outlet 320 and nucleic acid point Subsample.

In some embodiments, waste collecting device 180 can include waste liquid storage tank 182, for storing via the row of liquid outlet 320 The waste liquid gone out.

In some embodiments, in order to prevent from polluting or preferably isolate waste liquid, waste collecting device 180 can include storage box 184, Waste liquid storage tank 182 is arranged in storage box 184.Storage box 184 can be reserved with waste liquid hole 1842, for supply and discharge liquid pipe by connect Logical liquid outlet 320 and waste liquid storage tank 182.

Nucleic acid sequencing chip 300 can discharge waste liquid under the suction function that syringe pump 140 is provided.

In some embodiments, waste collecting device 180 can include monitoring modular (not shown), and monitoring modular is used to detect waste liquid Whether storage tank 182 is filled with.

In some embodiments, monitoring modular is additionally operable to remind user to empty waste liquid storage tank 182 simultaneously after waste liquid storage tank 182 is filled with Sample load apparatus 100 is notified to close until waste liquid storage tank 182 is emptied.

Certainly, in other embodiments, the composition of waste collecting device 180, component kind, shape and position are not limited to beg for above The embodiment of opinion, and can be arranged as required to.

Fig. 1-4 are referred to, in some embodiments, sample load apparatus 100 also includes shell 190.Shell 190 is used to cover to protect The parts such as support platform 130, syringe pump 140, motion platform 150 and control device 160.

In some embodiments, shell 190 is generally rectangular, and the left side including front side board 192, with the substantially vertical connection of front side board 192 Side plate 194, right plate 196 and with front side board 192, left plate 194 and right plate 196 top plate 198 connected vertically.

In some embodiments, the part of the correspondence of left plate 194 central processing unit 162 could be formed with thermovent 1942, in being easy to Centre processing unit 162 radiates.

In some embodiments, the part of the corresponding power 170 of left plate 194 could be formed with power switch 1944, be easy to control power supply 170 are turned on and off.

In some embodiments, the corresponding waste liquid storage tank 182 of right plate 196 be formed in part with waste liquid door 1962, be easy to open take out Waste liquid storage tank 182.

In some embodiments, shell 190 also includes the preceding eaves portion point 191 of connection front side board 192 and top plate 198.Preceding eaves portion point 191 Including connecting the back incline 1912 of top plate 198 and the bottom plate 1914 of connection back incline 1912 and front side board 192.

In this way, shell 190 is handsome in appearance, and conveniently recognized direction.

In some embodiments, left plate 194 and right plate 196 formed respectively be connected with back incline 1912 crosswise projection 1946, 1964。

In this way, one can strengthen the support strength of left plate 194 and right plate 196, two can further improve U.S. of shell 190 Sight degree.

In some embodiments, top plate 198 and preceding eaves portion points 191 and chip fixing component 120 and the corresponding part of kit 200 be also It is formed with and renovates 193, renovate 193 and rotated with top plate 198 and be connected, for stirring, to open sample load apparatus 100, is put into or more Change kit 200 or nucleic acid sequencing chip 300.193 shaft parallel is renovated in front side board 192.

In some embodiments, renovating 193 includes the top plate portion 1932 of correspondence top plate 198, the back incline of correspondence back incline 1912 Part 1934 and the bottom parts 1936 of correspondence bottom plate 1914.The formation operating groove 19362 of bottom parts 1936, is easy to user's hand to buckle into 193 are renovated to operate.

In some embodiments, the corresponding chip fixing component 120 of top plate portion 1932 and kit 200 are formed in part with transparent panel 19322。

In this way, user can observe the inner workings of sample load apparatus by transparent panel 19322.

It is appreciated that the shape and structure of shell 190 are not limited to embodiments discussed above, and real needs should can be regarded at this Other suitable changes are made in the spirit of invention.

In some embodiments, sample load apparatus 100 also includes user interface 10a.User interface 10a is used to sample add for user Carry instrument 100 and realize man-machine interaction.

In this way, can be with user-friendly, control sample load apparatus 100.

In some embodiments, user interface 10a is touch display screen, and is arranged on back incline 1912.

In this way, facilitating user to browse and operate.

It is appreciated that in other embodiments, user interface 10a can do other suitable changes, for example, it can be shown using independent Show device, keyboard and mouse, however it is not limited to present embodiment.

In some embodiments, sample load apparatus 100 also includes scanner 10b, for scanning the bar code on kit 200, to add Carry the information of the reagent and nucleic acid molecules sample in kit 200.

In some embodiments, scanner 10b is arranged on bottom plate 1914.

So user is facilitated to be scanned operation.

It is appreciated that scanner 10b is not limited to present embodiment, and it should can regard real needs and use other suitable modes, example Such as, can be using the scanner being connected with sample load apparatus 100.

In some embodiments, user interface 10a and scanner 10b can be connected with central processing unit 162.Central processing unit 162 are additionally operable to control the work of whole sample load apparatus 100.

In other embodiments or control device 160 is connected with external computer, whole sample load apparatus 100 is controlled by computer Work.

To more fully understand the invention, the workflow to sample load apparatus 100 is described below, and these steps are only used for auxiliary Understand the present invention, practical operation is not limited to this：

That opens sample load apparatus 100 renovates 193；

Open clamping jaw 124；

The 110 or chip carrier 110a of chip seat in mounting seat 122；

Applicable kit 200 is chosen, scanner 10b scans the bar code of kit 200, by used reagent and nucleic acid molecules sample Product Data Enter sample load apparatus 100, then kit 200 is put into kit bracket 1584；

Scanner 10b scanning nucleic acid sequencings chip 300, by the number information typing sample load apparatus 100 of nucleic acid sequencing chip 300, It is then mounted in mounting seat 122；

Stationary jaw 124 is so that nucleic acid sequencing chip 300 is fixed in mounting seat 122 by chip carrier 110 or chip carrier 110a；

Cover and renovate 193；

Dependent instruction and information are inputted by user interface 10a；

Start sample load apparatus 100；

Sample load apparatus 100 controls the mobile reagent box of motion platform 150 so that suction pipe 114 can be aligned and inserted into corresponding accommodation space 210；

Syringe pump 140 starts provides negative pressure for nucleic acid sequencing chip 300, for example, can be connected to provide with liquid outlet 320 by discharging tube Negative pressure；

Reagent and nucleic acid molecules sample flow path in accommodation space 210 are：Accommodation space 210->Suction pipe 114->Liquid-entering hole 1122 or Liquid-entering hole 1122a->Liquid inlet 310->Liquid outlet 320->Fluid hole 1124 or fluid hole 1124a->Discharging tube->Waste liquid storage tank 182.

The continuous mobile reagent box 200 of motion platform 150 can be controlled so that suction pipe 114 can draw the examination in different accommodation spaces 210 Agent and nucleic acid molecules sample；

It can be opened after the loading nucleic acid molecules sample of nucleic acid sequencing chip 200 and renovate 193, open clamping jaw 124, take out nucleic acid sequencing core Piece 300, the nucleic acid sequencing chip 300 for being loaded with nucleic acid molecules sample is saved, the gene sequencing needed after being used for；

Furthermore it is possible to which the chip carrier 110 more renewed, repeats the above steps, it is possible to carry out sample to different nucleic acid sequencing chips 300 Loading.

From above embodiment it can be seen that chip carrier 110 or 110a cause the installation and replacing of nucleic acid sequencing chip 300 to become simple, Therefore become efficient.Additionally, due to be provided with the second locating slot 1127 and the grade of oriented structure 1129 also so that operation precision uprise, improve Success rate.

After sample load apparatus 100 installs kit 200 and nucleic acid sequencing chip 300, the connection kit 200 of suction pipe 114 and nucleic acid are surveyed Sequence chip 300, therefore, syringe pump 140 set up negative pressure in nucleic acid sequencing chip 300, just can be in the presence of negative pressure by kit 200 Interior reagent and nucleic acid molecules sample is passed through and is carried in nucleic acid sequencing chip 300, realizes the automatic loading of nucleic acid molecules sample, can be with Avoid manual operations.

In addition, chip carrier 110 or chip carrier 110a can be disposable products, because there may be inside the grade original paper of suction pipe 114 When the secondary reagent and nucleic acid molecules sample for being sequenced and using, if reused, cross-infection may be caused.Therefore, thrown aside after use Chip carrier 110 or chip carrier 110a just can avoid cross pollution.And also cause due to loading nucleic acid molecules sample outside gene sequencer Gene sequencer will not be contaminated.

To sum up, the chip carrier 110 or chip carrier 110a of embodiment of the present invention, chip fixing component 120 and sample load apparatus 100 have The advantage that simple to operate, efficient, precision is high and success rate is high, and artificial operation and pollution gene sequencer can be avoided.

Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is exemplary, it is impossible to be interpreted as Limitation of the present invention, one of ordinary skill in the art can be changed to above-described embodiment, changes, replace within the scope of the invention Change and modification.

Claims (10)

1. a kind of chip carrier, it is characterised in that including：

Chip link, the chip link is used to place nucleic acid sequencing chip, and the nucleic acid sequencing chip is formed with liquid inlet and goes out liquid Mouthful；And

Suction pipe, described suction pipe one end is connected with the chip link and connected with the liquid inlet, and the suction pipe other end is used to draw core Acid molecule sample and reagent.

2. chip carrier as claimed in claim 1, it is characterised in that the chip link molds shaping using PC, PP or PEEK；

Optionally, the chip link is formed with the liquid-entering hole for connecting the liquid inlet and the suction pipe, the liquid inlet with it is described enter liquid Hole is docked, and the suction pipe is connected with the liquid-entering hole；

The chip link is formed with the fluid hole for connecting the liquid outlet, and the liquid outlet is docked with the fluid hole.

3. chip carrier as claimed in claim 2, it is characterised in that the nucleic acid sequencing chip includes die bottom surface, the chip connects Connect frame and include connection top of support and link bottom surface,

The liquid inlet and/or the liquid outlet are formed at the die bottom surface, and the liquid-entering hole and/or the fluid hole run through the connection Top of support and the link bottom surface.

4. chip carrier as claimed in claim 2, it is characterised in that the chip link includes being arranged on the liquid-entering hole and/or institute The sealing ring of fluid hole is stated, the liquid inlet and/or the liquid outlet are docked with the sealing ring, and the suction pipe is connected with the sealing ring；

Optionally, the sealing ring is using medical grade silica gel or rubber die sinking shaping.

5. chip carrier as claimed in claim 2, it is characterised in that the connection top of support be formed with the liquid-entering hole or it is described go out liquid The accepting groove of hole connection,

The chip link includes the elastomeric pad for being contained in the accepting groove, and the elastomeric pad includes and the liquid-entering hole or described The sealing ring portion of fluid hole connection,

The liquid inlet or the liquid outlet are docked with the sealing ring portion, and the suction pipe is connected with the sealing ring portion；

Optionally, the elastomeric pad is using medical grade silica gel or rubber die sinking shaping.

6. chip carrier as claimed in claim 2, it is characterised in that the liquid inlet include it is multiple, the liquid outlet also include it is multiple, Each liquid outlet is connected with corresponding one liquid inlet, the number of the liquid-entering hole and the suction pipe and the number pair of the liquid inlet Should, the number of the fluid hole is corresponding with the number of the liquid outlet.

7. a kind of chip fixing component, it is characterised in that including：

Mounting seat, the mounting seat is used to place chip carrier as claimed in any one of claims 1 to 6；And

Clamping jaw, the clamping jaw is rotated with the mounting seat and is connected, described for the nucleic acid sequencing chip to be fixed on by the chip carrier In mounting seat.

8. chip fixing component as claimed in claim 7, it is characterised in that the mounting seat includes the peace for being used to install the chip carrier Dress face and the first side and second side positioned at the mounting surface opposite end, the mounting seat include being formed at the of the first side One pin-jointed structure and the first snap-in structure positioned at the second side；

The clamping jaw includes the 3rd side corresponding with the first side and four side corresponding with the second side, the clamping jaw bag Include be formed at the 3rd side and with first pin-jointed structure coordinate the second pin-jointed structure and positioned at the four side and with it is described The second snap-in structure that first snap-in structure coordinates；

The clamping jaw is rotated with the mounting seat by the pivot joint of first pin-jointed structure and second pin-jointed structure and is connected, and passes through institute The cooperation for stating the first snap-in structure and second snap-in structure is fixed in the mounting seat；

Optionally, the mounting seat includes the positioning boss that is upwardly extended from the mounting surface, the nucleic acid sequencing chip be formed with it is described The first locating slot that positioning boss coordinates, the chip carrier is formed with the second locating slot coordinated with the positioning boss, and the chip carrier leads to The cooperation for crossing second locating slot and the positioning boss is positioned in the mounting seat, and the nucleic acid sequencing chip is fixed by described first The cooperation of position groove and the positioning boss is positioned on the chip carrier；

Optionally, the side of first locating slot is formed with the first oriented structure, and the side of second locating slot is formed with the second orientation Structure, the side of the positioning boss be formed with the 3rd oriented structure that coordinates with first oriented structure and with second oriented structure The 4th oriented structure coordinated, second oriented structure coordinates with the 4th oriented structure to be installed for limiting the chip carrier described Direction on seat, first oriented structure coordinates for limiting the nucleic acid sequencing chip in the mounting seat with the 3rd oriented structure On direction；

Optionally, the chip carrier includes hog frame, and the hog frame is used to fix the suction pipe, and the chip fixing component includes strengthening Stand, for fixing the hog frame to limit the bearing of trend of the suction pipe；

Optionally, the hog frame includes installation sheet and fixes fin；The installation sheet is rectangular, and includes installation sheet top surface, installation Piece bottom surface, leading flank and trailing flank, the installation sheet are formed through the sipper pore of the installation sheet top surface and the installation sheet bottom surface；Institute State the mounting hole that installation sheet is also formed with running through the leading flank and the trailing flank；

The fixing fin includes two, and outwards and forward extends from the two ends of the installation sheet width respectively；The fixing fin The card muscle extended outwardly including lateral surface and from the outside；

The reinforcement stand is formed with contiguous block and mounting blocks, and the contiguous block connects the mounting seat and the mounting blocks, the mounting blocks Positioned at mounting seat downside and the position of the correspondence suction pipe；

The mounting blocks are formed with the mounting groove for housing the installation sheet；The mounting groove is formed with groove bottom and hung down with the groove bottom It is direct-connected to connect and outside groove side；The mounting blocks are formed through the sipper pore and the assembly hole positioned at the groove side of the groove bottom； The side wall of the mounting groove has been inwardly formed projection；

The installation sheet is placed in the mounting groove, and the fixing fin engages with the side wall, and the card muscle engages with projection so that institute State hog frame and pre-fix or be fixed on the installation mounting；

The mounting hole, which is equipped with after fastener, to be fixed in the assembly hole.

9. a kind of sample load apparatus, it is characterised in that including：

Support platform；

Chip fixing component as described in claim 7-8 any one, the chip fixing component is arranged in the support platform；

Syringe pump, the syringe pump is connected with the nucleic acid sequencing chip, for providing negative pressure to the nucleic acid sequencing chip；

Motion platform, the motion platform is arranged in the support platform, and the kit is provided on the motion platform；And

Control device, the control device can be used for controlling the motion platform to move the kit so that the suction pipe and the kit Connection.

10. sample load apparatus as claimed in claim 9, it is characterised in that the support platform includes substrate and support, the support It is arranged on the substrate；

The support includes four support columns being vertically arranged on the substrate and the supporting plate being arranged on the support column；

The chip fixing component is set on the bracket；

Optionally, the motion platform includes：

Mounting platform on the substrate is set；

It is movably arranged on the longitudinally-moving platform on the mounting platform；

Longitudinal driving device, for driving the longitudinally-moving platform to be vertically moved on the mounting platform；

It is movably arranged on the laterally movable platform on the longitudinally-moving platform；

The lateral driver device on the longitudinally-moving platform is arranged on, for driving the laterally movable platform in the longitudinally-moving platform Upper transverse shifting；

Optionally, the mounting platform includes underframe, upper frame and underframe mounting post connected vertically, and the mounting post can be with respect to institute State upper frame sliding；

The longitudinally-moving platform includes the portable plate being arranged in the mounting post and above the upper frame and is arranged on the activity Guide rail on plate, the guiding direction of the guide rail is extended in the longitudinal；

The longitudinal driving device includes the longitudinal motor being fixed on the upper frame and coupled with the longitudinal motor and living with the longitudinal direction The longitudinal drive shaft of moving platform connection；

The laterally movable platform includes the sliding block being slidably arranged on the guide rail and the kit bracket being arranged on the sliding block；

The lateral driver device include the cross motor that is arranged on the portable plate and coupled with the cross motor and with the transverse direction The horizontal power transmission shaft of movable platform connection；

Optionally, the sample load apparatus includes waste collecting device, the waste liquid for collecting the nucleic acid sequencing chip discharge, described useless Liquor collecting device is arranged in the sample load apparatus；

Optionally, the waste collecting device includes waste liquid storage tank, for storing the waste liquid；

Optionally, the waste collecting device includes monitoring modular, and the monitoring modular is used to detect whether waste liquid storage tank is filled with；

Optionally, the sample load apparatus include shell, the shell can be used for covering with protect the support platform, the syringe pump, The motion platform and the control device；

Optionally, the shell include front side board, with the left plate of the substantially vertical connection of the front side board, right plate and with the front side board, The left plate and right plate top plate connected vertically；The left plate is formed with thermovent, for being radiated for the sample load apparatus；

Optionally, the right plate correspondence waste liquid storage tank is formed in part with waste liquid door, is easy to open and takes out the waste liquid storage tank；

Optionally, the top plate is corresponding with the chip fixing component and the kit is formed in part with renovating, it is described renovate with it is described Top panel turns are connected, for stirring, to open the sample load apparatus, to be put into or change the kit or the nucleic acid sequencing chip, The shaft parallel renovated is in the front side board；

Optionally, the top plate portion correspondence chip fixing component and the kit are formed in part with transparent panel；

Optionally, the sample load apparatus also includes user interface, and the user interface is used to realize people with the sample load apparatus for user Machine is interacted；

Optionally, the user interface is touch display screen, and is arranged on the shell；

Optionally, the sample load apparatus also includes scanner, for scanning the bar code on the kit or the nucleic acid sequencing chip, To load the information of reagent and nucleic acid molecules sample in the kit；

Optionally, the scanner is set on the housing.