CN106967141A - 核苷氨基磷酸酯化合物及其医药组合物和用途 - Google Patents
核苷氨基磷酸酯化合物及其医药组合物和用途 Download PDFInfo
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- CN106967141A CN106967141A CN201710299733.3A CN201710299733A CN106967141A CN 106967141 A CN106967141 A CN 106967141A CN 201710299733 A CN201710299733 A CN 201710299733A CN 106967141 A CN106967141 A CN 106967141A
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960002935 telaprevir Drugs 0.000 description 1
- 108010017101 telaprevir Proteins 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical group OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- FSDYDBAXNANUQE-UHFFFAOYSA-N tris(2,4-dichlorophenyl) phosphate Chemical compound ClC1=CC(Cl)=CC=C1OP(=O)(OC=1C(=CC(Cl)=CC=1)Cl)OC1=CC=C(Cl)C=C1Cl FSDYDBAXNANUQE-UHFFFAOYSA-N 0.000 description 1
- 229950010342 uridine triphosphate Drugs 0.000 description 1
- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
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CN112175031A (zh) * | 2020-10-21 | 2021-01-05 | 佛山科学技术学院 | 尿苷酸混合氨基磷酸酯化合物、其药物组合物及其应用 |
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CN104470939A (zh) * | 2012-05-22 | 2015-03-25 | 埃迪尼克斯医药公司 | 用于肝脏疾病的d型氨基酸化合物 |
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WO2015116248A1 (en) * | 2013-02-01 | 2015-08-06 | Enanta Pharmaceuticals, Inc. | 5, 6-d2 uridine nucleoside/tide derivatives |
CN105294795A (zh) * | 2014-11-20 | 2016-02-03 | 南京曼杰生物科技有限公司 | 新型核苷氨基磷酸酯衍生物及其应用 |
WO2016073756A1 (en) * | 2014-11-06 | 2016-05-12 | Enanta Pharmaceuticals, Inc. | Deuterated nucleoside/tide derivatives |
CN106543253A (zh) * | 2015-11-24 | 2017-03-29 | 杨学聪 | 抗病毒核苷氨基磷酸酯及其药物组合和用途 |
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CN104470939A (zh) * | 2012-05-22 | 2015-03-25 | 埃迪尼克斯医药公司 | 用于肝脏疾病的d型氨基酸化合物 |
WO2014078436A1 (en) * | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-alanine ester of sp-nucleoside analog |
WO2014078427A1 (en) * | 2012-11-14 | 2014-05-22 | Idenix Pharmaceuticals, Inc. | D-alanine ester of rp-nucleoside analog |
WO2015116248A1 (en) * | 2013-02-01 | 2015-08-06 | Enanta Pharmaceuticals, Inc. | 5, 6-d2 uridine nucleoside/tide derivatives |
WO2015017713A1 (en) * | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
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CN104672288A (zh) * | 2014-11-07 | 2015-06-03 | 王彩琴 | 一种氘代索菲布韦及其用途 |
CN105294795A (zh) * | 2014-11-20 | 2016-02-03 | 南京曼杰生物科技有限公司 | 新型核苷氨基磷酸酯衍生物及其应用 |
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CN112175031A (zh) * | 2020-10-21 | 2021-01-05 | 佛山科学技术学院 | 尿苷酸混合氨基磷酸酯化合物、其药物组合物及其应用 |
CN112175031B (zh) * | 2020-10-21 | 2022-04-26 | 佛山科学技术学院 | 尿苷酸混合氨基磷酸酯化合物、其药物组合物及其应用 |
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