CN106963908A - 用于治疗脾虚胃弱所致贫血病的中药复方制剂及制备方法 - Google Patents

用于治疗脾虚胃弱所致贫血病的中药复方制剂及制备方法 Download PDF

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CN106963908A
CN106963908A CN201710309507.9A CN201710309507A CN106963908A CN 106963908 A CN106963908 A CN 106963908A CN 201710309507 A CN201710309507 A CN 201710309507A CN 106963908 A CN106963908 A CN 106963908A
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马力
王维蔚
齐燕松
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Tianjin City Hongxing Good Economic Technology Development Co Ltd
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Abstract

一种用于治疗脾虚胃弱所致贫血病的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成：生黄芪18‑48、党参6‑15、炒白术6‑15、茯苓9‑24、当归6‑15、炒白芍9‑24、陈皮6‑15、姜半夏6‑15、炒鸡内金6‑15、焦麦芽6‑15、焦神曲6‑15、绿萼梅4‑10、玫瑰花4‑10、生甘草4‑10。本发明制剂是采用水煮提取方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度提高，而且有助于药物的吸收，从而能提高其生物利用度。另外，药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。

Description

用于治疗脾虚胃弱所致贫血病的中药复方制剂及制备方法
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗脾虚胃弱所致贫血病的中药复方制剂及其制备方法。
背景技术
贫血是指外周血单位体积血液中的血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)低于可比人群正常值的下限，其中以血红蛋白最为重要。贫血属于中医学“虚劳”、“黄病”、“虚黄”等范畴，多由于先天禀賦不足、饮食不节、长期失血、烦劳过度、妊娠失养和大病久病虚损等引起脾肾亏损，脾虚则运化失职，气血生化无源，肾虚则精气不足，无以生髓化血，导致气血亏虚。虽然目前临床上用于治疗贫血病的药物品种很多，但由于导致贫血病的因素有多种，因此贫血病也分多种类型，所以这些药物缺乏针对性，疗程相对较长，且部分药物具有一定副作用或过敏反应，所以服用后对于治疗属于脾虚胃弱所致的贫血病这种疾病来说效果不理想。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗脾虚胃弱所致贫血病的中药复方制剂及其制备方法。
为了达到上述目的，本发明提供的用于治疗脾虚胃弱所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生黄芪18-48 党参6-15 炒白术6-15 茯苓9-24 当归6-15
炒白芍9-24 陈皮6-15 姜半夏6-15 炒鸡内金6-15 焦麦芽6-15
焦神曲6-15 绿萼梅4-10 玫瑰花4-10 生甘草4-10
所述的用于治疗脾虚胃弱所致贫血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗脾虚胃弱所致贫血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗脾虚胃弱所致贫血病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
贫血病症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于健脾和胃，益气生血。方中生黄芪甘微温，健脾补中，升阳举陷，益卫固表，利尿，托毒生肌，为补中益气之要药，为君药。党参甘平，补脾肺气，补血，生津；茯苓甘淡平，利水渗湿，健脾化痰，宁心安神；炒白芍苦酸微寒，养血敛阴，柔肝止痛，平抑肝阳；姜半夏辛温，燥湿化痰，降逆止呕，消痞散结，为化痰止呕之要药；焦麦芽甘平，消食健胃，尤能促进淀粉性食物的消化；绿萼梅微酸涩平，疏肝解郁，和中，化痰，以上诸药，健脾养胃，和中化痰，共为臣药。炒白术甘苦温，益气健脾，燥湿利尿，为补气健脾第一要药；当归甘辛温，补血，活血止痛；陈皮辛苦温，理气健脾，燥湿化痰；炒鸡内金甘平，消食健胃；焦神曲甘辛温，消食和胃；玫瑰花甘微苦温，疏肝解郁，活血止痛，以上诸药，理气健脾，健胃消食，宽中化痰，共为佐药。生甘草甘平，补脾益气，清热解毒止痛，调和诸药，以为使药。本方健脾和胃，补气生血，具有化湿和中，宽中解郁之功，故适用于治疗脾虚胃弱所致的贫血病。
下面结合实施例对本发明提供的用于治疗脾虚胃弱所致贫血病的中药复方制剂及其制备方法进行详细说明。
实施例1：
本实施例用于治疗脾虚胃弱所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生黄芪48 党参15 炒白术15 茯苓24 当归15
炒白芍24 陈皮15 姜半夏15 炒鸡内金15 焦麦芽15
焦神曲15 绿萼梅10 玫瑰花10 生甘草10
所述的用于治疗脾虚胃弱所致贫血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗脾虚胃弱所致贫血病的中药复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例用于治疗脾虚胃弱所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生黄芪18 党参6 炒白术6 茯苓9 当归6
炒白芍9 陈皮6 姜半夏6 炒鸡内金6 焦麦芽6
焦神曲6 绿萼梅4 玫瑰花4 生甘草4
制备方法同实施例1。
实施例3：
本实施例用于治疗脾虚胃弱所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生黄芪32 党参12 炒白术12 茯苓17 当归12
炒白芍17 陈皮12 姜半夏12 炒鸡内金12 焦麦芽12
焦神曲12 绿萼梅8 玫瑰8 生甘草8
制备方法同实施例1。
本发明提供的用于治疗脾虚胃弱所致贫血病的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对285例患有脾虚胃弱型贫血病的患者进行了系统临床观察，其中21-30岁患者68例，31-40岁105例，41-50岁112例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)等主要症状明显改善)135例，占47.4％；有效(各项化验检查明显改善，主要症状有改善)124例，占43.5％；无效(各项化验检查无变化，主要症状无改善)26例，占9.1％；总有效率为90.9％。经2个疗程治疗后共治愈209例，占73.3％；有效68例，占23.9％；无效8例，占2.8％；总有效率为97.2％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗脾虚胃弱型贫血病，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗脾虚胃弱型贫血病，随着治疗的深入，治愈率、有效率均明显提高。

Claims (3)

1.一种用于治疗脾虚胃弱所致贫血病的中药复方制剂，其特征在于：所述的中药复方制剂由用量为重量比的下列药物原料制成：
生黄芪18-48 党参6-15 炒白术6-15 茯苓9-24 当归6-15
炒白芍9-24 陈皮6-15 姜半夏6-15 炒鸡内金6-15 焦麦芽6-15
焦神曲6-15 绿萼梅4-10 玫瑰花4-10 生甘草4-10。
2.一种如权利要求1所述的用于治疗脾虚胃弱所致贫血病的中药复方制剂的制备方法，其特征在于：所述的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗脾虚胃弱所致贫血病的中药复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
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