CN106963876A - 用于治疗脾肾阴虚所致贫血病的中药复方制剂及制备方法 - Google Patents
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Abstract
一种用于治疗脾肾阴虚所致贫血病的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成:熟地黄12‑32、山药9‑24、山茱萸6‑15、玉竹6‑15、黄精6‑15、当归6‑15、炙龟甲9‑24、知母9‑24、黄柏6‑15、女贞子6‑15、墨旱莲6‑15、怀牛膝9‑24。本发明制剂是采用水煮提取的方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度大大提高,且有助于药物的吸收,从而能提高其生物利用度。另外,药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,本发明的制备方法工艺简单,操作方便。
Description
技术领域
本发明涉及一种中药制剂及其制备方法,特别是涉及一种以中药为原料制成的用于治疗脾肾阴虚所致贫血病的中药复方制剂及制备方法。
背景技术
贫血是指外周血单位体积血液中的血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)低于可比人群正常值的下限,其中以血红蛋白最为重要。贫血属于中医学“虚劳”、“黄病”、“虚黄”等范畴,多由于先天禀賦不足、饮食不节、长期失血、烦劳过度、妊娠失养和大病久病虚损等引起脾肾亏损,脾虚则运化失职,气血生化无源,肾虚则精气不足,无以生髓化血,导致气血亏虚。虽然目前临床上用于治疗贫血病的药物品种很多,但由于导致贫血病的因素有多种,因此贫血病也分多种类型,所以这些药物缺乏针对性,疗程相对较长,且部分药物具有一定副作用或过敏反应,所以服用后对于治疗属于脾肾阴虚所致的贫血病这种疾病来说效果不理想。
发明内容
为了解决上述问题,本发明的目的在于提供一种用于治疗脾肾阴虚所致贫血病的中药复方制剂及制备方法。
为了达到上述目的,本发明提供的用于治疗脾肾阴虚所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成:
熟地黄12-32山药9-24山茱萸6-15玉竹6-15黄精6-15当归6-15
炙龟甲9-24知母9-24黄柏6-15女贞子6-15墨旱莲6-15怀牛膝9-24
所述的用于治疗脾肾阴虚所致贫血病的中药复方制剂的制备方法是按照下列步骤顺序进行:
(a)将炙龟甲按照配比进行称量,然后加水浸煎煮30分钟;
(b)将上述药物原料中除炙龟甲之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,再将上述步骤(a)中的炙龟甲及其煎煮液加入混合,煎煮30分钟,过滤去渣即可制成所述的治疗脾肾阴虚所致贫血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗脾肾阴虚所致贫血病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度大大提高,而且有助于药物的吸收,从而能够提高其生物利用度。另外,本发明的药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,本发明的制备方法工艺简单,操作方便。
具体实施方式
贫血病症状复杂,病程迁延,并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于健脾益肾,滋养阴血。方中熟地黄甘微温,补血养阴,填精益髓,故为君药。山药甘平,补脾养胃,为慢性久病调补脾胃之佳品;玉竹甘微寒,养阴润燥,生津止渴;当归甘辛温,补血,活血止痛;知母苦甘寒,清热泻火,生津润燥;女贞子甘苦凉,滋补肝肾,乌须明目,以上诸药,养阴补虚,生津活血,共为臣药。山茱萸酸涩微温,补益肝肾,收敛固涩,为平补阴阳之要药;黄精甘平,补气养阴,健脾润肺,益肾;炙龟甲甘寒,滋阴潜阳,益肾健骨,养血补心;黄柏苦寒,清热燥湿,泻火除蒸,解毒疗疮;墨旱莲甘酸寒,滋补肝肾,凉血止血,以上诸药,滋补肝肾,养阴清热,共为佐药。怀牛膝苦甘酸平,活血通经,补肝肾,强筋骨,利水通淋,引火(血)下行,以为使药。本方滋补肝脾肾,具有清热润燥,养阴生津等作用,故适用于治疗脾肾阴虚所致的贫血病。
下面结合实施例对本发明提供的用于治疗脾肾阴虚所致贫血病的中药复方制剂及制备方法进行详细说明。
实施例1:
本实施例提供的用于治疗脾肾阴虚所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成:
熟地黄32山药24山茱萸15玉竹15黄精15当归15
炙龟甲24知母24黄柏15女贞子15墨旱莲15怀牛膝24
所述的用于治疗脾肾阴虚所致贫血病的中药复方制剂的制备方法是按照下列步骤顺序进行:
(a)将炙龟甲按照配比进行称量,然后加水浸煎煮30分钟;
(b)将上述药物原料中除炙龟甲之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,再将上述步骤(a)中的炙龟甲及其煎煮液加入混合,煎煮30分钟,过滤去渣即可制成所述的治疗脾肾阴虚所致贫血病的中药复方制剂。
另外,所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2:
本实施例提供的用于治疗脾肾阴虚所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成:
熟地黄12山药9山茱萸6玉竹6黄精6当归6
炙龟甲9知母9黄柏6女贞子6墨旱莲6怀牛膝9
制备方法同实施例1。
实施例3:
本实施例提供的用于治疗脾肾阴虚所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成:
熟地黄22山药17山茱萸12玉竹12黄精12当归12
炙龟甲17知母17黄柏12女贞子12墨旱莲12怀牛膝17
制备方法同实施例1。
本发明提供的用于治疗脾肾阴虚所致贫血病的中药复方制剂呈棕色至棕褐色;气淡,味微苦。为了验证该中药复方制剂的治疗效果,本发明人利用上述中药复方制剂对420例患有脾肾阴虚型贫血病的患者进行了系统临床观察,其中21-30岁患者102例,31-40岁129例,41-50岁189例,每次用药150ml,每日3次,120天为1个疗程。经1个疗程治疗后共治愈(血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)等主要症状明显改善)198例,占47.1%;有效(各项化验检查明显改善,主要症状有改善)146例,占34.8%;无效(各项化验检查无变化,主要症状无改善)76例,占18.1%;总有效率为81.9%。经2个疗程治疗后共治愈311例,占74.0%;有效79例,占18.8%;无效30例,占7.1%;总有效率为92.9%。
同时,本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析,分析结果分别见表1、表2。
表1:本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算,结果为0.050>P>0.025,由此可以证明服用本发明提供的中药复方制剂来治疗脾肾阴虚型贫血病,对各年龄组的治疗效果不随年龄而变化。
表2:本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算,结果为P<0.005,由此可以证明服用本发明提供的中药复方制剂来治疗脾肾阴虚型贫血病,随着治疗的深入,治愈率、有效率均明显提高。
Claims (3)
1.一种用于治疗脾肾阴虚所致贫血病的中药复方制剂,其特征在于:所述的中药复方制剂由用量为重量比的下列药物原料制成:
熟地黄12-32 山药9-24 山茱萸6-15 玉竹6-15 黄精6-15 当归6-15
炙龟甲9-24 知母9-24 黄柏6-15 女贞子6-15 墨旱莲6-15 怀牛膝9-24。
2.一种如权利要求1所述的用于治疗脾肾阴虚所致贫血病的中药复方制剂的制备方法,其特征在于:所述的制备方法是按照下列步骤顺序进行∶
(a)将炙龟甲按照配比进行称量,然后加水浸煎煮30分钟;
(b)将上述药物原料中除炙龟甲之外的其它药物原料按照配比进行称量并混合,然后加水浸泡25分钟,再将上述步骤(a)中的炙龟甲及其煎煮液加入混合,煎煮30分钟,过滤去渣即可制成所述的治疗脾肾阴虚所致贫血病的中药复方制剂。
3.根据权利要求2所述的制备方法,其特征在于:所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
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周永明: "《中医血液病临床手册》", 30 September 2005, 上海中医药大学出版社 * |
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