CN106963845A - 一种用于保坤延春的中药组合物及其制备方法 - Google Patents
一种用于保坤延春的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于保坤延春的中药组合物及其制备方法,解决了现有技术中单一的营养卵巢的方式其抗衰延年的效果并不十分明显的问题。本发明的中药原料包括大豆异黄酮、仙灵脾、女贞子、制首乌、当归、白芍、枸杞、人参、牡蛎、红花;本发明的制备方法包括:(1)分别将仙灵脾、女贞子、制首乌、当归、白芍、枸杞、人参、牡蛎、红花进行煎煮,煎煮后过滤获得过滤液;(2)将过滤液混合均匀后获得混合液;(3)将大豆异黄酮加入到混合液中煎煮、浓缩后制成成品。本发明具有同时达到补肾调经、营养卵巢的作用,对卵巢早衰、月经不调、月经量少有治本的作用,能够明显改善围绝经期症状,效果十分显著。
Description
技术领域
本发明涉及一种中药组合物,具体涉及一种用于保坤延春的中药组合物,以及该中药组合物的制备方法。
背景技术
由于生活压力、环境污染、生育、流产等原因,很多女性提前出现卵巢功能减退、细胞老化凋亡而进入围绝经期,面部出现色斑、皱纹,乳房干瘪萎缩、松弛,阴道泌液减少,性机能减退,失眠,烦躁、烘热,出汗等症状。尤其是近年来,这种现象更为普遍,女性早衰已经成为社会和医学界关注的一个热点。研究女性卵巢早衰的根本原因和最安全最有效的治疗方法,是当今妇科最广泛关注的课题。
现有技术中通常认为女性衰老大都是由于卵巢的因素,因而在治疗过程中大多都采用营养卵巢的方式达到抗衰延年的目的,但在实际应用过程中发现,单一的营养卵巢的方式其抗衰延年的效果并不十分明显。
发明内容
本发明所要解决的技术问题是:现有技术中单一的营养卵巢的方式其抗衰延年的效果并不十分明显的问题,目的在于提供了一种用于保坤延春的中药组合物及其制备方法。
发明人经过多年的临床和理论研究发现:肾脏、卵巢在女性衰老变化的过程中起到决定性作用,两者紧密联系,缺一不可,靠单一补肾或单一营养卵巢都无法从根本上达到抗衰延年的目的,只有通过补肾、营养卵巢同时进行,才是真正解决女性早衰的唯一途径。
鉴于上述发现,本发明通过下述技术方案实现:
一种用于保坤延春的中药组合物,大豆异黄酮、仙灵脾、女贞子、制首乌、当归、白芍、枸杞、人参、牡蛎、红花。
其中,大豆异黄酮是从黑大豆或黄大豆中提取的精华,富含植物雌激素,本草汇言记载有黄大豆能“润脾燥,消积痢”,黑大豆能“润肾燥、止盗汗”。故大豆异黄酮补肾健脾,补肾为固冲之本,健脾乃益血之源,本固充血,阴平阳秘,诸症自愈,是为君药。
仙灵脾味甘气香,性温不寒,能益精气,具有温肾壮阳、益精补髓之效,本经有“主阴痿、绝伤——益气力,强志”的记载,协助君药温肾壮阳,以补肾阳之不足;
女贞子味甘苦,性凉,归肝、肾二经,本品善补肝肾之阴。《本草备要》谓女贞子“益肝肾,安五脏,强腰膝,明耳以,乌须发,补风虚,除百病”,既助君药滋肾益阴,补肾阴之不足,又助仙灵脾补阴以助阳,有“阴中求阳”之意;
制首乌甘、涩,微温,归肝、肾经。有补益精血,固肾乌须之功。《本草纲目》谓“此物气温味涩,苦补肾,温补肝,涩能收敛精气,所以能养血益肝,固精益肾,健筋骨,马须发,为滋补良药。不寒不燥,功在地黄、天门冬诸药之上”;
以上仙灵脾、女贞子和制首乌三药,共为臣药。
当归甘温质润,既能补血活血,又能调经,为妇科要药;
白芍苦、酸、甘、微寒。归肝、脾经,有养血调经之效;
枸杞子甘、平。归肝、肾经,有补肝肾,益精血之功;
人参甘、微苦,微温。归心、肺、脾经。有大补元气,生津安神之功;
红花辛、温,归心、肝经。本品辛散温通,专入血分,功能活血祛癖,通调经脉;
以上诸药公用,有补肾,养血活血,营养卵巢之功,共为佐药。
牡蛎味咸、涩,性微寒,归肾、肝、胆经,有益阴潜阳,镇惊安神之功,本品味咸质重,咸以入肾,重以沉降,能引诸药入肾,直达病所是为使药。
诸药配伍,既温肾阳,补肾阴,又养血和血,使阳生阴长,气充血沛,阴平阳秘,脏腑功能恢复正常,围绝经期诸证自然消失矣。
并且,现代药理学研究认为:
仙灵脾类植物的化学成分主要是黄酮类化合物,能增强下丘脑一一垂体一一性腺轴及肾上腺皮质轴、胸腺轴等内分泌系统的分泌功能。据报道:服用仙灵脾等物质,对治疗骨质疏松和防治早衰有显著疗效;
女贞子可增强非特异性免疫功能,对异常的免疫功能具有双向调节作用,对化疗和放疗所致的白细胞减少有升高作用,可降低血清胆固醇,有顶防和消减动脉粥样硬化斑块和减轻斑块厚度的作用,能减少冠状动脉粥样硬化病变数并减轻其阻塞程度,有强心、利尿、降血糖及保肝作用,并有一定抗衰老作用;
枸杞子对免疫有促进作用,同时具有免疫调节作用,可提高血睾酮水平,起强壮作用;对造血功能有促进作用;对正常健康人也有显著提升白细胞作用,还有抗衰老、抗突变、抗肿瘤、降血脂、保肝及抗脂肪肝、降血糖、降血压作用;
当归水浸液能显著促进血红蛋白及红细胞的生成,当归中性油对缺血性心肌有明显保护作用,当归及其阿魏酸钠有酸钙有明显的抗血栓作用;
白芍有调节免疫功能、抗炎的作用,芍药中的主要成分芍药苷具有较好的解痉止痛作用;
牡蛎含碳酸钙、磷酸钙及硫酸钙,并含铜、铁、锌、锰、锶、铬等微量元素及多种氨基酸。
本发明同时根据辨病与辩证相结合,以从大豆中提取的纯天然植物雌激素,配伍仙灵脾、女贞子、制首乌等中药组成。本发明制剂具有补肾、调节阴阳平衡,恢复脏腑正常的生理功能。
本发明通过对数百位患者的临床实践发现,本发明能明显改善围绝经期症状,对许多中老年妇女雌激素消退相关的疾病,如:血脂升高、动脉粥样硬化和骨质酥松等,有一定的防治作用,从而达到延缓衰老、养颜驻容、提高妇女生存质量的目的。更为神奇的还是,本发明能有效使已经绝经的妇女月经又正常来潮或出现乳房丰满、青春靓丽的效果,填补了当今妇科应用纯中医中药治疗围绝经期综合症及其相关性疾病的空白。因而,本发明通过本发明药材的相互伍配后达到了同时补肾、营养卵巢的目的,真正解决了女性早衰的问题。
通过对上述数百例患者的临床实践发现,本发明具有以下治疗效果:
(1)改善围绝经期症状:围绝经期出现的一系列症状主要是由于雌激素下降所致,国内外多数妇产科学者推荐绝经后采用激素替代治疗对妇女生活质量的有益作用远远超过其潜在的有害作用。西药雌激素或多或少存在一些副作用,西方发达国家现已废用合成雌激素中的乙烯雌酚,主要运用天然制剂。如,妊马雌酮和17B-雌二醇。大豆异黄酮是一种结构与雌激素相似,具有雌激素活性的植物性雌激素,服用本发明对改善围绝经期出现的一系列症状疗效显著而无副作用。
(2)治疗卵巢早衰、月经不调、月经量少:妇女40岁以前停经者即为卵巢早衰,卵巢早衰、月经不调、月经量少是妇科的常见疾病。中医学认为,肾虚是卵巢早衰、月经不调、月经量少的根木原因。《素问·上古天真论》云:“女子七岁,肾气盛,齿更发长;二七而天癸至,任脉通,太冲脉盛,月事以时一下,故有子……七七任脉虚,太冲脉衰少,天葵竭,地道不通,故形坏而无子也。”本发明补肾调经,营养卵巢的作用,对卵巢早衰、月经不调、月经量少有治本的作用。
(3)推迟绝经、延缓衰老:据有关研究,妇女45岁左右,卵巢卵母细胞平均数有上万个之多,月经停止的发生机理有可能是由于卵巢内剩余的卵泡对下丘脑—垂体轴激素缺乏反应,使卵泡不能正常成熟和排卵所致。本发明具有补肾调经,营养卵巢,更中药的是中药能对大脑皮层及下丘脑—垂体—肾上腺及卵巢轴各个环节都有调整作用,尤其通过卵巢内调节使“垂死”的卵泡复苏,延缓卵巢的老化,其功能是单纯雌激素代并疗法所不能比拟的。服用本发明,从理论上讲推迟绝经2-3年是完全可能的。
(4)养颜驻容,永葆青春:美国阿拉巴马州大学1992年证实异黄酮是他们研究过的各种抗氧化剂中最有效的一种。由于大豆异黄酮有杭氧化作用,能延缓机体的衰老,恢复机体功能,恢复皮肤润滑、细腻和弹性。枸杞子、当归有滋补肝肾、养血和血之功,是常用的养颜美容药物。因此,服用本发明能养颜驻容,永葆青春。
(5)丰满乳房,降脂减肥:雌激素能促进乳腺腺管增生,孕激素能促进乳腺腺泡发育。本发明具有营养卵巢、调节内分泌,补充女性激素水平,又同时有降脂、降胆固醇作用。服用后乳房饱满,瘦身减肥就不足为奇了。
(6)降血脂、降胆固醇、软化血管:大豆异黄酮有明显的降血脂、降胆固醇、软化血管的作用,本发明中枸杞子、女贞子等具有降血脂、降胆固醇、软化血管。因此,本发明对心脏病、冠心病、动脉硬化有显著的防治作用。
(7)防癌、抗癌,抑制子宫肌瘤、乳腺增生:人体内的氧自由基引起细胞的生物大分子的氧化应激损伤,导致细胞的突变和癌变,大豆异黄酮的抗氧化作用能减少共而能消除细胞的突变和癌变。西医学研究证明,绝经前期(多始于40岁)卵巢功能开始减退,多无排卵及黄体形成,卵巢仅能分泌一定的雌激素而无孕激素,围绝经期是女性子宫肌瘤、乳腺增生和妇科肿瘤的好发时期。大豆异黄酮对雌激素具有双向调节平衡功能,体内雌激素低下时,能补充雌激素,体内激素过高时,能抗雌激素活性功能一一少补多抑(竞争和占用雌性激素受体,抑制体内高效能雌激素发辉作用)。因而服用本发明能防癌、抗癌、抑制子宫肌瘤、乳腺增生。
(8)防治骨质疏松:雌激素是女性一生维持骨矿含量的关键激素。绝经后骨矿含量将以每年3-5%的速率丢失,绝经头5年骨丢失最快,并将持续10-15年。绝经期给予雌激素可阻止骨矿含量丢失,具有预防骨质疏松和骨折的作用。本发明中仙灵脾、牡蛎对治疗骨质疏松有效,因此,本发明能防治骨质疏松。
进一步,本发明包括以下重量份的中药原料:
大豆异黄酮450-500克、仙灵脾200-250克、女贞子250-300克、制首乌200-250克、当归150-200克、白芍100-150克、枸杞150-200克、人参150-200克、红花100-150克、牡蛎80-130克。
更进一步地,本发明包括以下重量份的中药原料:
大豆异黄酮480-500克、仙灵脾220-240克、女贞子250-280克、制首乌230-250克、当归150-180克、白芍120-140克、枸杞150-170克、人参180-200克、红花100-120克、牡蛎80-100克。
一种用于保坤延春的中药组合物的制备方法,包括:
(1)分别将仙灵脾、女贞子、制首乌、当归、白芍、枸杞、人参、牡蛎、红花进行煎煮,煎煮后过滤获得过滤液;
(2)将过滤液混合均匀后获得混合液;
(3)将大豆异黄酮加入到混合液中煎煮、浓缩后制成成品。
优选地,所述步骤(1)中的中药原料均破碎成粉末状后进行煎煮,煎煮的时间为30~60min。
优选地,所述步骤(3)中煎煮的时间为5-10min,浓缩采用低压真空浓缩方式,浓缩压力采用0.02~0.06MPa。
优选地,所述步骤(3)中浓缩后制成的成品的含水率为25%~35%,并在成品中加入辅料制成丸状。
本发明通过上述制备方法的优化,能有效提高有效成份的含量,提高药效。
本发明与现有技术相比,具有如下的优点和有益效果:
1、本发明具有同时达到补肾调经、营养卵巢的作用,对卵巢早衰、月经不调、月经量少有治本的作用,能够明显改善围绝经期症状,效果十分显著;
2、本发明还具有推迟绝经、延缓衰老,养颜驻容、永葆青春,丰满乳房、降脂减肥,降血脂、降胆固醇、软化血管,防癌、抗癌,防治骨质疏松等优点;
3、本发明方法的提取效率高,有效成分的破坏少,极大地增强了药效。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚明白,下面结合实施例,对本发明作进一步的详细说明,本发明的示意性实施方式及其说明仅用于解释本发明,并不作为对本发明的限定。
实施例1
一种用于保坤延春的中药组合物,包括以下重量份的中药原料:
大豆异黄酮500克、仙灵脾220克、女贞子280克、制首乌250克、当归150克、白芍120克、枸杞170克、人参180克、红花100克、牡蛎80克。
上述一种用于保坤延春的中药组合物的制备方法,包括:
(1)分别将仙灵脾、女贞子、制首乌、当归、白芍、枸杞、人参、牡蛎、红花进行粉碎,粉碎成3mm以下粒径大小的颗粒,将颗粒放入到煎煮容器中,添加水,水的加入量为煎煮容器中中药原料体积的1.5~2.5倍,煎煮40min后过滤获得过滤液。
(2)将过滤液混合均匀后获得混合液。
(3)将大豆异黄酮加入到混合液中煎煮,煎煮时间为10min,然后通过低压浓缩的方式进行浓缩,浓缩压力采用0.04MPa左右,浓缩后制成成品,成品的含水率为30%,浓缩后的物料中加入辅料制成丸状。
本发明选取了100名40岁以内的停经者作为实验组,对实验组服用实施例1制备出的药剂,并对实验组不同时间的症状进行统计,统计结果如表1所示。同时采用另外40名40岁以内的停经者作为对照组,对照组均服用清水,并对对照组不同时间的症状进行统计,统计结果如表2所示。
表1
0 | 1月 | 3月 | 6月 | |
绝经人数 | 100 | 89 | 57 | 39 |
胸围平均尺寸 | 86cm | 87cm | 90cm | 91cm |
平均体重 | 52kg | 50kg | 49kg | 49kg |
平均血脂含量 | 159mg/dl | 155mg/dl | 146mg/dl | 137mg/dl |
平均胆固醇含量 | 6.42mmol/L | 6.17mmol/L | 5.91mmol/L | 5.61mmol/L |
表2
0 | 1月 | 3月 | 6月 | |
绝经人数 | 40 | 39 | 38 | 39 |
胸围平均尺寸 | 85cm | 84cm | 83cm | 84cm |
平均体重 | 54kg | 53kg | 54kg | 54kg |
平均血脂含量 | 161mg/dl | 163mg/dl | 159mg/dl | 160mg/dl |
平均胆固醇含量 | 6.28mmol/L | 6.35mmol/L | 6.12mmol/L | 6.31mmol/L |
通过上述表1和表2的对比可知,本发明的药剂能有效对卵巢早衰、月经不调、月经量少有治本的作用,能够明显改善围绝经期症状,还具有推迟绝经、延缓衰老,养颜驻容、永葆青春,丰满乳房、降脂减肥,降血脂、降胆固醇、软化血管,防癌、抗癌,防治骨质疏松等优点。
实施例2
本实施例与实施例1的区别在于,本实施例中各中药原料的组成配比不同,具体设置如下:
大豆异黄酮480克、仙灵脾240克、女贞子260克、制首乌240克、当归170克、白芍140克、枸杞150克、人参190克、红花120克、牡蛎100克。
实施例3
本实施例与实施例1的区别在于,本实施例中各中药原料的组成配比不同,具体设置如下:
大豆异黄酮450克、仙灵脾210克、女贞子290克、制首乌220克、当归190克、白芍110克、枸杞180克、人参160克、红花140克、牡蛎120克。
以上所述的具体实施方式,对本发明的目的、技术方案和有益效果进行了进一步详细说明,所应理解的是,以上所述仅为本发明的具体实施方式而已,并不用于限定本发明的保护范围,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (7)
1.一种用于保坤延春的中药组合物,包括以下中药原料:
大豆异黄酮、仙灵脾、女贞子、制首乌、当归、白芍、枸杞、人参、牡蛎、红花。
2.根据权利要求1所述的一种用于保坤延春的中药组合物,其特征在于,包括以下重量份的中药原料:
大豆异黄酮450-500克、仙灵脾200-250克、女贞子250-300克、制首乌200-250克、当归150-200克、白芍100-150克、枸杞150-200克、人参150-200克、红花100-150克、牡蛎80-130克。
3.根据权利要求2所述的一种用于保坤延春的中药组合物,其特征在于,包括以下重量份的中药原料:
大豆异黄酮480-500克、仙灵脾220-240克、女贞子250-280克、制首乌230-250克、当归150-180克、白芍120-140克、枸杞150-170克、人参180-200克、红花100-120克、牡蛎80-100克。
4.如权利要求1-3任一项所述的一种用于保坤延春的中药组合物的制备方法,其特征在于,包括:
(1)分别将仙灵脾、女贞子、制首乌、当归、白芍、枸杞、人参、牡蛎、红花进行煎煮,煎煮后过滤获得过滤液;
(2)将过滤液混合均匀后获得混合液;
(3)将大豆异黄酮加入到混合液中煎煮、浓缩后制成成品。
5.根据权利要求4所述的一种用于保坤延春的中药组合物的制备方法,其特征在于,所述步骤(1)中的中药原料均破碎成粉末状后进行煎煮,煎煮的时间为30~60min。
6.根据权利要求4所述的一种用于保坤延春的中药组合物的制备方法,其特征在于,所述步骤(3)中煎煮的时间为5-10min,浓缩采用低压真空浓缩方式,浓缩压力采用0.02~0.06MPa。
7.根据权利要求4所述的一种用于保坤延春的中药组合物的制备方法,其特征在于,所述步骤(3)中浓缩后制成的成品的含水率为25%~35%,并在成品中加入辅料制成丸状。
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