CN106963809A - A kind of ferment profit nose cream for repairing schneiderian membrane and preparation method thereof - Google Patents
A kind of ferment profit nose cream for repairing schneiderian membrane and preparation method thereof Download PDFInfo
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- CN106963809A CN106963809A CN201710176890.5A CN201710176890A CN106963809A CN 106963809 A CN106963809 A CN 106963809A CN 201710176890 A CN201710176890 A CN 201710176890A CN 106963809 A CN106963809 A CN 106963809A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to a kind of ferment profit nose cream for repairing schneiderian membrane and preparation method thereof, belong to reparation schneiderian membrane preparation technique field.The ferment profit nose cream for the reparation schneiderian membrane that the present invention is provided includes the component of following weight/mass percentage composition:Ferment elite 12~18%.Seaweeds 2~8%, peppermint oil 4~10%, glycerine 10~16%, vaseline 50~70%.The ferment profit nose cream for the reparation schneiderian membrane that the present invention is provided balances intranasal flora by ferment, and component is natural, has no toxic side effect, can be used for a long time, there is good remission effect to rhinitis.
Description
Technical field
The present invention relates to repairing schneiderian membrane preparation technique field, more particularly to a kind of ferment profit nose cream for repairing schneiderian membrane and
Its preparation method.
Background technology
Rhinitis is due to virus, be damaged in the presence of courses of infection, or stimulant caused by.The typical symptom of rhinitis is led to
Often show as nasal obstruction, runny nose, sneeze, the headache of rhinitis type, giddy etc..Rhinitis does not influence nose simply singly, while can also shadow
Ring throat and eyes, this sleep quality that will have a strong impact on people, hearing and learning ability etc..
The product of existing nasal nursing is more using glucocorticoid, ephedrine drops, antihistamine formulations is main components, or makes
Prepared, or prepared using Chinese medicine with different types of hormone;Hormone can treat acute rhinitis but can not be long-term, in
Medicine can be with toxin expelling, but has denser flavour of a drug, it is impossible to by big well-established;And existing nasal nursing product holding time is short.
The content of the invention
Moisten nose cream it is an object of the invention to provide a kind of ferment for repairing schneiderian membrane.The reparation schneiderian membrane that the present invention is provided
Ferment profit nose cream intranasal flora is balanced by ferment, component is natural, has no toxic side effect, can be used for a long time, have very well to rhinitis
Remission effect.
Moisten nose cream the invention provides a kind of ferment for repairing schneiderian membrane, it is characterised in that contain including following quality percentage
The component of amount:Ferment elite 12~18%.Seaweeds 2~8%, peppermint oil 4~10%, glycerine 10~16%, vaseline 50~
70%.
Preferably, the component of following weight/mass percentage composition is included:Ferment elite 15%.Seaweeds 5%, peppermint oil 7%,
Glycerine 13%, vaseline 60%.
Preferably, the ferment elite is obtained by water fruits and vegetables, sugar, water, wine and trace element fermentation.
Preferably, the method for the fermentation includes:Fruits and vegetables after defibrination is mixed into progress nothing with water, sugar and wine
Aerobe fermentation, is filtrated to get fermenation raw liquid;Stoste is mixed with water and sugar, oxygenation aeration fermentation adds trace element, obtains ferment
Elite.
Preferably, the preparation method of the seaweeds is:Marine alga is crushed, and containing diatomite and activated carbon
Water is mixed, stirring sedimentation;Take supernatant to be centrifuged, abandon addition crystal seed after precipitation and freezed, filtered after thawing, take supernatant to be dissolved in
Water obtains seaweeds.
Preferably, the preparation method of the peppermint oil includes:Dried peppermint leaf after drying is mixed with water, distilled,
When liquid to be distilled has oil-water mixture outflow, 1~2h is distilled in the case where keeping distillate temperature to be 36~40 DEG C, it is to be distilled
When liquid liquid is clarified, take efflux to stand, obtain the peppermint oil on upper strata.
Present invention also offers the preparation method that ferment described in above-mentioned technical proposal moistens nose cream, comprise the following steps:By original
Material mixing, is heated to cooled and solidified after 200 DEG C.
Moisten nose cream the invention provides a kind of ferment for repairing schneiderian membrane.Ferment elite, seaweeds, peppermint, glycerine and all
The profit nose cream that the combination of intellectual circle is made can resist haze, unobstructed breathing, remove itch, moistening nasal cavity, quick-acting ventilations, long-acting guarantor
It is wet, alleviate clear nasal discharge, composition is natural, has no toxic side effect.And preservative, stabilizer need not be added, you can ensure nasal nursing product
Lasting stability.
Brief description of the drawings
The profit nose cream action principle figure that Fig. 1 provides for description of the invention, Fig. 1-1 is without smearing the application profit nose cream
Anaphylactogen invades situation schematic diagram, and Fig. 1-2 invades situation schematic diagram to have smeared anaphylactogen after profit nose cream of the invention;
Fig. 2 is the profit nose cream of the offer of the embodiment of the present invention 2 to various nasal cavity remission effectiveness results figures.
Embodiment
Moisten nose cream the invention provides a kind of ferment for repairing schneiderian membrane, include the component of following weight/mass percentage composition:Ferment
Plain elite 12~18%, seaweeds 2~8%, peppermint 4~10%, glycerine 10~16%, vaseline 50~70%.
The raw material that the present invention repairs the ferment profit nose cream of schneiderian membrane includes the ferment essence that weight/mass percentage composition is 12~18%
China, more preferably 15%.In the present invention, the ferment elite is fermented by water fruits and vegetables, sugar, water, wine and trace element
Arrive.The present invention is to the source of the water fruits and vegetables, sugar, water, wine and trace element without special restriction, people in the art
Water fruits and vegetables, sugar, water, wine and micro- commercially available prod known to member.In the present invention, the ferment elite hair
The method of ferment includes:Fruits and vegetables after defibrination is mixed with water, sugar and wine, anaerobic fermentation is filtrated to get fermenation raw liquid;Will
Stoste is mixed with water and sugar, oxygenation aeration fermentation, is added trace element, is obtained ferment elite.In the present invention, the ferment essence
The effect of China is stabilizing cell membrane, the acceptor on control cell membrane, by the activation and suppression of enzyme, is influenceed intracellular
CAMP/cGMP ratio, prevents the synthesis such as inflammatory lipid medium.
The raw material that the present invention repairs the ferment profit nose cream of schneiderian membrane includes the seaweeds that weight/mass percentage composition is 2~8%, more
Preferably 5%.The preparation method of the seaweeds is:Marine alga is crushed, mixed with the water containing diatomite and activated carbon,
Stirring sedimentation;Take supernatant to be centrifuged, abandon addition crystal seed after precipitation and freezed, filtered after thawing, take supernatant to be dissolved in water and obtain
Seaweeds.
The raw material that the present invention repairs the ferment profit nose cream of schneiderian membrane includes the peppermint that weight/mass percentage composition is 4~10%, more
Preferably 7%.In the present invention, the preparation method of the peppermint oil includes:Dried peppermint leaf after drying is mixed with water, steamed
Evaporate, when liquid to be distilled has oil-water mixture outflow, distill 1~2h in the case where keeping distillate temperature to be 36~40 DEG C, treat
When distillate liquid is clarified, take efflux to stand, obtain the peppermint oil on upper strata.In the present invention, the peppermint oil can adjust profit
The fragrance of nose cream.
The raw material that the present invention repairs the ferment profit nose cream of schneiderian membrane includes the glycerine that weight/mass percentage composition is 10~16%, more
Preferably 13%.The present invention originates without special limitation to the glycerine, using glycerine well known to those skilled in the art
Commercially available prod.In the present invention, the effect of the glycerine is the moisture in absorption air, nasal cavity is kept moistening.
The raw material that the present invention repairs the ferment profit nose cream of schneiderian membrane includes the vaseline that weight/mass percentage composition is 50~70%,
More preferably 60%.The present invention originates without special limitation to the vaseline, using well known to those skilled in the art
The commercially available prod of vaseline.In the present invention, the vaseline act as lubrication, moisturizing, it is to avoid nasal cavity inner membrance is because too
Dry and bleed, or prevent nostril continuous bleeding.
Present invention also offers the preparation method that ferment described in above-mentioned technical proposal moistens nose cream, comprise the following steps:By original
Material mixing, is heated to cooled and solidified after 200 DEG C.
In the present invention, the application method of the ferment profit nose cream is:Lotion is extruded to nasal cavity, the thickness smeared every time is
1~2 millimeter, 4~5 times on the one, after smearing, gently massage the wing of nose.32 gram of one course for the treatment of.
Fig. 1 is present invention profit nose cream action principle figure, and Fig. 1-1 is to invade feelings without the anaphylactogen for smearing the application profit nose cream
Condition schematic diagram, Fig. 1-2 invades situation schematic diagram to have smeared anaphylactogen after profit nose cream of the invention, it is seen then that profit nose cream of the invention
It is to play nasal cavity protective effect by forming physical barriers, i.e., is nano level mucoid gel in nasal mucosal surface formation aperture
Film, stops anaphylactogen, such as pollen, dust mite, animal scurf and PM2.5 fine particles enter body, and body self-defense
Mechanism plays a role together.
The ferment of the reparation schneiderian membrane provided with reference to specific embodiment the present invention, which moistens nose cream and preparation method thereof, to be done
Further details of to introduce, technical scheme includes but is not limited to following examples.
Embodiment 1
Nasal obstruction:After the courses for the treatment of of medication 32g mono-, have a stuffy nose sensible rear stable.
Xeromycteria, rhiocnesmus, nosebleed:One repeatedly, gradually alleviates to symptom and disappears.
Sneeze, clear nasal discharge:Repeatedly there is the over-education phenomenon of sneeze exacerbation to early stage in 30% people, and four are adhered to after alleviation on 1st
The course for the treatment of symptoms of 32g mono- disappear, uneasy to recur.
Haze, pollen, the temperature difference:Moistened using posterula, it is not easy to which sensitivity produces the malaise symptoms such as nasal obstruction, rhiocnesmus, runny nose.
Embodiment 2
To different nasal cavity patient with sympotoms schedule to last the experiment of surrounding, weekly using 8g the application profit nose cream, 32g is one
The individual course for the treatment of, Fig. 2 is present invention profit nose cream to various nasal cavity remission effectiveness results figures, it is seen that:
First week serious symptom grade 2.3 of rhinorrhea, second week 1.3, the 3rd week 0.8,4th week 0.6;
Sneeze first week 1.9, second week 0.9, the 3rd week 0.8,4th week 0.6;
Rhiocnesmus first week 1.8, second week 0.7, the 3rd week 0.8,4th week 0.4;
Have a stuffy nose first week 2.4, second week 1.3, the 3rd week 1,4th week 0.7;
Eye is itched first week 1.5, second week 0.5, the 3rd week 0.7,4th week 0.5;
Nasopharynx is itched first week 1.4, second week 0.7, the 3rd week 0.5,4th week 0.4.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (7)
1. a kind of ferment profit nose cream for repairing schneiderian membrane, it is characterised in that include the component of following weight/mass percentage composition:Ferment essence
China 12~18%.Seaweeds 2~8%, peppermint oil 4~10%, glycerine 10~16%, vaseline 50~70%.
2. ferment according to claim 1 moistens nose cream, it is characterised in that include the component of following weight/mass percentage composition:Ferment
Plain elite 15%.Seaweeds 5%, peppermint oil 7%, glycerine 13%, vaseline 60%.
3. ferment according to claim 1 or 2 moistens nose cream, it is characterised in that the ferment elite by water fruits and vegetables, sugar,
Water, wine and trace element fermentation are obtained.
4. ferment according to claim 3 moistens nose cream, it is characterised in that the method for the fermentation includes:After defibrination
Fruits and vegetables mixes progress anaerobic fermentation with water, sugar and wine, is filtrated to get fermenation raw liquid;Stoste is mixed with water and sugar, increased
Oxygen aerated fermentation, adds trace element, obtains ferment elite.
5. ferment according to claim 1 or 2 moistens nose cream, it is characterised in that the preparation method of the seaweeds is:By sea
Algae is crushed, and is mixed with the water containing diatomite and activated carbon, stirring sedimentation;Take supernatant to be centrifuged, abandon after precipitation and add
Crystal seed is freezed, and is filtered after thawing, is taken supernatant to be dissolved in water and obtain seaweeds.
6. ferment according to claim 1 or 2 moistens nose cream, it is characterised in that the preparation method of the peppermint oil includes:Will
Dried peppermint leaf after drying is mixed with water, is distilled, when liquid to be distilled has oil-water mixture outflow, is keeping distillate temperature
1~2h is distilled in the case of 36~40 DEG C, during liquid liquid clarification to be distilled, takes efflux to stand, obtains the peppermint oil on upper strata.
7. ferment described in claim 1~6 any one moistens the preparation method of nose cream, comprise the following steps:Raw material is mixed, plus
Heat is to cooled and solidified after 200 DEG C.
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CN201710176890.5A CN106963809A (en) | 2017-03-23 | 2017-03-23 | A kind of ferment profit nose cream for repairing schneiderian membrane and preparation method thereof |
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CN201710176890.5A CN106963809A (en) | 2017-03-23 | 2017-03-23 | A kind of ferment profit nose cream for repairing schneiderian membrane and preparation method thereof |
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CN201710176890.5A Pending CN106963809A (en) | 2017-03-23 | 2017-03-23 | A kind of ferment profit nose cream for repairing schneiderian membrane and preparation method thereof |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110064047A (en) * | 2019-04-23 | 2019-07-30 | 深圳前海千水生物科技有限公司 | A kind of plant complex enzyme nasal cavity detoxicating hydro-peening agent |
CN114159353A (en) * | 2022-01-07 | 2022-03-11 | 贵州省畜牧兽医研究所 | Honeycomb nose moistening cream for repairing nasal mucosa and preparation method thereof |
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CN104069059A (en) * | 2014-07-09 | 2014-10-01 | 青岛明月爱熙化妆品有限公司 | Seaweed extracting solution as well as preparation method and application thereof |
CN104473170A (en) * | 2014-12-30 | 2015-04-01 | 北海万物盛生物技术开发有限公司 | Method for preparing composite fruit enzyme |
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2017
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Patent Citations (3)
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CN102731188A (en) * | 2012-06-28 | 2012-10-17 | 黑龙江省京福龙农牧科技开发有限公司 | Plant essence enzyme and preparation method thereof |
CN104069059A (en) * | 2014-07-09 | 2014-10-01 | 青岛明月爱熙化妆品有限公司 | Seaweed extracting solution as well as preparation method and application thereof |
CN104473170A (en) * | 2014-12-30 | 2015-04-01 | 北海万物盛生物技术开发有限公司 | Method for preparing composite fruit enzyme |
Non-Patent Citations (1)
Title |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110064047A (en) * | 2019-04-23 | 2019-07-30 | 深圳前海千水生物科技有限公司 | A kind of plant complex enzyme nasal cavity detoxicating hydro-peening agent |
CN114159353A (en) * | 2022-01-07 | 2022-03-11 | 贵州省畜牧兽医研究所 | Honeycomb nose moistening cream for repairing nasal mucosa and preparation method thereof |
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Application publication date: 20170721 |
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