CN106946812B - 作为个性化抗癌药的胱天蛋白酶原活化化合物的设计、合成和评价 - Google Patents

作为个性化抗癌药的胱天蛋白酶原活化化合物的设计、合成和评价 Download PDF

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CN106946812B
CN106946812B CN201610922720.2A CN201610922720A CN106946812B CN 106946812 B CN106946812 B CN 106946812B CN 201610922720 A CN201610922720 A CN 201610922720A CN 106946812 B CN106946812 B CN 106946812B
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cancer
compound
caspase
compounds
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CN106946812A (zh
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P·J·赫根罗特
Q·P·彼得森
D·C·许
D·C·韦斯特
T·M·范
C·J·诺沃特尼
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University of Illinois System
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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CN201610922720.2A 2009-02-09 2010-02-09 作为个性化抗癌药的胱天蛋白酶原活化化合物的设计、合成和评价 Active CN106946812B (zh)

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BRPI1008651B1 (pt) 2020-01-21
EP2393794B1 (en) 2017-03-22
US9643960B2 (en) 2017-05-09
EP2393794A1 (en) 2011-12-14
CN106946812A (zh) 2017-07-14
WO2010091382A1 (en) 2010-08-12
JP2012517442A (ja) 2012-08-02
US20150344452A1 (en) 2015-12-03
JP2015025021A (ja) 2015-02-05
AU2010210403A1 (en) 2011-09-01
JP5896746B2 (ja) 2016-03-30
EP2393794A4 (en) 2012-10-31
US20120040995A1 (en) 2012-02-16
AU2010210403B2 (en) 2016-07-28
CA2751987A1 (en) 2010-08-12
CA2751987C (en) 2017-11-28
US8778945B2 (en) 2014-07-15
US9102661B2 (en) 2015-08-11
BRPI1008651A2 (pt) 2016-03-08
US20140315915A1 (en) 2014-10-23

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