CN106940375B - 预测不良临床结果的风险的方法 - Google Patents
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| WO2002038794A2 (en) | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| ES2573471T3 (es) | 2002-05-09 | 2016-06-08 | The Brigham And Women's Hospital, Inc. | 1L1RL-1 como un marcador de enfermedades cardiovasculares |
| ATE476657T1 (de) | 2006-04-24 | 2010-08-15 | Critical Care Diagnostics Inc | Vorhersage von letalität und detektion von schweren erkrankungen |
| EP2021799B1 (en) * | 2006-04-27 | 2011-07-20 | Critical Care Diagnostics, Inc. | Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease |
| PT2021796E (pt) | 2006-05-01 | 2012-04-19 | Critical Care Diagnostics Inc | Diagnóstico de doença cardiovascular |
| EP2995951B1 (en) * | 2006-05-02 | 2019-02-13 | Critical Care Diagnostics, Inc. | Method for selecting treatment based on differential diagnosis between pulmonary and cardiovascular disease |
| PT2827152T (pt) | 2008-04-18 | 2016-09-13 | Critical Care Diagnostics Inc | Previsão do risco de eventos cardíacos adversos maiores |
| HRP20160461T1 (hr) | 2010-04-09 | 2016-06-17 | Critical Care Diagnostics, Inc. | Solubilna humana st-2 antitijela i eseji |
| US8728742B2 (en) | 2011-03-17 | 2014-05-20 | Critical Care Diagnostics, Inc. | Methods predicting risk of an adverse clinical outcome |
| EP2734222B1 (en) | 2011-07-18 | 2016-10-19 | Critical Care Diagnostics, Inc. | Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy |
| MX357740B (es) | 2012-05-18 | 2018-07-23 | Critical Care Diagnostics Inc | Métodos para determinar el pronóstico del tratamiento de un sujeto con un desfibrilador cardíaco implantado, un dispositivo de tratamiento de resincronización cardíaca o un dispositivo combinado de desfibrilador cardíaco implantado y de resincronización cardíaca. |
| PL2885641T3 (pl) | 2012-08-16 | 2018-04-30 | Critical Care Diagnostics, Inc. | Metody przewidywania ryzyka rozwoju nadciśnienia tętniczego krwi |
| MX375520B (es) | 2012-08-21 | 2025-03-06 | Critical Care Diagnostics Inc | Estratificación de riesgo para marcador múltiple. |
| CN104521298B (zh) * | 2013-08-08 | 2018-07-03 | 华为技术有限公司 | 传输信号的方法、网络侧设备和用户设备 |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| EP3448245A4 (en) * | 2016-04-25 | 2019-03-06 | Siemens Healthcare Diagnostics Inc. | DIAGNOSTIC PROCEDURE FOR DETECTING AND TREATING POST-INFARM MYOKARD REMODELING AND DIFFUSER MYOCARDIBLE FIBROSIS |
| WO2019023247A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND |
| US10799138B2 (en) | 2018-04-05 | 2020-10-13 | University Of Maryland, Baltimore | Method of administering sotalol IV/switch |
| RU2677611C1 (ru) * | 2018-04-16 | 2019-01-17 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ прогнозирования неблагоприятных сердечно-сосудистых событий в течение 12 месяцев у больных хронической сердечной недостаточностью с рецидивом стенокардии после реваскуляризации миокарда |
| US12396970B2 (en) | 2021-08-20 | 2025-08-26 | AltaThera Pharmaceuticals LLC | Anti-arrhythmic compositions and methods |
| US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
| US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
| US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
| EP3918323A4 (en) | 2019-01-30 | 2022-12-28 | TrueBinding, Inc. | ANTI-GAL3 ANTIBODIES AND USES THEREOF |
| CN113425271B (zh) * | 2021-05-20 | 2024-02-06 | 上海小芃科技有限公司 | 日间手术出院判断方法、装置、设备及存储介质 |
| WO2024092136A2 (en) * | 2022-10-28 | 2024-05-02 | Memorial Sloan-Kettering Cancer Center | Machine learning modeling for inpatient prediction |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1543352A (zh) * | 2001-06-22 | 2004-11-03 | ����ƻ���ϵͳ��˾ | 用于治疗免疫性疾病的方法和材料 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6176962B1 (en) | 1990-02-28 | 2001-01-23 | Aclara Biosciences, Inc. | Methods for fabricating enclosed microchannel structures |
| GB9211686D0 (en) | 1992-06-03 | 1992-07-15 | Medisinsk Innovation A S | Chemical compounds |
| US6066322A (en) | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| PT1493439E (pt) | 1997-04-02 | 2012-01-10 | Brigham & Womens Hospital | Meio de avaliação do perfil de risco de um indivíduo para uma doença aterosclerótica |
| ATE489633T1 (de) | 1997-06-10 | 2010-12-15 | Lpath Inc | Verfahren zum frühzeitigen nachweis herzerkrankungen |
| US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
| GB9827348D0 (en) | 1998-12-12 | 1999-02-03 | Univ Leicester | Natriuretic peptide |
| EP1140137A2 (en) | 1998-12-18 | 2001-10-10 | Scios Inc. | Method for detection and use of differentially expressed genes in disease states |
| AU4055000A (en) * | 1999-04-13 | 2000-11-14 | Daniel K. Hsu | Galectin expression is induced in cirrhotic liver and hepatocellular carcinoma |
| WO2000073498A1 (en) | 1999-06-02 | 2000-12-07 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| US6323334B1 (en) | 1999-09-24 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding a 103 gene product and uses therefor |
| WO2001070817A1 (en) | 2000-03-21 | 2001-09-27 | Medical & Biological Laboratories Co., Ltd. | Monoclonal antibody and method and kit for the immunoassay of soluble human st2 with the use of the same |
| BR0107157A (pt) | 2000-08-22 | 2002-07-16 | Brigham And Womens Hospital In | Diagnose e tratamento de condições cardiovasculares |
| WO2002038794A2 (en) | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US6905827B2 (en) | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| WO2003022987A2 (en) | 2001-07-26 | 2003-03-20 | Eos Biotechnology, Inc. | Methods of diagnosis of hepatitis c infection, compositions and methods of screening for modulators of hepatitis c infection |
| US6810284B1 (en) | 2001-11-21 | 2004-10-26 | Pacesetter, Inc. | Implantable cardiac stimulation system and method for monitoring diastolic function |
| ES2573471T3 (es) | 2002-05-09 | 2016-06-08 | The Brigham And Women's Hospital, Inc. | 1L1RL-1 como un marcador de enfermedades cardiovasculares |
| AU2003299441A1 (en) | 2002-12-19 | 2004-07-14 | Centre National De La Recherche Scientifique - Cnrs | Nf-hev compositions and methods of use |
| US20040133079A1 (en) | 2003-01-02 | 2004-07-08 | Mazar Scott Thomas | System and method for predicting patient health within a patient management system |
| WO2004111654A2 (en) * | 2003-06-06 | 2004-12-23 | Ciphergen Biosystems, Inc. | Serum biomarkers in ischaemic heart disease |
| EP1522857A1 (en) | 2003-10-09 | 2005-04-13 | Universiteit Maastricht | Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2 |
| US20050250156A1 (en) | 2003-10-31 | 2005-11-10 | Shebuski Ronald J | Detection of acute myocardial infarction biomarkers |
| CA3050151C (en) | 2003-11-26 | 2023-03-07 | Celera Corporation | Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof |
| US20050196817A1 (en) | 2004-01-20 | 2005-09-08 | Molecular Staging Inc. | Biomarkers for sepsis |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| JP2005291899A (ja) | 2004-03-31 | 2005-10-20 | Akira Matsumori | 心疾患の検査法 |
| EP1731910A1 (en) | 2005-06-07 | 2006-12-13 | F. Hoffmann-La Roche Ag | Use of NT-proANP and NT-proBNP for diagnosing cardiac diseases |
| ATE476657T1 (de) | 2006-04-24 | 2010-08-15 | Critical Care Diagnostics Inc | Vorhersage von letalität und detektion von schweren erkrankungen |
| EP2021799B1 (en) | 2006-04-27 | 2011-07-20 | Critical Care Diagnostics, Inc. | Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease |
| PT2021796E (pt) | 2006-05-01 | 2012-04-19 | Critical Care Diagnostics Inc | Diagnóstico de doença cardiovascular |
| EP2995951B1 (en) | 2006-05-02 | 2019-02-13 | Critical Care Diagnostics, Inc. | Method for selecting treatment based on differential diagnosis between pulmonary and cardiovascular disease |
| US8147817B2 (en) | 2006-05-04 | 2012-04-03 | The Brigham And Women's Hospital, Inc. | IL-33 in the treatment and diagnosis of diseases and disorders |
| EP2282757B1 (en) * | 2008-04-07 | 2013-05-22 | Kalobios Pharmaceuticals, Inc. | Neutralization of gm-csf for the treatment of heart failure |
| PT2827152T (pt) | 2008-04-18 | 2016-09-13 | Critical Care Diagnostics Inc | Previsão do risco de eventos cardíacos adversos maiores |
| WO2010007041A1 (en) * | 2008-07-14 | 2010-01-21 | Roche Diagnostics Gmbh | Multimarker panel for diagnosing, monitoring and selecting the therapy for patients with heart failure |
| EP3971570A3 (en) * | 2008-10-29 | 2022-11-09 | BG Medicine, Inc. | Galectin-3 immunoassay |
| HRP20160461T1 (hr) | 2010-04-09 | 2016-06-17 | Critical Care Diagnostics, Inc. | Solubilna humana st-2 antitijela i eseji |
| US8728742B2 (en) | 2011-03-17 | 2014-05-20 | Critical Care Diagnostics, Inc. | Methods predicting risk of an adverse clinical outcome |
| EP2734222B1 (en) | 2011-07-18 | 2016-10-19 | Critical Care Diagnostics, Inc. | Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy |
| MX357740B (es) | 2012-05-18 | 2018-07-23 | Critical Care Diagnostics Inc | Métodos para determinar el pronóstico del tratamiento de un sujeto con un desfibrilador cardíaco implantado, un dispositivo de tratamiento de resincronización cardíaca o un dispositivo combinado de desfibrilador cardíaco implantado y de resincronización cardíaca. |
| PL2885641T3 (pl) | 2012-08-16 | 2018-04-30 | Critical Care Diagnostics, Inc. | Metody przewidywania ryzyka rozwoju nadciśnienia tętniczego krwi |
| MX375520B (es) | 2012-08-21 | 2025-03-06 | Critical Care Diagnostics Inc | Estratificación de riesgo para marcador múltiple. |
| MX2016009060A (es) | 2014-01-10 | 2016-09-09 | Critical Care Diagnostics Inc | Metodos y sistemas para determinar el riesgo de falla cardiaca. |
| USD770057S1 (en) | 2014-04-14 | 2016-10-25 | Critical Care Diagnostics, Inc. | Blood test kit |
| USD800332S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| USD800333S1 (en) | 2014-09-23 | 2017-10-17 | Critical Care Diagnostics, Inc. | Blood test kit |
| US10324089B2 (en) | 2014-12-11 | 2019-06-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
| US10079073B2 (en) | 2014-12-11 | 2018-09-18 | Critical Care Diagnostics, Inc. | Test apparatus and methods for ST2 cardiac biomarker |
-
2012
- 2012-03-16 US US13/422,574 patent/US8728742B2/en active Active
- 2012-03-16 JP JP2013558218A patent/JP6215713B2/ja not_active Expired - Fee Related
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1543352A (zh) * | 2001-06-22 | 2004-11-03 | ����ƻ���ϵͳ��˾ | 用于治疗免疫性疾病的方法和材料 |
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| US20140234875A1 (en) | 2014-08-21 |
| JP6215713B2 (ja) | 2017-10-18 |
| WO2012141844A2 (en) | 2012-10-18 |
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| CN106940375A (zh) | 2017-07-11 |
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| ES2897419T3 (es) | 2022-03-01 |
| US9823257B2 (en) | 2017-11-21 |
| US9239333B2 (en) | 2016-01-19 |
| US8728742B2 (en) | 2014-05-20 |
| EP3605104A1 (en) | 2020-02-05 |
| JP2014514536A (ja) | 2014-06-19 |
| WO2012141844A3 (en) | 2013-03-21 |
| CN103718046B (zh) | 2016-10-12 |
| EP2686689B1 (en) | 2019-08-07 |
| EP2686689A4 (en) | 2014-09-03 |
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| US20180292415A1 (en) | 2018-10-11 |
| JP2018021926A (ja) | 2018-02-08 |
| US10393756B2 (en) | 2019-08-27 |
| ES2750126T3 (es) | 2020-03-25 |
| EP3605104B1 (en) | 2021-09-15 |
| US20160299153A1 (en) | 2016-10-13 |
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