CN106938010A - A kind of dendrobium nobile flower tea with effect for reducing blood fat and preparation method thereof - Google Patents
A kind of dendrobium nobile flower tea with effect for reducing blood fat and preparation method thereof Download PDFInfo
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- CN106938010A CN106938010A CN201710304227.9A CN201710304227A CN106938010A CN 106938010 A CN106938010 A CN 106938010A CN 201710304227 A CN201710304227 A CN 201710304227A CN 106938010 A CN106938010 A CN 106938010A
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- herba dendrobii
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The invention discloses a kind of dendrobium nobile flower tea with effect for reducing blood fat and preparation method thereof, by HERBA DENDROBII spends 1 20 parts, 1 20 parts of 1 20 parts of lotus leaf and hawthorn be made.Lotus leaf strengthens internal organs metaplasia, promotes food to make full use of, hawthorn digesting oil removing, promotes nutriment used by body, is altogether monarch drug in a prescription.HERBA DENDROBII flower, effective anti-lipid peroxidation and removing free radical are equipped with, reinforcing blood vessel makes blood operation smooth, and protection channels and collaterals blood vessels function is normally played, and is ministerial drug.Three medicines are cooperateed with, and Li Shui dehumidifying disperse accumulations, salubrity are played altogether and disappears turbid lipid-loweringing, clearing heat and detoxicating, resolving phlegm and dissipating blood stasis, product benefit except dirty effect.
Description
Technical field
The present invention relates to field containing Chinese medicinal health-care drink, specially a kind of dendrobium nobile flower tea and its system with effect for reducing blood fat
Preparation Method.
Background technology
Hyperlipidemia（Hyperlipidemia, HLP）It is common disease, the frequently-occurring disease of today's society, is common in the elderly, but
With dietary structure and the change of habits and customs, the rejuvenation of hyperlipemia is increasingly severe.The disease is that Human Lipid Metabolism loses
Often, blood plasma inner lipid concentration exceedes a kind of disease of normal high limit, is the independent risk factor of atherosclerosis, is coronary disease
The associated disease and risk factor of disease, pancreatitis, fatty liver, diabetes, obesity etc..Cured in the prevention and treatment category of hyperlipemia
Not sick category.The traditional Chinese medical science thinks hyperlipemia for asthenia in origin and asthenia in superficiality, category " blood stasis ", " phlegm is turbid " category, is attributed to liver deficiency of the kidney clinical syndrome differentiation more
Empty, insufficiency of the spleen phlegm is turbid, qi depression to blood stasis, during treatment mostly using tonifying the liver and kidney, strengthening the spleen and replenishing qi, nourishing yin and nourishing blood, promoting blood circulation and removing blood stasis, heat-clearing lead to
Just the medicine, eliminated indigestion and phlegm.
Green naturally requirement is pursued to meet modern, meets the meter that country advocates healthy living and drug safety
Draw, it is significant to " anti-not sick ", the quality of life of people can be preferably improved, health care purpose is reached.The present invention intend with
Pure plant Chinese medicine preparation is research object, by proving hyperlipemia mouse experiment, and exploitation is a kind of to be had in effect for reducing blood fat
Medicine health drink.
The content of the invention
It is an object of the invention to provide a kind of dendrobium nobile flower tea of pure plant Chinese medicine preparation with effect for reducing blood fat and its
Preparation method.
To reach above-mentioned purpose, the technical scheme used for：
A kind of dendrobium nobile flower tea with effect for reducing blood fat, by weight, by 1-20 parts of HERBA DENDROBII flower, 1-20 parts of lotus leaf and mountain
1-20 parts of short, bristly hair or beard is made.
The optimum ratio of above-mentioned dendrobium nobile flower tea, by HERBA DENDROBII spends 2 parts, 5 parts of 4 parts of lotus leaf and hawthorn be made.
The preparation method of above-mentioned dendrobium nobile flower tea is：HERBA DENDROBII flower, lotus leaf and hawthorn, the water that 6 times of totalling amount are taken in proportion
Immersion 30 minutes, is then refluxed for extracting 3 times, merging filtrate, and it is 1 g/ml that 60 DEG C, which are concentrated under reduced pressure into medicine and the relative density of water,.
By HERBA DENDROBII spent, lotus leaf and the taste medicine of hawthorn three are constituted by fat decreasing tea for HERBA DENDROBII flower, and lotus leaf strengthens internal organs in side
It is raw, promote food to make full use of, hawthorn digesting oil removing promotes nutriment used by body, is altogether monarch drug in a prescription.It is equipped with HERBA DENDROBII
Flower, effective anti-lipid peroxidation and removing free radical, reinforcing blood vessel makes blood operation smooth, and protection channels and collaterals blood vessels function is normal
Play, be ministerial drug.Three medicines are cooperateed with, and Li Shui dehumidifying disperse accumulations, salubrity are played altogether and disappears turbid lipid-loweringing, clearing heat and detoxicating, resolving phlegm and dissipating blood stasis, product benefit except dirty
Effect.
Brief description of the drawings
Fig. 1 is index compares figure of each experimental group of the invention to mouse liver pathology damage.
Fig. 2 is the mouse liver pathology comparison picture of each experimental group of the invention.
Embodiment
The present invention is further described with reference to embodiment and accompanying drawing, but the present invention is not limited only to following embodiments, can be with
Those skilled in the art are predicted in the case where combining prior art, there may be many variations for performance.
A kind of dendrobium nobile flower tea with effect for reducing blood fat, by weight, 1-20 parts, 1-20 parts of lotus leaf is spent by HERBA DENDROBII
1-20 parts are made with hawthorn.By HERBA DENDROBII spent, lotus leaf and the taste medicine of hawthorn three are constituted by fat decreasing tea for HERBA DENDROBII flower, and lotus leaf is strong in side
Change internal organs metaplasia, promote food to make full use of, hawthorn digesting oil removing promotes nutriment used by body, is altogether monarch drug in a prescription.It is equipped with
HERBA DENDROBII is spent, effective anti-lipid peroxidation and removing free radical, and reinforcing blood vessel makes blood operation smooth, protects channels and collaterals blood vessels
Function is normally played, and is ministerial drug.Three medicines are cooperateed with, play altogether Li Shui dehumidifying disperse accumulations, salubrity disappear turbid lipid-loweringing, clearing heat and detoxicating, resolving phlegm and dissipating blood stasis,
Product benefit removes dirty effect.
The materials and methods of confirmatory experiment
1.1 experimental animals
ICR mouse, SPF grades, male and female are not limited, 18 ~ 22g of body weight, are provided by Chengdu up to large bio tech ltd.Experimental animal
Quality certification number SCXK2008-24.
1.2 medicines and preparation
Take HERBA DENDROBII spend 2g, lotus leaf 4g, hawthorn 5g, plus 6 times amount water soak 30 minutes after, refluxing extraction 3 times, merging filtrate,
60 DEG C are concentrated under reduced pressure into relative density for 1g crude drugs/ml.
1.3 key instruments and reagent
Automatic clinical chemistry analyzer（Model：TC6010L, Jiangxi Tekang Science ＆ Technology Co., Ltd.）；Type centrifuge（Model：LXJ-ⅡB
Shanghai Analytical Instrument Co., Ltd of Jinpeng）；Ultrasonic cleaner（Model：KQ-400DB Kunshan Ultrasonic Instruments Co., Ltd.）；
Assay balance（Model：BSA 224S Sai Duolisi scientific instrument（Beijing）Co., Ltd）；Triton WR-1339（Lot number：
E120523, U.S. SIGMA）Simvastatin capsules（Product batch number 20120306, Xiamen Fuman Pharmaceutical Co., Ltd.）
1.4 experiment packets and administration
After Animal adaptability is fed 7 days, 6 groups, every group 12 are randomly divided into.Respectively as：1. Normal group：It is isometric pure
Water；2. model group：Isometric pure water；3. Simvastatin group：3.3 mg·kg-1；4.~6. high, medium and low dose of lotus leaf Jiangzhi Recipe
Amount group, dosage is respectively 36,18,9gkg-1.10 d are administered in each experimental group continuous gavage, 1 time a day.
1.5 modeling methods
2 hours after 10d administrations, except isometric physiological saline is injected in Normal group abdominal cavity, remaining each group presses 400 mgkg-1The Triton WR-1339 normal saline solutions of dosage abdominal cavity injection 4%[3], fasting can't help the h of water 18.
1.6 observation index and method
Each experimental mice body weight is recorded daily, calculates body weight increase amount.After modeling fasting 18 hours, pluck eyeball and take blood, 4000
r·min-110 min are centrifuged, serum is separated.Using automatic clinical chemistry analyzer to cholesterol in serum（TC）, triglycerides
（TG）, HDL-C（HDL-C）, LDL-C（LDL-C）Content be measured, and calculate
Atherosclerosis index：AI1=(TC-HDL-C)
/HDL-C；AI2=LDL-C/HDL-C.De- cervical vertebra puts to death mouse, and subcutaneous and epididymal adipose tissues are taken rapidly, are weighed；Hepatic tissue
Pathomorphology is checked：Left lobe of liver is taken, 10 % formalin are fixed, carry out routine paraffin wax embedded section, Hematoxylin-eosin（HE）
Dyeing, micro- Microscopic observation level of fibrosis change.Liver tissue injury grade uses marking system：" 0 point " expression is disease-free
Become；" 1 point " expression mild damage, " 2 points " represent moderate infringement, and " 3 points " represent severe infringement.
1.7 statistical methods
Statistical analysis is carried out using SPSS13.0 statistical softwares.Data are represented with Mean ± SD, are compared between multisample mean and are adopted
Examined with One-Way ANOVA, variance is then examined using LSD together, heterogeneity of variance is then examined using Tamhane ' s T2；Grade is provided
Material compares between using non-parametric test group；Examine withp<Think that its group difference has conspicuousness when 0.05.
As a result
The influence of 2.1 pairs of acute HLP Mouse Weights
Table 1 shows that each group Mouse Weight has different degrees of growth during experiment, and there was no significant difference for body weight.But with model
Group is compared, and HERBA DENDROBII flower each dosage group Mouse Weight increment of fat decreasing tea is smaller, shows significant difference（P<0.05）.
2.2 couples of acute HLP mice serums TC, TG, HDL-C, LDL-C influence
Table 2 is shown, is compared with Normal group, and model group serum TG, LDL-C are significantly raised（P<0.05）, TC extremely significantly rises
It is high（P<0.01）, and HDL-C is then significantly reduced（P<0.05）.Compared with model group, high dose group serum TC pole is significantly reduced（P<
0.05）, HDL-C poles are dramatically increased（P<0.01）, TG, LDL-C are significantly reduced（P<0.05）；Middle dose group serum TC, TG, LDL-
C is significantly reduced（P<0.05）, HDL-C dramatically increases（P<0.05）；Low dose group serum TC, LDL-C are significantly reduced（P<0.05）,
HDL-C is dramatically increased（P<0.05）, TG significantly reduces（P<0.05）.
The influence of 2.3 pairs of acute HLP rat aortas atherosis indexes
Table 3 is shown, compared with Normal group, model group mouse AI1And AI2There is pole to significantly increase（P<0.01）, illustrate anxious
Property HLP causes mouse to suffer from atherosclerosis（AS）Dangerous increase.Compared with model group, HERBA DENDROBII each dose of fat decreasing tea of flower
Amount group mouse AI1And AI2There is pole to be substantially reduced（P<0.01）, illustrate that there is lotus leaf Jiangzhi Recipe the acute HLP mouse of reduction to suffer from AS's
Risk.
The influence of 2.4 pairs of acute HLP mouse adiposes weight
Table 4 is shown, is compared with Normal group, and model group mouse adipose weight is significantly increased（P<0.05）；Compared with model group,
The HERBA DENDROBII flower high, medium and low dosage group mouse adipose weight of fat decreasing tea is substantially reduced（P<0.05）.
The influence of 2.5 pairs of hepatic pathology damage index
Fig. 1 shows influence of the HERBA DENDROBII flower fat decreasing tea to mouse liver pathology damage index, is compared with Normal group, model
Group mouse liver pathology damage index is significantly increased（P<0.05）；Compared with model group, the high, medium and low dosage group of lotus leaf Jiangzhi Recipe
Mouse liver pathology damage index is substantially reduced（P<0.05）.Fig. 2 shows each experimental mice hepatic pathology picture（HE, ×
100）, Normal group murine liver tissue structure is intact.The hardened structure of liver that liver cell outwards radially distributes from central vein
Clear, marshalling, hepatic sinusoid has no expansion, and liver cell size is more uniform, and cytoplasm of liver enriches.Its nucleolus, it is plentiful,
It can be seen that double-core.Remaining each group hepatic tissue has different degrees of pathomorphism to change respectively, mainly based on cell infiltration, and
With swelling of liver cell, sinus hepaticus dilatation and congestion.Generally speaking in addition to model group, other each group lesion degrees are lighter, have no that liver is thin
Born of the same parents' necrosis and fibrosed tissue hyperplasia.
Claims (3)
1. a kind of dendrobium nobile flower tea with effect for reducing blood fat, by weight, it is characterized in that：1-20 parts, lotus are spent by HERBA DENDROBII
1-20 parts of 1-20 parts of leaf and hawthorn are made.
2. dendrobium nobile flower tea according to claim 1, by weight, it is characterized in that：2 parts, 4 parts of lotus leaf are spent by HERBA DENDROBII
5 parts are made with hawthorn.
3. the preparation method of dendrobium nobile flower tea as claimed in claim 1 or 2, it is characterized in that：Take in proportion HERBA DENDROBII flower, lotus leaf and
Hawthorn, the water that 6 times of totalling amount soaks 30 minutes, is then refluxed for extracting 3 times, merging filtrate, 60 DEG C are concentrated under reduced pressure into medicine and water
Relative density be 1 g/ml.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710304227.9A CN106938010A (en) | 2017-05-03 | 2017-05-03 | A kind of dendrobium nobile flower tea with effect for reducing blood fat and preparation method thereof |
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| CN201710304227.9A CN106938010A (en) | 2017-05-03 | 2017-05-03 | A kind of dendrobium nobile flower tea with effect for reducing blood fat and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108029828A (en) * | 2017-12-28 | 2018-05-15 | 河南健特生物科技集团有限公司 | A kind of pouring type fruit tea containing stem of noble dendrobium flower and preparation method thereof |
| CN111329958A (en) * | 2020-03-26 | 2020-06-26 | 浙江中医药大学 | Dendrobium officinale leaf traditional Chinese medicine composition for regulating blood fat and preparation method and application thereof |
| CN114287623A (en) * | 2021-12-31 | 2022-04-08 | 安徽阳光药业有限公司 | Dendrobium enzyme particle and preparation method thereof |
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| CN104042708A (en) * | 2013-03-14 | 2014-09-17 | 成都百草和济科技有限公司 | Composition for improving dyslipidemia and its preparation method and use |
| CN104286272A (en) * | 2014-10-28 | 2015-01-21 | 王春红 | Application of dendrobium candidum flowers and tea leaf product thereof |
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2017
- 2017-05-03 CN CN201710304227.9A patent/CN106938010A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104042708A (en) * | 2013-03-14 | 2014-09-17 | 成都百草和济科技有限公司 | Composition for improving dyslipidemia and its preparation method and use |
| CN104286272A (en) * | 2014-10-28 | 2015-01-21 | 王春红 | Application of dendrobium candidum flowers and tea leaf product thereof |
Non-Patent Citations (3)
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| 敬松: "《中国花膳与花疗——花卉疗法小百科》", 31 January 2013 * |
| 童筱: "《食疗与养生》", 31 January 2006 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108029828A (en) * | 2017-12-28 | 2018-05-15 | 河南健特生物科技集团有限公司 | A kind of pouring type fruit tea containing stem of noble dendrobium flower and preparation method thereof |
| CN111329958A (en) * | 2020-03-26 | 2020-06-26 | 浙江中医药大学 | Dendrobium officinale leaf traditional Chinese medicine composition for regulating blood fat and preparation method and application thereof |
| CN114287623A (en) * | 2021-12-31 | 2022-04-08 | 安徽阳光药业有限公司 | Dendrobium enzyme particle and preparation method thereof |
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Application publication date: 20170711 |