CN106928268B - A method of preparing iodotrimethylsilane - Google Patents
A method of preparing iodotrimethylsilane Download PDFInfo
- Publication number
- CN106928268B CN106928268B CN201710134989.9A CN201710134989A CN106928268B CN 106928268 B CN106928268 B CN 106928268B CN 201710134989 A CN201710134989 A CN 201710134989A CN 106928268 B CN106928268 B CN 106928268B
- Authority
- CN
- China
- Prior art keywords
- iodotrimethylsilane
- preparation
- reaction
- iodide
- iodine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- CSRZQMIRAZTJOY-UHFFFAOYSA-N trimethylsilyl iodide Chemical compound C[Si](C)(C)I CSRZQMIRAZTJOY-UHFFFAOYSA-N 0.000 title claims abstract description 108
- 238000000034 method Methods 0.000 title abstract description 24
- 238000006243 chemical reaction Methods 0.000 claims abstract description 53
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims abstract description 52
- 238000002360 preparation method Methods 0.000 claims abstract description 31
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims abstract description 29
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 20
- 239000011780 sodium chloride Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Chemical compound [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 claims description 79
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 33
- 239000003054 catalyst Substances 0.000 claims description 17
- 239000003960 organic solvent Substances 0.000 claims description 14
- 238000004064 recycling Methods 0.000 claims description 12
- 235000009518 sodium iodide Nutrition 0.000 claims description 11
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical group [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 claims description 6
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 4
- 235000019441 ethanol Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract description 23
- 229910052740 iodine Inorganic materials 0.000 abstract description 23
- 239000011630 iodine Substances 0.000 abstract description 23
- 239000000047 product Substances 0.000 abstract description 15
- JCHGDLSNQMRKGZ-UHFFFAOYSA-N [SiH4].[I] Chemical compound [SiH4].[I] JCHGDLSNQMRKGZ-UHFFFAOYSA-N 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 10
- NEXSMEBSBIABKL-UHFFFAOYSA-N hexamethyldisilane Chemical compound C[Si](C)(C)[Si](C)(C)C NEXSMEBSBIABKL-UHFFFAOYSA-N 0.000 abstract description 9
- 239000006227 byproduct Substances 0.000 abstract description 8
- 239000002699 waste material Substances 0.000 abstract description 8
- 239000012299 nitrogen atmosphere Substances 0.000 abstract description 7
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 229910052700 potassium Inorganic materials 0.000 abstract description 4
- 239000011591 potassium Substances 0.000 abstract description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 229910052708 sodium Inorganic materials 0.000 abstract description 3
- 239000011734 sodium Substances 0.000 abstract description 3
- 230000001681 protective effect Effects 0.000 abstract description 2
- 229910052782 aluminium Inorganic materials 0.000 description 11
- 239000004411 aluminium Substances 0.000 description 11
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000012043 crude product Substances 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 238000003786 synthesis reaction Methods 0.000 description 8
- 238000001035 drying Methods 0.000 description 7
- 150000001335 aliphatic alkanes Chemical class 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 229940073561 hexamethyldisiloxane Drugs 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 238000004821 distillation Methods 0.000 description 4
- IVSZLXZYQVIEFR-UHFFFAOYSA-N m-xylene Chemical group CC1=CC=CC(C)=C1 IVSZLXZYQVIEFR-UHFFFAOYSA-N 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 3
- SZYWUQQAVKOBQA-UHFFFAOYSA-N [Si].CI(C)C Chemical compound [Si].CI(C)C SZYWUQQAVKOBQA-UHFFFAOYSA-N 0.000 description 3
- 230000036632 reaction speed Effects 0.000 description 3
- 229910000077 silane Inorganic materials 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- -1 amino, hydroxyl Chemical group 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001351 cycling effect Effects 0.000 description 2
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 2
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 238000011017 operating method Methods 0.000 description 2
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- MZQCFPABNHFYAT-UHFFFAOYSA-M sodium;propan-2-one;iodide Chemical compound [Na+].[I-].CC(C)=O MZQCFPABNHFYAT-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 229930186147 Cephalosporin Natural products 0.000 description 1
- CECABOMBVQNBEC-UHFFFAOYSA-K aluminium iodide Chemical compound I[Al](I)I CECABOMBVQNBEC-UHFFFAOYSA-K 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229960002100 cefepime Drugs 0.000 description 1
- HVFLCNVBZFFHBT-ZKDACBOMSA-O cefepime(1+) Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-O 0.000 description 1
- DKOQGJHPHLTOJR-WHRDSVKCSA-N cefpirome Chemical compound N([C@@H]1C(N2C(=C(C[N+]=3C=4CCCC=4C=CC=3)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CSC(N)=N1 DKOQGJHPHLTOJR-WHRDSVKCSA-N 0.000 description 1
- 229960000466 cefpirome Drugs 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- YGZSVWMBUCGDCV-UHFFFAOYSA-N chloro(methyl)silane Chemical compound C[SiH2]Cl YGZSVWMBUCGDCV-UHFFFAOYSA-N 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- UYZARHCMSBEPFF-UHFFFAOYSA-N diiodo(dimethyl)silane Chemical compound C[Si](C)(I)I UYZARHCMSBEPFF-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- KHSYJTZEZKTABB-UHFFFAOYSA-N iodomethane silane Chemical compound [SiH4].CI KHSYJTZEZKTABB-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- FZAXZVHFYFGNBX-UHFFFAOYSA-M lithium iodate Chemical compound [Li+].[O-]I(=O)=O FZAXZVHFYFGNBX-UHFFFAOYSA-M 0.000 description 1
- FHRASHKICNZNDI-UHFFFAOYSA-L lithium sodium chloride iodide Chemical compound [Cl-].[Na+].[I-].[Li+] FHRASHKICNZNDI-UHFFFAOYSA-L 0.000 description 1
- WTFCBWXBJBYVOS-UHFFFAOYSA-L lithium;sodium;dichloride Chemical compound [Li+].[Na+].[Cl-].[Cl-] WTFCBWXBJBYVOS-UHFFFAOYSA-L 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- ODGTVVCTZIKYTG-UHFFFAOYSA-N tert-butyl-iodo-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)I ODGTVVCTZIKYTG-UHFFFAOYSA-N 0.000 description 1
- 125000003698 tetramethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/12—Organo silicon halides
- C07F7/121—Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20
- C07F7/123—Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20 by reactions involving the formation of Si-halogen linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710134989.9A CN106928268B (en) | 2017-03-08 | 2017-03-08 | A method of preparing iodotrimethylsilane |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710134989.9A CN106928268B (en) | 2017-03-08 | 2017-03-08 | A method of preparing iodotrimethylsilane |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106928268A CN106928268A (en) | 2017-07-07 |
CN106928268B true CN106928268B (en) | 2018-08-14 |
Family
ID=59433053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710134989.9A Active CN106928268B (en) | 2017-03-08 | 2017-03-08 | A method of preparing iodotrimethylsilane |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106928268B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3894418A4 (en) * | 2018-12-10 | 2022-08-31 | Entegris, Inc. | Preparation of triiodosilanes |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109836448A (en) * | 2019-04-08 | 2019-06-04 | 浙江海洲制药有限公司 | A method of preparing Iodotrimethylsilane |
JP7495995B2 (en) * | 2020-04-24 | 2024-06-05 | インテグリス・インコーポレーテッド | Method for preparing iodosilanes and compositions therefrom |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104961759A (en) * | 2015-06-25 | 2015-10-07 | 浙江海洲制药有限公司 | Trimethyl halogenosilane preparation method |
CN105294752A (en) * | 2015-11-22 | 2016-02-03 | 青岛麦瑞特医药技术有限公司 | Trimethyliodosilane preparation method |
-
2017
- 2017-03-08 CN CN201710134989.9A patent/CN106928268B/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104961759A (en) * | 2015-06-25 | 2015-10-07 | 浙江海洲制药有限公司 | Trimethyl halogenosilane preparation method |
CN105294752A (en) * | 2015-11-22 | 2016-02-03 | 青岛麦瑞特医药技术有限公司 | Trimethyliodosilane preparation method |
Non-Patent Citations (3)
Title |
---|
《Selective Synthesis of Functional Alkynylmono- and -trisilanes》;Hoffmann, Florian等;《European Journal of Inorganic Chemistry》;20100113(第7期);1133-1142页 * |
《Simple method for the preparation of iodotrimethylsilane》;Lissel, Manfred等;《Synthesis》;19831231(第6期);459页 * |
无水碘化锂的新制法;黄枢等;《化学试剂》;19911231;第13卷(第5期);311、319页 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3894418A4 (en) * | 2018-12-10 | 2022-08-31 | Entegris, Inc. | Preparation of triiodosilanes |
JP7348285B2 (en) | 2018-12-10 | 2023-09-20 | インテグリス・インコーポレーテッド | Preparation of triiodosilane |
Also Published As
Publication number | Publication date |
---|---|
CN106928268A (en) | 2017-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106928268B (en) | A method of preparing iodotrimethylsilane | |
Hayashi et al. | Reaction of organotin oxides, alkoxides and acyloxides with organosilicon hydrides. New preparative method of organotin hydrides | |
DE2260282C3 (en) | Process for the preparation of silanes from disilanes | |
JP6349246B2 (en) | Method for producing neutral complex of cyclic silane and method for producing cyclic hydrogenated silane or cyclic organosilane | |
DE112014005811B4 (en) | Cyclic silane neutral complex, manufacturing method therefor, and method for manufacturing cyclic hydrogenated silane or cyclic organic silane | |
DE69022491T2 (en) | Manufacture of tertiary hydrocarbon silyl compounds. | |
JPH02221110A (en) | Method for reduction of halide of silicon, germanium, and tin | |
CN105175729A (en) | Method for preparing short-chain hydroxyl silicone oil | |
CN102993226A (en) | Method for preparing phenyl dimethylchlorosilane | |
CN100564384C (en) | Preparation method of iodotrimethylsilane | |
CN107698765A (en) | A kind of Nitrogen-and Phosphorus-containing silicon fire retardant and preparation method thereof | |
CN104151342B (en) | A kind of method synthesizing connection boric acid pinacol ester | |
CN105820111A (en) | Preparation method of catalyst and method for preparing 2,2-dipyridyl through catalysis by virtue of catalyst | |
CN103880873B (en) | Method for preparing phenyldisilane from organic silicon high-boiling material | |
CN110183481A (en) | The technique of catalytic pyrolysis organosilicon high-boiling product | |
CN104592284B (en) | 1,2 pairs of trimethylsiloxy group cyclohexene and its preparation technology | |
CN101691379A (en) | Method of preparing tert-butyl diphenyl chlorosilane | |
CN101648967A (en) | Preparation method of 3-(methacryloxypropyl) propyl-triethoxysilicane | |
CN114524839B (en) | Preparation method of stearoxy trimethylsilane | |
CN106986890A (en) | A kind of environment-friendly preparation method of the pentamethyl cyclotrisiloxane of 2 vinyl 2,4,4,6,6 | |
CN111978245A (en) | Preparation method of 3-fluoro-2-isobutyl pyridine | |
US5171467A (en) | Synthesis of organometallic/organobimetallic compositions | |
Lochmann et al. | Facile coupling of alkyl or aryl halogenides with organolithium compounds in the presence of alkoxides of heavier alkali metals | |
CN105732692B (en) | The synthetic method of aminomethyl phenyl dimethoxysilane | |
US7741504B2 (en) | Method for preparing an ω-haloalkyl dialkylhalosilane |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: 262725 Shandong city of Weifang province Shouguang Hou town project area nine west 500 meters north of the new road Patentee after: Shandong Boyuan Pharmaceutical Chemical Co., Ltd Address before: 262725 Shandong city of Weifang province Shouguang Hou town project area nine west 500 meters north of the new road Patentee before: SHANDONG BOYUAN PHARMACEUTICAL & CHEMICAL Co.,Ltd. |
|
CP01 | Change in the name or title of a patent holder | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Chenglin Inventor after: Zhai Yongli Inventor after: Chu Rongqiang Inventor before: Li Chenglin Inventor before: Wang Qingmin Inventor before: Zhai Yongli Inventor before: Chu Rongqiang |
|
CB03 | Change of inventor or designer information | ||
CP02 | Change in the address of a patent holder |
Address after: 262725 200m north of the intersection of Xinhai road and Dajiu Road, marine chemical park, Hou Town, Shouguang City, Weifang City, Shandong Province Patentee after: Shandong Boyuan Pharmaceutical Chemical Co.,Ltd. Address before: 262725 Xinsha Road North, 500m west of Dajiu Road, Houzhen project area, Shouguang City, Weifang City, Shandong Province Patentee before: Shandong Boyuan Pharmaceutical Chemical Co.,Ltd. |
|
CP02 | Change in the address of a patent holder |