CN106924342A - A kind of ammonia sugar microcapsules oral liquid and preparation method thereof - Google Patents
A kind of ammonia sugar microcapsules oral liquid and preparation method thereof Download PDFInfo
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- CN106924342A CN106924342A CN201710104586.XA CN201710104586A CN106924342A CN 106924342 A CN106924342 A CN 106924342A CN 201710104586 A CN201710104586 A CN 201710104586A CN 106924342 A CN106924342 A CN 106924342A
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- oral liquid
- microcapsules
- sugar
- preparation
- ammonia
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention discloses a kind of ammonia sugar microcapsules oral liquid and preparation method thereof, and the preparation method includes step：A, dried peppermint leaf is cleaned and dried, be subsequently adding deionized water extraction, obtain leaching liquor；B, the leaching liquor is carried out into purified treatment, then concentrated, obtain concentrate；C, to ammonia sugar microcapsules are added in the concentrate, and add appropriate additive, then carry out sterilization processing；Filtered and dispensed after the completion of D, sterilization, obtained final product ammonia sugar microcapsules oral liquid finished product.The present invention solves the sugared oral liquid of ammonia in the prior art without slow releasing function, it is impossible to problems that are lasting, effectively alleviating middle-aged and old degenerative osteoarthropathy diseases.
Description
Technical field
The present invention relates to oral liquid field, more particularly to a kind of ammonia sugar microcapsules oral liquid and preparation method thereof.
Background technology
Ammonia sugar is the important component of the extremely strong proteoglycan of hydrophily, be to be formed cartilage cell important nutrient it
One, it is also the basis of cartilage matrix and joint fluid, and ammonia sugared content is reduced with age in human body, it is old in causing
There are the arthropathies such as osteoporosis, cartilage be impaired in year people.It is to alleviate middle-aged and old degenerative joint diseases to take ammonia sugar oral liquid
A kind of mode, but existing ammonia sugar oral liquid without slow releasing function, can not effectively alleviate middle-aged and old degenerative osteoarthropathy diseases.
Therefore, prior art has yet to be improved and developed.
The content of the invention
In view of above-mentioned the deficiencies in the prior art, it is an object of the invention to provide a kind of ammonia sugar microcapsules oral liquid and its system
Preparation Method, it is intended to solve the sugared oral liquid of ammonia in the prior art without slow releasing function, it is impossible to continue, effectively alleviate middle-aged and old degenerations
The problem of osteoarthrosis.
Technical scheme is as follows：
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, including step：
A, dried peppermint leaf is cleaned and dried, be subsequently adding deionized water extraction, obtain leaching liquor；
B, the leaching liquor is carried out into purified treatment, then concentrated, obtain concentrate；
C, to ammonia sugar microcapsules are added in the concentrate, and add appropriate additive, then carry out sterilization processing；
Filtered and dispensed after the completion of D, sterilization, obtained final product ammonia sugar microcapsules oral liquid finished product.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, the additive includes stabilizer.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, the additive also includes flavouring, preservative and increasing
Thick dose.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, the flavouring is honey, simple syrup, glycyrrhizic acid, sweet
One or more in chrysanthemum glycosides, the preservative is one or more in sorbic acid, benzoic acid, propionic acid, and the thickener is
One or more in pectin, carragheen, xanthans.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, in the step A, extraction time is 10 ~ 25min, temperature
Spend is 80 DEG C ~ 100 DEG C.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, in the step B, purified treatment uses ferment treatment method.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, the enzyme that the ferment treatment method is used is for by pectase, fibre
The complex enzyme formulation of the plain enzyme of dimension and AMS composition.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, in the step B, concentration is using vacuum distillation
Concentration method, temperature is 70-80 DEG C, and vacuum is 0.01-0.02MPa, is concentrated 4-5 hours.
A kind of preparation method of ammonia sugar microcapsules oral liquid, wherein, in the step C, the sterilization processing uses Pasteur
Sterilization, sterilization temperature is 90~100 DEG C, and the time is 25~30min.
A kind of ammonia sugar microcapsules oral liquid, wherein, using the preparation side of any of the above-described described ammonia sugar microcapsules oral liquid
Method is prepared from.
Beneficial effect：The present invention is subsequently adding Glucosamine microcapsules by extracting dried peppermint leaf and concentrating leaching liquor,
Ammonia sugar microcapsules oral liquid is made, wherein ammonia sugar microcapsules are the health product containing drug-loading microcapsule, and contained medicine is amino
Glucosamine sulphate salt and chondroitin sulfate, have not only played the property of medicine of sulfate and chondroitin sulfate, the anti-inflammatory of peppermint, antibacterial,
Relieve the pain performance, more make use of the characteristic of microencapsulation, slow and sustained release aminoglucose sulfate and chondroitin sulfate, from
And effectively alleviate middle-aged and old degenerative osteoarthropathy diseases, the sugared oral liquid of ammonia in the prior art is solved without slow releasing function, it is impossible to
Problem that is lasting, effectively alleviating middle-aged and old degenerative osteoarthropathy diseases.
Brief description of the drawings
Fig. 1 is the preferred embodiment flow chart of ammonia sugar microcapsules oral liquor of the present invention.
Specific embodiment
The present invention provides a kind of ammonia sugar microcapsules oral liquid and preparation method thereof, to make the purpose of the present invention, technical scheme
And effect is clearer, clear and definite, the present invention is described in more detail below.It should be appreciated that specific implementation described herein
Example is only used to explain the present invention, is not intended to limit the present invention.
A kind of preparation method of ammonia sugar microcapsules oral liquid, as shown in figure 1, comprising the following steps：
S1, dried peppermint leaf is cleaned and dried, be subsequently adding deionized water extraction, obtain leaching liquor；
S2, the leaching liquor is carried out into purified treatment, then concentrated, obtain concentrate；
S3, to ammonia sugar microcapsules are added in the concentrate, and add appropriate additive, then carry out sterilization processing；
Filtered and dispensed after the completion of S4, sterilization, obtained final product ammonia sugar microcapsules oral liquid finished product.
The present invention has obvious alleviation and analgesic activity and anti-inflammatory anti-by using to neuralgia and rheumatic arthritis
The dried peppermint leaf of the effects such as bacterium, stomach invigorating wind-dispelling, soaks filtered juice and adds Glucosamine microcapsules after concentrating, and is subsequently adding addition
Agent, is obtained and has peppermint effect, the aminoglucose sugar property of medicine and microcapsules drug effect ammonia sugar microcapsules oral liquid high concurrently simultaneously, can
Slow and sustained release aminoglucose sulfate and chondroitin sulfate, so as to more can effectively alleviate middle-aged and old degeneration bones close
Section illness.
The Glucosamine microcapsule solution is by ammonia sugar-chondroitin sulfate compound formulation microcapsules addition distilled water
It is made, the ammonia sugar-chondroitin sulfate compound formulation microcapsules are prior art, can be using existing ammonia sugar-sulfuric acid on the market
Chondroitin compound formulation microcapsules, its preparation method substantially is as follows：
By shitosan（CHS）It is dissolved in the acetic acid that mass percentage concentration is 1%（HAc）In be made into CHS acetums, and by sulphur
Aching and limp ossein（CS）It is soluble in water to be made into CS solution；Take during appropriate aminoglucose sulfate is dissolved in CHS acetums and obtain
Ammonia sugar chitosan solution, the ammonia sugar chitosan solution that will be prepared is added in the oil phase containing Span-80 and magnesium stearate, is stirred
Mix to system in emulsion form, emulsify 0.5 ~ 1h, emulsification after CS solution is slowly added dropwise in 0.5 ~ 1.5h, continue to stir 0.5 ~
1h, is then slowly added dropwise appropriate crosslinking agent, and 0.5 ~ 3h is reacted at being 20 ~ 80 DEG C in temperature；Stop stirring, centrifugation is produced
Thing, then washing, filtering and vacuum drying obtain ammonia sugar-chondroitin sulfate compound formulation microcapsules successively.
In the step S1, dried peppermint leaf is cleaned, baking go it is water stain, be subsequently adding deionized water extraction, obtain leaching liquor, for example
Desirable 200-250g dried peppermint leaves, add deionized water, are made into 1000ml mint juices, under conditions of being 80 DEG C ~ 100 DEG C in temperature
10 ~ 25min of extraction, the color that presentation is extracted at different temperature can be variant, and extraction temperature is easily caused Huang when being higher than 100 DEG C
Brown is excessively thick and heavy, and temperature be less than 80 DEG C when leaching liquor yellowish-brown it is excessively shallow.In addition, the time difference of extraction is suited one's taste also and is had
Considerable influence, when extraction time is less than 10mins, the refrigerant sense of leaching liquor is not obvious, with the extension of extraction time, refrigerant sense
Constantly strong, when extraction time is more than 25mins, no longer there is significant change in refrigerant sense.
In the step S2, purified treatment first is carried out to leaching liquor, to reduce the sediment in final oral liquid to improve product
Mouthfeel and quality, it is preferred that the purified treatment uses ferment treatment method, it is possible to decrease cost, improve quality.More preferably, the enzyme
The enzyme that facture is used is the complex enzyme formulation being made up of pectase, cellulase and AMS, can substantially accelerate clarification
Speed, reaches more preferable clarifying effect, while increasing cell-oligosaccharide, cellobiose content in mint juice, improves the guarantor of fruit juice
Strong effect, increases soluble maltose, glucose and low molecule dextrin content in mint juice, and the solid content that improve fruit juice contains
Amount, in addition, each enzyme system mutually acts synergistically in compound enzyme system, increases mint juice yield, and need not freeze, and has saved the energy
And use cost.
For example in the mint juice of 1000mL, pectase 0.2g, cellulase 0.2g and AMS 0.2g are added, i.e., can
It is rapidly completed purified treatment, and Improving The Quality of Products.
After purified treatment is completed, liquid is purified, then concentration is carried out to scavenging solution, obtained concentrate, this
Step can remove excessive moisture, to increase active ingredient concentration, it is preferred that the concentration is using vacuum distillation concentration method,
Great quantities of spare moisture can be removed, is avoided that composition in Essence is destroyed again, for example, in temperature can be 70-80 by scavenging solution
DEG C, vacuum be 0.01-0.02MPa under conditions of carry out vacuum distillation concentration 4-5 hours, you can the scavenging solution of 1000mL is dense
30-60mL is reduced to, great quantities of spare moisture is eliminated, product quality is improved.
In the step S3, by aminoglucose sugar microcapsules are added in concentrate, and adding appropriate additive, then
Sterilization processing is carried out, so as to oral liquid is obtained, such as it is the additive of 2g that quality is added in 100mL concentrates.It is preferred that institute
Stating additive includes stabilizer, to increase the stability of product, in addition, the additive also includes flavouring, preservative and increasing
Thick dose, to lift the mouthfeel of product, extend the shelf-life of product.More preferably, the flavouring be honey, simple syrup, glycyrrhizic acid,
One or more in stevioside, the preservative is one or more in sorbic acid, benzoic acid, propionic acid, the thickener
It is one or more in pectin, carragheen, xanthans.For example, can by added in mass volume ratio concentrate 1.0% pectin,
0.5% carragheen and 0.2% xanthans.
Sterilization processing is carried out in addition additive and after stirring, it is preferred that the sterilization processing is gone out using Pasteur
Spoilage organisms is not only eliminated in bacterium method, pasteurize, and can enable the enzyme for causing chemical change（Pectase etc.）Passivation, due to adding
Heat makes the quality decline of peppermint juice, therefore, in order to both reach sterilized purpose, and the influence to product quality is reduced as far as possible,
Rational acid extraction must just be selected.The sterilization temperature of the pasteurization that the present invention is used is 90~100 DEG C, when
Between be 25~30min.
Carry out aseptic filtration operation again after the completion of sterilization operation, it is preferred that coarse filtration can be carried out first, then carry out refined filtration, with
Indissoluble thing, sediment effectively in removal product etc., finally obtain ammonia sugar microcapsules oral liquid finished product.
Based on the above method, present invention also offers a kind of ammonia sugar microcapsules oral liquid, on above-mentioned ammonia sugar microcapsules mouthful
The ins and outs for taking liquid have been described in detail in method above, therefore repeat no more, wherein, it is micro- using any of the above-described described ammonia sugar
The preparation method of capsule oral liquid is prepared from.
The present invention is subsequently adding Glucosamine microcapsules by extracting dried peppermint leaf and concentrating leaching liquor, is made ammonia sugar
Microcapsules oral liquid, wherein ammonia sugar microcapsules are the health product containing drug-loading microcapsule, and contained medicine is Glucosamine sulphur
Hydrochlorate and chondroitin sulfate, have not only played the property of medicine of sulfate and chondroitin sulfate, and the anti-inflammatory of peppermint, antibacterial, relieve the pain performance,
The characteristic of microencapsulation is more make use of, slow and sustained release aminoglucose sulfate and chondroitin sulfate, so as to effectively delay
The middle-aged and old degenerative osteoarthropathy diseases of solution, solve the sugared oral liquid of ammonia in the prior art without slow releasing function, it is impossible to lasting, effective
Alleviate the problem of middle-aged and old degenerative osteoarthropathy diseases.
It should be appreciated that application of the invention is not limited to above-mentioned citing, and for those of ordinary skills, can
To be improved according to the above description or converted, all these modifications and variations should all belong to the guarantor of appended claims of the present invention
Shield scope.
Claims (10)
1. the preparation method of a kind of ammonia sugar microcapsules oral liquid, it is characterised in that including step：
A, dried peppermint leaf is cleaned and dried, be subsequently adding deionized water extraction, obtain leaching liquor；
B, the leaching liquor is carried out into purified treatment, then concentrated, obtain concentrate；
C, to ammonia sugar microcapsules are added in the concentrate, and add appropriate additive, then carry out sterilization processing；
Filtered and dispensed after the completion of D, sterilization, obtained final product ammonia sugar microcapsules oral liquid finished product.
2. the preparation method of ammonia according to claim 1 sugar microcapsules oral liquid, it is characterised in that the additive includes
Stabilizer.
3. the preparation method of ammonia according to claim 2 sugar microcapsules oral liquid, it is characterised in that the additive is also wrapped
Include flavouring, preservative and thickener.
4. the preparation method of ammonia according to claim 3 sugar microcapsules oral liquid, it is characterised in that the flavouring is honeybee
One or more in honey, simple syrup, glycyrrhizic acid, stevioside, the preservative is the one kind in sorbic acid, benzoic acid, propionic acid
Or it is various, the thickener is one or more in pectin, carragheen, xanthans.
5. the preparation method of ammonia according to claim 1 sugar microcapsules oral liquid, it is characterised in that in the step A, leaching
The time is carried for 10 ~ 25min, temperature is 80 DEG C ~ 100 DEG C.
6. the preparation method of ammonia according to claim 1 sugar microcapsules oral liquid, it is characterised in that in the step B, only
Change treatment and use ferment treatment method.
7. the preparation method of ammonia according to claim 6 sugar microcapsules oral liquid, it is characterised in that the ferment treatment method is adopted
Enzyme is the complex enzyme formulation being made up of pectase, cellulase and AMS.
8. the preparation method of ammonia according to claim 1 sugar microcapsules oral liquid, it is characterised in that dense in the step B
Contracting treatment is 70-80 DEG C using vacuum distillation concentration method, temperature, and vacuum is 0.01-0.02MPa, is concentrated 4-5 hours.
9. the preparation method of ammonia according to claim 1 sugar microcapsules oral liquid, it is characterised in that in the step C, institute
State sterilization processing and use pasteurization, sterilization temperature is 90~100 DEG C, and the time is 25~30min.
10. a kind of ammonia sugar microcapsules oral liquid, it is characterised in that using the sugared microcapsules of ammonia as described in claim 1 ~ 9 is any
The preparation method of oral liquid is prepared from.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710104586.XA CN106924342A (en) | 2017-02-24 | 2017-02-24 | A kind of ammonia sugar microcapsules oral liquid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710104586.XA CN106924342A (en) | 2017-02-24 | 2017-02-24 | A kind of ammonia sugar microcapsules oral liquid and preparation method thereof |
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| CN106924342A true CN106924342A (en) | 2017-07-07 |
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| CN201710104586.XA Pending CN106924342A (en) | 2017-02-24 | 2017-02-24 | A kind of ammonia sugar microcapsules oral liquid and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114288272A (en) * | 2021-12-29 | 2022-04-08 | 佛山职业技术学院 | Preparation method of colon-targeted microcapsule |
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| CN1947724A (en) * | 2006-03-10 | 2007-04-18 | 北京阜康仁生物制药科技有限公司 | Compound amino-glucose hydrochloride, chondroitin sulfate effervescent, tablets prepn. method and use thereof |
| CN102670657A (en) * | 2012-06-01 | 2012-09-19 | 山东卫康生物医药科技有限公司 | Percutaneous absorption preparation for treating bone joint disease |
| CN105395520A (en) * | 2015-12-10 | 2016-03-16 | 佛山职业技术学院 | Glucosamine microcapsule and preparation method thereof |
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2017
- 2017-02-24 CN CN201710104586.XA patent/CN106924342A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006024492A3 (en) * | 2004-08-30 | 2006-08-10 | Interstitial Therapeutics | Medical implant provided with inhibitors of atp synthesis |
| CN1947724A (en) * | 2006-03-10 | 2007-04-18 | 北京阜康仁生物制药科技有限公司 | Compound amino-glucose hydrochloride, chondroitin sulfate effervescent, tablets prepn. method and use thereof |
| CN102670657A (en) * | 2012-06-01 | 2012-09-19 | 山东卫康生物医药科技有限公司 | Percutaneous absorption preparation for treating bone joint disease |
| CN105395520A (en) * | 2015-12-10 | 2016-03-16 | 佛山职业技术学院 | Glucosamine microcapsule and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114288272A (en) * | 2021-12-29 | 2022-04-08 | 佛山职业技术学院 | Preparation method of colon-targeted microcapsule |
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Application publication date: 20170707 |