CN106924336A - One kind treats arthralgic traditional Chinese medicine emulsifiable paste and preparation method thereof - Google Patents
One kind treats arthralgic traditional Chinese medicine emulsifiable paste and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract
The present invention relates to pharmaceutical technology field, and in particular to one kind treats arthralgic traditional Chinese medicine emulsifiable paste and preparation method thereof.The preparation method of the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of comprises the following steps：(1) by Ligusticum wallichii, myrrh, levisticum, safflower, Radix Glycyrrhizae and kuh-seng, it is ground into powder and obtains herb powder；By oil phase component raw material：Wintergreen and menthol mix to obtain oil mixture；By water phase components raw material：Chlorphenamine maleate, tetracaine hydrochloride, Carbomer and purified water, mix to obtain aqueous mixture；(2) oil mixture is added into aqueous mixture, adds herb powder, obtain medicinal mixture；(3) medicinal mixture being carried out into homogeneous must treat arthralgic traditional Chinese medicine emulsifiable paste.To make medicine coordinating the drug actions of a prescription and kuh-seng collaboration play antiallergy, antipruritic effect, chlorphenamine maleate can also prevent allergy allergy to Radix Glycyrrhizae in the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of of the invention, greatly reduce the allergy rate that traditional Chinese medicine emulsifiable paste of the present invention is used.
Description
Technical field
The present invention relates to pharmaceutical technology field, and in particular to one kind treats arthralgic traditional Chinese medicine emulsifiable paste and preparation method thereof.
Background technology
Modern society people rhythm of life is accelerated, and operating pressure is big, and arthralgia turns into common disease and frequently-occurring disease, with joint
Pain and limitation of activity are characterized, mostly person in middle and old age's frequently-occurring disease, and the incidence of disease is also in rising trend in young man in recent years.Joint
Mainly having chronic strain, wound muscles and bones, insufficiency of vital energy and blood, several causes of disease of rheumatism cold-evil bitterly causes.At present, doctor trained in Western medicine is mostly clinically
Drug therapy is carried out to the ill, can only alleviate a period of time pain, be difficult radical cure, be also easy to produce side effect, there is significant limitation.Tradition
Chinese medicinal ointment preparation technology is complicated, quality is difficult to control to, medicine utilization rate is low, in-convenience in use and local excitation is stronger, may
Cause skin to be itched, redden, the allergic phenomena such as purple plague purpura.
The content of the invention
It is hypo-allergenic it is an object of the invention to provide one kind to solve defect present in above-mentioned prior art, biography is overcome again
Slow arthralgic traditional Chinese medicine emulsifiable paste for the treatment of of system Chinese Herbs and preparation method thereof.
The technical scheme is that a kind of preparation method for treating arthralgic traditional Chinese medicine emulsifiable paste is provided, including following step
Suddenly：
(1) by the traditional Chinese medicinal components of following weight portion：2-3 parts of Ligusticum wallichii, 2-3 parts of myrrh, 2-3 parts of levisticum, 2-3 parts of safflower, 1-2
Part Radix Glycyrrhizae and 1-2 parts of kuh-seng, are ground into powder and obtain herb powder；
By the oil phase component raw material of following weight portion：10-20 portions of wintergreen and 3-8 parts of menthol mix to obtain oil phase mixing
Thing；
By the water phase components raw material of following weight portion：0.3-0.5 parts of chlorphenamine maleate, 0.5-1 parts of tetracaine hydrochloride,
0.2-0.5 parts of Carbomer and 40-50 parts of purified water, mix to obtain aqueous mixture；
(2) oil mixture is slowly added into aqueous mixture at a temperature of 55-65 DEG C, the aqueous mixture keeps
500rpm stirrings add herb powder up to adding oil mixture, continue to stir 30 minutes, obtain medicinal mixture；
(3) medicinal mixture is cooled to 35-40 DEG C, homogeneous is carried out using high speed homogenization device, setting speed is 3000-
5000rpm, homogenizing time is 10-15 minutes, and going out container and be aged must treat arthralgic traditional Chinese medicine emulsifiable paste.
Preferably, in the preparation method of the above-mentioned arthralgic traditional Chinese medicine emulsifiable paste for the treatment of, the herb powder, oil mixture
The weight part ratio for being mixed with water compound is：10：13：42.
Preferably, in the preparation method of the above-mentioned arthralgic traditional Chinese medicine emulsifiable paste for the treatment of, the herb powder, oil mixture
The weight part ratio for being mixed with water compound is：14：28：52.
Preferably, in the preparation method of the above-mentioned arthralgic traditional Chinese medicine emulsifiable paste for the treatment of, the step (3) is specially：By medicine
Thing mixture is cooled to 35-40 DEG C, adds the ethyl-para-hydroxybenzoate of medicinal mixture quality 0.2-0.5%, using at a high speed
Homogenizer carries out homogeneous, and setting speed is 3000rpm, and homogenizing time is 10-15 minutes, and going out container and be aged must treat arthralgic
Traditional Chinese medicine emulsifiable paste.
Preferably, in the preparation method of the above-mentioned arthralgic traditional Chinese medicine emulsifiable paste for the treatment of, the step (1) is specially：
(1) by the traditional Chinese medicinal components of following weight portion：2kg Ligusticum wallichiis, 2kg myrrhs, 2kg levisticums, 2kg safflowers, 1kg Radix Glycyrrhizaes and
1kg kuh-sengs, are ground into powder and obtain herb powder；
By the oil phase component raw material of following weight portion：10kg wintergreens and 3kg menthols mix to obtain oil mixture；
By the water phase components raw material of following weight portion：0.3kg chlorphenamine maleates, 0.5kg tetracaine hydrochlorides, 0.2kg
Carbomer and 40kg purified waters, mix to obtain aqueous mixture；
Another technical scheme of the invention is to provide a kind of preparation method system of the above-mentioned arthralgic traditional Chinese medicine emulsifiable paste for the treatment of
Standby traditional Chinese medicine emulsifiable paste.
Beneficial effect of the present invention：The arthralgic traditional Chinese medicine emulsifiable paste for the treatment of of the invention has good effect to treatment arthralgia,
Penetration is strong, have no toxic side effect, and is difficult allergy and easy to use, and men and women, old children are all suitable.The arthralgic Chinese medicine for the treatment of of the invention
In emulsifiable paste, natural winter-green oil, as principle active component, is applied to DOMS position, can promote the blood of painful area
Rapid Circulation, regulates channels and activates collateral, pain of alleviation；There is Ligusticum wallichii blood-activating and qi-promoting, wind-expelling pain-stopping to obtain effect；Myrrh has promoting blood circulation and stopping pain
Effect；Levisticum：Expelling wind and eliminating dampness, eliminating cold to stop pain；Safflower has promoting blood circulation and removing blood stasis, and effect of dissipate wet effect going to swell, each traditional Chinese medicinal components are cooperateed with
To the arthralgic effect of mitigation.
Radix Glycyrrhizae in the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of of the invention plays anti-to make medicine coordinating the drug actions of a prescription with kuh-seng collaboration
Allergy, antipruritic effect, chlorphenamine maleate can also prevent allergy allergy, and greatly reducing traditional Chinese medicine emulsifiable paste of the present invention makes
Allergy rate.
Specific embodiment
To describe technology contents of the invention, structural feature, the objects and the effects in detail, below in conjunction with implementation method
It is explained in detail.
Key ideas of the present invention：Radix Glycyrrhizae in the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of of the invention is to make medicine coordinating the drug actions of a prescription, and
Antiallergy is played with kuh-seng collaboration, antipruritic effect, chlorphenamine maleate can also prevent allergy allergy, greatly reduce
The allergy rate that traditional Chinese medicine emulsifiable paste of the present invention is used.
Wintergreen, with anti-inflammatory analgesic effect, is applied to arthralgia position, and the blood of painful area can be promoted quickly to follow
Ring, regulates channels and activates collateral, pain of alleviation.
Menthol, acting on skin can produce strong refrigerant sense, can mitigate myalgia sense of discomfort and pain.
Chlorphenamine maleate, the effect with antihistaminicum H1 acceptors, Central nervous have stronger inhibitory action,
Allergy allergy is prevented, the allergy rate that medicine is used is greatly reduced.
Tetracaine hydrochloride, it acts on skin peripheral nerve, and stabilization neural tissue cell film reduces sodium ion inflow, makes
Normal polarization replaces with depolarising is obstructed, and nerve impulse transmission cannot be carried out, and play analgesic effect.
Embodiment 1
A kind of preparation method for treating arthralgic traditional Chinese medicine emulsifiable paste, comprises the following steps：
(1) by the traditional Chinese medicinal components of following weight portion：2kg Ligusticum wallichiis, 2kg myrrhs, 2kg levisticums, 2kg safflowers, 1kg Radix Glycyrrhizaes and
1kg kuh-sengs, are ground into powder and obtain herb powder；
By the oil phase component raw material of following weight portion：10kg wintergreens and 3kg menthols mix to obtain oil mixture；
By the water phase components raw material of following weight portion：0.3kg chlorphenamine maleates, 0.5kg tetracaine hydrochlorides, 0.2kg
Carbomer and 40kg purified waters, mix to obtain aqueous mixture；
(2) oil mixture is slowly added into aqueous mixture at a temperature of 55-65 DEG C, the aqueous mixture keeps
500rpm stirrings add herb powder up to adding oil mixture, continue to stir 30 minutes, obtain medicinal mixture；
(3) medicinal mixture is cooled to 35-40 DEG C, homogeneous is carried out using high speed homogenization device, setting speed is 3000-
5000rpm, homogenizing time is 10-15 minutes, and going out container and be aged must treat arthralgic traditional Chinese medicine emulsifiable paste.
Embodiment 2
A kind of preparation method for treating arthralgic traditional Chinese medicine emulsifiable paste, comprises the following steps：
(1) by the traditional Chinese medicinal components of following weight portion：3kg Ligusticum wallichiis, 3kg myrrhs, 3kg levisticums, 3kg safflowers, 2kg Radix Glycyrrhizaes and
2kg kuh-sengs, are ground into powder and obtain herb powder；
By the oil phase component raw material of following weight kg：20kg wintergreens and 8kg menthols mix to obtain oil mixture；
By the water phase components raw material of following weight portion：0.5kg chlorphenamine maleates, 1kg tetracaine hydrochlorides, 0.5kg cards
Ripple nurse and 50kg purified waters, mix to obtain aqueous mixture；
(2) oil mixture is slowly added into aqueous mixture at a temperature of 55-65 DEG C, the aqueous mixture keeps
500rpm stirrings add herb powder up to adding oil mixture, continue to stir 30 minutes, obtain medicinal mixture；
(3) medicinal mixture is cooled to 35-40 DEG C, the ethyl-para-hydroxybenzoate of 0.3kg is added, using high speed homogenization
Device carries out homogeneous, and setting speed is 3000-5000rpm, and homogenizing time is 10-15 minutes, and going out container and be aged must treat arthralgia
Traditional Chinese medicine emulsifiable paste.
Embodiment 3
A kind of preparation method for treating arthralgic traditional Chinese medicine emulsifiable paste, comprises the following steps：
(1) by the traditional Chinese medicinal components of following weight portion：2.5kg Ligusticum wallichiis, 2.5kg myrrhs, 2.5kg levisticums, 2.5kg safflowers,
1.5kg Radix Glycyrrhizaes and 1.5kg kuh-sengs, are ground into powder and obtain herb powder；
By the oil phase component raw material of following weight portion：15kg wintergreens and 5kg menthols mix to obtain oil mixture；
By the water phase components raw material of following weight portion：0.5kg chlorphenamine maleates, 1kg tetracaine hydrochlorides, 0.5kg cards
Ripple nurse and 40kg purified waters, mix to obtain aqueous mixture；
(2) oil mixture is slowly added into aqueous mixture at a temperature of 55-65 DEG C, the aqueous mixture keeps
500rpm stirrings add herb powder up to adding oil mixture, continue to stir 30 minutes, obtain medicinal mixture；
(3) medicinal mixture is cooled to 35-40 DEG C, the ethyl-para-hydroxybenzoate of 0.4kg is added, using high speed homogenization
Device carries out homogeneous, and setting speed is 5000rpm, and homogenizing time is 10-15 minutes, and going out container and be aged must treat arthralgic Chinese medicine
Emulsifiable paste.
Comparative example
(having lacked Radix Glycyrrhizae, kuh-seng and chlorphenamine maleate in simply raw material identical with the condition of embodiment 3)
A kind of preparation method for treating arthralgic traditional Chinese medicine emulsifiable paste, comprises the following steps：
(1) by the traditional Chinese medicinal components of following weight portion：2.5kg Ligusticum wallichiis, 2.5kg myrrhs, 2.5kg levisticums, 2.5kg safflowers, powder
It is broken into powder and obtains herb powder；
By the oil phase component raw material of following weight portion：15kg wintergreens and 5kg menthols mix to obtain oil mixture；
By the water phase components raw material of following weight portion：1kg tetracaine hydrochlorides, 0.5kg Carbomers and 40kg purified waters, mixing
Obtain aqueous mixture；
(2) oil mixture is slowly added into aqueous mixture at a temperature of 55-65 DEG C, the aqueous mixture keeps
500rpm stirrings add herb powder up to adding oil mixture, continue to stir 30 minutes, obtain medicinal mixture；
(3) medicinal mixture is cooled to 35-40 DEG C, the ethyl-para-hydroxybenzoate of 0.4kg is added, using high speed homogenization
Device carries out homogeneous, and setting speed is 5000rpm, and homogenizing time is 10-15 minutes, and going out container and be aged must treat arthralgic Chinese medicine
Emulsifiable paste.
Efficacy analysis：
Participate in the standard of respondent：It is diagnosed as arthralgia patient.Age bracket is 30-60 Sui, and men and women does not limit.The sample of investigation
This quantity is 80.It is divided into 2 groups, every group of quantity 40, respectively by the arthralgic Chinese medicine of the treatment of above-described embodiment 3 and comparative example
Emulsifiable paste is applied directly to two groups of arthralgia patient affected parts, daily to smear 3 times.Continuously use 7 day time.
Evaluation criterion：After 7 days, patient pain and allergic symptom situation are followed the trail of by paying a return visit, be divided into engineering noise, " effective "
" allergy " three situations.The number of cases of each symptomatic condition is recorded respectively, and curative effect is as shown in table 1.
Table 1
| It is invalid | Effectively | Allergy | |
| Embodiment 3 | 2 | 38 | 0 |
| Comparative example | 3 | 37 | 2 |
Result of the test as can be seen from Table 1：The arthralgic traditional Chinese medicine emulsifiable paste group for the treatment of of the present invention is smeared, after smearing 7 days,
There are 38 patients to show " effective ", overall effectively cure rate is 95%, and without allergic conditions.
In sum, treatment of the invention arthralgic traditional Chinese medicine emulsifiable paste treatment arthralgia has a good effect, penetration is strong,
Have no toxic side effect, be difficult allergy and easy to use, men and women, old children are all suitable.In the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of of the invention, day
Right wintergreen, as principle active component, is applied to DOMS position, can promote the blood Rapid Circulation of painful area,
Regulate channels and activate collateral, pain of alleviation；There is Ligusticum wallichii blood-activating and qi-promoting, wind-expelling pain-stopping to obtain effect；Myrrh has functions that promoting blood circulation and stopping pain；Solely
It is living：Expelling wind and eliminating dampness, eliminating cold to stop pain；Safflower has promoting blood circulation and removing blood stasis, effect of dissipate wet effect going to swell.The collaboration of each traditional Chinese medicinal components is played mitigation and is closed
Save the effect of pain.
Radix Glycyrrhizae in the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of of the invention plays anti-to make medicine coordinating the drug actions of a prescription with kuh-seng collaboration
Allergy, antipruritic effect, chlorphenamine maleate can also prevent allergy allergy, and greatly reducing traditional Chinese medicine emulsifiable paste of the present invention makes
Allergy rate.
Embodiments of the invention are the foregoing is only, the scope of the claims of the invention is not thereby limited, it is every to utilize this hair
Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (6)
1. a kind of preparation method for treating arthralgic traditional Chinese medicine emulsifiable paste, it is characterised in that comprise the following steps：
(1) by the traditional Chinese medicinal components of following weight portion：2-3 parts of Ligusticum wallichii, 2-3 parts of myrrh, 2-3 parts of levisticum, 2-3 parts of safflower, 1-2 parts it is sweet
Grass and 1-2 parts of kuh-seng, are ground into powder and obtain herb powder；
By the oil phase component raw material of following weight portion：10-20 portions of wintergreen and 3-8 parts of menthol mix to obtain oil mixture；
By the water phase components raw material of following weight portion：0.3-0.5 parts of chlorphenamine maleate, 0.5-1 parts of tetracaine hydrochloride, 0.2-
0.5 part of Carbomer and 40-50 parts of purified water, mix to obtain aqueous mixture；
(2) oil mixture is slowly added into aqueous mixture at a temperature of 55-65 DEG C, the aqueous mixture keeps 500rpm
Stirring adds herb powder up to adding oil mixture, continues to stir 30 minutes, obtains medicinal mixture；
(3) medicinal mixture is cooled to 35-40 DEG C, homogeneous is carried out using high speed homogenization device, setting speed is 3000-
5000rpm, homogenizing time is 10-15 minutes, and going out container and be aged must treat arthralgic traditional Chinese medicine emulsifiable paste.
2. the preparation method of the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of according to claim 1, it is characterised in that the traditional Chinese medicine powder
End, oil mixture are mixed with water the weight part ratio of compound：10：13：42.
3. the preparation method of the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of according to claim 1, it is characterised in that the traditional Chinese medicine powder
End, oil mixture are mixed with water the weight part ratio of compound：14：28：52.
4. the preparation method of the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of according to claim 1, it is characterised in that the step
(3) it is specially：Medicinal mixture is cooled to 35-40 DEG C, the P-hydroxybenzoic acid of medicinal mixture quality 0.2-0.5% is added
Ethyl ester, homogeneous is carried out using high speed homogenization device, and setting speed is 3000rpm, and homogenizing time is 10-15 minutes, goes out container ageing
Arthralgic traditional Chinese medicine emulsifiable paste must be treated.
5. the preparation method of the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of according to claim 1, it is characterised in that the step
(1) it is specially：
(1) by the traditional Chinese medicinal components of following weight portion：2kg Ligusticum wallichiis, 2kg myrrhs, 2kg levisticums, 2kg safflowers, 1kg Radix Glycyrrhizaes and 1kg are bitter
Ginseng, is ground into powder and obtains herb powder；
By the oil phase component raw material of following weight portion：10kg wintergreens and 3kg menthols mix to obtain oil mixture；
By the water phase components raw material of following weight portion：0.3kg chlorphenamine maleates, 0.5kg tetracaine hydrochlorides, 0.2kg card ripples
Nurse and 40kg purified waters, mix to obtain aqueous mixture.
6. the Chinese medicine breast that prepared by the preparation method of the arthralgic traditional Chinese medicine emulsifiable paste for the treatment of according to claim any one of 1-4
Cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710300705.9A CN106924336A (en) | 2017-05-02 | 2017-05-02 | One kind treats arthralgic traditional Chinese medicine emulsifiable paste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710300705.9A CN106924336A (en) | 2017-05-02 | 2017-05-02 | One kind treats arthralgic traditional Chinese medicine emulsifiable paste and preparation method thereof |
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| Publication Number | Publication Date |
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| CN106924336A true CN106924336A (en) | 2017-07-07 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142697A (en) * | 2013-03-01 | 2013-06-12 | 福建美菰林生物科技有限公司 | Pharmaceutical composition for relieving muscular soreness and preparation method thereof |
| CN103385914A (en) * | 2013-06-26 | 2013-11-13 | 山东无棣精盐厂 | Hot compress salt and preparation method thereof |
| CN103463164A (en) * | 2013-08-15 | 2013-12-25 | 孙金堂 | Plaster for treating pains in neck, shoulder, waist and leg |
| CN105535159A (en) * | 2014-10-28 | 2016-05-04 | 孙继芝 | Rheumatism joint and muscle pain treating oral-taking traditional Chinese medicine wine |
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2017
- 2017-05-02 CN CN201710300705.9A patent/CN106924336A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142697A (en) * | 2013-03-01 | 2013-06-12 | 福建美菰林生物科技有限公司 | Pharmaceutical composition for relieving muscular soreness and preparation method thereof |
| CN103385914A (en) * | 2013-06-26 | 2013-11-13 | 山东无棣精盐厂 | Hot compress salt and preparation method thereof |
| CN103463164A (en) * | 2013-08-15 | 2013-12-25 | 孙金堂 | Plaster for treating pains in neck, shoulder, waist and leg |
| CN105535159A (en) * | 2014-10-28 | 2016-05-04 | 孙继芝 | Rheumatism joint and muscle pain treating oral-taking traditional Chinese medicine wine |
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Application publication date: 20170707 |
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