CN106918577A - The detection means and method of a kind of medicine - Google Patents
The detection means and method of a kind of medicine Download PDFInfo
- Publication number
- CN106918577A CN106918577A CN201710121327.8A CN201710121327A CN106918577A CN 106918577 A CN106918577 A CN 106918577A CN 201710121327 A CN201710121327 A CN 201710121327A CN 106918577 A CN106918577 A CN 106918577A
- Authority
- CN
- China
- Prior art keywords
- specimen cup
- detection means
- integrating sphere
- light source
- detector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N2021/557—Detecting specular reflective parts on sample
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/065—Integrating spheres
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention provides the detection means and method of a kind of medicine, including the integrating sphere with specimen cup entrance, detector mouthful and incident light hole, be positioned in integrating sphere by the specimen cup entrance at the top of integrating sphere and with the specimen cup of specimen cup entrance clamping, it is installed on the light source on the incident light hole of integrating sphere outer wall, it is installed on the detector on the detector of integrating sphere outer wall mouthful, and the microprocessor being connected with detector and light source respectively, also including scribbling the specimen cup inlet cover of diffusing reflection layer with specimen cup entrance connect setting and inner surface；Light source is set to multiple, and one of light source corresponds at specimen cup in being installed on integrating sphere bottom；Specimen cup includes two coaxial and nested pipes for setting, and is connected to the annular bottom between two bottoms of pipe.When being detected using the detection means, certainty of measurement and accuracy are improve.
Description
Technical field
The present invention relates to drug measurement techniques field, and in particular to the detection means and method of a kind of medicine.
Background technology
Medicine is substantially all and is made up of various chemical substances, wherein the treatment of ratio and concentration for medicine of chemical composition
Effect plays conclusive effect.But the component content in medicine is often more small, this proposes very high to its Concentration Testing
Required precision.
In drug abuse test, near-infrared spectral analysis technology has been a differentiation means for the medicine true and false of large-scale popularization.
Also there is application in terms of analysis of effective component of the near-infrared spectral analysis technology in the quality differentiation of Chinese herb and preparation.
China is abounded in tea, and the on-line checking of tea grades and tea product process has quickly been studied with near-infrared spectral analysis technology all
Have been reported that.In recent years, near-infrared spectrum analysis are widely used in petrochemical field, and are gradually applied in line process point
Analysis.
However, in the near infrared light spectral apparatus of existing drug test, specimen cup is usually the cylinder cup with one end open,
And cylinder cup is relatively large in diameter, therefore the amount of the medicine of required filling is larger；And it is larger straight to cause filled out medicine to have
Footpath, and the medicine for there was only outside when detecting can be absorbed to light, and the medicine inside specimen cup cannot be absorbed to light, so that
Influence certainty of measurement and accuracy.Meanwhile, specimen cup entrance is hollow so that light easily scatters and disappears, and can also influence measurement essence
Degree and accuracy.
The content of the invention
Therefore, the technical problem to be solved in the present invention is to overcome certainty of measurement in the prior art and accuracy scarce the bottom of compared with
Fall into.
Therefore, the invention provides a kind of detection means of medicine, including enter with specimen cup entrance, detector mouthful and light
The integrating sphere of perforation, be positioned in the integrating sphere by the specimen cup entrance at the top of the integrating sphere and with the sample
The specimen cup of product cup entrance clamping, is installed on the light source on the incident light hole of the integrating sphere outer wall, is installed on the integrating sphere
Detector on the detector mouthful of outer wall, and the microprocessor being connected with the detector and the light source respectively, also include
With the specimen cup inlet cover that the specimen cup entrance connect setting and inner surface scribble diffusing reflection layer；The light source is set to many
Individual, one of them described light source corresponds at the specimen cup in being installed on the integrating sphere bottom；The specimen cup includes two
The individual coaxial and nested pipe for setting, and it is connected to the annular bottom between two bottoms of pipe.
Preferably, the specimen cup entrance of the integrating sphere is provided with the groove and alignment pin for fixing specimen cup, specimen cup
Integrating sphere, and rotary sample cup are inserted until alignment pin enters groove by specimen cup entrance.
Preferably, the detection means also includes housing, and the integrating sphere, light source, detector and microprocessor are built-in
In the housing.
Preferably, the detection means also includes input through keyboard and device displaying result and computer digital animation unit,
Computer digital animation unit is connected by USB interface with microprocessor, and input through keyboard is placed in the shell with device displaying result
It is connected on the outer surface of body and with microprocessor.
Preferably, the detection means also includes that what is be installed on the outer surface of the housing and be connected with microprocessor opens
Close button, and be connected with microprocessor and extend the plug of the hull outside.
Preferably, the detection means also includes the support being installed in the shell bottom wall, and the integrating sphere is installed on
On the rack upper surface.
Preferably, the light source is semiconductor laser.
Present invention also offers a kind of detection method carried out using above-mentioned detection device, comprise the following steps：By medicine
Thing is positioned in the specimen cup of the detection means, then specimen cup is put into integrating sphere by specimen cup entrance, is then covered
Specimen cup inlet cover, finally opens the detection means and is detected.
Technical solution of the present invention, has the following advantages that：
Specimen cup is designed as to include two coaxial and nested pipes for setting, and is connected to two bottoms of pipe
Between annular bottom, and by sample as between two pipes, while a light source also is installed on into the integrating sphere bottom
Correspond at the specimen cup in end, and set and scribble diffusing reflection layer with the specimen cup entrance connect setting and inner surface
Specimen cup inlet cover, when being detected using the detection means, be installed on and correspond to the sample in the integrating sphere bottom
The light meeting directive specimen cup that light source at cup is sent, and pass through the hollow region of specimen cup to arrival specimen cup inlet cover, this
When the diffusing reflection layer that scribbles of its inner surface light is carried out into diffusing reflection, and then light is scattered into the medicine that specimen cup inner surface goes out
In absorbed, the light after absorption is reflected and then detected by detector, so as to improve certainty of measurement and accurate
Property.
Brief description of the drawings
In order to illustrate more clearly of the specific embodiment of the invention or technical scheme of the prior art, below will be to specific
The accompanying drawing to be used needed for implementation method or description of the prior art is briefly described, it should be apparent that, in describing below
Accompanying drawing is some embodiments of the present invention, for those of ordinary skill in the art, before creative work is not paid
Put, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the detection means of the medicine of offer in embodiments of the present invention；
Fig. 2 is the structural representation of integrating sphere in Fig. 1.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with accompanying drawing, it is clear that described implementation
Example is a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill
The every other embodiment that personnel are obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
In the description of the invention, it is necessary to explanation, term " " center ", " on ", D score, "left", "right", " vertical ",
The orientation or position relationship of the instruction such as " level ", " interior ", " outward " be based on orientation shown in the drawings or position relationship, merely to
Be easy to the description present invention and simplify describe, rather than indicate imply signified device or element must have specific orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.Additionally, term " first ", " second ",
" the 3rd " is only used for describing purpose, and it is not intended that indicating or implying relative importance.Additionally, invention described below
As long as involved technical characteristic does not constitute conflict and can just be combined with each other each other in different embodiments.
As depicted in figs. 1 and 2, the detection means of the medicine that the present embodiment is provided, including with specimen cup entrance, detector
The integrating sphere 1 of mouth and incident light hole, the integrating sphere 1 is positioned over by the specimen cup entrance positioned at the top of the integrating sphere 1
In and with the specimen cup 2 of the specimen cup entrance clamping, be installed on the light source 3 on the incident light hole of the outer wall of the integrating sphere 1, pacify
Detector 4 on detector loaded on the outer wall of the integrating sphere 1 mouthful, and be connected with the detector 4 and the light source 3 respectively
Microprocessor 5, also including scribbling the specimen cup entrance of diffusing reflection layer with the specimen cup entrance connect setting and inner surface
Lid 11；The light source 3 is set to multiple, and one of them described light source 3 corresponds to the sample in being installed on the bottom of the integrating sphere 1
At cup 2；The specimen cup 2 includes two coaxial and nested pipes 21 for setting, and is connected to two bottoms of pipe 21
Between annular bottom 22；The specimen cup entrance of the integrating sphere 1 is provided with the groove 12 and alignment pin 13 for fixing specimen cup 2,
Specimen cup 2 inserts integrating sphere 3, and rotary sample cup 2 until alignment pin 13 enters groove 12 by specimen cup entrance；The detection dress
Putting also includes housing 6, and the integrating sphere 1, light source 3, detector 4 and microprocessor 5 are built in the housing 6；The inspection
Surveying device also includes input through keyboard and device displaying result 7 and computer digital animation unit 10, computer digital animation unit
10 are connected by USB interface with microprocessor 5, and input through keyboard is placed on the outer surface of the housing 6 simultaneously with device displaying result 7
It is connected with microprocessor 5；The detection means also includes being installed on the outer surface of the housing 6 and being connected with microprocessor 5
Shift knob 8, and be connected with microprocessor 5 and extend the plug 9 outside the housing 6；The detection means also includes
The support 12 on the bottom wall of the housing 6 is installed on, the integrating sphere 1 is installed on the upper surface of the support 12.
The detection method carried out using above-mentioned detection device, is comprised the following steps：Medicine is positioned over the detection dress
In the specimen cup 2 put, then specimen cup 2 is put into integrating sphere 1 by specimen cup entrance, then covers specimen cup inlet cover 11,
The detection means is finally opened to be detected.
Specifically, when being detected using the detection means, it is installed on and corresponds to the sample in the integrating sphere bottom
The light meeting directive specimen cup that light source at cup is sent, and pass through the hollow region of specimen cup to arrival specimen cup inlet cover, this
When the diffusing reflection layer that scribbles of its inner surface light is carried out into diffusing reflection, and then light is scattered into the medicine that specimen cup inner surface goes out
In absorbed, the light after absorption is reflected and then detected by detector, so as to improve certainty of measurement and accurate
Property.
Obviously, above-described embodiment is only intended to clearly illustrate example, and not to the restriction of implementation method.It is right
For those of ordinary skill in the art, can also make on the basis of the above description other multi-forms change or
Change.There is no need and unable to be exhaustive to all of implementation method.And the obvious change thus extended out or
Among changing still in the protection domain of the invention.
Claims (8)
1. a kind of detection means of medicine, including the integrating sphere (1) with specimen cup entrance, detector mouthful and incident light hole, by
The specimen cup entrance at the top of the integrating sphere (1) be positioned in the integrating sphere (1) and with the specimen cup entrance
The specimen cup (2) of clamping, is installed on the light source (3) on the incident light hole of the integrating sphere (1) outer wall, is installed on the integrating sphere
(1) detector (4) on the detector mouthful of outer wall, and the micro- place being connected with the detector (4) and the light source (3) respectively
Reason device (5), it is characterised in that
Also include being scribbled with the specimen cup entrance connect setting and inner surface the specimen cup inlet cover (11) of diffusing reflection layer；Institute
State light source (3) and be set to multiple, one of them described light source (3) corresponds to the sample in being installed on the integrating sphere (1) bottom
Cup (2) place；The specimen cup (2) includes two coaxial and nested pipes (21) for setting, and is connected to two pipes
(21) the annular bottom (22) between bottom.
2. detection means according to claim 1, it is characterised in that the specimen cup entrance of the integrating sphere (1) is provided with
Make the fixed groove (12) of specimen cup (2) and alignment pin (13), specimen cup (2) inserts integrating sphere (3) by specimen cup entrance, and revolves
Turn specimen cup (2) until alignment pin (13) enters groove (12).
3. detection means according to claim 1, it is characterised in that the detection means also includes housing (6), the product
Bulb separation (1), light source (3), detector (4) and microprocessor (5) are built in the housing (6).
4. detection means according to claim 3, it is characterised in that the detection means also includes input through keyboard and result
Display device (7) and computer digital animation unit (10), computer digital animation unit (10) is by USB interface and microprocessor
Device (5) be connected, input through keyboard be placed on the outer surface of the housing (6) with device displaying result (7) and with microprocessor (5) phase
Even.
5. detection means according to claim 3, it is characterised in that the detection means also includes being installed on the housing
(6) shift knob (8) being connected on outer surface and with microprocessor (5), and be connected with microprocessor (5) and extend described
The outside plug (9) of housing (6).
6. detection means according to claim 3, it is characterised in that the detection means also includes being installed on the housing
(6) support (12) on bottom wall, the integrating sphere (1) is installed on the support (12) upper surface.
7. detection means according to any one of claim 1 to 6, it is characterised in that the light source (3) is swashed for semiconductor
Light device.
8. the detection method for being carried out using the detection means any one of claim 1 to 7, it is characterised in that including
Following steps：Medicine is positioned in the specimen cup of the detection means (2), then specimen cup (2) is put by specimen cup entrance
Enter in integrating sphere (1), then cover specimen cup inlet cover (11), finally open the detection means and detected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710121327.8A CN106918577A (en) | 2017-03-02 | 2017-03-02 | The detection means and method of a kind of medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710121327.8A CN106918577A (en) | 2017-03-02 | 2017-03-02 | The detection means and method of a kind of medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106918577A true CN106918577A (en) | 2017-07-04 |
Family
ID=59461835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710121327.8A Pending CN106918577A (en) | 2017-03-02 | 2017-03-02 | The detection means and method of a kind of medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106918577A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109406428A (en) * | 2018-12-07 | 2019-03-01 | 浙江大学昆山创新中心 | A kind of gas-detecting device based on integrating sphere multiple reflections |
| CN109490239A (en) * | 2018-12-27 | 2019-03-19 | 重庆医科大学 | A kind of dedicated infrared transflector spectral measurement attachment of glass slide sample preparation |
| CN109916846A (en) * | 2019-02-19 | 2019-06-21 | 中国科学院合肥物质科学研究院 | A kind of flux detection integrating sphere dodging device |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003004631A (en) * | 2001-06-18 | 2003-01-08 | Kawasaki Kiko Co Ltd | Component-measuring apparatus |
| US20080165349A1 (en) * | 2007-01-09 | 2008-07-10 | Hon Hai Precision Industry Co., Ltd. | Apparatus for testing reflectivity of lens |
| CN102539378A (en) * | 2012-01-16 | 2012-07-04 | 江苏大学 | Semiconductor laser array near infrared spectrometer |
| CN202886274U (en) * | 2012-09-14 | 2013-04-17 | 江苏惠通集团有限责任公司 | Micro electro mechanical system technology-based agricultural product quality near infrared spectrum analyzer |
| CN105424604A (en) * | 2015-10-02 | 2016-03-23 | 黄辉 | Sensor based on sleeved waveguide tube |
| CN105628680A (en) * | 2016-03-23 | 2016-06-01 | 中国科学院上海技术物理研究所 | Blood identification method based on infrared Raman super-continuum diffuse comprehensive spectrum |
| CN205910112U (en) * | 2016-06-30 | 2017-01-25 | 北京市农林科学院 | Spectrum appearance total mark football shirt is put and spectrum appearance |
-
2017
- 2017-03-02 CN CN201710121327.8A patent/CN106918577A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003004631A (en) * | 2001-06-18 | 2003-01-08 | Kawasaki Kiko Co Ltd | Component-measuring apparatus |
| US20080165349A1 (en) * | 2007-01-09 | 2008-07-10 | Hon Hai Precision Industry Co., Ltd. | Apparatus for testing reflectivity of lens |
| CN102539378A (en) * | 2012-01-16 | 2012-07-04 | 江苏大学 | Semiconductor laser array near infrared spectrometer |
| CN202886274U (en) * | 2012-09-14 | 2013-04-17 | 江苏惠通集团有限责任公司 | Micro electro mechanical system technology-based agricultural product quality near infrared spectrum analyzer |
| CN105424604A (en) * | 2015-10-02 | 2016-03-23 | 黄辉 | Sensor based on sleeved waveguide tube |
| CN105628680A (en) * | 2016-03-23 | 2016-06-01 | 中国科学院上海技术物理研究所 | Blood identification method based on infrared Raman super-continuum diffuse comprehensive spectrum |
| CN205910112U (en) * | 2016-06-30 | 2017-01-25 | 北京市农林科学院 | Spectrum appearance total mark football shirt is put and spectrum appearance |
Non-Patent Citations (1)
| Title |
|---|
| 严衍禄 等: "《近红外光谱分析的原理、技术与应用》", 31 January 2013 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109406428A (en) * | 2018-12-07 | 2019-03-01 | 浙江大学昆山创新中心 | A kind of gas-detecting device based on integrating sphere multiple reflections |
| CN109490239A (en) * | 2018-12-27 | 2019-03-19 | 重庆医科大学 | A kind of dedicated infrared transflector spectral measurement attachment of glass slide sample preparation |
| CN109490239B (en) * | 2018-12-27 | 2024-02-02 | 重庆医科大学 | Special infrared transmission and reflection spectrum measurement accessory for glass slide sample preparation |
| CN109916846A (en) * | 2019-02-19 | 2019-06-21 | 中国科学院合肥物质科学研究院 | A kind of flux detection integrating sphere dodging device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108463711A (en) | Optical sensor for detecting the free hemoglobin in whole blood sample | |
| CN106918577A (en) | The detection means and method of a kind of medicine | |
| CN206177798U (en) | Diffuse reflection total mark ball detection device | |
| CN103575913B (en) | The urinalysis test card of microdose urine protein/UCr | |
| WO2008140473A2 (en) | Optical system and method for inspection and characterization of liquids in vessels | |
| WO2007121287A3 (en) | Fluid level detector and analyzer | |
| CN104132913A (en) | Detection and/or quantitation of endotoxin | |
| CN111380855A (en) | Method for screening illegal drugs in health care products on site | |
| CN109085347A (en) | The colloidal gold strip and preparation method thereof of crystal methamphetamine, ketamine, morphine, hemp, head-shaking pill is detected simultaneously | |
| CN107064044A (en) | The quick determination method and device of polyphenol content in a kind of tea extract | |
| CN106153581A (en) | For detecting the spr sensor without reference of benzopyrene | |
| CN103063648A (en) | Method for detecting liquid preparation by utilizing Raman spectra | |
| CN107314953B (en) | A kind of measuring method of paper-process reconstituted tobacco coating fluid permeance property | |
| CN207488183U (en) | Near-infrared spectrometer and transmission platform | |
| CN105136967B (en) | For differentiating the inverse thin layer chromatography method of Flos Chrysanthemi and Flos Chrysanthemi | |
| US3627419A (en) | Method of detection, dosage and the like, of a hydrocarbon in a fluid and apparatus for working such method | |
| CN105158185A (en) | Water quality online monitoring device based on optical integrating sphere | |
| CN107389708B (en) | Liquid sample introduction bottle and liquid sample introduction method for micro-area X-ray fluorescence spectrometer | |
| CN108375549A (en) | A kind of extraction device and method being automatically separated petroleum component | |
| CN108627373A (en) | A kind of preparation method and application of chafing dish food matrix papaverine standard substance | |
| CN105372338A (en) | Compound yinlingtong capsule quality detection method | |
| CN103884627A (en) | Intelligent type Engler viscosity meter | |
| CN103278498A (en) | Detecting method and kit of sibutramine hydrochloride | |
| CN207689348U (en) | Vacuum tube for detecting sodium formaldehyde sulfoxylate content in food | |
| CN106442349A (en) | Colorimetric measuring device and use method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Caixia Inventor after: Yu Lu Inventor after: Han Bengao Inventor after: Wang Jinrui Inventor before: Zhang Caixia Inventor before: Yu Xiaofeng Inventor before: Han Bengao Inventor before: Wang Jinrui |
|
| CB03 | Change of inventor or designer information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170704 |
|
| RJ01 | Rejection of invention patent application after publication |