CN106916746A - Deep-well plates - Google Patents
Deep-well plates Download PDFInfo
- Publication number
- CN106916746A CN106916746A CN201510982743.8A CN201510982743A CN106916746A CN 106916746 A CN106916746 A CN 106916746A CN 201510982743 A CN201510982743 A CN 201510982743A CN 106916746 A CN106916746 A CN 106916746A
- Authority
- CN
- China
- Prior art keywords
- outer rim
- deep hole
- deep
- plate structure
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
Abstract
The present invention relates to a kind of Deep hole plate structure for biological study.Including outer rim and the substrate being arranged in outer rim, the outer rim and the substrate connection, the substrate is concavely provided with some deep holes, and the bottom of the outer rim is provided with volume pin, and being provided between the lateral surface of the outer rim and the top of the volume pin increases the structure of intensity.Compared with prior art, Deep hole plate structure of the invention is provided with the structure for increasing intensity between the lateral surface of outer rim and the top of volume pin, improve the pressure tolerance degree of outer rim, even if the outer rim that also can guarantee that deep-well plates under conditions of high pressure or high centrifugal force is complete, profile is constant, while can also improve the stability that deep-well plates superposition is placed.The cross section on the deep hole top is rounded square.Compared with prior art, Deep hole plate structure of the invention carries out round edge treatment to the corner of deep hole, it is to avoid the generation of sample carryover and capillarity, improves the rate of recovery of sample, reduces the risk of cross pollution.
Description
Technical field
The present invention relates to a kind of storage, deep-well plates with reaction treatment are pipetted, more particularly to a kind of 96 hole depth orifice plates for biological study.
Background technology
At present in biological research fields, deep-well plates are applied to the experiment such as microculture, plasmid purification, the ultralow temperature culture of cell or tissue, genome and protein analysis and storage, the screening of pharmaceutically active substance and synthesis, using the laboratory for widely, being suitably adapted for blood station, legal medical expert, diagnosis, examination and automation.To meet the demand of different experiments, deep-well plates have high requirements in mechanical strength, high temperature high voltage resistant, chemical resistance, ultraviolet-resistent property and corrosion resistance.Deep-well plates depth is higher, and its profile causes to be used in automated machine by being more easily deformed after HTHP；Deep-well plates bottom hole is designed for U-shaped, and bottom strength bears inequality can be caused to rupture leakage, and not only sample loss will also result in machine and be corroded；The lateral surface of the outer rim of Deep hole plate structure is set with the plan vertical of volume pin, easily occur outer rim under conditions of high pressure or high speed centrifugation and bear that pressure is excessive and the rupture that causes to turn up, and then cause the substrate deformation even technical matters of sample leakage, the square hole top for solving Deep hole plate structure of the prior art simultaneously is susceptible to sample carryover or capillarity, causes sample loss excessive or cross-infection technical matters.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of deep-well plates, with stronger tolerance, can quickly be recognized under the conditions of sight line is bad, the bottom hole portion and outer rim for depositing liquid are not easily broken, and reduce that sample carryover reduction sample loss in plate is excessive or technical matters of cross-infection.
In order to solve the above technical problems, the present invention provides a kind of deep-well plates, including outer rim and the substrate being arranged in outer rim, the outer rim and the substrate connection, the substrate is concavely provided with some deep holes, and the outer rim is provided with corner cut.
The corner cut is arranged on first jiao of the outer rim.
Described first jiao is connected by first side and second side and is formed, and the first side is provided with numeral mark, and the second side is provided with alphabetic flag.
The outer rim and the substrate are connected by some reinforcements being arranged between the outer rim and the substrate.
The reinforcement includes the reinforcement for being arranged on the substrate-side wall and the reinforcement being arranged on the angle of the substrate.
The base plate bottom is provided with a mat, and the top surface of the mat is adapted with the external structure of the base plate bottom, and the bottom surface of the bottom surface of the mat and the outer rim is in same level.
Some deep-hole structures are identical and in a row arrangement in column.
The cross section of the deep hole is square, and the top length of side is identical with base diameter, and surface is provided with fillet.
The deep hole bottom is set to arc-shaped, four smooth-sided compression candles connection of the arc-shaped bottom and the deep hole.
The bottom of the outer rim is provided with volume pin, and being provided between the lateral surface of the outer rim and the top of the volume pin increases the structure of intensity.
The structure for increasing intensity includes clinohedral, and the one side of the clinohedral is connected with the top of the volume pin, and simultaneously the lateral surface with the outer rim is connected.
The lateral surface of the clinohedral, the top of the volume pin and the outer rim is made into integration.
The cross section on the deep hole top is rounded square.
The bottom of the deep hole is U-shaped, and the bottom inside face of the deep hole is smoothly connected with the medial surface on the deep hole top.
The cross section on the deep hole top is rounded square.
Compared with prior art, the invention has the advantages that：
1st, be provided with corner cut in outer rim, though under conditions of sight line is bad, such as in Biohazard Safety Equipment, wear goggles in the case of, also can quickly recognize and position upper and lower, the both forward and reverse directions of substrate, error rate is reduced, while improving operating efficiency；
2nd, the obvious digital alphabet mark of some contrasts is provided with the frame of substrate, form latticed with deep hole, even if also can quickly be recognized and localizing sample at (such as in Biohazard Safety Equipment, wear goggles in the case of) under conditions of sight line is bad, reduce error rate, simultaneously, also sample classification can be carried out according to different projects, experiment and user, improve operating efficiency；
3rd, reinforcement is provided between substrate and outer rim, it is ensured that outer rim can bear bigger pressure in use, reduces the generation of fracture phenomena of turning up, reduce the risk that experiment can not be carried out；
4th, Deep hole plate structure is provided with the structure for increasing intensity between the lateral surface of outer rim and the top of volume pin, improve the pressure tolerance degree of outer rim, even if the outer rim that also can guarantee that deep-well plates (such as in the case of the middle and high fast centrifuge of pressing jig) under conditions of high pressure or high centrifugal force is complete, profile is constant, so as to prevent sample from leaking outside, while can also improve the stability that deep-well plates superposition is placed；
5th, the surface of deep hole is provided with fillet, the i.e. surface to all deep holes and carries out round edge smoothing processing, it is to avoid the generation of sample carryover and capillarity, improves the rate of recovery of sample, reduces cross pollution rate risk, while, it is ensured that to the accuracy of sample treatment；
6th, high-accuracy manufacturing process is used to deep hole, improves the precision of deep-well plates, make the size of deep-well plates and rigidity that there is high stability, it is adaptable to severe experiment condition, the unified design of deep hole plate surface allows it to be superimposed placement；
7th, the height of deep hole account for substrate height ratio it is very big, i.e. the distance from bottom very little of the distance from bottom substrate of deep hole, this is the distance not reached in the prior art so that the effective depth of deep hole is uprised, and dischargeable capacity becomes big, there is provided optimum storage volume.
Brief description of the drawings
Fig. 1 is the dimensional structure diagram of Deep hole plate structure of the invention；
Fig. 2 is the sectional view of Deep hole plate structure superposition of the invention；
Fig. 3 is the partial sectional view of Deep hole plate structure of the invention；
Fig. 4 is the partial sectional view of Deep hole plate structure of the invention；
Fig. 5 is the schematic diagram of existing Deep hole plate structure；
Fig. 6 is the use state figure of existing Deep hole plate structure；
Fig. 7 is the use state figure of the Deep hole plate structure of invention.
Fig. 8 is top view of the present invention for 96 hole depth AND DEWATERING FOR ORIFICE STRUCTUREs of biological study；
Fig. 9 is part-structure schematic diagram of the invention.
Specific embodiment
Below in conjunction with accompanying drawing, the present invention is described in detail.
Refer to Fig. 1-4, Deep hole plate structure of the present invention, including outer rim 2 and the substrate 3 being arranged in outer rim 2, outer rim 2 and substrate 3 are connected, substrate 3 is concavely provided with some deep holes 31, the bottom of outer rim 2 is provided with volume pin 22, and the structure for increasing intensity is provided between the lateral surface 21 of outer rim 2 and the top of volume pin 22.
In this example, from the high-quality polypropylene material with outstanding rigidity, homogeneous transparent degree and high fluidity, this material has high-chemical-resistance and uvioresistant performance, is resistant to UV and chemical attack substrate 3.
In this example, increasing the structure of intensity includes clinohedral 23, and the one side of clinohedral 23 is connected with the top of volume pin 22, is simultaneously connected with the lateral surface 21 of outer rim 2, as shown in Figure 4.In this example, the lateral surface 21 of clinohedral 23, the top of volume pin 22 and outer rim is made into integration.Deep hole plate structure of the invention is provided with the structure for increasing intensity between the lateral surface of outer rim and the top of volume pin, improve the pressure tolerance degree of outer rim, even if the outer rim that also can guarantee that deep-well plates (such as in the case of the middle and high fast centrifuge of pressing jig) under conditions of high pressure or high centrifugal force is complete, profile is constant, so as to prevent sample from leaking outside, while can also improve the stability that deep-well plates superposition is placed.
In this example, the cross section on the top of deep hole 31 is rounded square, as shown in Figure 7.Deep hole plate structure of the invention carries out round edge treatment to the corner of deep hole, the generation of sample carryover and capillarity (phenomenon in deep hole 4 as shown in Figure 6) is avoided, the rate of recovery of sample is improve, the risk of cross pollution is reduced, simultaneously, it is ensured that to the accuracy of sample treatment.In this example, the bottom of deep hole 31 is U-shaped, and bottom inside face and the medial surface on the top of deep hole 31 of deep hole 31 are smoothly connected, and can further reduce the residual of sample.
Disclosed above is only several specific embodiments of the application, but the application is not limited to this, the changes that any person skilled in the art can think of, should all fall in the protection domain of the application.
Claims (5)
1. a kind of Deep hole plate structure, including outer rim and the substrate being arranged in outer rim, the outer rim and the substrate connection,
The substrate is concavely provided with some deep holes, and the bottom of the outer rim is provided with volume pin, it is characterised in that the outside of the outer rim
Being provided between the top of face and the volume pin increases the structure of intensity.
2. Deep hole plate structure as claimed in claim 1, it is characterised in that the structure of the increase intensity includes clinohedral, described
The one side of clinohedral is connected with the top of the volume pin, and simultaneously the lateral surface with the outer rim is connected.
3. Deep hole plate structure as claimed in claim 2, it is characterised in that the clinohedral, the top of the volume pin and described outer
The lateral surface of frame is made into integration.
4. the Deep hole plate structure as described in any one in claim 1-3, it is characterised in that the cross section on the deep hole top is
Rounded square.
5. Deep hole plate structure as claimed in claim 4, it is characterised in that the bottom of the deep hole is U-shaped, the bottom of the deep hole
Portion's medial surface is smoothly connected with the medial surface on the deep hole top.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510982743.8A CN106916746A (en) | 2015-12-24 | 2015-12-24 | Deep-well plates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510982743.8A CN106916746A (en) | 2015-12-24 | 2015-12-24 | Deep-well plates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106916746A true CN106916746A (en) | 2017-07-04 |
Family
ID=59457017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510982743.8A Pending CN106916746A (en) | 2015-12-24 | 2015-12-24 | Deep-well plates |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106916746A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202281775U (en) * | 2011-07-20 | 2012-06-20 | 上海双螺旋生物科技有限公司 | 96-aperture deep orifice plate structure for biology research |
| CN202410697U (en) * | 2011-12-16 | 2012-09-05 | 上海双螺旋生物科技有限公司 | Deep hole plate structure |
| CN202849414U (en) * | 2012-10-30 | 2013-04-03 | 无锡耐思生物科技有限公司 | Deep-hole plate structure |
| NZ598183A (en) * | 2009-09-05 | 2013-10-25 | Lonza Biologics Plc | Deepwell plate system with lid |
-
2015
- 2015-12-24 CN CN201510982743.8A patent/CN106916746A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ598183A (en) * | 2009-09-05 | 2013-10-25 | Lonza Biologics Plc | Deepwell plate system with lid |
| CN202281775U (en) * | 2011-07-20 | 2012-06-20 | 上海双螺旋生物科技有限公司 | 96-aperture deep orifice plate structure for biology research |
| CN202410697U (en) * | 2011-12-16 | 2012-09-05 | 上海双螺旋生物科技有限公司 | Deep hole plate structure |
| CN202849414U (en) * | 2012-10-30 | 2013-04-03 | 无锡耐思生物科技有限公司 | Deep-hole plate structure |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170704 |
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