CN106902440A - A kind of medical drainage tube of Internal Medicine-Oncology - Google Patents
A kind of medical drainage tube of Internal Medicine-Oncology Download PDFInfo
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- CN106902440A CN106902440A CN201710105324.5A CN201710105324A CN106902440A CN 106902440 A CN106902440 A CN 106902440A CN 201710105324 A CN201710105324 A CN 201710105324A CN 106902440 A CN106902440 A CN 106902440A
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- drainage tube
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- tube main
- internal medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/043—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
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- A—HUMAN NECESSITIES
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
- A61L29/103—Carbon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
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- A61L29/106—Inorganic materials other than carbon
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/148—Materials at least partially resorbable by the body
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
- C08K3/04—Carbon
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
- C08L25/02—Homopolymers or copolymers of hydrocarbons
- C08L25/04—Homopolymers or copolymers of styrene
- C08L25/06—Polystyrene
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L69/00—Compositions of polycarbonates; Compositions of derivatives of polycarbonates
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D169/00—Coating compositions based on polycarbonates; Coating compositions based on derivatives of polycarbonates
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D7/00—Features of coating compositions, not provided for in group C09D5/00; Processes for incorporating ingredients in coating compositions
- C09D7/40—Additives
- C09D7/60—Additives non-macromolecular
- C09D7/61—Additives non-macromolecular inorganic
- C09D7/62—Additives non-macromolecular inorganic modified by treatment with other compounds
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/206—Biguanides, e.g. chlorohexidine
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
Abstract
A kind of medical drainage tube of Internal Medicine-Oncology, it includes tip body（1）, perimeter cavity（2）, drainage tube main body（3）With contact sucker（4）, the drainage tube main body（3）Front portion be attached with tip body（1）, drainage tube main body（3）Anterior outer wall on multiple evenly spaced perimeter cavities are set（2）, contact sucker（4）It is tightly sleeved in drainage tube main body（3）It is upper and can be along drainage tube main body（3）Slide, multiple perimeter cavities（2）Positioned at tip body（1）With contact sucker（4）Between, drainage tube main body（3）The settable push rod in inside（5）；The tip body（1）It is made up of biodegradable material, appendix has antineoplastic, drainage tube main body thereon（3）On be coated with sterilizing medicament.The present invention can improve drainage efficiency, improve tumour cell recall rate, and medicine can be applied directly into the purpose that tumor locus realize directly treatment, the excellent effect with one tube multipurpose.
Description
Technical field
The present invention relates to technical field of medical instruments, especially, it is related to a kind of medical drainage tube of Internal Medicine-Oncology.
Background technology
Drainage tube is that internal medicine often uses apparatus.The postoperative indwelling drainage tube that is frequently necessary to of patient is remained in vitro with drainage body
Liquid.Existing drainage tube is a common medical plastic expects pipe, and drainage is directly carried out from external insertion body.Body is drained in drainage tube
While interior liquid, partially liq can be oozed out in vitro along drainage pipe outer wall by the wound at intubation, and then clothing of making dirty, sleeping
Tool etc..Therefore, the upper usual measure for using of nursing at present is to cover pipe week wound with dressing, for absorbing diffusate.But, by
It is special in the shape of drainage cannula wound, and diffusate can be such that dressing is saturated in a short time, cause and frequently change wound
Dressing, or even trigger adhesion, changing difficult, increase patient is painful, and the workload of doctor and nursing staff is also greatly increased, and
Easily cause wound infection.
Secondly, Internal Medicine-Oncology is easily blocked in tumour sealing drainage process is carried out, and replacing instrument is when not only wasting
Between and efficiency, can also bring discomfort to patient, bring very big pain to patient.Intra-tumor residual fluid inspection is clinically used
In the reason for tumour is formed and the cause of disease is determined by checking the property of Liquid Residue, the treatment to clinical disease plays directiveness work
With.Therefore it is cause of disease determination to be carried out to patient and has been taken in time clinically to find cancer cell in the intra-tumor Liquid Residue for extracting
Imitate the premise for the treatment of.Clinically often outwards extract the Liquid Residue censorship of 5-10ml at random with drainage tube；However, due in cancer
Disease initial stage, cancer cell number is less, therefore occurs and fail to pinpoint a disease in diagnosis phenomenon, so that delay conditions of patients.
Finally, the treatment of tumour is that medicine is applied directly into tumor locus for most effective, but prior art be will be anti-swollen
Tumor medicine enters human lesion tissue by way of intravascular injection, can reduce liver,spleen,kidney etc. suffered due to the pair of medicine generation
Effect, but vascular perfusion mode enters the medicine of focal zone, can reabsorb and enter blood circulation, and focal zone VPV is fast,
Medicine is of short duration in the residence time of focal zone tissue after entering, and drug concentration is relatively low, and medicinal effects are poor, influence tumour sufferer
Curative effect.
The content of the invention
To solve the above problems, the invention provides a kind of medical drainage tube of Internal Medicine-Oncology.The present invention solves drainage
Pipe causes a series of problem of infection, Liquid Residue seepage etc. to the wound at body intubation.Using Internal Medicine-Oncology of the invention
Medical drainage tube can improve drainage efficiency, improve tumour cell recall rate, and medicine can be applied directly into tumour
Realize the purpose of directly treatment, the excellent effect with one tube multipurpose in position.
The present invention is a kind of medical drainage tube of Internal Medicine-Oncology to solve the technical scheme that above-mentioned technical problem is used, its
Including tip body, perimeter cavity, drainage tube main body and contact sucker, the front portion of the drainage tube main body is attached with tip body, draws
Multiple evenly spaced perimeter cavities are set on the anterior outer wall of flow tube main body, on the anterior outer wall of drainage tube main body and circumference
Multiple conduction holes are set between the interval of cavity, and contact sucker is tightly sleeved in drainage tube main body and can be slided along drainage tube main body
Dynamic, multiple perimeter cavities are located between tip body and contact sucker, and drainage tube body interior can be set push rod；The tip body by
Biodegradable material is made, and appendix has antineoplastic thereon, and sterilizing medicament is coated with drainage tube main body.
Preferably, the tip body is macromolecular material main body, is had thereon containing medicine film, and the outside containing medicine film is covered and is wrapped with degraded
Film layer；Macromolecular material main body is pyramid type structure, and the macromolecular material is poly- ethylenecarbonate, lactone and polyethylene glycol
During the blend of ether, its mass ratio is 2:1:1；The macromolecular material main body is obtained by following step：Take the macromolecule
Material obtains the silk material of a diameter of 1-1.5mm by melt spinning technology, and machine is carried out using the box-loom of rigid rapier 1 × 4
Knit machine-shaping.
In any of the above-described scheme preferably, be organized as based on the woven machine-shaping plain weave, 2 times twills on 2,
1 time twill on 3, warp-wise silk material monofilament linear density is 0.2-0.3mm, and broadwise silk material monofilament linear density is 0.4-0.5mm；It is through close
90-100r/10cm, filling density is 110-130r/10cm, and weaving speed is 40-50r/min.
In any of the above-described scheme preferably, it is described to include hydrophilic carbon black, polytrimethylene carbon containing medicine film
The NaOH that acid ester copolymer, concentration are 0.9% sodium chloride solution and concentration is 10%, its weight ratio is 0.5-1:1.5-2:
5:1, it is described to be obtained by following step containing medicine film：It is raw material to use carbon black, by ethyl acetate degreasing, pickling alkali cleaning reduction ash
Divide and heavy metal, then massive laundering removes acid, alkali, is made purified nanotubes charcoal；The purified nanotubes charcoal is added in 67% concentrated nitric acid
Temperature flows back 80-90 hours at such a temperature to 80-90 DEG C；15-20 DEG C is dropped at a temperature of carbon black salpeter solution after question response
Afterwards, concentrated 10 minutes with 6000-6500rpm on a rotary evaporator；Take upper strata black liquor and be heated to 100-120 DEG C, then
Black solid is obtained after being evaporated under reduced pressure at a temperature of 50-60 DEG C, the engrafted nanometer carbon that particle diameter is 40-50nm is obtained final product；Again to grafting
The sodium chloride solution that concentration is 0.9% is added in Nano carbon, makes engrafted nanometer carbon dispersed in the solution by ultrasonic vibration method
Into suspension；10% sodium hydroxide solution is subsequently adding, is reconciled uniformly afterwards with 0.2 μm of filtering with microporous membrane, added afterwards
PTMC copolymer, stirs 3-5 minutes, will be finally sprayed in macromolecular material main body after its ultrasonic atomization
Formed and contain medicine film.
In any of the above-described scheme preferably, the degraded film layer also includes antineoplastic.
In any of the above-described scheme preferably, the contact sucker is by microporous polyethylene layer, hydroxypropylation cellulose, poly-
The structure sheaf of the blend of vinyl alcohol and phosphorylated starch, collodion film and the suction for producing contact on collodion film
Disk body is constituted, and microporous polyethylene layer, the structure sheaf of blend, collodion film and sucker body are cascading, micropore
The permeability hole of mesh is provided with polyethylene layer, the sucker body includes the raw material components of following weight portion：Butadiene with
Copolymer 5-10 parts of acrylonitrile, polystyrene resin 50-80 parts, stearic acid 1-2 parts, repefral 5-10 parts,
Sulphur 3-5 parts, aluminium hydroxide 2-3 parts and silane coupler 0.1-0.2 parts.
In any of the above-described scheme preferably, the sterilizing medicament includes the component of following weight portion：Trichlorine hydroxyl
Yl diphenyl ether 0.5-1 parts, chlorhexidine gluconate 0.8-1.2 parts, 1-3 parts of hydroxypropyl chitosan, polyoxyethylene polyoxy
3-5 parts of propylene ether block copolymers, tetrasodium salt of EDTA 7-8 parts, ethanol 5-8 parts, wherein 100 parts of sublimate, second two
The concentration of amine tetraacethyl tetrasodium salt is 7%-8%mg/ml.
In any of the above-described scheme preferably, the hydroxypropylation cellulose, polyvinyl alcohol and phosphorylated starch
The mass ratio of each composition is 1 in blend:1:2.
In any of the above-described scheme preferably, the push rod is used for after the drainage tube completes drainage, is inserted into described
In drainage tube main body, the tip body is promoted it is separated with drainage tube main body.
The present invention is according to clinical application practice for many years and experience gained, using optimal technological means and operational group
Close, the optimal medical supplies of acquisition are not the simple superposition of prior art and are pieced together, therefore the present invention has significant meaning
Justice.
Beneficial effects of the present invention：
1. the present invention solves drainage tube and causes that infection, Liquid Residue seepage etc. are a series of to ask to the wound at body intubation
Topic.Drainage efficiency can be improved using the medical drainage tube of Internal Medicine-Oncology of the invention, tumour can be retained in the perimeter cavity
Liquid Residue, it is detected can improve tumour cell recall rate, and it is direct medicine can be applied directly into tumor locus realization
The purpose for the treatment of, the excellent effect with one tube multipurpose.
2. drainage tube of the invention coordinates push rod to use, and push rod is used for after the drainage tube completes drainage, is inserted into
In the drainage tube main body, promote the tip body it is separated with drainage tube main body, tip body is stayed in tumor locus, it contains
There is antineoplastic, drug effect can be played directly against tumor locus, improve therapeutic effect.Tip body is biodegradable, without entering
Row operation is taken out again, reduces the pain of sufferer, and medical treatment cost is greatly reduced.
3. the sucker that drainage tube of the invention is set prevents diffusate from the leakage at intubation position, not only causes overall knot
Structure is simple, reduces product cost, and reduce the difficulty of cleaning work so that cleaning work is relatively sanitary, convenient, accordingly
Improve therapeutic effect.
4. sterilizing medicament is coated with drainage tube main body of the invention, wound healing can be promoted, coordinate sucker again
It is resistant to ooze out, moreover it is possible to antibacterial anti-infection.
5. the medical drainage tube of Internal Medicine-Oncology of the invention has and is significantly worth with wide market and medical applications.
Brief Description Of Drawings
Fig. 1 is the structural representation of the medical drainage tube of Internal Medicine-Oncology of the invention.
Specific embodiment
Below in conjunction with specific embodiment and accompanying drawing, the invention will be further described, but claimed scope not office
It is limited to this.
Embodiment 1
A kind of medical drainage tube of Internal Medicine-Oncology, it includes tip body 1, perimeter cavity 2, drainage tube main body 3 and contact sucker 4,
The front portion of the drainage tube main body 3 is attached with tip body 1, sets multiple evenly spaced on the anterior outer wall of drainage tube main body 3
Perimeter cavity 2, sets multiple conduction holes on the anterior outer wall of drainage tube main body 3 and between the interval of perimeter cavity 2, contact is inhaled
Disk 4 is tightly sleeved in drainage tube main body 3 and can be slided along drainage tube main body 3, and multiple perimeter cavities 2 are located at tip body 1 and connect
Touch between sucker 4, the inside of drainage tube main body 3 can be set push rod 5；The tip body 1 is made up of biodegradable material, thereon
Appendix has antineoplastic, and sterilizing medicament is coated with drainage tube main body 3.
The tip body 1 is macromolecular material main body, is had thereon containing medicine film, and the outside containing medicine film is covered and is wrapped with degraded film layer；
Macromolecular material main body is pyramid type structure, and the macromolecular material is poly- ethylenecarbonate, lactone and polyglycol ether
During blend, its mass ratio is 2:1:1；The macromolecular material main body is obtained by following step：Take the macromolecular material
The silk material of a diameter of 1mm is obtained by melt spinning technology, woven being processed into is carried out using the box-loom of rigid rapier 1 × 4
Type.
Plain weave, 2 times twills on 2,1 time twill, warp-wise silk material monofilament lines on 3 are organized as based on the woven machine-shaping
Density is 0.3mm, and broadwise silk material monofilament linear density is 0.4mm.Through it is close be 100r/10cm, filling density is 110r/10cm, weaving speed
It is 50r/min to spend.
It is described to include hydrophilic carbon black, PTMC copolymer, the chlorine that concentration is 0.9% containing medicine film
Change sodium solution and the NaOH that concentration is 10%, its weight ratio are 0.5:2:5:1, it is described to be obtained by following step containing medicine film：
It is raw material to use carbon black, and by ethyl acetate degreasing, pickling alkali cleaning reduces ash content and heavy metal, and then massive laundering removes acid, alkali,
It is made purified nanotubes charcoal；The purified nanotubes charcoal is heated up to 80 DEG C in 67% concentrated nitric acid, is flowed back 90 hours at such a temperature；Treat
After dropping to 15 DEG C at a temperature of reacted carbon black salpeter solution, concentrated 10 minutes with 6500rpm on a rotary evaporator；Take
Layer black liquor is heated to 100 DEG C, and black solid is obtained after being then evaporated under reduced pressure at a temperature of 60 DEG C, and it is 40nm's to obtain final product particle diameter
Engrafted nanometer carbon；Again to the sodium chloride solution that concentration is 0.9% is added in engrafted nanometer carbon, grafting is set to receive by ultrasonic vibration method
Rice charcoal is dispersed into suspension in the solution；Be subsequently adding 10% sodium hydroxide solution, reconcile it is uniform after it is micro- with 0.2 μm
Hole membrane filtration, adds PTMC copolymer afterwards, stirs 5 minutes, will finally be sprayed after its ultrasonic atomization
Formed in macromolecular material main body and contain medicine film.
The degraded film layer also includes antineoplastic.
By microporous polyethylene layer, hydroxypropylation cellulose, polyvinyl alcohol and phosphorylated starch are total to the contact sucker 4
The structure sheaf of mixed thing, collodion film and for producing the sucker body of contact to constitute on collodion film, microporous polyethylene layer,
The structure sheaf of blend, collodion film and sucker body are cascading, and mesh is provided with microporous polyethylene layer
Permeability hole, the sucker body includes the raw material components of following weight portion：5 parts of copolymer, the polyphenyl second of butadiene and acrylonitrile
80 parts of olefine resin, 1 part of stearic acid, 10 parts of repefral, 3 parts of sulphur, 3 parts of aluminium hydroxide and silane coupler 0.1
Part.
The sterilizing medicament includes the component of following weight portion：1 part of Triclosan, chlorhexidine gluconate
0.8 part, 3 parts of hydroxypropyl chitosan, 3 parts of polyoxyethylene poly-oxygen propylene aether block copolymer, tetrasodium ethylenediamine tetraacetate
8 parts of salt, 5 parts of ethanol, wherein 100 parts of sublimate, the concentration of tetrasodium salt of EDTA are 8%mg/ml.
The mass ratio of each composition is 1 in the blend of the hydroxypropylation cellulose, polyvinyl alcohol and phosphorylated starch:
1:2.
The push rod 5 is used for after the drainage tube completes drainage, is inserted into the drainage tube main body 3, promotes the point
End body 1 makes it be separated with drainage tube main body 3.
Embodiment 2
A kind of medical drainage tube of Internal Medicine-Oncology, it includes tip body 1, perimeter cavity 2, drainage tube main body 3 and contact sucker 4,
The front portion of the drainage tube main body 3 is attached with tip body 1, sets multiple evenly spaced on the anterior outer wall of drainage tube main body 3
Perimeter cavity 2, sets multiple conduction holes on the anterior outer wall of drainage tube main body 3 and between the interval of perimeter cavity 2, contact is inhaled
Disk 4 is tightly sleeved in drainage tube main body 3 and can be slided along drainage tube main body 3, and multiple perimeter cavities 2 are located at tip body 1 and connect
Touch between sucker 4, the inside of drainage tube main body 3 can be set push rod 5；The tip body 1 is made up of biodegradable material, thereon
Appendix has antineoplastic, and sterilizing medicament is coated with drainage tube main body 3.
The tip body 1 is macromolecular material main body, is had thereon containing medicine film, and the outside containing medicine film is covered and is wrapped with degraded film layer；
Macromolecular material main body is pyramid type structure, and the macromolecular material is poly- ethylenecarbonate, lactone and polyglycol ether
During blend, its mass ratio is 2:1:1；The macromolecular material main body is obtained by following step：Take the macromolecular material
The silk material of a diameter of 1.5mm is obtained by melt spinning technology, woven processing is carried out using the box-loom of rigid rapier 1 × 4
Shaping.
Plain weave, 2 times twills on 2,1 time twill, warp-wise silk material monofilament lines on 3 are organized as based on the woven machine-shaping
Density is 0.2mm, and broadwise silk material monofilament linear density is 0.5mm；Through it is close be 90r/10cm, filling density is 130r/10cm, weaving speed
It is 40r/min.
It is described to include hydrophilic carbon black, PTMC copolymer, the chlorine that concentration is 0.9% containing medicine film
Change sodium solution and the NaOH that concentration is 10%, its weight ratio are 1:1.5:5:1, it is described to be obtained by following step containing medicine film：
It is raw material to use carbon black, and by ethyl acetate degreasing, pickling alkali cleaning reduces ash content and heavy metal, and then massive laundering removes acid, alkali,
It is made purified nanotubes charcoal；The purified nanotubes charcoal is heated up to 90 DEG C in 67% concentrated nitric acid, is flowed back 80 hours at such a temperature；Treat
After dropping to 20 DEG C at a temperature of reacted carbon black salpeter solution, concentrated 10 minutes with 6000rpm on a rotary evaporator；Take
Layer black liquor is heated to 120 DEG C, and black solid is obtained after being then evaporated under reduced pressure at a temperature of 50 DEG C, and it is 50nm's to obtain final product particle diameter
Engrafted nanometer carbon；Again to the sodium chloride solution that concentration is 0.9% is added in engrafted nanometer carbon, grafting is set to receive by ultrasonic vibration method
Rice charcoal is dispersed into suspension in the solution；Be subsequently adding 10% sodium hydroxide solution, reconcile it is uniform after it is micro- with 0.2 μm
Hole membrane filtration, adds PTMC copolymer afterwards, stirs 3 minutes, will finally be sprayed after its ultrasonic atomization
Formed in macromolecular material main body and contain medicine film.
The degraded film layer also includes antineoplastic.
By microporous polyethylene layer, hydroxypropylation cellulose, polyvinyl alcohol and phosphorylated starch are total to the contact sucker 4
The structure sheaf of mixed thing, collodion film and for producing the sucker body of contact to constitute on collodion film, microporous polyethylene layer,
The structure sheaf of blend, collodion film and sucker body are cascading, and mesh is provided with microporous polyethylene layer
Permeability hole, the sucker body includes the raw material components of following weight portion：0 part of copolymer 1, the polyphenyl second of butadiene and acrylonitrile
50 parts of olefine resin, 2 parts of stearic acid, 5 parts of repefral, 5 parts of sulphur, 2 parts of aluminium hydroxide and silane coupler 0.2
Part.
The sterilizing medicament includes the component of following weight portion：0.5 part of Triclosan, gluconic acid chlorine oneself
It is fixed 1.2 parts, 1 part of hydroxypropyl chitosan, 5 parts of polyoxyethylene poly-oxygen propylene aether block copolymer, ethylenediamine tetra-acetic acid four
7 parts of sodium salt, 8 parts of ethanol, wherein 100 parts of sublimate, the concentration of tetrasodium salt of EDTA are 7%mg/ml.
The mass ratio of each composition is 1 in the blend of the hydroxypropylation cellulose, polyvinyl alcohol and phosphorylated starch:
1:2.
The push rod 5 is used for after the drainage tube completes drainage, is inserted into the drainage tube main body 3, promotes the point
End body 1 makes it be separated with drainage tube main body 3.
Embodiment 3
As further improvement, in addition to possessing above-mentioned technical characteristic, the contact sucker 4 include for fit skin and
Microporous polyethylene layer, the hydroxypropylation cellulose for absorbing penetrating fluid, polyvinyl alcohol and phosphorylation containing adhesive form sediment
The structure sheaf of the blend of powder, for forming enclosed space and appearing the collodion film of aqueous vapor and in collodion film
The sucker body of contact, microporous polyethylene layer, the structure sheaf of blend, collodion film and suction body pad is produced to stack gradually and set
Put, the permeability hole of mesh is provided with microporous polyethylene layer, the sucker body includes the raw material components of following weight portion：Fourth
Copolymer 5-10 parts, polystyrene resin 50-80 parts, stearic acid 1-2 parts, repefral 5- of diene and acrylonitrile
10 parts, sulphur 3-5 parts, aluminium hydroxide 2-3 parts, silane coupler 0.1-0.2 parts.Selected adhesive using silica gel or other can connect
Touch the adhesive of medical of wound.
Embodiment 4
Used as further improvement, in addition to possessing above-mentioned technical characteristic, the collodion film is obtained by the following steps：
1. it is 10 by volume ratio:1 water and concentration is well mixed for the concentrated nitric acid of 14.1g/mL, is cooled to 22-25 DEG C；Then wherein
Absorbent cotton is added, absorbent cotton is taken out after immersion 15-20min, fully cleaned, airing obtains cellulose nitrate.2. by mass ratio
It is 1:1:1 ether, ethanol and above-mentioned dry cellulose nitrate are well mixed, place 24-30h, form transparent collodion
Liquid.3. above-mentioned collodion is uniformly poured on planarizing substrate, ether, ethanol is constantly evaporated, until drying forms film, then
Phased separation film, gently takes out, standby in immersion distilled water, obtains final product described collodion film.
Embodiment 5
Used as further improvement, in addition to possessing above-mentioned technical characteristic, the sterilizing medicament is by the following steps
It is obtained：By in Triclosan and chlorhexidine gluconate addition purified water, under 60 DEG C -80 DEG C of water bath condition, lead to
Crossing stirring makes it be completely dissolved in purified water, then, under 65 DEG C -75 DEG C of water bath condition and keep liquid stirring exist
70-80 revs/min, to hydroxypropyl chitosan is added in liquid, stir 3-5 minutes, then add polyoxyethylene to gather simultaneously
Oxypropylene ether block copolymers and tetrasodium salt of EDTA, stir 3-5 minutes, are eventually adding ethanol, mix solution and fill
Point, add the time of component to be no more than every time 1 minute, the order and effect for so adding can be such that each component reacts more fully, kill
The effect of bacterium sterilization reaches most preferably, and result of the test shows, the sterilizing medicament disappears than the sterilization of medicament in conventional prior art
Toxic effect fruit improves 10%-15%.This be by verifying the result for obtaining repeatedly, it is not any and be.Finally, the sterilization is disappeared
Toxicant ultrasound is coated on the surface of drainage tube main body 3.
Embodiment 6
Used as further improvement, in addition to possessing above-mentioned technical characteristic, the preparation method of the degraded film layer is normal
Pressure, at 10 DEG C -20 DEG C by poly-aspartate and polyethylene glycol in mass ratio it is 5:1 dispersion in deionized water, is subsequently adding contracting
Mixture, its quality is the 1/3 of poly-aspartate, keeps aforementioned temperature and reacts 5-10h under agitation, after the reaction time expires,
By reacting liquid filtering, gained filtrate is concentrated, filtered after being precipitated in gained concentrate addition petroleum ether, by gained filter cake
Washed with acetone to remove raw material and accessory substance, by the filter cake vacuum drying after washing, add antineoplastic, filter cake is swollen with anti-
The mass ratio of tumor medicine is 20：1, be subsequently adding with filter cake quality identical distilled water, stir, in normal pressure, at room temperature surpass
Phonoresponse 10-15min, after the ultrasonic reaction time expires, 5-8h is stood at normal pressure, 10-15 DEG C, is then coated with containing medicine film
Obtain final product the degraded film layer.
The present invention solves drainage tube and causes that infection, Liquid Residue seepage etc. are a series of to ask to the wound at body intubation
Topic.Drainage efficiency can be improved using the medical drainage tube of Internal Medicine-Oncology of the invention, tumour can be retained in the perimeter cavity
Liquid Residue, it is detected can improve tumour cell recall rate, and it is direct medicine can be applied directly into tumor locus realization
The purpose for the treatment of, the excellent effect with one tube multipurpose.
Drainage tube of the invention coordinates push rod to use, and push rod is used for after the drainage tube completes drainage, is inserted into institute
State in drainage tube main body, promote the tip body it is separated with drainage tube main body, tip body is stayed in tumor locus, it contains
Antineoplastic, can play drug effect directly against tumor locus, improve therapeutic effect.Tip body is biodegradable, without carrying out
Operation is taken out again, reduces the pain of sufferer, and medical treatment cost is greatly reduced.
The sucker that drainage tube of the invention is set prevents diffusate from the leakage at intubation position, not only causes overall structure
Simply, product cost is reduced, and reduces the difficulty of cleaning work so that cleaning work is relatively sanitary, convenient, correspondingly
Improve therapeutic effect.
Sterilizing medicament is coated with drainage tube main body of the invention, wound healing can be promoted, coordinate sucker energy again
It is impervious go out, moreover it is possible to antibacterial anti-infection.Therefore, the medical drainage tube of Internal Medicine-Oncology of the invention have significantly and wide market and
Medical applications are worth.
The above, is only presently preferred embodiments of the present invention, is not the limitation for making other forms to the present invention, is appointed
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But it is every without departing from technical solution of the present invention content, according to technical spirit of the invention to above example institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.
Claims (9)
1. the medical drainage tube of a kind of Internal Medicine-Oncology, it is characterised in that including tip body（1）, perimeter cavity（2）, drainage tube master
Body（3）With contact sucker（4）, the drainage tube main body（3）Front portion be attached with tip body（1）, drainage tube main body（3）Front portion
Multiple evenly spaced perimeter cavities are set on outer wall（2）, in drainage tube main body（3）Anterior outer wall on and perimeter cavity（2）
Interval between multiple conduction holes are set, contact sucker（4）It is tightly sleeved in drainage tube main body（3）It is upper and can be along drainage tube main body
（3）Slide, multiple perimeter cavities（2）Positioned at tip body（1）With contact sucker（4）Between, drainage tube main body（3）Inside is settable
Push rod（5）；The tip body（1）It is made up of biodegradable material, appendix has antineoplastic, drainage tube main body thereon
（3）On be coated with sterilizing medicament.
2. the medical drainage tube of Internal Medicine-Oncology according to claim 1, it is characterised in that the tip body（1）It is high score
Sub- body of material, has containing medicine film thereon, and the outside containing medicine film is covered and is wrapped with degraded film layer；Macromolecular material main body is pyramid type knot
Structure, when the macromolecular material is the blend of poly- ethylenecarbonate, lactone and polyglycol ether, its mass ratio is 2:1:1；
The macromolecular material main body is obtained by following step：Take the macromolecular material and obtain a diameter of by melt spinning technology
The silk material of 1-1.5mm, woven machine-shaping is carried out using the box-loom of rigid rapier 1 × 4.
3. the medical drainage tube of Internal Medicine-Oncology according to claim 2, it is characterised in that the woven machine-shaping is base
Plinth is organized as plain weave, 2 times twills on 2,1 time twill on 3, and warp-wise silk material monofilament linear density is 0.2-0.3mm, broadwise silk material monofilament
Line density is 0.4-0.5mm；Through it is close be 90-100r/10cm, filling density is 110-130r/10cm, and weaving speed is 40-50r/
min。
4. the medical drainage tube of Internal Medicine-Oncology according to claim 1-3, it is characterised in that it is described containing medicine film include it is hydrophilic
Property engrafted nanometer carbon, PTMC copolymer, the sodium chloride solution that concentration is 0.9% and the hydroxide that concentration is 10%
Sodium, its weight ratio is 0.5-1:1.5-2:5:1, it is described to be obtained by following step containing medicine film：It is raw material to use carbon black, by second
Acetoacetic ester degreasing, pickling alkali cleaning reduces ash content and heavy metal, and then massive laundering removes acid, alkali, is made purified nanotubes charcoal；This is pure
Change Nano carbon and 80-90 DEG C is heated up in 67% concentrated nitric acid, flow back 80-90 hours at such a temperature；Carbon black nitre after question response
After dropping to 15-20 DEG C at a temperature of acid solution, concentrated 10 minutes with 6000-6500rpm on a rotary evaporator；Take upper strata black
Liquid is heated to 100-120 DEG C, and black solid is obtained after being then evaporated under reduced pressure at a temperature of 50-60 DEG C, obtains final product particle diameter for 40-
The engrafted nanometer carbon of 50nm；Again to the sodium chloride solution that concentration is 0.9% is added in engrafted nanometer carbon, made by ultrasonic vibration method
Engrafted nanometer carbon is dispersed into suspension in the solution；10% sodium hydroxide solution is subsequently adding, 0.2 is used after reconciling uniformly
μm filtering with microporous membrane, afterwards add PTMC copolymer, stir 3-5 minutes, finally by its ultrasonic fog
It is sprayed on after change in macromolecular material main body and is formed containing medicine film.
5. the medical drainage tube of Internal Medicine-Oncology according to claim 1-4, it is characterised in that the degraded film layer also includes
Antineoplastic.
6. the medical drainage tube of Internal Medicine-Oncology according to claim 1-5, it is characterised in that the contact sucker（4）By
Microporous polyethylene layer, the structure sheaf of the blend of hydroxypropylation cellulose, polyvinyl alcohol and phosphorylated starch, collodion film with
And for producing the sucker body of contact to constitute on collodion film, microporous polyethylene layer, the structure sheaf of blend, collodion film
And sucker body is cascading, the permeability hole of mesh is provided with microporous polyethylene layer, the sucker body includes
The raw material components of following weight portion：Copolymer 5-10 parts, polystyrene resin 50-80 parts, stearic acid of butadiene and acrylonitrile
1-2 parts, repefral 5-10 parts, sulphur 3-5 parts, aluminium hydroxide 2-3 parts and silane coupler 0.1-0.2 parts.
7. the medical drainage tube of Internal Medicine-Oncology according to claim 1-6, it is characterised in that the sterilizing medicament bag
Include the component of following weight portion：Triclosan 0.5-1 parts, chlorhexidine gluconate 0.8-1.2 parts, hydroxypropyl is deacetylated
Chitin 1-3 parts, 3-5 parts of polyoxyethylene poly-oxygen propylene aether block copolymer, tetrasodium salt of EDTA 7-8 parts, ethanol 5-8
Part, 100 parts of sublimate, the wherein concentration of tetrasodium salt of EDTA are 7%-8%mg/ml.
8. the medical drainage tube of Internal Medicine-Oncology according to claim 1-7, it is characterised in that the hydroxypropylation fiber
The mass ratio of each composition is 1 in the blend of element, polyvinyl alcohol and phosphorylated starch:1:2.
9. the medical drainage tube of Internal Medicine-Oncology according to claim 1-8, it is characterised in that the push rod（5）For
The drainage tube is completed after drainage, is inserted into the drainage tube main body（3）In, promote the tip body（1）Make itself and drainage
Pipe main body（3）Separate.
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| CN201710105324.5A CN106902440B (en) | 2017-02-26 | 2017-02-26 | A kind of medical drainage tube of Internal Medicine-Oncology |
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| CN201710105324.5A CN106902440B (en) | 2017-02-26 | 2017-02-26 | A kind of medical drainage tube of Internal Medicine-Oncology |
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| CN106902440B CN106902440B (en) | 2019-09-24 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108543198A (en) * | 2018-05-24 | 2018-09-18 | 自贡市第四人民医院(自贡市急救中心) | A kind of catheter anchoring system |
| CN116535969A (en) * | 2023-05-06 | 2023-08-04 | 广汽本田汽车有限公司 | Novel IPA pretreatment solvent and preparation method thereof |
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|---|---|
| CN106902440B (en) | 2019-09-24 |
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