CN106901864B - Vascular flow lashing wire - Google Patents
Vascular flow lashing wire Download PDFInfo
- Publication number
- CN106901864B CN106901864B CN201710120355.8A CN201710120355A CN106901864B CN 106901864 B CN106901864 B CN 106901864B CN 201710120355 A CN201710120355 A CN 201710120355A CN 106901864 B CN106901864 B CN 106901864B
- Authority
- CN
- China
- Prior art keywords
- constraint
- sections
- lashing wire
- vascular flow
- main section
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002792 vascular Effects 0.000 title claims abstract description 47
- 239000008280 blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- -1 polypropylene Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 12
- 238000010171 animal model Methods 0.000 abstract description 6
- 238000011017 operating method Methods 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 210000004204 blood vessel Anatomy 0.000 description 10
- 210000000709 aorta Anatomy 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 210000001367 artery Anatomy 0.000 description 5
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 3
- 230000006378 damage Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 1
- 206010069803 Injury associated with device Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 210000000702 aorta abdominal Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Prostheses (AREA)
Abstract
The present invention provides the application methods of a kind of vascular flow lashing wire and vascular flow lashing wire, belong to medicine technology field.And precision inconvenient for operation to fine vascular is low during it solves the problems, such as existing zoopery.This vascular flow lashing wire is an integral structure, vascular flow lashing wire includes constraint main section and two sections of anchor line (string) sections, one end of two sections of anchor line (string) sections is connected with one end of constraint main section or one end of two sections of anchor line (string) sections corresponds system with the both ends of constraint main section respectively and is connected；The raised node of one end connecting place of anchor line (string) section and constraint main section, the other end for fettering main section is at least provided with a constraint hole.This vascular flow lashing wire and using this vascular flow lashing wire carry out aortic coaractation operating method have it is easy to operate, experimental error is small, and experimental result is accurate, and the experimental animal death rate is low, the advantage that operator's labor intensity is low and operating effect is high.
Description
Technical field
The invention belongs to medicine technology fields, are related to a kind of vascular flow control, especially a kind of vascular flow lashing wire.
Background technique
Zoopery refers in laboratory, in order to obtain the new knowledge in relation to biology, medicine etc. or solve tool
Body problem and use animal carry out scientific research.In the research of human myocardium's plumpness, exact related mechanism is not yet complete
It illustrates, therefore zoopery can be to provide fundamental basis for it.
There are Pressure Overload-induced method, capacity negative the method that experimental animal (rat, mouse) carries out myocardial hypertrophy model foundation
If Ganlei such as lotus method, heart infarction method and hormone induction methods.Wherein belong to the aortic coaractation method of Pressure Overload-induced method because of animal dead
The features such as rate is low, model success rate is high, favorable repeatability and experimental animal myocardial hypertrophy formation time are short, and obtain extensive
With.The mode of operation of aortic coaractation method is to find free target arterial section under 10~16 powered microscope fields first,
Horizontal one No. 5 or No. 6 silk threads under it, while one section of syringe needle and aorta being taken to be placed on silk thread parallel, silk thread is knotted
Bind artery and syringe needle；Target arterial section is usually one section of aorta pectoralis or abdominal aorta, and needle diameter is dynamic according to target
The diameter of arteries and veins is selected, but needle diameter should be less than the diameter of target arterial.Then, syringe needle is withdrawn, it is dynamic to leave knot binding
Arteries and veins.Since the cross section of artery at knot reduces than before, improve the resistance of blood flow of knot or more, cardiac load increases, into
And gradually form myocardial hypertrophy.
Aortic coaractation method has the following problems in actual operation: 1, the optional syringe needle in the section 0.3~0.5mm of φ compared with
It is few, thus it is unable to satisfy all operational requirements.2, the aorta diameter of mouse (by taking 25 g male C57/B6J mouse as an example) is usual
It in 0.8~1.0mm, is broken when intercepting syringe needle usually using vessel forceps, because syringe needle is hollow pipe, external force can during clamp
Causing it, deformation occurs and changes its diameter, and subtle operating error will affect experimental result with mouse.3, after syringe needle is broken
The usual out-of-flatness of the broken ends of fractured bone, easily band burr, when withdrawing syringe needle, easy damaged local organization and blood vessel.4, silk thread is admired used in knotting
For multi cord, its length meeting slight change under different stress conditions, and then influence experimental result；Have in multi cord more residual
It interspaces, increases experimental animal infection probability.5, admire the meticulous dissection that will increase to artery of silk thread, damage blood vessel；Admire silk
Line will slightly will affect blood vessel control precision excessively, and then influence experimental result；Excessive knot can also have an impact to blood vessel.6, it ties up
When syringe needle, since syringe needle is not auxiliarily fixed, often there is syringe needle sliding or break-off, need repetitive operation, take time and effort.
Summary of the invention
The invention proposes a kind of vascular flow lashing wire, the technical problems to be solved in the utility model is in medical domain
How vascular flow control operation convenience and accuracy are improved, especially to the operation of fine vascular during zoopery.
Technical problems to be solved of the invention can be realized by the following technical scheme: a kind of vascular flow lashing wire is
Integral structure, vascular flow lashing wire include constraint main section and two sections of anchor line (string) sections, one end of two sections of anchor line (string) sections with constraint
One end of main section is connected or one end of two sections of anchor line (string) sections corresponds system with the both ends of constraint main section respectively and is connected；
The raised node of one end connecting place of anchor line (string) section and constraint main section, the other end for fettering main section is at least provided with one
Fetter hole.
Aortic coaractation operating method is carried out using this vascular flow lashing wire are as follows: first by this vascular flow lashing wire packet
It is wound in target blood；Then, one section of anchor line (string) section is passed through into constraint hole, pulling two sections of anchor line (string) sections makes node be partially submerged into constraint hole
It is interior, and then constraint main section is made to form the constraint circle for being trapped among in target blood and determining perimeter；Finally two sections of anchor line (string) sections are intersected
It tenses and knots, realize locking, keep the perimeter of constraint circle, that is, constraint circle is avoided to expand and lead to flow failure of adjustment.This blood vessel
The constraint main line segment length of flow lashing wire determines according to desired control flow, i.e., length is just between determining constraint hole and node
The constraint circle for determining perimeter can be formed；And then it is used for accuracy controlling vascular flow.
Compared with prior art, aortic coaractation operation is carried out using this vascular flow lashing wire, does not depend on the bundle such as syringe needle
Object is tied up, and then avoids syringe needle landing or break-off, needle diameter is avoided and changes the problem for causing experimental result impacted,
Avoid syringe needle injury experiment animal local organization and blood vessel；Avoiding leads to part aorta because of the limitation of needle diameter size
The problem of constriction operation can not carry out.
The constraint circle length that this vascular flow lashing wire is formed is accurate, is not influenced by stress condition, guarantees flow control essence
Accuracy and consistency are spent, and then improves experimental result accuracy.This vascular flow lashing wire is an integral structure, inside
Tight, and then significantly reduce experimental animal infection risk.
The constraint main section of this vascular flow lashing wire can make that straticulation is flat, guarantee constraint main section and blood vessel
Contact area not only ensure that constraint precision, but also reduce vascular flow lashing wire to the cutting damage of blood vessel.
In short, this vascular flow lashing wire and utilize this vascular flow lashing wire carry out aortic coaractation operating method tool
There is experimental error small, experimental result is accurate, and the experimental animal death rate is low, and operator's labor intensity is low and operating effect is high
Advantage.
Detailed description of the invention
Fig. 1 is the front view structure enlarged diagram of one medium vessels flow lashing wire of embodiment.
Fig. 2 is the enlarged structure schematic diagram that one medium vessels flow lashing wire of embodiment is mounted on mouse aorta.
Fig. 3 is the front view structure enlarged diagram of two medium vessels flow lashing wire of embodiment.
Fig. 4 is the front view structure enlarged diagram of three medium vessels flow lashing wire of embodiment.
Fig. 5 is the front view structure enlarged diagram of example IV medium vessels flow lashing wire.
Fig. 6 is the front view structure enlarged diagram of five medium vessels flow lashing wire of embodiment.
In figure, 1, anchor line (string) section；2, main section is fettered；3, hole is fettered；4, node；5, constraint circle；6, target blood；7, anti-skidding
Salient point.
Specific embodiment
Following is a specific embodiment of the present invention in conjunction with the accompanying drawings, technical scheme of the present invention will be further described,
However, the present invention is not limited to these examples.
Embodiment one
As shown in Figure 1, this vascular flow lashing wire is an integral structure, vascular flow lashing wire uses polypropylene material system
At.Vascular flow lashing wire includes two sections of anchor line (string) sections 1 and one section of constraint main section 2.It is flat in thin layer to tie up main section 2, anchor line (string)
The circular in cross-section of section 1.
One end of two sections of anchor line (string) sections 1 is connected with one end of constraint main section 2 and the raised node 4 of connecting place,
Node 4 is hemispherical.The other end of constraint main section 2 is provided with a constraint hole 3；The diameter for fettering hole 3 is less than the ball of node 4
The diameter of diameter, constraint hole 3 is greater than the diameter of anchor line (string) section 1.
This vascular flow lashing wire is applied in the aortic coaractation method of mouse；Caliber after the target blood 6 of mouse fetters
For 0.5mm, the vascular flow lashing wire that length is 1.57mm between constraint hole 3 and node 4 is selected；Beam in vascular flow lashing wire
The width for tiing up main section 2 is 0.3mm, i.e. the width of constraint main section 2 is the 0.25~0.5 of 6 caliber of target blood.Fetter main line
Section 2 with a thickness of 0.05mm.
As depicted in figs. 1 and 2, mouse aorta constriction operating method is carried out using this vascular flow lashing wire by illustrating
The advantages of further illustrating this vascular flow lashing wire: firstly, the constraint main section 2 of this vascular flow lashing wire is surrounded mesh
It marks on blood vessel 6.Then, one section of anchor line (string) section 1 is passed through into constraint hole 3, pulling two sections of anchor line (string) sections 1 makes node 4 be partially submerged into constraint hole 3
It is interior, so that constraint main section 2 is formed the constraint circle 5 for being trapped among in target blood 6 and determining perimeter；It is above-mentioned by guaranteeing when operation every time
State can guarantee that the length of constraint circle 5 is consistent.Two sections of anchor line (string) sections 1 are finally intersected tension to knot, realization locking, in holding
State the perimeter of constraint circle 5.Node 4, which is partially submerged into also to have in constraint hole 3, improves contact surface product, reduces constraint hole 3 and deforms
Rate, and then improve the precision of constraint 5 perimeters of circle.
Embodiment two
The present embodiment is essentially identical with the structure and principle of embodiment one, and the no longer burden description of essentially identical place is only retouched
Different place is stated, the difference is that: as shown in figure 3, the other end of constraint main section 2 is provided with multiple constraint holes
3；Multiple constraint holes 3 are along the longitudinal arrangement for fettering main section 2；The quantity that Figure of description provides constraint hole 3 is 3.It selects
Length vascular flow lashing wire identical with 6 perimeter of target blood of mouse between one of constraint hole 3 and node 4；It utilizes
One section of anchor line (string) section 1 is passed through into corresponding constraint hole 3 when this vascular flow lashing wire carries out the operation of mouse aorta constriction.
Embodiment three
The present embodiment is essentially identical with the structure and principle of embodiment one, and the no longer burden description of essentially identical place is only retouched
State different place, the difference is that: as shown in figure 4, one end of two sections of anchor line (string) sections 1 respectively with constraint main section 2
Both ends correspond system be connected；The raised node 4 of one end connecting place of anchor line (string) section 1 and constraint main section 2.
Example IV
The present embodiment is essentially identical with the structure and principle of embodiment three, and the no longer burden description of essentially identical place is only retouched
Different place is stated, the difference is that: as shown in figure 5, in the anchor line (string) section 1 being connected with one end of constraint main section 2
There is anti-skidding salient point 7 at node 4, anti-skidding salient point 7 can be forced to cross constraint hole 3 by pulling anchor line (string) section 1, can avoid in this way
The back skating under the effect of blood vessel elastic force of anchor line (string) section 1, and then influence the precision of constraint 5 perimeters of circle.This structure also have make fetter 3 liang of hole
The anchor line (string) section 1 of side be tied more convenient operation the advantages of.
Embodiment five
The present embodiment is essentially identical with the structure and principle of embodiment one, and the no longer burden description of essentially identical place is only retouched
Different place is stated, the difference is that: as shown in fig. 6, the constraint formation from beginning to end of main section 2 fetters hole 3, constraint
The middle part of main section 2, which is folded with, is arranged in parallel both ends.The width of constraint main section 2 is in this vascular flow lashing wire
0.2mm, this vascular flow lashing wire are especially suitable for applying in the aortic coaractation operation of rat.
Claims (5)
1. a kind of vascular flow lashing wire, which is characterized in that this vascular flow lashing wire is an integral structure, this vascular flow beam
Thread includes constraint main section (2) and two sections of anchor line (string) sections (1), and constraint main section (2) is that thin layer is flat；Two sections of anchor line (string) sections (1)
One end be connected with one end of constraint main section (2), one end connecting place of two sections of anchor line (string) sections (1) and constraint main section (2)
With a raised node (4), the other end for fettering main section (2) is at least provided with a constraint hole (3)；In use, one
For section anchor line (string) section (1) across hole (3) are fettered, node (4), which is partially submerged into constraint hole (3), makes to fetter main section (2) formation determining week
Long constraint circle (5), and two sections of anchor line (string) sections (1) are intersected to tense and are knotted.
2. vascular flow lashing wire according to claim 1, which is characterized in that this vascular flow lashing wire uses polypropylene
Material is made.
3. vascular flow lashing wire according to claim 1, which is characterized in that it is described constraint main section (2) width be
The 0.25~0.5 of free target blood (6) caliber.
4. vascular flow lashing wire according to claim 1 or 2 or 3, which is characterized in that the node (4) is hemispherical,
The diameter for fettering hole (3) is less than the sphere diameter of node (4)；The diameter for fettering hole (3) is greater than the diameter of anchor line (string) section (1).
5. vascular flow lashing wire according to claim 1 or 2 or 3, which is characterized in that constraint main section (2)
The other end is provided with multiple constraint holes (3), and multiple constraints hole (3) are arranged along the longitudinal arrangement of constraint main section (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120355.8A CN106901864B (en) | 2017-03-02 | 2017-03-02 | Vascular flow lashing wire |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120355.8A CN106901864B (en) | 2017-03-02 | 2017-03-02 | Vascular flow lashing wire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106901864A CN106901864A (en) | 2017-06-30 |
| CN106901864B true CN106901864B (en) | 2018-12-07 |
Family
ID=59187309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710120355.8A Active CN106901864B (en) | 2017-03-02 | 2017-03-02 | Vascular flow lashing wire |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106901864B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200977177Y (en) * | 2006-12-01 | 2007-11-21 | 天津怡美医疗器械有限公司 | Blood vessel compression styptic closure device |
| CN103815944A (en) * | 2014-03-03 | 2014-05-28 | 北京大学人民医院 | Blood vessel flow restriction band |
| CN104507399A (en) * | 2012-07-06 | 2015-04-08 | 可吸收设备公司 | Device and method for tissue ligation |
| CN106175871A (en) * | 2016-08-01 | 2016-12-07 | 张洪宇 | Blood vessel blocking band |
-
2017
- 2017-03-02 CN CN201710120355.8A patent/CN106901864B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200977177Y (en) * | 2006-12-01 | 2007-11-21 | 天津怡美医疗器械有限公司 | Blood vessel compression styptic closure device |
| CN104507399A (en) * | 2012-07-06 | 2015-04-08 | 可吸收设备公司 | Device and method for tissue ligation |
| CN103815944A (en) * | 2014-03-03 | 2014-05-28 | 北京大学人民医院 | Blood vessel flow restriction band |
| CN106175871A (en) * | 2016-08-01 | 2016-12-07 | 张洪宇 | Blood vessel blocking band |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106901864A (en) | 2017-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6410980B2 (en) | A suture that does not require a knot work and a kit including the suture | |
| CN204133530U (en) | Occluder for left auricle | |
| CN109820588A (en) | A kind of rib bone connection apparatus system of thoracoscope | |
| US7699857B2 (en) | Hydrodynamic suture passer | |
| CN106901864B (en) | Vascular flow lashing wire | |
| CN204318820U (en) | Nook closing member is the great saphenous vein bushing type syringe needle of arteria coronaria probe | |
| CN207590785U (en) | Vascular flow lashing wire | |
| CN208769867U (en) | Down-lead device is used in a kind of suture of wound | |
| CN206342564U (en) | A kind of aorta tectorial membrane stent system of controllable support portions release order | |
| CN205795748U (en) | Knotting line group is sewed up under the mirror of chamber | |
| CN105433990B (en) | A kind of human pathology or doctor's source chamber road locking device | |
| CN102440812B (en) | Deep knotting forceps | |
| CN208958193U (en) | A kind of guide with two-way hangnail fish-bone line | |
| CN204797932U (en) | Vein blood vessel ligator | |
| CN209421997U (en) | A kind of myocardial infarction merges the defect occlusion catheter of perforation of ventricular septum | |
| CN208551900U (en) | A kind of blood vessel anastomat | |
| CN209827078U (en) | Knotting-free skin suture for animals | |
| CN202235513U (en) | Deep knotting forceps | |
| CN105769270B (en) | A kind of micro-vascular surgery tractor | |
| CN207253352U (en) | Blood vessel snare pin | |
| CN205758755U (en) | Animal hearts instantaneous set device | |
| CN206548555U (en) | A kind of anchor tail suture | |
| CN207400822U (en) | Retain the vascular ligation pin of blood flow | |
| CN208598466U (en) | A kind of novel mouse aorta line bundle device | |
| CN204698631U (en) | Novel semi-loop open wound ligation stitching knotter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |