CN106901864A - The application method of vascular flow lashing wire and vascular flow lashing wire - Google Patents
The application method of vascular flow lashing wire and vascular flow lashing wire Download PDFInfo
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- CN106901864A CN106901864A CN201710120355.8A CN201710120355A CN106901864A CN 106901864 A CN106901864 A CN 106901864A CN 201710120355 A CN201710120355 A CN 201710120355A CN 106901864 A CN106901864 A CN 106901864A
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Abstract
The invention provides a kind of vascular flow lashing wire and the application method of vascular flow lashing wire, belong to medicine technology field.It is solved the problems, such as during existing zoopery to fine vascular inconvenient operation and precision is low.This vascular flow lashing wire is integral type structure, vascular flow lashing wire includes constraint main section and two sections of anchor line (string) sections, two sections of one end of anchor line (string) section are connected with the one end for fettering main section, or two sections of one end of anchor line (string) section correspond system and are connected with the two ends of constraint main section respectively；Anchor line (string) section has raised node with one end connecting place of constraint main section, and the other end for fettering main section is at least provided with a constraint hole.This vascular flow lashing wire and carry out aortic coaractation operating method using this vascular flow lashing wire and have easy to operate, experimental error is small, and experimental result is accurate, and the experimental animal death rate is low, the advantage that operator's labour intensity is low and operating effect is high.
Description
Technical field
The invention belongs to medicine technology field, it is related to a kind of vascular flow to control, particularly a kind of vascular flow lashing wire.
The invention belongs to medicine technology field, it is related to a kind of vascular flow to control, particularly a kind of vascular flow lashing wire
Application method.
Background technology
Zoopery refers in laboratory, in order to obtain new knowledge or solution tool about aspects such as biology, medical science
Body problem and the scientific research that is carried out using animal.In the plump research of human myocardium, definite related mechanism is not yet complete
Illustrate, therefore zoopery can think that it is provided fundamental basis.
There are Pressure Overload-induced method, capacity to bear to the method that experimental animal (rat, mouse) carries out myocardial hypertrophy model foundation
If Ganlei such as lotus method, heart infarction method and hormone induction methods.Wherein belong to the aortic coaractation method of Pressure Overload-induced method because of animal dead
Rate is low, model success rate high, favorable repeatability and experimental animal myocardial hypertrophy formed the time it is short the features such as, and obtain extensive
With.The mode of operation of aortic coaractation method is to find free target arterial section under 10~16 powered microscope fields first,
Horizontal one No. 5 or No. 6 silk threads under it, while take one section of syringe needle being positioned on silk thread parallel with sustainer, silk thread are knotted
Artery is set to be bound with syringe needle；Target arterial section is usually a section of aorta pectoralis or abdominal aorta, and needle diameter is dynamic according to target
The diameter of arteries and veins is selected, but needle diameter should be less than the diameter of target arterial.Then, syringe needle is withdrawn, knot binding is left dynamic
Arteries and veins.Because the cross section of artery at knot relatively reduces before, improve resistance of blood flow more than knot, cardiac load increases, and enters
And gradually form myocardial hypertrophy.
There is problems with practical operation in aortic coaractation method：1st, the interval optional syringe needles of 0.3~0.5mm of φ compared with
It is few, thus all operational requirements cannot be met.2nd, the aorta diameter of mouse (by taking 25g male C57/B6J mouse as an example) is usual
In 0.8~1.0mm, broken usually using vessel forceps when syringe needle is intercepted, because syringe needle is hollow pipe, external force can during clamp
Cause it to deform upon and change its diameter, trickle operating error can influence experimental result with mouse.3rd, after syringe needle is broken
The usual out-of-flatness of the broken ends of fractured bone, easily band burr, when syringe needle is withdrawn, easy damaged local organization and blood vessel.4th, silk thread is admired used by knotting
It is multi cord, its length meeting slight change under different stressing conditions, and then influence experimental result；Have more residual in multi cord
Interspace, increase experimental animal infection probability.5th, the meticulous dissection that can increase to artery of silk thread, injured blood vessel are admired；Admire silk
Line will slightly influence blood vessel control accuracy excessively, and then influence experimental result；Excessive knot can also have an impact to blood vessel.6th, tie up
During syringe needle, do not aid in fixing due to syringe needle, syringe needle often occur and slide or break-off, need to repeat, take time and effort.
The content of the invention
The present invention proposes a kind of vascular flow lashing wire and a kind of application method of vascular flow lashing wire, and the present invention will
The technical problem of solution is how to improve vascular flow control operation convenience and accuracy in medical domain, especially in animal reality
To the operation of fine vascular during testing.
The technical problem to be solved of the invention can be realized by following technical proposal：A kind of vascular flow lashing wire is
Integral structure, vascular flow lashing wire includes constraint main section and two sections of anchor line (string)s section, two sections of one end of anchor line (string) section with constraint
One end of main section is connected, or two sections of one end of anchor line (string) section correspond system and are connected with the two ends of constraint main section respectively；
Anchor line (string) section has raised node with one end connecting place of constraint main section, and the other end for fettering main section is at least provided with one
Constraint hole.
Carrying out aortic coaractation operating method using this vascular flow lashing wire is：First by this vascular flow lashing wire bag
It is wound in target blood；Then, by one section of anchor line (string) section through constraint hole, pulling two sections of anchor line (string) sections makes node be partially submerged into constraint hole
It is interior, and then constraint main section is formed the constraint circle for being trapped among in target blood and determining girth；Finally two sections of anchor line (string) sections are intersected
Tense and knot, realize locking, keep the girth of constraint circle, that is, avoid constraint circle from expanding and cause Flow-rate adjustment to fail.This blood vessel
The constraint main line segment length of flow lashing wire determines that length is just between the constraint hole for determining and node according to desired control flow
The constraint circle for determining girth can be formed；And then for accuracy controlling vascular flow.
Compared with prior art, aortic coaractation operation is carried out using this vascular flow lashing wire, is independent of the bundle such as syringe needle
Tie up thing, and then avoid syringe needle and slide or break-off, it is to avoid needle diameter change causes the impacted problem of experimental result,
Avoid syringe needle injury experiment animal local organization and blood vessel；Avoid causes part sustainer because needle diameter size is limited
The problem that constriction operation cannot be carried out.
The constraint circle length that this vascular flow lashing wire is formed is accurate, is not influenceed by stressing conditions, it is ensured that flow control essence
Degree accuracy and uniformity, and then improve experimental result accuracy.This vascular flow lashing wire is integral type structure, inside it
Tight, and then significantly reduce experimental animal infection risk.
The constraint main section of this vascular flow lashing wire can make straticulation flat, it is ensured that constraint main section and blood vessel
Contact area, both ensure that constraint precision, and cutting damage of the vascular flow lashing wire to blood vessel is reduced again.
In a word, this vascular flow lashing wire and aortic coaractation operating method tool is carried out using this vascular flow lashing wire
There is experimental error small, experimental result is accurate, and the experimental animal death rate is low, and operator's labour intensity is low and operating effect is high
Advantage.
Brief description of the drawings
Fig. 1 is the front view structure enlarged diagram of the medium vessels flow lashing wire of embodiment one.
Fig. 2 is the mplifying structure schematic diagram that the medium vessels flow lashing wire of embodiment one is arranged on mouse aorta.
Fig. 3 is the front view structure enlarged diagram of the medium vessels flow lashing wire of embodiment two.
Fig. 4 is the front view structure enlarged diagram of the medium vessels flow lashing wire of embodiment three.
Fig. 5 is the front view structure enlarged diagram of example IV medium vessels flow lashing wire.
Fig. 6 is the front view structure enlarged diagram of the medium vessels flow lashing wire of embodiment five.
In figure, 1, anchor line (string) section；2nd, main section is fettered；3rd, hole is fettered；4th, node；5th, constraint circle；6th, target blood；7th, it is anti-skidding
Salient point.
Specific embodiment
The following is specific embodiment of the invention and with reference to accompanying drawing, technical scheme is further described,
But the present invention is not limited to these embodiments.
Embodiment one
As shown in figure 1, this vascular flow lashing wire is integral type structure, vascular flow lashing wire uses polypropylene material system
Into.Vascular flow lashing wire includes two sections of anchor line (string) sections 1 and one section of constraint main section 2.Main section 2 is tied up in thin layer flat, anchor line (string)
The circular in cross-section of section 1.
Two sections of one end of anchor line (string) section 1 are connected with one end of constraint main section 2 and connecting place has raised node 4,
Node 4 is in hemispherical.The other end for fettering main section 2 is provided with a constraint hole 3；Fetter the ball of the diameter less than node 4 in hole 3
Footpath, the diameter with diameter greater than anchor line (string) section 1 in constraint hole 3.
This vascular flow lashing wire is applied in the aortic coaractation method of mouse；Caliber after the constraint of target blood 6 of mouse
It is 0.5mm, is the vascular flow lashing wire of 1.57mm from length between constraint hole 3 and node 4；Beam in vascular flow lashing wire
The width of main section 2 is tied up for 0.3mm, that is, it is the 0.25~0.5 of the caliber of target blood 6 to fetter the width of main section 2.Constraint main line
The thickness of section 2 is 0.05mm.
As depicted in figs. 1 and 2, carry out mouse aorta constriction operating method using this vascular flow lashing wire by illustrating
Further illustrate the advantage of this vascular flow lashing wire：First, the constraint main section 2 of this vascular flow lashing wire is surrounded into mesh
On mark blood vessel 6.Then, by one section of anchor line (string) section 1 through constraint hole 3, pulling two sections of anchor line (string) sections 1 makes node 4 be partially submerged into constraint hole 3
It is interior, constraint main section 2 is formed the constraint circle 5 for being trapped among in target blood 6 and determining girth；It is above-mentioned by ensureing during operation every time
State, just can ensure that the length of constraint circle 5 is consistent.Finally two sections of anchor line (string) sections 1 are intersected to tense and knotted, locking is realized, in holding
State the girth of constraint circle 5.Node 4 is partially submerged into also to have in constraint hole 3 and improves connection contact area, reduces constraint hole 3 and deforms
Rate, and then improve the precision of constraint 5 girths of circle.
Embodiment two
The present embodiment is essentially identical with the structure and principle of embodiment one, the no longer burden description of essentially identical part, only retouches
Different place is stated, different place is：As shown in figure 3, the other end of constraint main section 2 is provided with multiple constraint holes
3；Multiple constraint hole 3 is along the longitudinal arrangement for fettering main section 2；The quantity that Figure of description provides constraint hole 3 is 3.From
The girth identical vascular flow lashing wire of target blood 6 of length and mouse between one of constraint hole 3 and node 4；Utilize
This vascular flow lashing wire is carried out one section of anchor line (string) section 1 through correspondence constraint hole 3 when mouse aorta constriction is operated.
Embodiment three
The present embodiment is essentially identical with the structure and principle of embodiment one, the no longer burden description of essentially identical part, only retouches
Different place is stated, different place is：As shown in figure 4, one end of two sections of anchor line (string)s section 1 respectively with constraint main section 2
Two ends correspond system be connected；Anchor line (string) section 1 has raised node 4 with one end connecting place of constraint main section 2.
Example IV
The present embodiment is essentially identical with the structure and principle of embodiment three, the no longer burden description of essentially identical part, only retouches
Different place is stated, different place is：As shown in figure 5, in the anchor line (string) section 1 being connected with one end of constraint main section 2
There is anti-skidding salient point 7 at node 4, by pulling anchor line (string) section 1 anti-skidding salient point 7 can be forced to cross constraint hole 3, can so avoid
The back skating under the effect of blood vessel elastic force of anchor line (string) section 1, and then influence the precision of constraint 5 girths of circle.This structure also has makes 3 liang of constraint hole
The advantage that the anchor line (string) section 1 of side is tied more convenient operation.
Embodiment five
The present embodiment is essentially identical with the structure and principle of embodiment one, the no longer burden description of essentially identical part, only retouches
Different place is stated, different place is：As shown in fig. 6, constraint main section 2 is from beginning to end to form constraint hole 3, constraint
The middle part of main section 2 is folded with makes both ends be arranged in parallel.The width of constraint main section 2 is in this vascular flow lashing wire
0.2mm, this vascular flow lashing wire is especially suitable for applying in the aortic coaractation operation of rat.
Claims (9)
1. a kind of vascular flow lashing wire, it is characterised in that this vascular flow lashing wire is integral type structure, this vascular flow beam
Thread includes constraint main section (2) and two sections of anchor line (string)s section (1), two sections of one end of anchor line (string) section (1) with fetter the one of main section (2)
End is connected, or two sections of one end of anchor line (string) section (1) correspond system and are connected with the two ends of constraint main section (2) respectively；Anchor line (string)
Section (1) has raised node (4) with one end connecting place of constraint main section (2), and the other end of constraint main section (2) is at least
It is provided with constraint hole (3).
2. vascular flow control line according to claim 1, it is characterised in that this vascular flow lashing wire uses polypropylene
Material is made.
3. vascular flow control line according to claim 1, it is characterised in that the constraint main section (2) is flat in thin layer
It is flat-shaped.
4. vascular flow control line according to claim 1, it is characterised in that the width of the constraint main section (2) is
The 0.25~0.5 of free target blood (6) caliber.
5. vascular flow control line as claimed in any of claims 1 to 4, it is characterised in that the node (4) is in
It is hemispherical, fetter the sphere diameter of the diameter less than node (4) of hole (3)；The diameter with diameter greater than anchor line (string) section (1) of constraint hole (3).
6. vascular flow control line as claimed in any of claims 1 to 4, it is characterised in that the constraint main line
The other end of section (2) is provided with multiple constraints hole (3), and multiple constraint hole (3) sets along the longitudinal arrangement of constraint main section (2)
Put.
7. vascular flow control line as claimed in any of claims 1 to 4, it is characterised in that when two sections of systems
When one end of line segment (1) is connected with the two ends one-to-one corresponding system of constraint main section (2) respectively, with constraint main section (2) one
There is the anti-skidding salient point (7) that can force to cross constraint hole (3) near node (4) place on connected anchor line (string) section (1) in end.
8. vascular flow control line according to claim 1, it is characterised in that the constraint main section (2) is from beginning to end
Form constraint hole (3).
9. in a kind of claim 1 to 8 vascular flow control line described in any one application method, it is characterised in that this blood
The application method of pipe flow control line is carried out according to the following steps：First, by one section of anchor line (string) section (1) through constraint hole (3)；Then,
Pulling two sections of anchor line (string)s section (1) makes node (4) be partially submerged into constraint hole (3) beam for making constraint main section (2) formation determine girth
Tie up circle (5)；Finally, two sections of anchor line (string)s section (1) are intersected to tense and knots, realize locking, keep the girth of above-mentioned constraint circle (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120355.8A CN106901864B (en) | 2017-03-02 | 2017-03-02 | Vascular flow lashing wire |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710120355.8A CN106901864B (en) | 2017-03-02 | 2017-03-02 | Vascular flow lashing wire |
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| Publication Number | Publication Date |
|---|---|
| CN106901864A true CN106901864A (en) | 2017-06-30 |
| CN106901864B CN106901864B (en) | 2018-12-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710120355.8A Active CN106901864B (en) | 2017-03-02 | 2017-03-02 | Vascular flow lashing wire |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200977177Y (en) * | 2006-12-01 | 2007-11-21 | 天津怡美医疗器械有限公司 | Blood vessel compression styptic closure device |
| CN103815944A (en) * | 2014-03-03 | 2014-05-28 | 北京大学人民医院 | Blood vessel flow restriction band |
| CN104507399A (en) * | 2012-07-06 | 2015-04-08 | 可吸收设备公司 | Device and method for tissue ligation |
| CN106175871A (en) * | 2016-08-01 | 2016-12-07 | 张洪宇 | Blood vessel blocking band |
-
2017
- 2017-03-02 CN CN201710120355.8A patent/CN106901864B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200977177Y (en) * | 2006-12-01 | 2007-11-21 | 天津怡美医疗器械有限公司 | Blood vessel compression styptic closure device |
| CN104507399A (en) * | 2012-07-06 | 2015-04-08 | 可吸收设备公司 | Device and method for tissue ligation |
| CN103815944A (en) * | 2014-03-03 | 2014-05-28 | 北京大学人民医院 | Blood vessel flow restriction band |
| CN106175871A (en) * | 2016-08-01 | 2016-12-07 | 张洪宇 | Blood vessel blocking band |
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| Publication number | Publication date |
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| CN106901864B (en) | 2018-12-07 |
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