CN106896062B - 生物样品用的光学测量装置中的校准和/或检错 - Google Patents
生物样品用的光学测量装置中的校准和/或检错 Download PDFInfo
- Publication number
- CN106896062B CN106896062B CN201611157483.1A CN201611157483A CN106896062B CN 106896062 B CN106896062 B CN 106896062B CN 201611157483 A CN201611157483 A CN 201611157483A CN 106896062 B CN106896062 B CN 106896062B
- Authority
- CN
- China
- Prior art keywords
- measurement
- measurement channel
- reference factor
- detection signal
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000005259 measurement Methods 0.000 title claims abstract description 732
- 230000003287 optical effect Effects 0.000 title claims abstract description 224
- 238000001514 detection method Methods 0.000 title claims abstract description 180
- 239000012472 biological sample Substances 0.000 title claims abstract description 130
- 238000000034 method Methods 0.000 claims abstract description 194
- 230000008569 process Effects 0.000 claims description 78
- 239000000523 sample Substances 0.000 description 23
- 230000003068 static effect Effects 0.000 description 17
- 230000008859 change Effects 0.000 description 15
- 239000003153 chemical reaction reagent Substances 0.000 description 13
- 238000012545 processing Methods 0.000 description 13
- 239000013307 optical fiber Substances 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 230000005540 biological transmission Effects 0.000 description 11
- 238000004458 analytical method Methods 0.000 description 8
- 238000012937 correction Methods 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000002950 deficient Effects 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 239000012491 analyte Substances 0.000 description 4
- 238000005345 coagulation Methods 0.000 description 4
- 230000015271 coagulation Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 210000003567 ascitic fluid Anatomy 0.000 description 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 210000004243 sweat Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 206010003445 Ascites Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 210000004381 amniotic fluid Anatomy 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000003705 background correction Methods 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012883 sequential measurement Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
- G01N21/274—Calibration, base line adjustment, drift correction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
- G01N21/474—Details of optical heads therefor, e.g. using optical fibres
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Engineering & Computer Science (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Quality & Reliability (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15200769.6A EP3182096B1 (en) | 2015-12-17 | 2015-12-17 | Calibration and/or error detection in an optical measurement device for biological samples |
| EP15200769.6 | 2015-12-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106896062A CN106896062A (zh) | 2017-06-27 |
| CN106896062B true CN106896062B (zh) | 2020-11-06 |
Family
ID=54979437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611157483.1A Active CN106896062B (zh) | 2015-12-17 | 2016-12-15 | 生物样品用的光学测量装置中的校准和/或检错 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11353471B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3182096B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6799454B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106896062B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2778677T3 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES3038129T3 (en) | 2015-06-26 | 2025-10-09 | Abbott Lab | Rotating device in a diagnostic analyzer |
| CN109477789B (zh) * | 2016-07-21 | 2021-10-22 | 西门子医疗保健诊断公司 | 使用比色皿之间的参考测量来消除源灯强度漂移效应 |
| EP3290905B1 (en) * | 2016-09-05 | 2022-10-19 | F. Hoffmann-La Roche AG | Signal offset determination and correction |
| CN111065914A (zh) * | 2017-09-01 | 2020-04-24 | 优志旺电机株式会社 | 酶标仪 |
| CA3089690A1 (en) * | 2018-01-30 | 2019-08-08 | Grainsense Oy | A method for calibrating an integrating cavity |
| US12097491B2 (en) | 2018-04-23 | 2024-09-24 | Meon Medical Solutions Gmbh & Co Kg | Automatic analyzer and optical measurement method for obtaining measurement signals from liquid media |
| EP3784400A1 (de) * | 2018-04-23 | 2021-03-03 | Meon Medical Solutions GmbH & Co. KG | Optische messeinheit und optisches messverfahren zur gewinnung von messsignalen von flüssigen medien |
| EP3614128B1 (en) * | 2018-08-22 | 2023-04-26 | F. Hoffmann-La Roche AG | A method to correct signal light intensities measured by a detector of a detection unit in a laboratory instrument |
| WO2020146727A1 (en) | 2019-01-10 | 2020-07-16 | Selim Olcum | Identifying cancer therapies |
| US11346755B2 (en) | 2019-01-10 | 2022-05-31 | Travera, Inc. | Calibration of a functional biomarker instrument |
| JP7276462B2 (ja) * | 2019-08-06 | 2023-05-18 | 株式会社島津製作所 | 生化学分析装置及び生化学分析方法 |
| KR102522278B1 (ko) * | 2021-10-29 | 2023-04-17 | 주식회사 신코 | 듀얼 어레이 센서를 이용한 고속 흡광도 측정 마이크로플레이트 리더기 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4591550A (en) | 1984-03-01 | 1986-05-27 | Molecular Devices Corporation | Device having photoresponsive electrode for determining analytes including ligands and antibodies |
| JPS62115348A (ja) * | 1985-09-30 | 1987-05-27 | モレキユラ− デバイスイズ コ−ポレイシヨン | 多ビ−ムによる光度測定装置および測定方法 |
| US7217574B2 (en) * | 2000-10-30 | 2007-05-15 | Sru Biosystems, Inc. | Method and apparatus for biosensor spectral shift detection |
| JP3838501B2 (ja) * | 2001-12-05 | 2006-10-25 | Kddi株式会社 | 光バースト信号ルーチング方式 |
| EP1566628B1 (en) * | 2002-08-28 | 2007-10-17 | FUJIFILM Corporation | Measuring apparatus |
| JP4483333B2 (ja) * | 2004-02-17 | 2010-06-16 | 株式会社島津製作所 | 光測定装置における測定方法及びチャンネル間偏差測定用標準器 |
| US7339668B2 (en) | 2005-10-18 | 2008-03-04 | Thermo Electron Scientific Instruments Llc | Spectrometer for analysis of multiple samples |
| CN200950139Y (zh) | 2006-07-19 | 2007-09-19 | 北京工业大学 | 用于生物pcr微通道荧光检测的标准芯片 |
| US7674616B2 (en) * | 2006-09-14 | 2010-03-09 | Hemosense, Inc. | Device and method for measuring properties of a sample |
| JP2009053029A (ja) | 2007-08-27 | 2009-03-12 | Olympus Corp | 自動分析装置 |
| US20110001963A1 (en) * | 2009-07-02 | 2011-01-06 | Durack Gary P | System and method for the measurement of multiple emissions from multiple parallel flow channels in a flow cytometry system |
| US9091637B2 (en) | 2009-12-04 | 2015-07-28 | Duke University | Smart fiber optic sensors systems and methods for quantitative optical spectroscopy |
| EP2630253B1 (en) * | 2010-10-20 | 2014-11-12 | Analogic Corporation | Method of calibrating and correcting color-bleed factors for color separation in dna analysis |
| US11035799B2 (en) | 2012-03-09 | 2021-06-15 | Siemens Healthcare Diagnostics Inc. | Calibration method for reagent card analyzers |
| GB2506375B (en) * | 2012-09-27 | 2017-10-18 | Epistem Ltd | Data processing and analysis systems |
| CN103528952B (zh) | 2013-10-25 | 2016-07-06 | 中国科学院合肥物质科学研究院 | 一种开放光路式气体分析仪通量校正测量装置及测量方法 |
| WO2015094303A1 (en) * | 2013-12-19 | 2015-06-25 | Halliburton Energy Services, Inc. | Cross-sensor standardization |
| CN104198382A (zh) | 2014-06-18 | 2014-12-10 | 上海理工大学 | 基于检测农药残留的双通道检测装置及方法 |
-
2015
- 2015-12-17 EP EP15200769.6A patent/EP3182096B1/en active Active
- 2015-12-17 ES ES15200769T patent/ES2778677T3/es active Active
-
2016
- 2016-12-13 US US15/376,704 patent/US11353471B2/en active Active
- 2016-12-15 CN CN201611157483.1A patent/CN106896062B/zh active Active
- 2016-12-15 JP JP2016242802A patent/JP6799454B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3182096A1 (en) | 2017-06-21 |
| JP2017111145A (ja) | 2017-06-22 |
| JP6799454B2 (ja) | 2020-12-16 |
| US20170176478A1 (en) | 2017-06-22 |
| EP3182096B1 (en) | 2020-01-15 |
| US11353471B2 (en) | 2022-06-07 |
| ES2778677T3 (es) | 2020-08-11 |
| CN106896062A (zh) | 2017-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106896062B (zh) | 生物样品用的光学测量装置中的校准和/或检错 | |
| EP3086123B1 (en) | Automatic analysis device | |
| US8313695B2 (en) | Automatic analyzer | |
| EP1887356B1 (en) | Automatic analyzer | |
| US10684298B2 (en) | Automated analyzer | |
| US9310388B2 (en) | Automatic analyzer and analysis method | |
| US11486886B2 (en) | Automatic analyzer and automatic analysis method | |
| CN114550826A (zh) | 一种实时荧光定量pcr的数据分析系统及其方法 | |
| US20220003685A1 (en) | Analyzer and analysis method | |
| WO2020121726A1 (ja) | 自動分析装置 | |
| US9746485B2 (en) | Automatic blood coagulation analysis device | |
| CN107796760B (zh) | 信号漂移确定与校正 | |
| US20080206100A1 (en) | Automatic analyzer | |
| US20240003923A1 (en) | Calibration and validation of cuvettes in automated chemical analyzers |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |