CN106890117A - A kind of bacterial plaque colour developing toothpaste blue containing food and preparation method thereof - Google Patents
A kind of bacterial plaque colour developing toothpaste blue containing food and preparation method thereof Download PDFInfo
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- CN106890117A CN106890117A CN201710169698.3A CN201710169698A CN106890117A CN 106890117 A CN106890117 A CN 106890117A CN 201710169698 A CN201710169698 A CN 201710169698A CN 106890117 A CN106890117 A CN 106890117A
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- toothpaste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
- A61K2800/432—Direct dyes
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- Oral & Maxillofacial Surgery (AREA)
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Abstract
The invention discloses a kind of bacterial plaque colour developing toothpaste blue containing food and preparation method thereof, component includes rubbing agent, NMF, thickener, foaming agent, sweetener, acid-base buffer agent, essence, developer and preservative, the content of each component is as follows, by weight percentage：Rubbing agent 5%~30%；NMF 5%~30%；Thickener 0.5%~5%；Foaming agent 0.3%~3%；Sweetener 0.005%~1%；Acid-base buffer agent 0.1%~1%；Essence 0.5%~1.5%；Developer 0.05%~1%；Preservative 0.03%~0.5%；Balance of water.The toothpaste just adds developer in manufacturing process, dispersed and stable more preferable, also effectively prevent the pollution that secondary operation brings.In addition, for this toothpaste has been arranged in pairs or groups the personnalité essence of a tool, it is deep to be liked by everybody, it is easier to commercially to promote.
Description
Technical field
The present invention relates to oral care techniques field, especially a kind of bacterial plaque colour developing toothpaste and its system blue containing food
Preparation Method.
Background technology
Bacterial plaque is the initiating agent of dental caries and periodontosis, is mainly made up of stickiness matrix and the bacterium being embedded, and is
A kind of typical biomembrane (biofilm, BF) structure and orderly microecosystem.Wherein to be mainly water solubility more for stickiness matrix
Sugar and water-insoluble polysaccharide, they both can provide energy, and also can bring protection to bacterium to bacterium, once formed mature and stable
Bacterial plaque, be just very difficult to remove.
Bacterial plaque is usually colourless, is with the naked eye difficult to observe, if not arousing attention in time and accomplishing have
Effect cleaning, will gradually be mineralized into " calculus dentalis " in salivary environment, then cause a series of oral health issues.Therefore, allow
Bacterial plaque naked eyes are visible can to appeal that people focus more on oral health, and bacterial plaque is removed in time.
Current bacterial plaque colour developing is typically all, by chemical staining method, to be developed the color by the attachment of pigment, in dental clinic
In have the product of some bacterial plaque nitrite ions etc, coordinate dentist to carry out the diagnosis of oral healthy condition.However, periodically
Go the people of dental clinic seldom, bacterial plaque developer is organically combined with toothpaste, can more effectively be pushed away with wider
The wide its people big fitness campaign in oral cavity.Bacterial plaque developer can aid in dentist or oneself it was observed that bacterial plaque, so as to clean in time
Removal bacterial plaque.The patent and document that bacterial plaque developer and toothpaste are combined together, only one at present,
CN101095649A, a kind of toothpaste containing staining components.And the toothpaste involved by the patent, simply by ordinary toothpaste with it is aobvious
Toner carries out simple centrifugation mixing, dispersiveness and less stable, also easily causes pollution, and the selection of its essence is also very in addition
Commonly.
The content of the invention
Based on this, the invention provides a kind of bacterial plaque colour developing toothpaste blue containing food and preparation method thereof.The toothpaste
Developer is just added in manufacturing process, it is dispersed and stable more preferable, also effectively prevent the pollution that secondary operation brings.Separately
Outward, it is that this toothpaste has been arranged in pairs or groups the personnalité essence of a tool, it is deep to be liked by everybody, it is easier to commercially to promote.
The object of the invention is achieved through the following technical solutions：
A kind of bacterial plaque blue containing food develops the color toothpaste, and component includes rubbing agent, NMF, thickener, foaming agent, sweet
Taste agent, acid-base buffer agent, essence, developer and preservative, the content of each component are as follows, by weight percentage：
The developer is food indigo plant 2, and food blue 2 is synthetic food color, and stability is high.
The essence is that perfume base mixture and blend of essential oils compounding are formed；Preferred mass compares 3:7, wherein perfume base mixture
It by orchid perfume base and lavender perfume base according to mass ratio is 7 to be:3 mixing；The blend of essential oils is by cool peppermint essential oil, green pepper
Sample Peppermint essential oil and spearmint essential oil are 1 according to mass ratio:2:3 mixing；
One of orchid, Chinese ten big famous flowers, it is simple and elegant noble and unsullied；Lavender, original producton location is French Provence, allows people to associate
Purple is romantic；Orchid perfume base and lavender perfume base are according to mass ratio 7:3 ratio mixing after thoroughly simple and elegant perfume (or spice), releive and pacify
God.Cool peppermint essential oil, American mint, spearmint are according to mass ratio 1:2:3 ratio mixing, peppermint is pure and fresh and gentle.Finally,
Perfume base is with essential oil according to mass ratio 3:7 ratio is mixed to get the essence that we want, and addition is liked by everybody deeply in toothpaste.
It is 1 according to mass ratio with the silica of conventional friction type that the rubbing agent uses friction-type high: (1~2) compounds.
The NMF includes but is not limited to sorbierite, glycerine, PEG-400；Sweetener includes but is not limited to saccharin sodium, acid
Alkali buffer is sodium pyrophosphate.
The thickener includes but is not limited to CMC, xanthans.
The foaming agent includes but is not limited to lauryl sodium sulfate.
Particularly, present invention also offers a kind of optimization formula of the bacterial plaque colour developing toothpaste blue containing food, each component
Content it is as follows, by weight percentage：
On the other hand, present invention also offers a kind of preparation method of the bacterial plaque colour developing toothpaste blue containing food, including
Following steps：
(1) thickener is scattered in part NMF, it is ensured that without conglomeration；
(2) sweetener, acid-base buffer agent, preservative are dissolved in water, add food indigo plant 2, remaining NMF, mixed；
(3) rubbing agent is added after the product of step (1) and step (2) is mixed, homogeneous is stirred, essence and foaming is added
Agent, stirs；
(4) vacuum outgas forms lotion.
Particularly, the preparation method selection process of the toothpaste is as follows：
(1) CMC and xanthans are scattered in PEG-400 and glycerine, it is ensured that without conglomeration；
(2) it is saccharin sodium, crystalline sodium pyrophosphate and Sodium Benzoate is soluble in water, add sorbierite, food indigo plant, stirring 15
~20min；
(3) silica, high speed under vacuum is added to stir 15~20min after the product of step (1) and (2) is mixed；
(4) essence and lauryl sodium sulfate are added, high speed under vacuum stirs 15~20min, and vacuum outgas forms lotion.
Step (3) described high-speed stirred is the rotating speed stirring of 3000r/min, and step (4) described high-speed stirred is 2000r/
The rotating speed stirring of min.
The present invention has the advantage that and beneficial effect relative to prior art：
(1) bacterial plaque developer used in toothpaste of the present invention is food indigo plant 2.The content of food indigo plant 2 is in toothpaste
0.05%~1%.Toothpaste makes one-time-reach-place, developer good dispersion in toothpaste, good stability.
(2) silica is compounded using friction-type high with conventional friction type in toothpaste, can preferably aid in bacterial plaque ground
Removal.
(3) essence in the toothpaste is unique, sedative action of not releiving only, is also rich in romance.
Specific embodiment
It is perfume base mixture and blend of essential oils according to mass ratio 3 used by the present invention:7 compoundings are formed, wherein perfume base mixing
It by orchid perfume base and lavender perfume base according to mass ratio is 7 that thing is:3 mixing；The blend of essential oils be by cool peppermint essential oil,
American mint essential oil and spearmint essential oil are 1 according to mass ratio:2:3 mixing.
Silica (MIG) is friction-type silica high, and remaining is plain edition
Embodiment 1：
The preparation method of the toothpaste is as follows：
(1) CMC and xanthans are scattered in PEG-400 and glycerine, dispersed with stirring is uniform, it is ensured that without conglomeration.
(2) by saccharin sodium, crystalline sodium pyrophosphate, Sodium Benzoate, soluble in water, it is blue to add sorbierite, food, stirring
15min is fully mixing.
(3) material of above-mentioned (1) and (2) is mixed and added into silica, 15min is stirred with 3000r/min under vacuum.
(4) essence and lauryl sodium sulfate are added, the rotating speed stirring 20min of 2000r/min under vacuum.It is qualified after testing
Afterwards,
Filling, packaging is made toothpaste finished product.
Embodiment 2：
(1) CMC and xanthans are scattered in PEG-400 and glycerine, dispersed with stirring is uniform, it is ensured that without conglomeration.
(2) by saccharin sodium, crystalline sodium pyrophosphate, Sodium Benzoate, soluble in water, it is blue to add sorbierite, food, stirring
15min is fully mixing.
(3) material of above-mentioned (1) and (2) is mixed and added into silica, 18min is stirred with 3000r/min under vacuum.
(4) essence and lauryl sodium sulfate are added, the rotating speed stirring 17min of 2000r/min under vacuum.
(5) filling after qualified after testing, packaging is made toothpaste finished product.
Embodiment 3：
(1) CMC and xanthans are scattered in PEG-400 and glycerine, dispersed with stirring is uniform, it is ensured that without conglomeration.
(2) by saccharin sodium, crystalline sodium pyrophosphate, Sodium Benzoate, soluble in water, it is blue to add sorbierite, food, stirring
15min is fully mixing.
(3) material of above-mentioned (1) and (2) is mixed and added into silica, 20min. is stirred with 3000r/min under vacuum
(4) essence and lauryl sodium sulfate are added, the rotating speed stirring 15min of 2000r/min under vacuum.
(5) filling after qualified after testing, packaging is made toothpaste finished product.
Comparative example 1：
Formulation of tooth-paste is as follows：(developer is identical, changes essence)
Essence is from orchid perfume base with cool peppermint essential oil according to mass ratio 3:7 compoundings are formed；
Preparation method carries out performance test with embodiment 1.
Comparative example 2：(essence is identical with the present invention, using the developer different from the present invention)
Formulation of tooth-paste is as follows：
Preparation method carries out performance test with embodiment 1.
2nd, performance verification experiment：
1st, stability test
The toothpaste of embodiment 1-3, comparative example 1-2 is put into -8 DEG C of refrigerators, is taken out after 8h, be subsequently placed into 45 ± 1 DEG C of perseverances
Taken out after 8h in warm incubator, 4h is placed at room temperature, check lotion, investigate its stability, the results are shown in Table 1.
The toothpaste stability test result of table 1
2nd, smell experiment
160 users have been randomly selected, using the toothpaste of the embodiment of the present invention 1, after 3 months, user's reaction
It is as follows：
The smell of table 2 is tested
| User feels | Fragrance and it is pure and fresh | Do not feel | It is horrible |
| 99% | 1% | 0 |
3rd, bacterial plaque removal experiment
160 subjects are randomly divided into 5 groups, use friction-type high from plain edition silica quality than different respectively
The toothpaste of (remaining formula is same as Example 2), brushes teeth respectively once sooner or later daily, continues 3 months, and detection respectively uses first
After month, the dental plaque index after the 3rd month, as a result such as table 3.
The removal experiment of the bacterial plaque of table 3
By table 1,2 it can be seen that after comparative example 1 changes species and the acid red compounding of essence, stability declines, contrast
Example 2 changes developer species, with flavor compound of the present invention after effect extreme difference, occur discoloration, it is spoiled it is smelly, separate water outlet and dry
Bind up one's hair hard phenomenon.And the developer of inventive formulation selection, unique essence and rubbing agent to be made toothpaste rear stability high,
Without there is layering water outlet and dry and hard phenomenon of hardening, pH value also in normal range (NR), and mixed taste fragrance and it is pure and fresh,
Addition is liked by everybody deeply in toothpaste, while user oneself is able to observe that bacterial plaque.
As can be seen from Table 3, silica uses friction-type high with conventional friction type according to 1 in toothpaste: (1~2) compounding,
Dental plaque index rate of change is substantially improved, and is 2 with friction-type high and conventional friction type:Effect when 1 is very nearly the same, but cost is big
Width reduction, therefore silica uses friction-type high with conventional friction type according to 1 in toothpaste: (1~2) compounding.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in specific embodiment disclosed and described above, to of the invention
Some modifications and changes should also be as falling into scope of the claims of the invention.Although additionally, being used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any limitation to the present invention.
Claims (10)
1. a kind of bacterial plaque blue containing food develops the color toothpaste, it is characterised in that component include rubbing agent, NMF, thickener,
Foaming agent, sweetener, acid-base buffer agent, essence, developer and preservative, the content of each component are as follows, by weight percentage：
The developer is food indigo plant 2.
2. toothpaste according to claim 1, it is characterised in that the essence be perfume base mixture and blend of essential oils according to
Mass ratio 3:7 compoundings are formed, and it by orchid perfume base and lavender perfume base according to mass ratio is 7 that wherein perfume base mixture is:3 mixing；
The blend of essential oils be by cool peppermint essential oil, American mint essential oil and spearmint essential oil according to mass ratio be 1:2:3 mixing.
3. toothpaste according to claim 1, it is characterised in that the rubbing agent is using friction-type high and conventional friction type
Silica is 1 according to mass ratio: (1~2) compounds.
4. toothpaste according to claim 1, it is characterised in that the NMF is sorbierite, glycerine, PEG-400；Sweet taste
Agent is saccharin sodium.
5. toothpaste according to claim 1, it is characterised in that the acid-base buffer agent is sodium pyrophosphate.
6. toothpaste according to claim 1, it is characterised in that the thickener is CMC, xanthans.
7. toothpaste according to claim 1, it is characterised in that the foaming agent is lauryl sodium sulfate.
8. toothpaste according to claim 1, it is characterised in that the content of each component is as follows, by weight percentage：
9. the method for preparing the described bacterial plaque colour developing toothpaste a kind of blue containing food of one of claim 1-7, its feature exists
In comprising the following steps：
(1) thickener is scattered in part NMF, it is ensured that without conglomeration；
(2) sweetener, acid-base buffer agent, preservative are dissolved in water, add food indigo plant 2, remaining NMF, mixed；
(3) rubbing agent is added after the product of step (1) and step (2) is mixed, homogeneous is stirred, essence and foaming agent is added,
Stir；
(4) vacuum outgas forms lotion.
10. the method for preparing the bacterial plaque colour developing toothpaste a kind of blue containing food described in claim 8, it is characterised in that bag
Include following steps：
(1) CMC and xanthans are scattered in PEG-400 and glycerine, it is ensured that without conglomeration；
(2) saccharin sodium, crystalline sodium pyrophosphate and Sodium Benzoate is soluble in water, it is blue to add sorbierite, food, and stirring 15~
20min；
(3) silica, high speed under vacuum is added to stir 15~20min after the product of step (1) and (2) is mixed；
(4) essence and lauryl sodium sulfate are added, high speed under vacuum stirs 15~20min, and vacuum outgas forms lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710169698.3A CN106890117B (en) | 2017-03-21 | 2017-03-21 | Plaque color developing toothpaste containing food blue and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710169698.3A CN106890117B (en) | 2017-03-21 | 2017-03-21 | Plaque color developing toothpaste containing food blue and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN106890117A true CN106890117A (en) | 2017-06-27 |
| CN106890117B CN106890117B (en) | 2020-07-28 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241251A (en) * | 2001-02-14 | 2002-08-28 | Tanpei Seiyaku Kk | Plaque dyeable toothpaste |
| JP2005325095A (en) * | 2004-04-16 | 2005-11-24 | Sato Shizai Kk | Composition for dyeing bacterial plaque |
| US20060115435A1 (en) * | 2002-11-09 | 2006-06-01 | Harald Wilkens | Dental toothpaste, solution, tablet and system with plaque color indicator and integrated decolorizing compound |
| CN101095649A (en) * | 2007-06-28 | 2008-01-02 | 同济大学 | Toothpaste having staining components |
| CN102068704A (en) * | 2009-11-23 | 2011-05-25 | 日进齿科材料(昆山)有限公司 | Dental plaque detection liquid |
-
2017
- 2017-03-21 CN CN201710169698.3A patent/CN106890117B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241251A (en) * | 2001-02-14 | 2002-08-28 | Tanpei Seiyaku Kk | Plaque dyeable toothpaste |
| US20060115435A1 (en) * | 2002-11-09 | 2006-06-01 | Harald Wilkens | Dental toothpaste, solution, tablet and system with plaque color indicator and integrated decolorizing compound |
| JP2005325095A (en) * | 2004-04-16 | 2005-11-24 | Sato Shizai Kk | Composition for dyeing bacterial plaque |
| CN101095649A (en) * | 2007-06-28 | 2008-01-02 | 同济大学 | Toothpaste having staining components |
| CN102068704A (en) * | 2009-11-23 | 2011-05-25 | 日进齿科材料(昆山)有限公司 | Dental plaque detection liquid |
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| Publication number | Publication date |
|---|---|
| CN106890117B (en) | 2020-07-28 |
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Effective date of registration: 20210430 Address after: 510555 room 922, No.2, Tengfei 1st Street, Zhongxin Guangzhou Knowledge City, Huangpu District, Guangzhou City, Guangdong Province (office only) Patentee after: Guangzhou Shuke Industrial Co.,Ltd. Address before: Room 704, 705, West, No. 64, 66, Jianzhong Road, Tianhe District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU WEIMEIZI INDUSTRIAL Co.,Ltd. |