CN106880644A - A kind of pharmaceutical composition for treating acquired obesity being made up of colesevelam - Google Patents
A kind of pharmaceutical composition for treating acquired obesity being made up of colesevelam Download PDFInfo
- Publication number
- CN106880644A CN106880644A CN201510932858.6A CN201510932858A CN106880644A CN 106880644 A CN106880644 A CN 106880644A CN 201510932858 A CN201510932858 A CN 201510932858A CN 106880644 A CN106880644 A CN 106880644A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- colesevelam
- pharmaceutical composition
- fat
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
The invention discloses a kind of pharmaceutical composition for treating acquired obesity and preparation method thereof, belong to pharmaceutical technology field.Described pharmaceutical composition contains colesevelam and vitamin E, vitamin C, is the solid pharmaceutical preparations such as ordinary tablet, capsule and granule.Experiment finds, containing colesevelam and vitamin E, ascorbic pharmaceutical composition reduction cholic acid, serum total cholesterol, serum triglyceride and LDL-C, and cooperates with antioxidant and anti-aging effect.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of by having that colesevelam and vitamin E, vitamin C are made
Fat-reducing and oxidation resistant pharmaceutical composition and preparation method.
Background technology
With social development, the raising of living standards of the people, adult because many foods or amount of exercise reduce the acquired obesity for causing
Into universal phenomenon.And people pursue beautiful, the hope for pursuing health is but very strong always.Therefore various slimming drugs arise at the historic moment,
While fat-reducing, many adverse reactions can be produced to body.Most common slimming drugs mainly have three classes in the market:One class is
Appetite inhibitor a, class is to accelerate metabolism to reduce absorbent, the another kind of preparation for being to aid in consumption fat and heat.Anorectic effect Alcohol
Agent medicine acts on central nervous system and carrys out appetite-suppressing, and the side effect to body is quite big, best；Accelerate metabolism, reduce and inhale
It is to make the thing eaten not absorbed into the body to receive agent medicine, or drains to reduce absorption as early as possible, reduces body intake heat
Summation reaches the purpose of weight reducing, smaller relative to appetite inhibitor risk, but long-term taking still hidden danger is not small；Help consumes fat
The preparation of fat and heat, the energy for daily intaking you is identical, but consumption is greatly increased, and can naturally also play the work of weight reducing loss of weight
With this is also the medicine for acting on central nervous system, and potential hazard is very big.As amphetamine (Amphetamine) suppresses food
It is intended to, promotes consumption fat and heat.Take the initial stage of this medicine, evening is excited, be not desired to sleep, the thing eaten is significantly reduced,
Also peculiar spirit, but with medicine time extend, it may appear that emotional instability, vainly hope, hallucinate, sleeping there is obstacle
Etc. mental symptom.Clinical test display slimming drugs Reductil can increase user suffer from a heart complaint and apoplexy risk, the slimming drugs life
Yi Jiangqiche cities of Abbott of the business men U.S.；Using slimming drugs appetite inhibitor fenfluramine hydrochloride have generation damaged heart valve and
The risk of pulmonary hypertension, fenfluramine hydrochloride (including bulk drug) has withdrawn from China market.Security is preferable in the market
With OTC medicines as orlistat, fall within and do not absorb substantially in vivo, suppress fat hydrolase by enteron aisle, and hinder machine
Absorption of the body to fat reaches fat-reducing purpose.But also because there may be the revised comment book warning that adverse reaction obtains FDA：
By the case on December 31st, 2010, national drug adverse reaction monitoring center case report data base about orlistat
More than 120 examples of report, main adverse reaction shows as constipation, stomachache, diarrhoea, dizziness, paramenia, fash etc..2010
September 1 day, State Food and Drug Administration's issue《Notice on revising orlistat preparation specification》(state's food medicine prison
Note [2010] 359), require at home to be updated orlistat preparation description, add related warning.
Can not only lose weight but also good medicine that the medicine of safety and Health is just dreamed of into people.It is generally believed that acquired overweight people's body
The quantity of fat cell hypertrophy does not increase, and is only showed only as the volume increase of fat cell.Acquired fat patient is general special
Do not have a sweet tooth or fried based food, and it is heavy, this kind of patient is often after adult because overnutrition just triggers fertilizer
It is fat, therefore also known as Adult Onset obesity.The development of acquired obesity can be efficiently controlled using weight-reducing by dieting therapy.
But it is very universal that acquired obese patient crosses drink overfeeding phenomenon, is lost weight from manual control appetite and diet kind, substantially
On be impossible mission.
Common name：Colesevelam, English name：Colesevelam, colesevelam has nonabsorbable, can avoid intestines and stomach
The characteristics of absorbing and degrade.Indication：Norcholesterol：Colesevelam hydrocholoride can independent medication or with statins drug combination
It is aided with to keep on a diet with moderate exercise and reduces primary hypercholesterolemia.Additionally, colesevelam hydrocholoride piece and supensoid agent are used for
Girl after 10~17 years old boy of heterozygosis heritable hyperlipidemic and menarche.It is hypoglycemic：Colesevelam hydrocholoride can also be double with diformazan
Guanidine, sulfonylurea hypoglycemic agent or insulin combination medication, be aided with keep on a diet with moderate exercise improve to diabetes B be grown up
The glycemic control of patient.
Bile acid sequestrant class cholesterol-lowering drug is one of medicine of lipidemia, and cholic acid chelating agent is applied to hypercholesterolemia
(II type hyperlipoprotememia), imitates to hypertriglyceridemia (I, III, IV and V type hyperlipoprotememia) *, solid to courage
Alcohol and triglycerides mix type hyperlipidemia all high (II b, broad beta disease) need to be with other kinds of regulating plasma lipid medicines
Thing use in conjunction could work.
Colesevelam hydrocholoride is the nonabsorbable bile acid sequestrant class fat-reducing medicament that drugmaker develops altogether of Japan one or three, it
The re-absorption of the latter can be combined with the cholic acid in enteron aisle and be substantially reduced, as diet and the complementary therapy of kinesiatrics.Hydrochloric acid is examined
Come tie up logical sequence by enteron aisle with cholic acid Irreversible binding, receive resorption of the cholic acid in enteron aisle and reduce what is discharged from enteron aisle with excrement
Cholic acid increases, and promotes liver cell to increase the synthesis of cholic acid, because the exhaustion of cholic acid can improve the balance that cholesterol is converted into cholic acid,
Therefore can be used for reducing cholesterol concentration, while accelerate the synthesis of ldl receptor by feedback mechanism cell cultured supernatant, with LDL in blood
Combination increase so that in blood LDL and T-CHOL content reduce.And the formation by HDL-C in enteron aisle increases HDL-C
Level.Colesevelam hydrocholoride is suitable for any kind of hypercholesterolemia in addition to homozygote familial hypercholesterolemia,
To any kind of hypertriglyceridemia DeGrain.To all elevated Combination fat high of Triglycerides in Serum and cholesterol
The treatment of mass formed by blood stasis, must be combined with other kinds of hypolipidemic.
Substantial amounts of clinical trial shows the alone LDL-C levels (15%~18%) that can substantially lower patient of colesevelam hydrocholoride, rises
HDL-C levels (3%) high, but influence to triglycerides is smaller.Colesevelam hydrocholoride with Statins (cut down by Atorvastatin, Lip river
Statin and Simvastatin) it is combined, the level for lowering LDL-C is more significantly (with the Statins individually extra reduction by 16% compared with),
It is less relative to Statins adverse reaction, relative to the level that alone colesevelam hydrocholoride is obviously improved lipid.
Vitamin E (Vitamin E) is a kind of liposoluble vitamin, is one of topmost antioxidant also known as tocopherol.
It is water insoluble, it is dissolved in the organic solvents such as fat and ethanol, it is unstable to alkali to heat, acid stabilization, it is sensitive to oxygen, to heat not
Sensitivity, but vitamin E, Vitamin C activity are substantially reduced when fried.Recently it has also been found that vitamin E, vitamin C can suppress eye
Peroxidization in eyeball crystalline lens, expands end blood vessel, improves blood circulation, pre- myopia prevention occurrence and development.
Vitamin C (English：Vitamin C, also known as L-AA) be High Primates animal with other it is a small number of it is biological must
Need nutrient.Ascorbic acid can be manufactured in most organism by metabolism, but the mankind are most significant exceptions.
That is most widely known by the people is a lack of vitamin C and can cause scurvy.In vivo, vitamin C is a kind of antioxidant, protection
From the threat of free radical, vitamin C is also simultaneously a kind of coenzyme to body.Its extensive food source is all kinds of fresh vegetables and fruits.
We have found that give renal insufficiency rat model by colesevelam gavage, it is same that rat serium inorganic phosphorus is reduced in zoopery
When, cholic acid, triglycerides, LDL-C, liposoluble vitamin level are also reduced, and enlighten us, oral to fill
Stomach is given rat colesevelam and can be lost weight with lipid-loweringing, but liposoluble vitamin level simultaneously needed by human declines.For this
Experiment finds that we devise various dose, the colesevelam of different ratio and vitamin and orally give rat again, observe its body
Weight, apparent condition, behavior and blood fat, vitamin level etc. change.It has been found through experiments that colesevelam is most preferably matched somebody with somebody with vitamin
The composition of ratio can reduce rat appetite, suppress rat body weight growth, reduction rat fat and its liposoluble vitamin level
It is held essentially constant, rat spirit is good, and behavior is normal.
Compound preparation formula science designed by the present invention, colesevelam is swelling after orally reaching in vivo, has both reached satiety reduction
Appetite, while fat-reducing effect can be reached by adsorbing the cholic acid and grease of enteron aisle and reduction blood fat again, coordinates vitamin to take,
Replenishing vitamins, play antioxidation, can prevent unrighted acid peroxidating, prevent the formation of lipofuscin from reaching reinforcement
Matter, the effect of anti-aging.
At present, both at home and abroad also without colesevelam (its carbonate or hydrochloride) and vitamin E, vitamin C drug combination
Report.
The content of the invention
It is an object of the invention to provide a kind of new pharmaceutical composition for acquired Bariatric.By lot of experiments, this
Invention is proposed and for colesevelam and vitamin E, vitamin C to be prepared into pharmaceutical composition, and has filtered out both optimal doses
And proportioning, excellent effect is shown in pharmacodynamics test.
Colesevelam is creatively combined and is prepared into pharmaceutical composition by the present inventor with vitamin E, vitamin C, for acquired
The treatment of obese patient, while also having anti-aging, improves the good result of patients ' life quality.Ground by Pre-clinical animal studies
Display is studied carefully, colesevelam is maximized favourable factors and minimized unfavourable ones with vitamin E, vitamin C use in conjunction, shows excellent synergy, in hair
The cholic acid and grease and reduction blood fat of colesevelam absorption enteron aisle are waved, while reaching fat-reducing effect, coordinates vitamin E, vitamin
C takes, vitamin E, vitamin C that supplement is removed by colesevelam absorption, plays vitamin E, ascorbic antioxygen and is turned into
With, unrighted acid peroxidating is prevented, prevent the formation of lipofuscin from reaching and build up health, the effect of anti-aging.
Medicine of the present invention includes that routinely oral solid formulation preparation method is made particle by the medicine of following component and ratio, then enters one
Step is made tablet, capsule or granule.
Colesevelam 10-300 parts, vitamin e1 part, 1 part of vitamin C.
It is preferred that 33 parts of colesevelam, vitamin e1 part, 1 part of vitamin C；The oral solid formulation Coming-of-Age Day dose being made
It is preferred that：Colesevelam：3000mg, vitamin E 90mg, vitamin C 90mg.
Pharmaceutical composition of the present invention can be according to general formulation method well known in the art, preferably including by following component and ratio
Bulk drug routinely oral solid formulation prepares piece agent, capsule or granule.
It is a further object of the present invention to provide the preparation method of this compound preparation medicine.Make the production method of pharmaceutical preparation by with
Lower step is carried out：
(1) pelletize：
It is well mixed with colesevelam medicinal powder after the vitamin E of recipe quantity, vitamin C silica are absorbed, is added appropriate auxiliary
Material, softwood processed crosses the granulation of 12-18 mesh sieves, is dried below 60 DEG C 2-3 hours and obtains medicament composition granule.
(2) it is made oral drug preparation
A. medicament composition granule obtained in step (1) is directly sub-packed into bag, acquired obese patient is used for as granule
Take；
B. medicament composition granule obtained in step (1) is distributed into capsule, capsule is distributed into PVC aluminum-plastic blisters,
Carton is reinstalled, is taken for acquired obese patient；
C. medicament composition granule obtained in step (1), according to conventional Chinese medical concrete tablet preparation method, is pressed into tablet, root
According to needing to carry out film coating, it is fitted into PVC aluminum-plastic blisters, reinstalls carton, is taken for acquired obese patient.
Specific embodiment
Embodiment is enumerated according to being prepared into as a example by granule below.
Embodiment 1
Colesevelam presses 67 with vitamin E, vitamin C:1:1 ratio, prepares 1000 bags by colesevelam 3g/ bags.
Prescription：
Embodiment 2
Colesevelam presses 67 with vitamin E, vitamin C:1:1 ratio, prepares 1000 bags by colesevelam 1g/ bags.
Prescription：
Embodiment 3
Colesevelam presses 133 with vitamin E, vitamin C:1:1 ratio, prepares 1000 bags by colesevelam 1g/ bags.
Prescription：
Embodiment 4
Colesevelam presses 133 with vitamin E, vitamin C：1:1 ratio, prepares 1000 bags by colesevelam 3g/ bags.
Prescription：
Embodiment 5
Colesevelam presses 33 with vitamin E, vitamin C：1：1 ratio, prepares 1000 bags by colesevelam 1g/ bags.
Prescription：
Embodiment 6
Colesevelam presses 33 with vitamin E, vitamin C：1：1 ratio, prepares 1000 bags by colesevelam 3g/ bags.
Prescription：
Preparation method：Weigh and mixed with colesevelam and other compositions after the vitamin E of recipe quantity, vitamin C silica absorb,
Add appropriate amount of starch slurry to prepare particle according to a conventional method, load Aluminum-plastic composite bag by setting loading amount afterwards, or load capsule, or
Person's compressing tablet, obtaining final product can be with the acquired fat medicine of oral medication.
The pharmacodynamic study of this compound preparation
Body weight to nutritive obesity in rats sets up high lipid food feeding " nutritive obesity in rats model ", observation according to literature method
The colesevelam vitamin E of different ratio various dose, vitamin C compound preparation to the body weight of the nutritive obesity rat,
The influence of Lee's indexes, blood fat, Serum Vitamin E, level of vitamin C and serum lipofuscin (LPO).
High lipid food feeding ablactation rat causes rat auxotype obese model after 12 weeks.Orlistat and colesevelam are alone
Just two dosage groups, colesevelam vitamin E, three ratio two dosage each groups of height of vitamin C compound can be resisted
The increased weight of rat and blood fat are raised；Two dosage of alone colesevelam, increase with dosage, and fat-reducing effect is incremented by, with giving
Pharmaceutical quantities are increased, and animal subject body weight and Lee ' indexes are significantly lower than model group, serum total cholesterol, triglycerides, low close
Degree lipoprotein cholesterol is less than model group, while Serum Vitamin E, level of vitamin C also decline；Colesevelam vitamin E,
Vitamin C compound each group rat blood serum vitamin E, level of vitamin C rising more notable than alone colesevelam；And colesevelam
Vitamin E, vitamin C (33:1:1) high dose group is significantly inhibiting rat body weight increase, while reduction blood fat, can carry again
Serum Vitamin E high, level of vitamin C, reduce serum lipofuscin level, and fat-reducing plays antioxidant and anti-aging effect again simultaneously.
Present invention discover that colesevelam (300mg/kg) vitamin E, vitamin C (9mg/kg) are with (33:1:1) ratio mixing
Rat is given, Weight-reducing and lipid-lowering, oxidation resistant effect can be played.It is daily oral colesevelam to promote clinical people's initial dose
3000mg, vitamin E 90mg, vitamin C 90mg compound preparations, take before the meal in three times, for preventing and treating pure fertilizer
It is fat, and the cosmetic result with antioxidant and anti-aging.
Claims (8)
1. it is a kind of for treat it is acquired obesity pharmaceutical composition, it is characterised in that described pharmaceutical composition contain colesevelam with
Vitamin E, vitamin C.
2. pharmaceutical composition as claimed in claim 1, it is characterised in that by weight, described pharmaceutical composition includes 10-300
The colesevelam hydrocholoride and 1 part of vitamin E, 1 part of vitamin C of part.
3. pharmaceutical composition as claimed in claim 1, it is characterised in that by weight, described pharmaceutical composition includes 10-300
The carbonic acid colesevelam and 1 part of vitamin E, 1 part of vitamin C of part.
4. pharmaceutical composition as claimed in claim 2 or claim 3, it is characterised in that by weight, be made contained by the pharmaceutical composition
The composition of the bulk drug of effective component is：Colesevelam 20-80 parts, 1 part of vitamin E, 1 part of vitamin C.
5. pharmaceutical composition as claimed in claim 2 or claim 3, it is characterised in that by weight, be made contained by the pharmaceutical composition
The composition of bulk drug be：33 parts of colesevelam, 1 part of vitamin E, 1 part of vitamin C.
6. pharmaceutical composition as claimed in claim 1, it is characterised in that daily carbon of adult's dose comprising 1000-5000mg
The vitamin E of sour colesevelam and 10-100mg, the vitamin C of 10-100mg.
7. pharmaceutical composition as claimed in claim 1, it is characterised in that daily carbonic acid of adult's dose comprising 3000mg is examined
Vitamin E, the vitamin C of 90mg of dimension logical sequence and 90mg.
8. pharmaceutical composition as claimed in claim 1, it is characterised in that the bulk drug of described pharmaceutical composition adds can pharmaceutically be connect
The auxiliary material received is made any oral solid formulation：Tablet, capsule and granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510932858.6A CN106880644A (en) | 2015-12-15 | 2015-12-15 | A kind of pharmaceutical composition for treating acquired obesity being made up of colesevelam |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510932858.6A CN106880644A (en) | 2015-12-15 | 2015-12-15 | A kind of pharmaceutical composition for treating acquired obesity being made up of colesevelam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106880644A true CN106880644A (en) | 2017-06-23 |
Family
ID=59174817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510932858.6A Pending CN106880644A (en) | 2015-12-15 | 2015-12-15 | A kind of pharmaceutical composition for treating acquired obesity being made up of colesevelam |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106880644A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005025673A1 (en) * | 2003-09-08 | 2005-03-24 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity comprising a hypoglycemic agent |
-
2015
- 2015-12-15 CN CN201510932858.6A patent/CN106880644A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005025673A1 (en) * | 2003-09-08 | 2005-03-24 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity comprising a hypoglycemic agent |
Non-Patent Citations (2)
| Title |
|---|
| 张翔等: ""胆汁酸、代谢手术与2型糖尿病"", 《腹腔镜外科杂志》 * |
| 王力，魏庆芳: "《管理你的腰围 抵御腹型肥胖》", 31 May 2013, 人民军医出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1686547A (en) | Long time use compound preparation for treating diabetes | |
| CN102215850B (en) | Composition containing fucoxanthin extract | |
| CN103479833B (en) | Hepatoprotective composition as well as preparation method and application thereof | |
| TW200304372A (en) | Compositions for diabetes | |
| CN1820647A (en) | Nutrition powder for increasing memory | |
| CN101450095A (en) | Medicine composition with blood-sugar reduction function and preparation method thereof | |
| CN105727270A (en) | Composition capable of increasing high-density lipoprotein and preventing and treating atherosclerosis and preparing method and application thereof | |
| CN102106895B (en) | Composition with function of regulating blood fat | |
| CN102240310B (en) | Blood-sugar-reducing composition and preparation method thereof | |
| CN106729123A (en) | A kind of composition of three high drop and preparation method thereof | |
| CN108653298B (en) | Monosaccharide composition, pharmaceutical preparation and application thereof | |
| CN108771248A (en) | A kind of health-care food for assisting blood fat lowering full of nutrition and preparation method thereof | |
| CN105380031A (en) | Health food and preparation method thereof | |
| CN106880644A (en) | A kind of pharmaceutical composition for treating acquired obesity being made up of colesevelam | |
| CN101491605A (en) | Combination with blood sugar reducing function and preparation method thereof | |
| CN107410642A (en) | It is a kind of to be used to improve kelp cordyceps sinensis pressed candy of male's renal function and preparation method thereof | |
| CN106349318A (en) | Application of pentacyclic triterpene compounds to preparation of medicine for treating adiposis | |
| CN111543638A (en) | Sea cucumber polysaccharide product with auxiliary blood sugar reducing effect and preparation method thereof | |
| JP2001086953A (en) | Analgesic food for assisting health | |
| JP2010168399A (en) | Pharmaceutical for controlling elevation of blood sugar | |
| CN105285977A (en) | Health-care product having efficacies of resisting ageing and improving immunity | |
| CN1826972A (en) | Health-caring product capable of reducing blood sugar | |
| JP2001048802A (en) | Health auxiliary food effective for diabetes, method of using the same and food combination preparation effective for diabetes | |
| CN1237066C (en) | Antihyperglycemic and oxidation resistant health products and preparing process thereof | |
| JP2019210269A (en) | Composition for treating diabetic disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170623 |