CN106860651A - A kind of preparation method of Lanqin oral liquid - Google Patents

A kind of preparation method of Lanqin oral liquid Download PDF

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Publication number
CN106860651A
CN106860651A CN201510933970.1A CN201510933970A CN106860651A CN 106860651 A CN106860651 A CN 106860651A CN 201510933970 A CN201510933970 A CN 201510933970A CN 106860651 A CN106860651 A CN 106860651A
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preparation
water
oral liquid
heated
added
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CN201510933970.1A
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Chinese (zh)
Inventor
刘鼎阔
张俊霞
张凤洪
王立红
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TIANJIN ZHICAOYUAN BIOLOGICAL SCIENCE & TECHNOLOGY Co Ltd
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TIANJIN ZHICAOYUAN BIOLOGICAL SCIENCE & TECHNOLOGY Co Ltd
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Priority to CN201510933970.1A priority Critical patent/CN106860651A/en
Publication of CN106860651A publication Critical patent/CN106860651A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of preparation method of Lanqin oral liquid, its technical process includes：1. the kinds of traditional Chinese medicines such as blue a kind of reed mentioned in ancient books, Radix Isatidis, cape jasmine are placed in beaker, add suitable quantity of water to decoct 3-5 times, filtering；2. 3-5 decoction filtering liquid is merged, be placed in specified containers, be concentrated into finite concentration；3. the preparation of chitosan clarifier：Shitosan is weighed, is added water and glacial acetic acid, stirred, be heated to 70-90 DEG C, add water to certain volume, be incubated 40-60min, it is standby；4. the chitosan clarifier for preparing is added, in 70-90 DEG C of constant temperature water bath heating, is heated while stirring, stir 15-30min, taken out, in standing at 0-5 DEG C；5. taking supernatant adds appropriate purified water to be tuned into certain volume, and filling, sterilizing gets product.The preparation method do not destroy in the effective elements of the medicine, active ingredient can farthest be retained, the unstability compositions such as aldehydes matter, protein, colloid in herbal medicine can be efficiently removed, it is economical and practical, expense can be greatlyd save, with certain application prospect, it is adapted to industrialized production.

Description

A kind of preparation method of Lanqin oral liquid
Technical field
The present invention relates to oral liquid and preparation method thereof technical field, especially a kind of preparation method of Lanqin oral liquid.
Background technology
Lanqin oral liquid is main to be formed by the important extraction of the multi-flavors such as Radix Isatidis, the root of large-flowered skullcap, cape jasmine, with clearing heat-fire, removing toxic substances Detumescence, effect of relieving sore throat and acesodyne.
The conventional method of the oral liquid is prepared for water extraction and alcohol precipitation method, technique is to weigh ingredients, plus suitable quantity of water by prescription Decoct 3 times, merge decoction liquor, be concentrated into relative density for 1.10, add ethanol, make amount of alcohol 60% or so, in More than 24h is stood at 0-5 DEG C, supernatant is taken, it is 1.15-1.20 that ethanol is recovered under reduced pressure to relative density to the greatest extent, is concentrated into, plus Appropriate purified water is tuned into 6 times of volume about medicinal material amount, and filling, sterilizing gets product.Conventional method needs a large amount of second Alcohol, process cycle is more long, cumbersome.
The content of the invention
Need a large amount of ethanol, process cycle long, cumbersome it is an object of the invention to be directed to the current Lanqin oral liquid for preparing In the case of, there is provided a kind of preparation method of Lanqin oral liquid.The oral liquor uses chitosan flocculating method generation For water extraction and alcohol precipitation method, can to greatest extent retain active ingredient, it is economical and practical, expense can be greatlyd save.It is above-mentioned to realize Purpose, the technical solution adopted by the present invention is：
A kind of preparation method of Lanqin oral liquid, comprises the following steps：
(1) kinds of traditional Chinese medicines such as blue a kind of reed mentioned in ancient books, Radix Isatidis, cape jasmine are placed in beaker, add suitable quantity of water to decoct 3-5 times, filtering；
(2) 3-5 decoction filtering liquid is merged, is placed in specified containers, be concentrated into finite concentration；
(3) preparation of chitosan clarifier：Shitosan is weighed, is added water and glacial acetic acid, stirred, be heated to 70-90 DEG C, certain volume is added water to, 40-60min is incubated, it is standby；
(4) chitosan clarifier for preparing is added, in 70-90 DEG C of constant temperature water bath heating, is heated while stirring, stirred 15-30min, takes out, in standing at 0-5 DEG C；
(5) taking supernatant adds appropriate purified water to be tuned into certain volume, and filling, sterilizing gets product.
Used as further scheme, be placed in the kinds of traditional Chinese medicines such as blue a kind of reed mentioned in ancient books, Radix Isatidis, cape jasmine in beaker by material in step (1), plus Enter suitable quantity of water to decoct 3 times, filtering.
As further scheme, 3-5 decoction filtering liquid is merged in step (2), be placed in specified containers, it is dense Relative density is reduced to for 1.15-1.20.
As further scheme, shitosan 1g is weighed in the preparation of chitosan clarifier in step (3), add water 50mL and 2mL glacial acetic acid, stirs, and is heated to 80 DEG C, adds water to 100mL, is incubated 45min, standby.
The chitosan clarifier for preparing is added as further scheme, in step (4), in 80 DEG C of constant temperature water bath heating, Heat while stirring, stir 20min, take out, in standing at 0-5 DEG C；
As further scheme, supernatant is taken in step (5) and adds appropriate purified water to be tuned into 6 times of volume about medicinal material amount, Filling, sterilizing, gets product.
The advantage of preparation method of the Lanqin oral liquid that the present invention is provided is：
1. active ingredient can to greatest extent be retained instead of water extraction and alcohol precipitation method using shitosan fining process in the present invention；
2. labile element in herbal medicine can efficiently be removed instead of water extraction and alcohol precipitation method using shitosan fining process in the present invention；
3. expense can be greatlyd save instead of water extraction and alcohol precipitation method using shitosan fining process in the present invention, it is economical and practical, it is adapted to work Industry metaplasia is produced, and has certain application prospect.
Specific embodiment
With reference to specific embodiment, the invention will be further described
Embodiment 1
A kind of preparation method of Lanqin oral liquid, comprises the following steps：
(1) by blue a kind of reed mentioned in ancient books 250g, Radix Isatidis 300g, cape jasmine 300g, golden cypress 100g, sterculia seed 100g is ground into meal, It is placed in beaker, adds suitable quantity of water to decoct 3 times, first time 2h, second and each 1h of third time, filtering；
(2) 3 decoction filtering liquid are merged by more than, are placed in specified containers, and it is 1.15 to be concentrated into relative density；
(3) preparation of chitosan clarifier：Shitosan 1g is weighed, add water 50mL and 2mL glacial acetic acid, stirs, 80 DEG C are heated to, 100mL is added water to, 45min is incubated, it is standby；
(4) chitosan clarifier for preparing is added, in 80 DEG C of constant temperature water bath heating, is heated while stirring, stir 20min, Take out, in standing at 0-5 DEG C；
(5) taking supernatant adds appropriate purified water to be tuned into 6 times of volume about medicinal material amount, and filling, sterilizing gets product.
Embodiment 2
A kind of preparation method of Lanqin oral liquid, comprises the following steps：
(1) by blue a kind of reed mentioned in ancient books 250g, Radix Isatidis 300g, cape jasmine 300g, golden cypress 100g, sterculia seed 100g is ground into meal, It is placed in beaker, adds suitable quantity of water to decoct 3 times, each each 1h, filtering；
(2) 3 decoction filtering liquid are merged by more than, are placed in specified containers, and it is 1.20 to be concentrated into relative density；
(3) preparation of chitosan clarifier：Shitosan 1g is weighed, add water 50mL and 2mL glacial acetic acid, stirs, 70 DEG C are heated to, 100mL is added water to, 60min is incubated, it is standby；
(4) chitosan clarifier for preparing is added, in 70 DEG C of constant temperature water bath heating, is heated while stirring, stir 30min, Take out, in standing at 0-5 DEG C；
(5) taking supernatant adds appropriate purified water to be tuned into 6 times of volume about medicinal material amount, and filling, sterilizing gets product.
Embodiment 3
A kind of preparation method of Lanqin oral liquid, comprises the following steps：
(1) by blue a kind of reed mentioned in ancient books 250g, Radix Isatidis 300g, cape jasmine 300g, golden cypress 100g, sterculia seed 100g is ground into meal, It is placed in beaker, adds suitable quantity of water to decoct 3 times, each each 2h, filtering；
(2) 3 decoction filtering liquid are merged by more than, are placed in specified containers, and it is 1.18 to be concentrated into relative density；
(3) preparation of chitosan clarifier：Shitosan 1g is weighed, add water 50mL and 2mL glacial acetic acid, stirs, 90 DEG C are heated to, 100mL is added water to, 40min is incubated, it is standby；
(4) chitosan clarifier for preparing is added, in 90 DEG C of constant temperature water bath heating, is heated while stirring, stir 15min, Take out, in standing at 0-5 DEG C；
(5) taking supernatant adds appropriate purified water to be tuned into 6 times of volume about medicinal material amount, and filling, sterilizing gets product.
The above, is only presently preferred embodiments of the present invention, not makees any formal to technical scheme Limitation.Every any simple modification made to above example according to technical spirit of the invention, equivalent variations and repair Decorations, still fall within the range of technical scheme.

Claims (6)

1. a kind of preparation method of Lanqin oral liquid, it is characterised in that the specific preparation method step of described oral liquid is as follows：
(1) kinds of traditional Chinese medicines such as blue a kind of reed mentioned in ancient books, Radix Isatidis, cape jasmine are placed in beaker, add suitable quantity of water to decoct 3-5 times, filtering；
(2) 3-5 decoction filtering liquid is merged, is placed in specified containers, be concentrated into finite concentration；
(3) preparation of chitosan clarifier：Shitosan is weighed, is added water and glacial acetic acid, stirred, be heated to 70-90 DEG C, add water to certain volume, be incubated 40-60min, it is standby；
(4) chitosan clarifier for preparing is added, in 70-90 DEG C of constant temperature water bath heating, is heated while stirring, stir 15-30min, taken out, in standing at 0-5 DEG C；
(5) taking supernatant adds appropriate purified water to be tuned into certain volume, and filling, sterilizing gets product.
2. the preparation method of a kind of Lanqin oral liquid according to claim 1, it is characterised in that be placed in the kinds of traditional Chinese medicines such as blue a kind of reed mentioned in ancient books, Radix Isatidis, cape jasmine in beaker by material in step (1), adds suitable quantity of water to decoct 3 times, filtering.
3. the preparation method of a kind of Lanqin oral liquid according to claim 1, it is characterised in that merge 3-5 decoction filtering liquid in step (2), be placed in specified containers, is concentrated into relative density for 1.15-1.20.
4. the preparation method of a kind of Lanqin oral liquid according to claim 1, it is characterised in that weigh shitosan 1g in the preparation of chitosan clarifier in step (3), add water 50mL and 2mL glacial acetic acid, stirs, and is heated to 80 DEG C, 100mL is added water to, 45min is incubated, it is standby.
5. the preparation method of a kind of Lanqin oral liquid according to claim 1, it is characterised in that the chitosan clarifier for preparing is added in step (4), in 80 DEG C of constant temperature water baths heating, heats while stirring, and stirs 20min, takes out, in being stood at 4 DEG C.
6. the preparation method of a kind of Lanqin oral liquid according to claim 1, it is characterised in that supernatant is taken in step (5) and adds appropriate purified water to be tuned into 6 times of volume about medicinal material amount, filling, sterilizing gets product.
CN201510933970.1A 2015-12-14 2015-12-14 A kind of preparation method of Lanqin oral liquid Pending CN106860651A (en)

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Publications (1)

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CN106860651A true CN106860651A (en) 2017-06-20

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110108825A (en) * 2019-05-08 2019-08-09 扬子江药业集团有限公司 The method for building up and its finger-print of Lanqin oral liquid finger-print and application
CN115869359A (en) * 2021-09-28 2023-03-31 扬子江药业集团有限公司 Blue scutellaria extract and its use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110108825A (en) * 2019-05-08 2019-08-09 扬子江药业集团有限公司 The method for building up and its finger-print of Lanqin oral liquid finger-print and application
CN115869359A (en) * 2021-09-28 2023-03-31 扬子江药业集团有限公司 Blue scutellaria extract and its use
CN115869359B (en) * 2021-09-28 2024-03-19 扬子江药业集团江苏龙凤堂中药有限公司 Radix Scutellariae extract and its application

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Application publication date: 20170620