CN106860433A - A kind of nanofiber and preparation method with medicine two-phase pulse release function - Google Patents
A kind of nanofiber and preparation method with medicine two-phase pulse release function Download PDFInfo
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- CN106860433A CN106860433A CN201710035710.1A CN201710035710A CN106860433A CN 106860433 A CN106860433 A CN 106860433A CN 201710035710 A CN201710035710 A CN 201710035710A CN 106860433 A CN106860433 A CN 106860433A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/10—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained by reactions only involving carbon-to-carbon unsaturated bonds as constituent
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- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Textile Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Inorganic Chemistry (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
Abstract
A kind of nanofiber with medicine two-phase pulse release function, including a main fiber beam, a collateral fiber beam is provided with the outside of main fiber beam, main fiber beam and collateral fiber beam extend in the longitudinal direction, on radial section, the periphery 40 ~ 70% of collateral fiber element covering main fiber beam, main fiber beam is made up of medicine and pharmaceutic adjuvant soluble in water, and the polymer pharmaceutic adjuvant that collateral fiber beam can dissolve by medicine and in neutral and alkaline conditions is constituted.The preparation method of above-mentioned nanofiber is additionally provided, medicine and pharmaceutic adjuvant soluble in water are deployed into a kind of solution altogether；The polymer pharmaceutic adjuvant that can be dissolved by medicine and in neutral and alkaline conditions is deployed into another solution altogether；Control two kinds of solution to inject the speed of spinneret arranged side by side by two syringe pumps, the nanofiber with medicine two-phase pulse release function is prepared in the presence of high-pressure electrostatic.The present invention can regulate and control contained medicine and be discharged by two-phase pulse mode.
Description
Technical field
The invention belongs to materialogy field, it is related to a kind of medicine sustained and controlled release nano material, it is specifically a kind of that there is medicine
The nanofiber and preparation method of thing two-phase pulse release function.
Background technology
High-voltage electrostatic spinning technology（Electrospinning）It is a kind of nano-fabrication technique of (top-down) from top to bottom, by additional
Electric field force overcomes the surface tension of liquid and viscoelastic power of shower nozzle tip drop and forms jet, in electrostatic repulsion, Coulomb force and table
Under the tension force collective effect of face, liquid jet is drafted thousands of times by high frequency flexural, drawing, division within a few tens of milliseconds, through solvent
Volatilization or melt cooling obtain nano-scale fiber in receiving terminal.The technical matters process is simple, manipulation is convenient, selection material ranges
Extensively, controllability is strong, it is considered to be a kind of most possible method for realizing continuous nano-fibre industrialized production, using the technology
Preparing functional nano-fiber has good prospect.
Electric spinning polymer functional nano-fiber is general with fibre-forming polymer as base material, assigns and receiving by adding active component
Rice fiber function, and make full use of the special performance of electro spinning nanometer fiber membrane and give full play to the effectiveness of active component.These are only
Special performance includes that fibre diameter is small, fiber surface area is huge, fiber is in three-dimensional netted loose structure, porosity be high, fiber tool
There is the diameter of nanoscale scope but while having length of macro-scope etc..In biomedicine field, typically medicine is added
Polymer solution, forms solution altogether and, as spinning solution, by the rapid draing and shaping of common electro-spinning process, obtains medicine equal
The even medicament-carrying nano-fiber for being distributed in whole nanofiber.Most medicament-carrying nano-fibers are all the distributions of such medicaments uniformity
, the nanofiber that structure is single, required for obtaining the characteristics of by the physicochemical property and nano fibrous membrane of polymeric substrate
Medicine sustained and controlled release performance.
With the development of electrospinning, people are gradually recognized in all of " top-down " nano-fabrication technique, electricity
Spinning technique most advantageous feature can be by the design of macro-level spinning header structure, and single step is effectively prepared with corresponding microcosmic
The nanofiber of architectural feature, such as prepares parallel construction nanofiber by inside and outside two-layer sleeve structure spinneret（DG Yu, LM
Zhu, C Branford-White, JH Yang, X Wang, Y Li, W Qian. Solid dispersions in the
form of electrospun core-sheath nanofibers. International Journal of
Nanomedicine, 2011,6: 3271-3280.）, by two capillaries side by side be spinneret prepare parallel construction nanometer
Fiber（Jalani G, Jung CW, Lee JS, Lim DW. Fabrication and characterization of
anisotropic nanofiber scaffolds for advanced drug delivery systems.
International journal of nanomedicine, 2014,9 (Suppl 1), 33.）.Though have pass through on a small quantity at present
The distribution of electrospinning and electrospinning regulating medicine arranged side by side in nanofiber arranged side by side, it is arranged side by side with the electrospinning for obtaining required medicine controlled releasing performance
Nanofiber and Qiao Nasi nanofibers, but design feature and the composition regulation and control using nanometer arranged side by side are had not found to obtain
The relevant report of medicine two-phase pulse controlled release.
The content of the invention
For above-mentioned technical problem of the prior art, there is medicine two-phase pulse release function the invention provides one kind
Nanofiber and preparation method, described this nanofiber and preparation method with medicine two-phase pulse release function will
Solve the not good technical problem of nanofiber two-phase pulse controlled-release effect of the prior art.
The invention provides a kind of nanofiber with medicine two-phase pulse release function, including a main fiber beam,
A collateral fiber beam is provided with the outside of described main fiber beam, described main fiber beam and described collateral fiber beam are in length
Degree side upwardly extends, and on radial section, the periphery 40 ~ 70% of the described main fiber beam of described collateral fiber element covering is described
Main fiber beam be made up of medicine and pharmaceutic adjuvant soluble in water, in main fiber beam, described medicine and soluble in water
The mass ratio of pharmaceutic adjuvant is 1：6~9；It is poly- that described collateral fiber beam can dissolve by medicine and in neutral and alkaline conditions
Compound pharmaceutic adjuvant is constituted, and in described collateral fiber beam, described medicine and the mass ratio of polymer pharmaceutic adjuvant are 1：
10~15。
Further, in main fiber beam, described medicine and the mass ratio of pharmaceutic adjuvant soluble in water are 1：7；Institute
The polymer pharmaceutic adjuvant that the collateral fiber beam stated can dissolve by medicine and in neutral and alkaline conditions is constituted, described and
In row fibre bundle, described medicine and the mass ratio of polymer pharmaceutic adjuvant are 1：13.
Further, described medicine is small-molecule chemical synthetic drug or active ingredient of Chinese herbs.
Further, described medicine is brufen.
Further, described pharmaceutic adjuvant soluble in water is polyvinylpyrrolidone K60；Described polymer is medicinal
Auxiliary material is fibre-forming polymer Utech L-100.
Present invention also offers a kind of preparation method of above-mentioned nanofiber with medicine two-phase pulse release function,
Comprise the following steps：
1) the first organic solvent is used, medicine and pharmaceutic adjuvant soluble in water solution altogether is deployed into, as main fiber beam
The working fluid on one side；
2) the second organic solvent is used, the polymer pharmaceutic adjuvant that can be dissolved by medicine and in neutral and alkaline conditions is deployed into
Common solution, as the working fluid on collateral fiber beam one side；
3) working fluid on main fiber beam one side is fitted into first syringe, the first described syringe is arranged on one
In first syringe pump；
4) working fluid on collateral fiber beam one side is fitted into second syringe, the second described syringe is arranged on one
In individual second syringe pump；
5) the first syringe and the second described syringe described in are connected with a two entrances for spinneret arranged side by side respectively；
6) high pressure generator, described high pressure generator and described spinneret arranged side by side connection are used；
7) control two kinds of solution to inject the speed of spinneret arranged side by side respectively by two syringe pumps, high pressure generator is opened, in height
In the presence of pressure electrostatic, with spinneret exit orifices arranged side by side as masterplate, flat panel collector nanofiber is received by being grounded fiber；Prepare
Nanofiber with medicine two-phase pulse release function.
Further, the first described organic solvent and the second described organic solvent are absolute ethyl alcohol.
Nanofiber of the invention has parallel construction feature, by the bilateral using different solubility properties of nanofiber
Polymeric substrate, under the support of structure, can regulate and control contained medicine and be discharged by two-phase pulse mode.One side medicine of fiber
Soluble in water with auxiliary material, after dissolution fluid is touched, can fast-pulse discharge some drugs contained therein；Fiber
The polymer auxiliary material on other one side is insoluble in acid condition, can quickly dissolve in neutral and alkaline conditions, therefore passes through
After oral, can fast-pulse discharge another part medicine for wherein being loaded, realize the two-phase pulse release mode of medicine.
Qiao Nasi nanofibers of the invention are prepared by electrospinning processes arranged side by side, preparation process is simple, and single step is effective, preparation
Nanofiber parallel construction is clear and nanometer diameter is small, good linearity, diameter are evenly distributed, fiber surface is smooth.
The present invention is compared with prior art, and its technological progress is significant.The fast quick-release of medicine of the invention pulse in the early stage
After putting once, by certain hour without drug release phase, medicine carries out second fast-pulse release, by by Nanowire
Dimension film shearing flakiness, can directly develop the oral administration system of medicine, there is provided safely and effectively medicine controlled releasing mode.Should
The thinking of parallel construction nanofiber can provide implementation for the two-phase pulse controlled release of numerous medicines.
Brief description of the drawings
Fig. 1 is that the electrospinning preparation process taylor cone arranged side by side of medicine two-phase pulse release Qiao Nasi nanofibers of the invention is clapped
Take the photograph figure；
Fig. 2 is electric spinning equipment schematic diagram arranged side by side of the present invention；
Fig. 3 is the scanning electron microscope diagram that medicine two-phase pulse of the invention discharges Qiao Nasi nanofibers；
Fig. 4 is the transmission electron microscope figure that medicine two-phase pulse of the invention discharges Qiao Nasi nanofibers；
Fig. 5 is the internal structure schematic diagram that medicine two-phase pulse of the invention discharges Qiao Nasi nanofibers；
Fig. 6 is the vitro Drug two-phase pulse controlled release figure that medicine two-phase pulse of the invention discharges Qiao Nasi nanofibers；
Specific embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.These embodiments be only used for explain the present invention and
It is not intended to the limitation present invention.All uses and same or analogous method of the invention, or the equivalent modifications made, all should fall into this
Invention protection domain.
Embodiment 1：Electrospinning processes arranged side by side implement the preparation with Qiao Nasi nanofibers
1 gram of medicine ibuprofen and 7 grams of polyvinylpyrrolidone K60 are codissolved in the absolute ethyl alcohol of 100 ml, are prepared on one side
Working fluid.
1 gram of medicine ibuprofen and 13 grams of fibre-forming polymer Utech L-100 are codissolved in 100 ml absolute ethyl alcohols, are prepared
Into the working fluid of electrospinning another side arranged side by side.
Above two working fluid is respectively charged into corresponding syringe 7,8, is installed on respective syringe pump 2,3, and
It is connected in the entrance of spinneret arranged side by side 4, connects high-pressure spinning first 4 and high pressure generator 1.
Solution arranged side by side is controlled to inject the speed of spinneret arranged side by side respectively by two syringe pumps 2,3, flow velocity arranged side by side is 1.0
ML/h, fiber receiver board 5 with a distance from spinning nozzle arranged side by side be 20 cm, environment temperature be (24 ± 1) DEG C, ambient humidity be 61 ±
4%.Under above-mentioned operating mode, high pressure generator 1 is opened, the kV of voltage 14 carries out bust shot in situ to electro-spinning process, as a result as schemed
Shown in 1, from spinneret arranged side by side 4, out two fluids forms a compound Taylor cone arranged side by side, and the top of cone sends one directly
Line jet, starts the unstable drawing process of high-voltage electrostatic spinning.
The electric spinning equipment a kind of arranged side by side that the present invention is used is as shown in Fig. 2 including high pressure generator 1；First syringe pump 2,
Two syringe pumps 3, spinneret arranged side by side 4, fiber receiver board 5, silica gel hose 6, the first syringe 7, the second syringe 8 are constituted, described
The first syringe 7 be arranged in the first described syringe pump 2, first syringe 7 is by described silica gel hose 6 and institute
One entrance connection of the spinneret arranged side by side 4 stated, the second described syringe 8 is arranged in the second syringe pump 3, second note
Another entrance connection of emitter 8 and described spinneret arranged side by side 4, described high pressure generator 1 and described spinning arranged side by side
First 4 connection, the described lower end of spinneret arranged side by side 4 is provided with a fiber receiver board 5.
Above-mentioned high pressure generator 1；First syringe pump 2, the second syringe pump 3, spinneret arranged side by side 4, fiber receiver board 5, silicon
Glue flexible pipe 6, the first syringe 7, the second syringe 8 can be bought by market and obtained.
Embodiment 2：The structure and morphology characterization of medicine two-phase pulse release Qiao Nasi nanofibers
Using field emission scanning electron microscope（FESEM）Observed after surface metal spraying is carried out to fiber prepared by embodiment 1, as a result such as Fig. 3
It is shown.Prepared fiber is presented good linear condition, do not have that bead structure, fiber surface be smooth, fiber accumulations are equal
It is even.A diameter of 670 ± 110 nm, than more uniform, concentration is compared in diameter distribution for distribution.
Using high resolution transmission electron microscopy（TEM）Prepared fibrous inner structure is observed, as a result such as Fig. 4 institutes
Show, the bilateral parallel construction feature of Qiao Nasi nanofibers is clear.The internal structure of fiber as shown in figure 5, medicine 33 equably
It is distributed among the Utech L-100 on the polyvinylpyrrolidone on the left side 11 of Qiao Nasi nanofibers and the right 22.
Embodiment 3：The drug controlled-releasing function analysis of medicine two-phase pulse release Qiao Nasi nanofibers
By D drug release determinations the second method slurry processes of 2015 editions annex of Chinese Pharmacopoeia Ⅹ, carried out using RCZ-8A intelligence dissolution experiment instruments
Medicament-carrying nano-fiber to above-mentioned gained carries out In Vitro Dissolution experiment.Control rotating speed 50rpm, temperature is 37 ± 0.1 DEG C.In preceding 2h
It is interior that to use not enzyme-added simulated gastric fluid 900mL be dissolution medium, behind use not enzyme-added simulated intestinal fluid（The phosphate of pH6.8
Cushioning liquid）900mL is dissolution medium, investigates the vitro Drug controlled release properties of nanofiber.5mL is sampled on schedule,
0.22 μm of filtering with microporous membrane, obtains dissolution fluid sample, and supplements same volume isothermal fresh medium at once.It is suitably dilute to sample
After releasing, at the nm of λ=257, ultraviolet determination is carried out using ultraviolet-uisible spectrophotometer, calculate medicine ibuprofen stripping quantity and
Accumulation dissolution percentage, is repeated 6 times.Result is as shown in fig. 6, it can be seen that the obvious two-phase pulse of medicine presentation is released
Put effect.Because the polymeric substrate of the polyvinylpyrrolidone on one side is soluble in water, after nanofiber contact simulated gastric fluid,
Whole medicines of the horse back pulse release first order.In 2 subsequent hours, PVP while disappear, because another side polymer is outstanding
Special strange L-100 does not dissolve in acid, so its contained brufen hardly discharges.After the simulated intestinal fluid of neutrality is transferred to, due to
The quick dissolving of polymer Utech L-100, medicine obtains the pulse release effect of two-phase.This medicine two-phase pulse controlled release
Effect can not only reduce poisonous side effect of medicine, extend medication effect, reduces administration number of times and improve bioavilability,
And can be many special diseases（So many angiocardiopathy hypertension, ischemic heart disease, angina pectoris etc. have obvious
Daily rhythmicity disease, some nights hair property and morning hair property disease）The pulse preparation of a kind of taking a medicine at bedtime and morning drug release is provided,
To the prevention and treatment of such disease.
Embodiment 4：The two-phase pulse of active ingredient of Chinese herbs resveratrol discharges nanofiber arranged side by side
According to the spinning solution concocting method and implementing process condition of examples of implementation 1, the two-phase pulse release for preparing resveratrol is tall
Receive this nanofiber, vitro Drug dissolution experiment carried out according to embodiment 3, detection fibers to the controlled release properties of medicine, as a result table
Bright, the release in vitro of medicine resveratrol has obvious two-phase pulse controlled release feature.
Claims (6)
1. a kind of nanofiber with medicine two-phase pulse release function, it is characterised in that：It is described including a main fiber beam
Main fiber beam on the outside of be provided with a collateral fiber beam, described main fiber beam and described collateral fiber beam are in length side
Upwardly extend, on radial section, the periphery 40 ~ 70% of the described main fiber beam of described collateral fiber element covering, described master
Fibre bundle is made up of medicine and pharmaceutic adjuvant soluble in water, in main fiber beam, described medicine and soluble in water medicinal
The mass ratio of auxiliary material is 1：6~9；The polymer that described collateral fiber beam can dissolve by medicine and in neutral and alkaline conditions
Pharmaceutic adjuvant is constituted, and in described collateral fiber beam, described medicine and the mass ratio of polymer pharmaceutic adjuvant are 1：10~
15。
2. a kind of nanofiber with medicine two-phase pulse release function according to claim 1, it is characterised in that：Institute
The medicine stated is small-molecule chemical synthetic drug or active ingredient of Chinese herbs.
3. a kind of nanofiber with medicine two-phase pulse release function according to claim 1, it is characterised in that：Institute
The medicine stated is brufen.
4. a kind of nanofiber with medicine two-phase pulse release function according to claim 1, it is characterised in that：Institute
The pharmaceutic adjuvant soluble in water stated is polyvinylpyrrolidone K60；Described polymer pharmaceutic adjuvant is that fibre-forming polymer is outstanding
Special strange L-100.
5. a kind of preparation method of the nanofiber with medicine two-phase pulse release function described in claim 1, its feature
It is to comprise the following steps：
1）Using the first organic solvent, medicine and pharmaceutic adjuvant soluble in water are deployed into solution altogether, as main fiber beam
The working fluid on one side；
2）Using the second organic solvent, the polymer pharmaceutic adjuvant that can be dissolved by medicine and in neutral and alkaline conditions is deployed into
Common solution, as the working fluid on collateral fiber beam one side；
3）The working fluid on main fiber beam one side is fitted into first syringe, the first described syringe is arranged on one
In first syringe pump；
4）The working fluid on collateral fiber beam one side is fitted into second syringe, the second described syringe is arranged on one
In individual second syringe pump；
5）The first described syringe and the second described syringe are connected with a two entrances for spinneret arranged side by side respectively；
6）Using a high pressure generator, described high pressure generator and described spinneret arranged side by side is connected；
7）Control two kinds of solution to inject the speed of spinneret arranged side by side respectively by two syringe pumps, high pressure generator is opened, in height
In the presence of pressure electrostatic, with spinneret exit orifices arranged side by side as masterplate, flat panel collector nanofiber is received by being grounded fiber；Prepare
Nanofiber with medicine two-phase pulse release function.
6. the preparation method of a kind of nanofiber with medicine two-phase pulse release function according to claim 5, its
It is characterised by：Described the first organic solvent and the second described organic solvent is absolute ethyl alcohol.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336885A (en) * | 2008-08-08 | 2009-01-07 | 东华大学 | Preparation method of microelement nano fibrofelt |
| CN102251317A (en) * | 2011-05-18 | 2011-11-23 | 东华大学 | Preparation method of electrospun fibers with controllable drug release |
| CN102824641A (en) * | 2012-09-07 | 2012-12-19 | 东华大学 | Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof |
| CN104611773A (en) * | 2015-01-19 | 2015-05-13 | 上海理工大学 | Eccentric sleeve type parallel spinning head and application thereof |
-
2017
- 2017-01-17 CN CN201710035710.1A patent/CN106860433A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336885A (en) * | 2008-08-08 | 2009-01-07 | 东华大学 | Preparation method of microelement nano fibrofelt |
| CN102251317A (en) * | 2011-05-18 | 2011-11-23 | 东华大学 | Preparation method of electrospun fibers with controllable drug release |
| CN102824641A (en) * | 2012-09-07 | 2012-12-19 | 东华大学 | Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof |
| CN104611773A (en) * | 2015-01-19 | 2015-05-13 | 上海理工大学 | Eccentric sleeve type parallel spinning head and application thereof |
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