CN106801294A - A kind of nanofiber bank for shipwreck soluble drug and preparation method thereof - Google Patents
A kind of nanofiber bank for shipwreck soluble drug and preparation method thereof Download PDFInfo
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- CN106801294A CN106801294A CN201710108185.1A CN201710108185A CN106801294A CN 106801294 A CN106801294 A CN 106801294A CN 201710108185 A CN201710108185 A CN 201710108185A CN 106801294 A CN106801294 A CN 106801294A
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/28—Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operation; Spinnerette packs therefor
- D01D5/30—Conjugate filaments; Spinnerette packs therefor
- D01D5/34—Core-skin structure; Spinnerette packs therefor
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
Abstract
The invention provides a kind of nanofiber bank for shipwreck soluble drug, including a core bank, the periphery of described core bank is provided with sheath portion, described core bank and described sheath portion coaxially extends, described core bank is made up of the nanocrystal that shipwreck soluble drug is constituted, and described sheath portion is made up of fiber-forming polymeric material.Present invention also offers above-mentioned nanofiber bank preparation method and, the device of above-mentioned preparation method is realized, the nanostructured and component distributing feature of the nanofiber for shipwreck soluble drug of the invention can provide at the uniform velocity Zero order controlled releasing releasing effect for numerous shipwreck soluble drugs.The inventive method preparation process is simple, single step is effective, preparation nanofiber core sheath structure is clear and nanofiber diameter is small, good linearity, diameter are evenly distributed, fiber surface is smooth.
Description
Technical field
The invention belongs to materialogy field, it is related to a kind of structure-activity relationship establishing techniques of novel nano level material, specifically
For be a kind of nanofiber bank for shipwreck soluble drug and preparation method thereof.
Background technology
High-voltage electrostatic spinning technology（Electrospinning）It is a kind of nano-fabrication technique of (top-down) from top to bottom, by additional
Electric field force overcomes the surface tension of liquid and viscoelastic power of shower nozzle tip drop and forms jet, in electrostatic repulsion, Coulomb force and table
Under the tension force collective effect of face, the liquid jet after being atomized is drafted thousand by high frequency flexural, drawing, division within a few tens of milliseconds
Wan Bei, nano-scale fiber is obtained through solvent volatilization or melt cooling in receiving terminal.The technical matters process is simple, manipulation is convenient,
Material ranges are extensive for selection, controllability is strong, be considered as one kind side for most possibly realizing continuous nano-fibre industrialized production
Method, preparing functional nano-fiber using the technology has good prospect.
Electric spinning polymer functional nano-fiber is general with fibre-forming polymer as base material, assigns and receiving by adding active component
Rice fiber function, and make full use of the unique performance of electro spinning nanometer fiber membrane and give full play to the effectiveness of active component.These are only
Special performance includes that fibre diameter is small, fiber surface area is huge, fiber is in three-dimensional netted loose structure, porosity be high, fiber tool
There is the diameter of nanoscale scope but while having length of macro-scope etc..In biomedicine field, typically medicine is added
Polymer solution, used as spinning solution, rapid draing and forming process by common electrospinning obtain medicine equal to form solution altogether
The even medicament-carrying nano-fiber being distributed in whole nanofiber.Most medicament-carrying nano-fibers are all the distributions of such medicaments uniformity
, the nanofiber that structure is single, using polymeric substrate physicochemical property and nano fibrous membrane the characteristics of and required for obtaining
Medicine sustained and controlled release performance.Though have it is a small amount of on being distributed in nanofiber by coaxial electrically spun and electrospinning regulating medicine arranged side by side,
Reported with the research of the core sheath nanofiber or Qiao Nasi nanofibers of medicine controlled releasing performance needed for obtaining, but these core sheaths and
In Qiao Nasi architectural features, medicine is usually still and mixes or be combined with each other with polymeric substrate, so as to obtain the micro- of medicine
See distribution characteristics.
The content of the invention
For above-mentioned technical problem of the prior art, the invention provides a kind of nanofiber for shipwreck soluble drug
Bank and preparation method thereof, described this nanofiber bank for shipwreck soluble drug and preparation method thereof will solve existing
Medicine mixes or is combined with each other with polymeric substrate in nanofiber in technology, so as to influence the technology of slow release effect to ask
Topic.
It is described the invention provides a kind of nanofiber bank for shipwreck soluble drug, including a core bank
The periphery of core bank is provided with sheath portion, and described core bank and described sheath portion coaxially extends, described core bank by
The nanocrystal of shipwreck soluble drug composition is constituted, and described sheath portion is made up of medicinal fiber-forming polymeric material.
Further, described shipwreck soluble drug include the various chemical synthetic drugs or active Chinese drug component for being insoluble in water into
Divide, particularly small-molecule drug, described fiber-forming polymeric material includes the various pharmaceutically acceptable polymer auxiliary materials for medical industry.
Present invention also offers a kind of preparation method of above-mentioned nanofiber bank for shipwreck soluble drug, including such as
Lower step：
1) using can the solution of spinning polymer be made into the sheath portion working fluid of coaxial electrically spun；
2) using the solution of shipwreck soluble drug as operating core fluid；
3) sheath portion working fluid and operating core fluid are respectively charged into sheath portion working fluid syringe and operating core fluid note
In emitter, described sheath portion working fluid syringe is arranged on a sheath portion working fluid syringe pump connection, described core work
Make fluid injector installed in an operating core fluid syringe pump connection；Using a coaxial spinneret, described coaxial spinning
Contain a core capillary and an outer capillary tube in silk head, described core capillary is arranged on described outer layer capillary
The inside of pipe, the outlet of described operating core fluid injector is connected by high elasticity silica sebific duct and described core capillary
Connect, the outlet of described sheath portion working fluid syringe is connected with described outer capillary tube；
4) high pressure generator, described high pressure generator and described coaxial spinneret connection are used
5) control the injection rate of coaxial spinneret SMIS sheath fluid respectively by two syringe pumps, open high pressure generator, and
Adjustment high-voltage value, in the presence of high-pressure electrostatic, with coaxial spinneret exit orifices as template, flat panel collector nanometer is received by fiber
Fiber, prepares the nanofiber bank for shipwreck soluble drug.
Present invention also offers the coaxial electrically spun device for realizing the above method, including a sheath portion working fluid syringe and one
Operating core fluid injector, described sheath portion working fluid syringe is arranged on a sheath portion working fluid syringe pump, institute
The operating core fluid injector stated is arranged on an operating core fluid syringe pump；Also include a coaxial spinneret, institute
The coaxial spinneret stated contains a core capillary and an outer capillary tube, and described core capillary is arranged on described
The inside of outer capillary tube, the port of export of described sheath portion working fluid syringe is straight with the sheath portion capillary of described spinneret
Connect connected, the port of export of described operating core fluid injector connects the core hair of coaxial spinneret by high elasticity silica sebific duct
Tubule；Also include a high pressure generator, described high pressure generator and described coaxial spinneret is directly connected to, described
The lower end at coaxial spinneret exit orifices end is provided with a fiber and receives flat board.
Nanofiber bank for shipwreck soluble drug of the invention, its fiber sheath portion is by polymer into fine base material independence group
Into fiber core is independently made up of the nanocrystal of shipwreck soluble drug, is conducive to the characteristics of this structure and composition are independently distributed
Shipwreck soluble drug is discharged with a kind of controlled manner of uniform constant speed.
The present invention is compared with prior art, and its technological progress is significant.Nanofiber bank of the invention can provide medicine
The release of the uniform constant speed of thing, the nanostructured and component distributing feature of fiber of the invention can be provided for numerous shipwreck soluble drugs
At the uniform velocity Zero order controlled releasing releasing effect.And, the inventive method preparation process is simple, single step is effective, preparation nanometer core sheath structure
Clearly and nanofiber diameter is small, good linearity, diameter are evenly distributed, fiber surface is smooth.
Brief description of the drawings
Fig. 1 is the coaxial electrically spun Product management model observation figure that the present invention is manufactured for the nanofiber bank of shipwreck soluble drug.
Fig. 2 is used coaxial electrically spun process unit schematic diagram by the present invention.
Fig. 3 is scanning electron microscope diagram of the present invention for the nanofiber bank of shipwreck soluble drug.
Fig. 4 is transmission electron microscope figure of the present invention for the nanofiber bank of shipwreck soluble drug.
Fig. 5 is structural representation of the present invention for the nanofiber bank of shipwreck soluble drug
Fig. 6 is X-ray crystallogram of the present invention for the nanofiber bank of shipwreck soluble drug.
Fig. 7 is medicament ferulic acid Zero order controlled releasing figure of the present invention for the nanofiber bank of shipwreck soluble drug.
Fig. 8 be the present invention for shipwreck soluble drug nanofiber bank insoluble drug release it is complete after transmission electron microscope
Figure.
Specific embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.These embodiments be only used for explain the present invention and
It is not intended to the limitation present invention.All uses and same or analogous method of the invention, or the equivalent modifications made, all should fall into this
Invention protection domain.
Embodiment 1：The implementation of coaxial electrically spun technique
12 grams of vinyl acetate celluloses are put into 100 grams by acetone and N,N-dimethylformamide in mass ratio 3:1 composition it is mixed
In bonding solvent, the outer sheath fluid with favorable spinning quality is made into.20 grams of forulic acids are put into 100 grams by acetone and ethanol by quality
Than 1:In the mixed solvent of 1 composition, clear solution is stirred into, as core liquid.Above-mentioned sheath fluid and core liquid are loaded into coaxial electrical
In the corresponding syringe of spinning system, quantitatively it is transported in coaxial spinneret by syringe pump, connects spinneret and high-pressure electrostatic hair
Raw device.Implement coaxial high pressure electrostatic spinning process according to following technological parameter：Sheath core fluid flow is 2.0/1.0 mL/
H, receiver board is 15 cm, the kV of voltage 15 with a distance from spinning nozzle.Environment temperature is (23 ± 3) DEG C, and ambient humidity is 56 ± 5
%.In the above operating condition, bust shot in situ, electro-spinning process are carried out to coaxial electrically spun process as shown in figure 1, being spun from coaxial
The silk head compound taylor cone that out a core sheath fluid is collectively forming, the top of cone sends a straight jet, straight jet
Here is the unstable region of high frequency stretching.The prepared nanofiber for shipwreck soluble drug is by an aluminium foil for ground connection
Parcel cardboard collector is collected.
The device of the above method is realized as shown in Fig. 2 being specifically described as follows：
Including a sheath portion working fluid syringe 4 and an operating core fluid injector 5, described sheath portion working fluid note
Emitter 4 is arranged on a sheath portion working fluid syringe pump 2, and described operating core fluid injector 5 is arranged on a core
On working fluid syringe pump 3；Also include a coaxial spinneret 7, described coaxial spinneret 7 containing a core capillary with
One outer capillary tube, described core capillary is arranged on the inside of described outer capillary tube, described sheath portion workflow
The port of export of body syringe 4 is joined directly together with the sheath portion capillary of described spinneret 7, described operating core fluid injector
5 port of export connects the core capillary of coaxial spinneret 7 by high elasticity silica sebific duct 8.
Also include a high pressure generator 1, described high pressure generator 1 and described coaxial spinneret 7 is directly connected to,
The lower end of the described port of export of coaxial spinneret 7 is provided with a fiber and receives flat board 6.
Embodiment 2：Pattern, structure and composition state representation analysis for the nanofiber of shipwreck soluble drug
Using field emission scanning electron microscope（FESEM）The prepared nanofiber bank for shipwreck soluble drug of embodiment 1 is carried out
Observed after the metal spraying of surface, as a result as shown in Figure 3.Prepared fiber bank is presented good linear condition, no bead structure
Produce, fiber surface is smooth, fiber accumulations are uniform.A diameter of 640 ± 130 nm, than more uniform, diameter distribution is compared for distribution
Concentrate.
Using high resolution transmission electron microscopy（TEM）Inside the prepared nanofiber bank for shipwreck soluble drug
Structure is observed, and as a result as shown in figure 4, the core sheath structure of nanofiber bank is clear, wherein inner core bank is because contain medicine
Thing crystallite, therefore the gray feature of darker is presented.The structure of specific nanofiber bank is as shown in figure 5, the core of core sheath structure
Portion's bank is the nano microcrystalline 22 of shipwreck soluble drug, and sheath portion is the outer wall 11 that pharmaceutically acceptable polymer auxiliary material is constituted.
Using wide-angle X-ray crystal diffraction instrument to the prepared nanofiber bank for shipwreck soluble drug, polymer matrix
Material vinyl acetate cellulose and forulic acid material medicine crystal powder are analyzed, as a result as shown in fig. 6, polymer acetic acid second
Alkene cellulose is presented two humps, illustrates that the polymeric substrate is a kind of unformed shape material.The bulk drug of insoluble medicine forulic acid
There are a large amount of sharp bragg peaks to occur in thing powder diffraction pattern, illustrate that forulic acid material medicine exists with crystal form.And water
The X-ray crystal diffraction pattern of the nanocrystal bank of insoluble medicine is said two devices " with reference to ", the camel of existing polymer
Peak, the sharp bragg peak for also having medicine illustrates the medicament ferulic acid for appearing in core sheath nanofiber core with medicine crystallite
Form is present.
Embodiment 3：For the slow controlled release properties of forulic acid that the nanofiber of shipwreck soluble drug is provided
By D drug release determinations the second method slurry processes of 2015 editions annex of Chinese Pharmacopoeia Ⅹ, using RCZ-8A intelligence dissolution experiment instruments to upper
The fibrous type medicament nano crystal bank for stating gained carries out In Vitro Dissolution experiment.Rotating speed is controlled for 50rpm, temperature is 37 ± 0.1
DEG C, dissolution medium investigates the nanofiber crystal of forulic acid with this understanding from the pH7.0 PBSs of 900mL
The vitro Drug controlled release properties of bank.5mL is sampled on schedule, dissolution fluid sample is obtained, and supplements same volume isothermal at once
Fresh medium.After to the appropriate dilution of sample, in λmax At=322 nm, ultraviolet survey is carried out using ultraviolet-uisible spectrophotometer
It is fixed, medicament ferulic acid accumulation dissolution percentage is calculated, it is repeated 6 times.Result is as shown in fig. 7, it can be seen that nanofiber
Bank can effectively eliminate the Initial burst effect of medicament ferulic acid, keep medicine with constant rate uniform discharge 16 hours with
On.Transmission electron microscope observing is carried out to the fiber bank after nanocrystalline drug release completely, as a result as shown in figure 8, fiber bank
Hollow state is presented, illustrates that nanofiber bank controls the slow dispersal events of medicine by the sheath wall of bank, obtain zero level at the uniform velocity
Releasing effect, and bank sheath wall keeps constant in itself.By this zero-order drug controlled release of Nanowire d type medicine crystal bank
Mode, caused by being expected to overcome patient's initial stage blood concentration too high toxic and side effect so as to strengthen drug safety, while by
The slow uniform release of long period can be kept in medicine, it is to avoid blood concentration is too low and loses therapeutic effect, it is to avoid patient
Frequent drug administration, by increasing capacitance it is possible to increase the tolerance and convenience of patient.
Embodiment 4：
According to the spinning solution concocting method and implementing process condition of embodiment 1, medicament ferulic acid is replaced with Ketoprofen, prepare nanometer
Fiber, carries out vitro Drug dissolution experiment, in λ according to embodiment 3 maxMedicine in In Vitro Dissolution sample is contained at=257 nm
Amount is measured, and with the nanocrystal bank of detection fibers type Ketoprofen to the controlled release properties of medicine, as a result shows, medicine ketone Lip river
Sweet smell is presented obvious Zero order controlled releasing feature, is discharged 20 hours with the speed of homogeneous constant.
Claims (5)
1. a kind of nanofiber bank for shipwreck soluble drug, it is characterised in that:Including a core bank, described core
The periphery of bank is provided with sheath portion, and described core bank and described sheath portion coaxially extends, and described core bank is by shipwreck
The nanocrystal of soluble drug composition is constituted, and described sheath portion is made up of fiber-forming polymeric material.
2. a kind of nanofiber bank for shipwreck soluble drug according to claim 1, it is characterised in that：Described water
Insoluble medicine includes the various chemical synthesis small-molecule drugs or active ingredient of Chinese herbs for being insoluble in water, described fibre-forming polymer
Material includes the various pharmaceutically acceptable polymer auxiliary materials for medical industry.
3. a kind of preparation method of the nanofiber bank for shipwreck soluble drug described in claim 1, it is characterised in that bag
Include following steps：
1）Using can the solution of spinning polymer be made into the sheath portion working fluid of coaxial electrically spun；
2）Using the solution of shipwreck soluble drug as operating core fluid；
3）Sheath portion working fluid and operating core fluid are respectively charged into sheath portion working fluid syringe and operating core fluid note
In emitter, described sheath portion working fluid syringe is arranged on a sheath portion working fluid syringe pump, described operating core
Fluid injector is arranged on an operating core fluid syringe pump；Using a coaxial spinneret, described coaxial spinneret
In contain a core capillary and an outer capillary tube, described core capillary is arranged on described outer capillary tube
Inside, the outlet of described operating core fluid injector is connected with described core capillary, described sheath portion working fluid
The port of export of syringe and described outer capillary tube are directly connected to；
4）Using a high pressure generator, described high pressure generator and described coaxial spinneret is connected；
5）Control the injection rate of coaxial spinneret SMIS sheath fluid respectively by two syringe pumps, open high pressure generator, and
Adjustment high-voltage value, in the presence of high-pressure electrostatic, with coaxial spinneret exit orifices as template, flat panel collector nanometer is received by fiber
Fiber, prepares the nanofiber for shipwreck soluble drug.
4. the coaxial electrically spun device of claim 2 methods described is realized, it is characterised in that：Including a sheath portion working fluid injection
Device and an operating core fluid injector, described sheath portion working fluid syringe are arranged on a sheath portion working fluid injection
On pump, described operating core fluid injector is arranged on an operating core fluid syringe pump；Also include a coaxial spinning
Silk head, described coaxial spinneret contains a core capillary and an outer capillary tube, and described core capillary is set
In the inside of described outer capillary tube, the port of export of described sheath portion working fluid syringe and the sheath portion of described spinneret
Capillary is joined directly together, and the port of export of described operating core fluid injector connects coaxial spinneret by high elasticity silica sebific duct
Core capillary；Also include a high pressure generator, described high pressure generator and described coaxial spinneret is directly connected to,
The lower end at described coaxial spinneret exit orifices end is provided with a fiber and receives flat board.
5. the coaxial electrically spun device of method according to claim 3, it is characterised in that：Described core fluid injector outlet
It is connected with the core capillary in coaxial spinneret by high resiliency silica gel hose.
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| CN201710108185.1A CN106801294A (en) | 2017-02-27 | 2017-02-27 | A kind of nanofiber bank for shipwreck soluble drug and preparation method thereof |
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| CN201710108185.1A CN106801294A (en) | 2017-02-27 | 2017-02-27 | A kind of nanofiber bank for shipwreck soluble drug and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113897691A (en) * | 2021-11-16 | 2022-01-07 | 上海理工大学 | Preparation method of bead nanofiber with composite structure |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101328624A (en) * | 2008-07-25 | 2008-12-24 | 东华大学 | Method for preparing superfine antibiotic nanofiber by coaxial electrostatic spinning method |
| CN101396337A (en) * | 2008-10-24 | 2009-04-01 | 东华大学 | Paclitaxel loaded sustained release nano fiber and preparation method and use thereof |
| CN101736419A (en) * | 2009-12-07 | 2010-06-16 | 东华大学 | Method for preparing core sheath structure fiber by using electrospun coaxial spinning head |
| JP2010236133A (en) * | 2009-03-31 | 2010-10-21 | National Institute Of Advanced Industrial Science & Technology | Apparatus for producing nanofiber by electrospinning method using double-pipe nozzle and nanofiber production method |
| US20110264235A1 (en) * | 2010-04-21 | 2011-10-27 | Taipei Medical University | Electrostatic-assisted fiber spinning method and production of highly aligned and packed hollow fiber assembly and membrane |
| CN103966680A (en) * | 2014-05-04 | 2014-08-06 | 东华大学 | Method for preparing drug sustained release nanofibers |
| CN106087107A (en) * | 2016-05-28 | 2016-11-09 | 安徽广信农化股份有限公司 | There is the preparation method of the Fluoxastrobin nanofiber of core shell structure |
| CN106381532A (en) * | 2016-11-21 | 2017-02-08 | 上海理工大学 | Electric spinning preparation method of nanometer fiber with material gradient distribution features |
-
2017
- 2017-02-27 CN CN201710108185.1A patent/CN106801294A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101328624A (en) * | 2008-07-25 | 2008-12-24 | 东华大学 | Method for preparing superfine antibiotic nanofiber by coaxial electrostatic spinning method |
| CN101396337A (en) * | 2008-10-24 | 2009-04-01 | 东华大学 | Paclitaxel loaded sustained release nano fiber and preparation method and use thereof |
| JP2010236133A (en) * | 2009-03-31 | 2010-10-21 | National Institute Of Advanced Industrial Science & Technology | Apparatus for producing nanofiber by electrospinning method using double-pipe nozzle and nanofiber production method |
| CN101736419A (en) * | 2009-12-07 | 2010-06-16 | 东华大学 | Method for preparing core sheath structure fiber by using electrospun coaxial spinning head |
| US20110264235A1 (en) * | 2010-04-21 | 2011-10-27 | Taipei Medical University | Electrostatic-assisted fiber spinning method and production of highly aligned and packed hollow fiber assembly and membrane |
| CN103966680A (en) * | 2014-05-04 | 2014-08-06 | 东华大学 | Method for preparing drug sustained release nanofibers |
| CN106087107A (en) * | 2016-05-28 | 2016-11-09 | 安徽广信农化股份有限公司 | There is the preparation method of the Fluoxastrobin nanofiber of core shell structure |
| CN106381532A (en) * | 2016-11-21 | 2017-02-08 | 上海理工大学 | Electric spinning preparation method of nanometer fiber with material gradient distribution features |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113897691A (en) * | 2021-11-16 | 2022-01-07 | 上海理工大学 | Preparation method of bead nanofiber with composite structure |
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Application publication date: 20170606 |