CN106929928A - One kind has drug material radial direction contrary distribution feature nanofiber and preparation method - Google Patents
One kind has drug material radial direction contrary distribution feature nanofiber and preparation method Download PDFInfo
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- CN106929928A CN106929928A CN201710107651.4A CN201710107651A CN106929928A CN 106929928 A CN106929928 A CN 106929928A CN 201710107651 A CN201710107651 A CN 201710107651A CN 106929928 A CN106929928 A CN 106929928A
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- working fluid
- sheath portion
- core
- inner core
- coaxial
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Classifications
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/28—Formation of filaments, threads, or the like while mixing different spinning solutions or melts during the spinning operation; Spinnerette packs therefor
- D01D5/30—Conjugate filaments; Spinnerette packs therefor
- D01D5/34—Core-skin structure; Spinnerette packs therefor
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/02—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from cellulose, cellulose derivatives, or proteins
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Nanotechnology (AREA)
- Textile Engineering (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
Abstract
The invention provides a kind of nanofiber with drug material radial direction contrary distribution feature, including an inner core, the periphery of described inner core is provided with outer sheath portion, described inner core and described outer sheath portion coaxially extends, contain medicine and polymeric material in described inner core and described outer sheath portion, along the diametric(al) of fiber from outside to inside in being incremented by distribution, the concentration of described polymeric material tapers off distribution the concentration of described medicine from outside to inside along the diametric(al) of fiber.The architectural feature of the drug material radial direction contrary distribution in nanofiber of the present invention can be that the design of the slow controlled-release material of numerous newtype drugs and preparation provide effective.The winged preparation process is simple of the present invention, single step is effective, preparation nanofiber core sheath structure is clear and nanometer diameter is small, good linearity, diameter are evenly distributed, fiber surface is smooth.
Description
Technical field
The invention belongs to materialogy field, it is related to a kind of establishing techniques of the structure-activity relationship of novel nano level material, has
It is that one kind has drug material radial direction contrary distribution feature nanofiber and preparation method for body.
Background technology
High-voltage electrostatic spinning technology（Electrospinning）It is a kind of nano-fabrication technique of (top-down) from top to bottom, by additional
Electric field force overcomes the surface tension of liquid and viscoelastic power of shower nozzle tip drop and forms jet, in electrostatic repulsion, Coulomb force and table
Under the tension force collective effect of face, the liquid jet after being atomized is drafted thousand by high frequency flexural, drawing, division within a few tens of milliseconds
Wan Bei, nano-scale fiber is obtained through solvent volatilization or melt cooling in receiving terminal.The technical matters process is simple, manipulation is convenient,
Material ranges are extensive for selection, controllability is strong, be considered as one kind side for most possibly realizing continuous nano-fibre industrialized production
Method, preparing functional nano-fiber using the technology has good prospect.
Electric spinning polymer functional nano-fiber is general with fibre-forming polymer as base material, assigns and receiving by adding active component
Rice fiber function, and make full use of the special performance of electro spinning nanometer fiber membrane and give full play to the effectiveness of active component.These are only
Special performance includes that fibre diameter is small, fiber surface area is huge, fiber is in three-dimensional netted loose structure, porosity be high, fiber tool
There is the diameter of nanoscale scope but while having length of macro-scope etc..In biomedicine field, typically medicine is added
Polymer solution, forms solution altogether and, as spinning solution, by the rapid draing and shaping of common electro-spinning process, obtains medicine equal
The even medicament-carrying nano-fiber for being distributed in whole nanofiber.Most medicament-carrying nano-fibers are all the distributions of such medicaments uniformity
, the nanofiber that structure is single, required for obtaining the characteristics of by the physicochemical property and nano fibrous membrane of polymeric substrate
Medicine sustained and controlled release performance.Though have pass through the distribution of coaxial electrically spun and electrospinning regulating medicine arranged side by side in nanofiber on a small quantity, with
The electrospinning core sheath nanofiber and Qiao Nasi nanofibers of medicine controlled releasing performance needed for obtaining, but on regulating and controlling fiber simultaneously
The report of the medicine of each part and the composition of polymer and composition is little in structure, structural fibers.
The content of the invention
For above-mentioned technical problem of the prior art, there is drug material radial direction contrary distribution the invention provides one kind
Feature nanofiber and preparation method, described is this with drug material radial direction contrary distribution feature nanofiber and preparation side
Method will solve the technical problem of nanometer fiber slow-releasing effect on driving birds is not good of the prior art.
The invention provides a kind of nanofiber with drug material radial direction contrary distribution feature, including an inner core
Portion, the periphery of described inner core is provided with outer sheath portion, and described inner core and described outer sheath portion coaxially extends, and described is interior
Contain medicine and polymeric material in core and described outer sheath portion, the concentration of described medicine along fiber diametric(al)
From outside to inside in distribution is incremented by, the concentration of described polymeric material presents deduction from outside to inside along the diametric(al) of fiber
Cloth.
Further, described polymeric material is the insoluble type pharmaceutically acceptable polymer auxiliary material of water.
Present invention also offers a kind of preparation of above-mentioned nanofiber with drug material radial direction contrary distribution feature
Method, comprises the following steps：
1) using can the solution of spinning polymer be made into the outer sheath portion working fluid and inner core working fluid of coaxial electrically spun, it is described
In outer sheath portion working fluid can spinning polymer solution concentration more than in inner core working fluid can spinning polymer solution
Concentration；
2) medicine, described outer sheath portion working fluid are added with described outer sheath portion working fluid and inner core working fluid
In medicine concentration of the concentration less than medicine in inner core working fluid；
3) by step 2）Outer sheath portion working fluid and inner core working fluid be respectively charged into outer sheath portion working fluid syringe and
In inner core working fluid syringe, sheath portion working fluid and operating core fluid are respectively charged into sheath portion working fluid syringe
In operating core fluid injector, described sheath portion working fluid syringe is arranged on a sheath portion working fluid syringe pump
On, described operating core fluid injector is arranged on an operating core fluid syringe pump；Using a coaxial spinneret,
Contain a core capillary and an outer capillary tube in described coaxial spinneret, described core capillary is arranged on institute
The inside of the outer capillary tube stated, the outlet of described operating core fluid injector is connected with described core capillary, institute
The port of export and described outer capillary tube of the sheath portion working fluid syringe stated are directly connected to；
4) high pressure generator, described high pressure generator and described coaxial spinneret connection are used
5) control the injection rate of coaxial spinneret SMIS sheath fluid respectively by two syringe pumps, open high pressure generator, and
Adjustment high-voltage value, in the presence of high-pressure electrostatic, with coaxial spinneret exit orifices as template, flat panel collector nanometer is received by fiber
Fiber, prepares the nanofiber with drug material radial direction contrary distribution feature.
Present invention also offers the coaxial electrically spun device for realizing the above method, including a sheath portion working fluid syringe and
One operating core fluid injector, described sheath portion working fluid syringe is arranged on a sheath portion working fluid syringe pump
On, described operating core fluid injector is arranged on an operating core fluid syringe pump；Also include a coaxial spinning
Head, described coaxial spinneret contains a core capillary and an outer capillary tube, and described core capillary is arranged on
The inside of described outer capillary tube, the port of export of described sheath portion working fluid syringe and the sheath portion hair of described spinneret
Tubule is joined directly together, and the port of export of described operating core fluid injector connects coaxial spinneret by high elasticity silica sebific duct
Core capillary；Also include a high pressure generator, described high pressure generator and described coaxial spinneret is directly connected to,
The lower end at described coaxial spinneret exit orifices end is provided with a fiber and receives flat board.
The core sheath structure nanofiber for radially carrying out contrary distribution by fiber with medicine and carrier material of the invention, it is fine
Dimension is internal from shell to inner core, and medicine is presented and is incremented by distribution, and polymeric substrate tapers off distribution, and this characteristic distributions are conducive to
Medicine is discharged with a kind of controlled manner of uniform constant speed.The architectural feature of the drug material radial direction contrary distribution can be numerous new
The design of slow controlled-release material and preparation of type medicine provide effective.
The present invention is compared with prior art, and its technological progress is significant.Present invention firstly provides a kind of electrospinning core sheath
Medicine and carrier material and go to realize this according to the concept of radial direction contrary distribution by conventional coaxial electrospinning processes in nanofiber
The preparation of core sheath nanofiber is planted, to provide the Zero order controlled releasing performance of medicine.And preparation process is simple of the invention, single step has
Effect, the nanometer core sheath clear in structure for preparing and nanometer diameter is small, good linearity, diameter are evenly distributed, fiber surface is smooth.
Brief description of the drawings
Fig. 1 is the coaxial electrically spun technical process amplifying observation figure that the present invention is used.
Fig. 2 is coaxial electrically spun schematic device used in the present invention.
Fig. 3 is the scanning electron microscope diagram with drug material radial direction contrary distribution feature nanofiber of the invention.
Fig. 4 is the transmission electron microscope figure with drug material radial direction contrary distribution feature nanofiber of the invention.
Fig. 5 is the structural representation with drug material radial direction contrary distribution feature nanofiber of the invention
The medicine Zero order controlled releasing figure that Fig. 6 is provided by nanofiber of the invention.
Specific embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.These embodiments be only used for explain the present invention and
It is not intended to the limitation present invention.All uses and same or analogous method of the invention, or the equivalent modifications made, all should fall into this
Invention protection domain.
Embodiment 1：The implementation of coaxial electrically spun technique
12 grams of vinyl acetate celluloses and 1 gram of brufen are put into 100 grams by acetone and N,N-dimethylformamide in mass ratio
3:In the mixed solvent of 1 composition, outer sheath portion working fluid is configured to.6 grams of vinyl acetate celluloses and 3 grams of brufens are put into
100 grams by acetone and N,N-dimethylformamide in mass ratio 3:In the mixed solvent of 1 composition, inner core workflow is configured to
Body.Above-mentioned outer sheath portion and inner core working fluid are respectively charged into the corresponding syringe of coaxial electrically spun system, by syringe pump
Quantitatively it is transported in coaxial spinneret, connects spinneret and HV generator.Implement same according to following technological parameter
Axle high-voltage electrostatic spinning technique：Sheath core fluid flow is 1.0/1.0 mL/h, and receiver board is 20 cm, electricity with a distance from spinning nozzle
Press 15 kV.Environment temperature is (22 ± 3) DEG C, and ambient humidity is 59 ± 5 %.In the above operating condition, to coaxial electrically spun mistake
Cheng Jinhang original positions bust shot, electro-spinning process are as shown in figure 1, from coaxial spinneret out answering of being collectively forming of core sheath fluid
Taylor cone is closed, the top of cone sends a straight jet, be the unstable region of high frequency stretching below straight jet.It is prepared
Drug material radial direction contrary distribution feature nanofiber by one ground connection aluminium foil wrap up cardboard collector be collected.
The device of the above method is realized as shown in Fig. 2 being specifically described as follows：
Including a sheath portion working fluid syringe 4 and an operating core fluid injector 5, described sheath portion working fluid note
Emitter 4 is arranged on a sheath portion working fluid syringe pump 2, and described operating core fluid injector 5 is arranged on a core
On working fluid syringe pump 3；Also include a coaxial spinneret 7, described coaxial spinneret 7 containing a core capillary with
One outer capillary tube, described core capillary is arranged on the inside of described outer capillary tube, described sheath portion workflow
The port of export of body syringe 4 is joined directly together with the sheath portion capillary of described spinneret 7, described operating core fluid injector
5 port of export connects the core capillary of coaxial spinneret 7 by high elasticity silica sebific duct 8.
Also include a high pressure generator 1, described high pressure generator 1 and described coaxial spinneret 7 is directly connected to,
The lower end of the described port of export of coaxial spinneret 7 is provided with a fiber and receives flat board 6.
Embodiment 2：Phenetic analysis with drug material radial direction contrary distribution feature nanofiber pattern Yu structure
Using field emission scanning electron microscope（FESEM）Observed after surface metal spraying is carried out to fiber prepared by embodiment 1, as a result such as Fig. 3
It is shown.Prepared fiber is presented good linear condition, do not have that bead structure, fiber surface be smooth, fiber accumulations are equal
It is even.A diameter of 670 ± 110 nm, than more uniform, concentration is compared in diameter distribution for distribution.
Using high resolution transmission electron microscopy（TEM）Prepared fibrous inner structure is observed, as a result such as Fig. 4 institutes
Show, the core sheath structure of nanofiber is clear, wherein inner core is because medicament contg is more and thickness is big, so the larger ash of presentation
Angle value.Specific structural features with drug material radial direction contrary distribution feature nanofiber are as shown in figure 5, epitheca 11 is by a large amount of
Polymer 33 and a small amount of medicine 44 are constituted, and inner core 22 is made up of a small amount of polymer 33 and high amount of drug 44.
Embodiment 3：With the slow controlled release properties of brufen that drug material radial direction contrary distribution feature nanofiber is provided
By D drug release determinations the second method slurry processes of 2015 editions annex of Chinese Pharmacopoeia Ⅹ, using RCZ-8A intelligence dissolution experiment instruments to upper
The medicament-carrying nano-fiber for stating gained carries out In Vitro Dissolution experiment.Rotating speed is controlled for 50rpm, temperature is 37 ± 0.1 DEG C, dissolution medium
From the pH7.0 PBSs of 900mL, receiving with drug material radial direction contrary distribution feature is investigated with this understanding
Rice fiber vitro Drug controlled release properties.5mL is sampled on schedule, dissolution fluid sample is obtained, and supplements same volume isothermal at once
Fresh medium.After to the appropriate dilution of sample, in λmax At=264 nm, ultraviolet determination is carried out using ultraviolet-uisible spectrophotometer,
Medicine ibuprofen accumulation dissolution percentage is calculated, is repeated 6 times.Result is as shown in fig. 6, it can be seen that due to medicine material
Material radial direction contrary distribution feature, therefore fiber can effectively eliminate the Initial burst effect of medicine, and medicine is kept with constant
Rate uniform discharges more than 16 hours.This zero-order drug controlled release side obtained by drug material radial direction contrary distribution feature
Formula, caused by being expected to overcome patient's initial stage blood concentration too high toxic and side effect so as to strengthen drug safety, simultaneously because
Medicine can keep the slow uniform release of long period, it is to avoid blood concentration is too low and loses therapeutic effect, it is to avoid patient's
Frequent drug administration, by increasing capacitance it is possible to increase the tolerance and convenience of patient.
Embodiment 4：With the C14H10Cl2NNaO2 controlled release properties that drug material radial direction contrary distribution feature nanofiber is provided
According to the spinning solution concocting method and implementing process condition of embodiment 1, preparing C14H10Cl2NNaO2 has drug material radially
The nanofiber of contrary distribution feature, carries out vitro Drug dissolution experiment, in sample at the nm of λ=276 according to embodiment 3
The content of medicine is measured, and with detection fibers to the controlled release properties of medicine, as a result shows, medicine C14H10Cl2NNaO2 presents obvious
Zero order controlled releasing feature, discharged more than 15 hours with the speed of homogeneous constant.
Claims (5)
1. a kind of nanofiber with drug material radial direction contrary distribution feature, it is characterised in that:Including an inner core, institute
The periphery of the inner core stated is provided with outer sheath portion, and described inner core and described outer sheath portion coaxially extends, described inner core
With contain medicine and polymeric material in described outer sheath portion, the concentration of described medicine is along the diametric(al) of fiber from outer
To interior in incremental distribution, the concentration of described polymeric material tapers off distribution from outside to inside along the diametric(al) of fiber.
2. a kind of nanofiber with drug material radial direction contrary distribution feature according to claim 1, its feature exists
In：Described polymeric material is the insoluble type pharmaceutically acceptable polymer auxiliary material of water.
3. the preparation method of a kind of nanofiber with drug material radial direction contrary distribution feature described in claim 1, its
It is characterised by comprising the following steps：
1）Using can the solution of spinning polymer be made into the outer sheath portion working fluid and inner core working fluid of coaxial electrically spun, it is described
In outer sheath portion working fluid can spinning polymer solution concentration more than in inner core working fluid can spinning polymer solution
Concentration；
2）Medicine, described outer sheath portion working fluid are added with described outer sheath portion working fluid and inner core working fluid
In medicine concentration of the concentration less than medicine in inner core working fluid；
3）By step 2）Outer sheath portion working fluid and inner core working fluid be respectively charged into outer sheath portion working fluid syringe and
In inner core working fluid syringe, sheath portion working fluid and operating core fluid are respectively charged into sheath portion working fluid syringe
In operating core fluid injector, described sheath portion working fluid syringe is arranged on a sheath portion working fluid syringe pump
On, described operating core fluid injector is arranged on an operating core fluid syringe pump；Using a coaxial spinneret,
Contain a core capillary and an outer capillary tube in described coaxial spinneret, described core capillary is arranged on institute
The inside of the outer capillary tube stated, the outlet of described operating core fluid injector is connected with described core capillary, institute
The port of export and described outer capillary tube of the sheath portion working fluid syringe stated are directly connected to；
4）Using a high pressure generator, described high pressure generator and described coaxial spinneret is connected；
5）Control the injection rate of coaxial spinneret SMIS sheath fluid respectively by two syringe pumps, open high pressure generator, and
Adjustment high-voltage value, in the presence of high-pressure electrostatic, with coaxial spinneret exit orifices as template, flat panel collector nanometer is received by fiber
Fiber, prepares the nanofiber with drug material radial direction contrary distribution feature.
4. the coaxial electrically spun device of claim 2 methods described is realized, it is characterised in that：Including a sheath portion working fluid injection
Device and an operating core fluid injector, described sheath portion working fluid syringe are arranged on a sheath portion working fluid injection
On pump, described operating core fluid injector is arranged on an operating core fluid syringe pump；Also include a coaxial spinning
Silk head, described coaxial spinneret contains a core capillary and an outer capillary tube, and described core capillary is set
In the inside of described outer capillary tube, the port of export of described sheath portion working fluid syringe and the sheath portion of described spinneret
Capillary is joined directly together, and the port of export of described operating core fluid injector connects coaxial spinneret by high elasticity silica sebific duct
Core capillary；Also include a high pressure generator, described high pressure generator and described coaxial spinneret is directly connected to,
The lower end at described coaxial spinneret exit orifices end is provided with a fiber and receives flat board.
5. the coaxial electrically spun device of method according to claim 4, it is characterised in that：Described inner core fluid injector leads to
Too high elastic silica gel flexible pipe is connected with the core capillary in coaxial spinneret.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710107651.4A CN106929928A (en) | 2017-02-27 | 2017-02-27 | One kind has drug material radial direction contrary distribution feature nanofiber and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710107651.4A CN106929928A (en) | 2017-02-27 | 2017-02-27 | One kind has drug material radial direction contrary distribution feature nanofiber and preparation method |
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| CN106929928A true CN106929928A (en) | 2017-07-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710107651.4A Pending CN106929928A (en) | 2017-02-27 | 2017-02-27 | One kind has drug material radial direction contrary distribution feature nanofiber and preparation method |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103173871A (en) * | 2011-12-22 | 2013-06-26 | 中国科学院大连化学物理研究所 | Method for producing nano electrospining with concentration gradient based on microfluidics technology |
| CN106381532A (en) * | 2016-11-21 | 2017-02-08 | 上海理工大学 | Electric spinning preparation method of nanometer fiber with material gradient distribution features |
-
2017
- 2017-02-27 CN CN201710107651.4A patent/CN106929928A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103173871A (en) * | 2011-12-22 | 2013-06-26 | 中国科学院大连化学物理研究所 | Method for producing nano electrospining with concentration gradient based on microfluidics technology |
| CN106381532A (en) * | 2016-11-21 | 2017-02-08 | 上海理工大学 | Electric spinning preparation method of nanometer fiber with material gradient distribution features |
Non-Patent Citations (1)
| Title |
|---|
| 张济忠等: "《现代薄膜技术》", 1 March 2009, 冶金工业出版社 * |
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Application publication date: 20170707 |