CN106860432A - It is a kind of to rush nanofiber of release function and preparation method thereof with medicine secondary vein - Google Patents
It is a kind of to rush nanofiber of release function and preparation method thereof with medicine secondary vein Download PDFInfo
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- CN106860432A CN106860432A CN201710035464.XA CN201710035464A CN106860432A CN 106860432 A CN106860432 A CN 106860432A CN 201710035464 A CN201710035464 A CN 201710035464A CN 106860432 A CN106860432 A CN 106860432A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/04—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers
- D01F8/10—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from synthetic polymers with at least one other macromolecular compound obtained by reactions only involving carbon-to-carbon unsaturated bonds as constituent
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- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Textile Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Medicinal Preparation (AREA)
Abstract
A kind of nanofiber that release function is rushed with medicine secondary vein, including an inner core and an outer sheath portion, outer sheath portion wraps up inner core, inner core and outer sheath portion extend along its length, inner core is made up of medicine and polymer pharmaceutic adjuvant, and outer sheath portion is made up of medicine and pharmaceutic adjuvant soluble in water.The preparation method of above-mentioned nanofiber is additionally provided, polymer pharmaceutic adjuvant and the modification of drug of inner core into solution altogether will be used for, as the working fluid of inner core；Pharmaceutic adjuvant soluble in water and the modification of drug of outer sheath portion into solution altogether will be used for, as the working fluid of outer sheath portion；Control core sheath solution to inject the speed of coaxial spinneret respectively by two syringe pumps, open high pressure generator, in the presence of high-pressure electrostatic, prepare nanofibers.The present invention, using the polymeric substrate of different solubility properties, under the support of structure, can be regulated and controled contained medicine and be discharged by the secondary vein mode of rushing by the outer sheath portion of nanofiber and inner core.
Description
Technical field
The invention belongs to materialogy field, it is related to a kind of medicine sustained and controlled release nano material, it is specifically a kind of that there is medicine
Thing secondary vein rushes nanofiber of release function and preparation method thereof.
Background technology
High-voltage electrostatic spinning technology（Electrospinning）It is a kind of nano-fabrication technique of (top-down) from top to bottom, by additional
Electric field force overcomes the surface tension of liquid and viscoelastic power of shower nozzle tip drop and forms jet, in electrostatic repulsion, Coulomb force and table
Under the tension force collective effect of face, the liquid jet after being atomized is drafted thousand by high frequency flexural, drawing, division within a few tens of milliseconds
Wan Bei, nano-scale fiber is obtained through solvent volatilization or melt cooling in receiving terminal.The technical matters process is simple, manipulation is convenient,
Material ranges are extensive for selection, controllability is strong, be considered as one kind side for most possibly realizing continuous nano-fibre industrialized production
Method, preparing functional nano-fiber using the technology has good prospect.
Electric spinning polymer functional nano-fiber is general with fibre-forming polymer as base material, assigns and receiving by adding active component
Rice fiber function, and make full use of the special performance of electro spinning nanometer fiber membrane and give full play to the effectiveness of active component.These are only
Special performance includes that fibre diameter is small, fiber surface area is huge, fiber is in three-dimensional netted loose structure, porosity be high, fiber tool
There is the diameter of nanoscale scope but while having length of macro-scope etc..In biomedicine field, typically medicine is added
Polymer solution, forms solution altogether and, as spinning solution, by the rapid draing and shaping of common electro-spinning process, obtains medicine equal
The even medicament-carrying nano-fiber for being distributed in whole nanofiber.Most medicament-carrying nano-fibers are all the distributions of such medicaments uniformity
, the nanofiber that structure is single, required for obtaining the characteristics of by the physicochemical property and nano fibrous membrane of polymeric substrate
Medicine sustained and controlled release performance.
With the development of electrospinning, people are gradually recognized in all of " top-down " nano-fabrication technique, electricity
The most advantageous feature of spinning technique can be by the design of macro-level spinning header structure, and single step is effectively prepared with corresponding micro-
The nanofiber of architectural feature is seen, core sheath structure nanofiber is such as prepared by inside and outside two-layer sleeve structure spinneret（DG Yu,
LM Zhu, C Branford-White, JH Yang, X Wang, Y Li, W Qian. Solid dispersions in
the form of electrospun core-sheath nanofibers. International Journal of
Nanomedicine, 2011,6: 3271-3280.）, by two capillaries side by side be spinneret prepare parallel construction nanometer
Fiber（Jalani G, Jung CW, Lee JS, Lim DW.Fabrication and characterization of
anisotropic nanofiber scaffolds for advanced drug delivery systems.
International journal of nanomedicine, 2014,9 (Suppl 1), 33.）.Though have pass through on a small quantity at present
The distribution of coaxial electrically spun and electrospinning regulating medicine arranged side by side in nanofiber, to obtain the electrospinning core sheath of required medicine controlled releasing performance
Nanofiber and Qiao Nasi nanofibers, but design feature and composition regulation and control using core sheath nanometer are had not found to obtain
Medicine secondary vein rushes the relevant report of controlled release.
The content of the invention
For above-mentioned technical problem of the prior art, the invention provides one kind there is medicine secondary vein to rush release function
Nanofiber and preparation method thereof, described this nanofiber and its preparation side that release function is rushed with medicine secondary vein
Method will solve nanofiber of the prior art can not effectively control medicine secondary vein to rush the technical problem of controlled release.
The invention provides a kind of nanofiber that release function is rushed with medicine secondary vein, including an inner core and one
Individual outer sheath portion, the described inner core of described outer sheath portion parcel, described inner core and described outer sheath portion is prolonged along its length
Stretch, described inner core is made up of medicine and polymer pharmaceutic adjuvant, described polymer pharmaceutic adjuvant is in acid condition not
It is molten, can dissolve in neutral and alkaline conditions, described medicine and the mass ratio of polymer pharmaceutic adjuvant are 1：6~10；It is described
Outer sheath portion be made up of medicine and pharmaceutic adjuvant soluble in water, described medicine and the mass ratio of pharmaceutic adjuvant soluble in water
It is 1：7~15.
Further, the mass ratio of described medicine and polymer pharmaceutic adjuvant is 1：7；Described medicine and soluble in water
Pharmaceutic adjuvant mass ratio be 1：9.
Further, described medicine is the small-molecule chemical synthetic drug for disease treatment, or is active Chinese drug component
Composition.
Further, described medicine is brufen, and described pharmaceutic adjuvant soluble in water is polyvinylpyrrolidone
K60, described polymer pharmaceutic adjuvant is fibre-forming polymer HPMCP.
Present invention also offers a kind of preparation method of above-mentioned nanofiber that release function is rushed with medicine secondary vein,
Comprise the following steps：
1) the first organic solvent is used, polymer pharmaceutic adjuvant and the modification of drug of inner core into solution altogether will be used for, as
The working fluid of inner core；
2) the second organic solvent is used, pharmaceutic adjuvant soluble in water and the modification of drug of outer sheath portion into solution altogether will be used for,
As the working fluid of outer sheath portion；
3) working fluid of inner core is loaded into the first syringe, the first described syringe is arranged on the first syringe pump；
4) working fluid of outer sheath portion is loaded into the second syringe, the second described syringe is arranged on the second syringe pump；
5) the first syringe and the second syringe are connected with a two entrances for coaxial spinneret respectively；
6) high pressure generator, described high pressure generator and described coaxial spinneret connection are used；
7) control core sheath solution to inject the speed of coaxial spinneret respectively by two syringe pumps, high pressure generator is opened, in height
In the presence of pressure electrostatic, with coaxial spinneret exit orifices as masterplate, flat panel collector nanofiber is received by being grounded, prepare medicine
Secondary vein punching release nanofiber.
Further, the first described organic solvent is the mixed solvent of absolute ethyl alcohol and dichloromethane composition, anhydrous second
Alcohol is 1 with the volume ratio of dichloromethane:1, the second described organic solvent is absolute ethyl alcohol.
Nanofiber of the invention has core sheath structure feature, and different dissolubilities are used by nanofiber sheath portion and core
The polymeric substrate of energy, under the support of structure, can regulate and control contained medicine and be discharged by the secondary vein mode of rushing.Fiber sheath portion
Pharmaceutic adjuvant is soluble in water, after dissolution fluid is touched, can fast-pulse discharge some drugs contained therein；Core
Portion's polymer auxiliary material is insoluble in acid condition, can quickly dissolve in neutral and alkaline conditions, discharges and is wherein loaded
Active constituents of medicine.Therefore after oral, can fast-pulse discharge another part medicine for wherein being loaded, realize
The secondary vein of medicine rushes release mode.
The present invention is compared with prior art, and its technological progress is significant.The present invention is prepared by coaxial electrically spun technique, medicine
Thing in the early stage pulse quick release once after, by certain hour without drug release phase, medicine carries out second fast rapid pulse
Punching release.Preparation process is simple of the invention, single step is effective, preparation nanofiber core sheath structure is clear and nanometer diameter
Small, good linearity, diameter are evenly distributed, fiber surface is smooth.The thinking of core sheath structure nanofiber of the invention can be numerous
The secondary vein of medicine rushes controlled release and provides implementation, and flakiness is sheared by by nano fibrous membrane, can directly develop medicine
Oral administration system, there is provided safely and effectively medicine controlled releasing mode.
Brief description of the drawings
Fig. 1 is that the coaxial electrically spun preparation process taylor cone of medicine secondary vein punching release core sheath nanofiber of the invention shoots
Figure.
Fig. 2 is the coaxial electrically spun preparation technology schematic diagram that the present invention is used.
Fig. 3 is the scanning electron microscope diagram of medicine secondary vein punching release core sheath nanofiber of the invention.
Fig. 4 is the transmission electron microscope figure of medicine secondary vein punching release core sheath nanofiber of the invention.
Fig. 5 is the structural representation of medicine secondary vein punching release core sheath nanofiber of the invention.
Fig. 6 is that the vitro Drug secondary vein of medicine secondary vein punching release core sheath nanofiber of the invention rushes controlled release figure.
Specific embodiment
Below in conjunction with drawings and Examples, the present invention is described in detail.These embodiments be only used for explain the present invention and
It is not intended to the limitation present invention.All uses and same or analogous method of the invention, or the equivalent modifications made, all should fall into this
Invention protection domain.
Embodiment 1：The preparation of coaxial electrically spun process implementing and core sheath nanofiber
1 gram of medicine ibuprofen and 7 grams of polyvinylpyrrolidone K60 are codissolved in the absolute ethyl alcohol of 100 ml, sheath portion is configured to
Working fluid.
1 gram of medicine ibuprofen and 9 grams of fibre-forming polymer HPMCPs are codissolved in 100
In the absolute ethyl alcohol and dichloromethane mixed solvent of ml（Volume ratio 1:1), it is configured to operating core fluid.
Above-mentioned working fluid is respectively charged into the syringe of inner core and outer sheath portion working fluid, corresponding injection is installed to
On pump, and it is connected respectively in the two entrances of coaxial spinneret, connects high-pressure spinning head and HV generator.
Core sheath solution is controlled to inject the speed of coaxial spinneret respectively by two syringe pumps, core sheath flow velocity is respectively 1.1
With 1.2 mL/h, fiber receiver board is 15 cm with a distance from coaxial spinning nozzle, and environment temperature is (23 ± 1) DEG C, and ambient humidity is
57±4%.Under above-mentioned operating mode, high pressure generator is opened, the kV of voltage 15 carries out bust shot in situ, as a result to electro-spinning process
As shown in figure 1, from coaxial spinneret, out two fluids forms a compound Taylor cone, and the top of cone sends a straight line
Jet, starts high-pressure electrostatic and spins process.
The present invention prepares the schematic diagram of the coaxial electrically spun device that core sheath nanofiber is used as shown in Fig. 2 including pressure high
Raw device 1；First syringe pump 2, the second syringe pump 3, coaxial spinneret 4, fiber receiver board 5, silica gel hose 6, the first syringe 7,
Second syringe 8 is constituted, and the first syringe 7 is arranged on the first described syringe pump 2, and first syringe 7 is by described
Silica gel hose 6 and described coaxial spinneret 4 the connection of an entrance, described second syringe 8 is arranged on the second injection
On pump 3, second syringe 8 and described another entrance of coaxial spinneret 4 connection, the described He of high pressure generator 1
Described coaxial spinneret 4 is connected, and the described lower end of coaxial spinneret 4 is provided with a fiber receiver board 5.
Above-mentioned high pressure generator 1；First syringe pump 2, the second syringe pump 3, coaxial spinneret 4, fiber receiver board 5, silicon
Glue flexible pipe 6, the first syringe 7, the second syringe 8 are bought by market and obtained.
Embodiment 2：The structure and morphology characterization of medicine secondary vein punching release core sheath nanofiber
Using field scan Electronic Speculum（FESEM）Observed after surface metal spraying is carried out to fiber prepared by embodiment 1, as a result as shown in Figure 3.
Prepared fiber is presented good linear condition, do not have that bead structure, fiber surface be smooth, fiber accumulations are uniform.Directly
Footpath is 640 ± 90 nm, and than more uniform, concentration is compared in diameter distribution for distribution.
Using high-resolution projection electron microscope（TEM）Prepared fibrous inner structure is observed, as a result such as Fig. 4 institutes
Show, the interior outer double-layer structure of core sheath nanofiber is clear, the internal structure of fiber as shown in figure 5, medicine 33 fiber epitheca
It is uniformly distributed in the polyvinylpyrrolidone K60 of portion 11 and the HPMCP of inner core 22.
Embodiment 3：The drug controlled-releasing function analysis of medicine secondary vein punching release core sheath nanofiber
By D drug release determinations the second method slurry processes of 2015 editions annex of Chinese Pharmacopoeia Ⅹ, carried out using RCZ-8A intelligence dissolution experiment instruments
Medicament-carrying nano-fiber to above-mentioned gained carries out In Vitro Dissolution experiment.Control rotating speed 50rpm, temperature is 37 ± 0.1 DEG C.In preceding 2h
It is interior that to use not enzyme-added simulated gastric fluid 900mL be dissolution medium, behind use not enzyme-added simulated intestinal fluid（The phosphate of pH6.8
Cushioning liquid）900mL is dissolution medium, investigates the vitro Drug controlled release properties of nanofiber.5mL is sampled on schedule,
0.22 μm of filtering with microporous membrane, obtains dissolution fluid sample, and supplements same volume isothermal fresh medium at once.It is suitably dilute to sample
After releasing, at the nm of λ=257, ultraviolet determination is carried out using ultraviolet-uisible spectrophotometer, calculate medicine ibuprofen stripping quantity and
Accumulation dissolution percentage, is repeated 6 times.Result is as shown in fig. 6, it can be seen that the obvious secondary vein punching of medicine presentation is released
Put effect.Because the polymeric substrate of outer sheath portion polyvinylpyrrolidone K60 is soluble in water, simulated gastric fluid is contacted in nanofiber
Afterwards, whole medicines of the horse back pulse release first order.In 2 subsequent hours, outer sheath portion disappears, due to inner core polymer
HPMCP is insoluble in acid, so its internal contained brufen release is little.In being transferred to
Property simulated intestinal fluid after, due to the quick dissolving of polymer hydroxypropyl methyl cellulose phthalate, medicine obtains the
Two grades of pulse release effect.This medicine controlled releasing effect can not only reduce poisonous side effect of medicine, extension drug therapy effect
Really, reduce administration number of times and improve bioavilability, and can be many special diseases（So many angiocardiopathy blood high
Pressure, ischemic heart disease, angina pectoris etc. have obvious daily rhythmicity disease, some nights hair property and morning hair property disease）There is provided
A kind of taking a medicine at bedtime and morning drug release pulse preparation, to such disease prevention with treatment.
Embodiment 4：The secondary vein punching release core sheath nanofiber of active ingredient of Chinese herbs forulic acid
According to the spinning solution concocting method and implementing process condition of examples of implementation 1, the secondary vein punching release core sheath of forulic acid is prepared
Nanofiber, vitro Drug dissolution experiment is carried out according to embodiment 3, and as a result detection fibers show the controlled release properties of medicine, medicine
There is the release in vitro of thing forulic acid obvious secondary vein to rush controlled release feature.
Claims (5)
1. a kind of nanofiber that release function is rushed with medicine secondary vein, an including inner core and an outer sheath portion, it is described
The described inner core of outer sheath portion parcel, described inner core and described outer sheath portion extend along its length, it is characterised in that：
Described inner core is made up of medicine and polymer pharmaceutic adjuvant, and described polymer pharmaceutic adjuvant is insoluble in acid condition,
Can dissolve in neutral and alkaline conditions, described medicine and the mass ratio of polymer pharmaceutic adjuvant are 1：6~10；Described
Outer sheath portion is made up of medicine and pharmaceutic adjuvant soluble in water, and described medicine and the mass ratio of pharmaceutic adjuvant soluble in water are
1：7~15.
2. a kind of nanofiber that release function is rushed with medicine secondary vein according to claim 1, it is characterised in that：Institute
The medicine stated is the small-molecule chemical synthetic drug for disease treatment, or is active ingredient of Chinese herbs.
3. a kind of nanofiber that release function is rushed with medicine secondary vein according to claim 1, it is characterised in that：Institute
The medicine stated is brufen, and described pharmaceutic adjuvant soluble in water is polyvinylpyrrolidone K60, and described polymer is medicinal
Auxiliary material is fibre-forming polymer HPMCP.
4. a kind of preparation method of the nanofiber that release function is rushed with medicine secondary vein described in claim 1, its feature
It is to comprise the following steps：
1）Using the first organic solvent, the polymer pharmaceutic adjuvant of inner core and modification of drug into solution altogether will to be used for, as
The working fluid of inner core；
2）Using the second organic solvent, the pharmaceutic adjuvant soluble in water of outer sheath portion and modification of drug into solution altogether will to be used for,
As the working fluid of outer sheath portion；
3）The working fluid of inner core is loaded into the first syringe, the first described syringe is arranged on the first syringe pump；
4）The working fluid of outer sheath portion is loaded into the second syringe, the second described syringe is arranged on the second syringe pump；
5）First syringe and the second syringe are connected with a two entrances for coaxial spinneret respectively；
6）Using a high pressure generator, described high pressure generator and described coaxial spinneret is connected；
7）Control core sheath solution to inject the speed of coaxial spinneret respectively by two syringe pumps, high pressure generator is opened, in height
In the presence of pressure electrostatic, with coaxial spinneret exit orifices as masterplate, flat panel collector nanofiber is received by being grounded, prepare medicine
Secondary vein punching release nanofiber.
5. the preparation method of a kind of nanofiber that release function is rushed with medicine secondary vein according to claim 4, its
It is characterised by：The first described organic solvent is the mixed solvent of absolute ethyl alcohol and dichloromethane composition, absolute ethyl alcohol and dichloro
The volume ratio of methane is 1:1, the second described organic solvent is absolute ethyl alcohol.
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| CN201710035464.XA CN106860432A (en) | 2017-01-17 | 2017-01-17 | It is a kind of to rush nanofiber of release function and preparation method thereof with medicine secondary vein |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336885A (en) * | 2008-08-08 | 2009-01-07 | 东华大学 | Preparation method of microelement nano fibrofelt |
| CN101736419A (en) * | 2009-12-07 | 2010-06-16 | 东华大学 | Method for preparing core sheath structure fiber by using electrospun coaxial spinning head |
| CN102251317A (en) * | 2011-05-18 | 2011-11-23 | 东华大学 | Preparation method of electrospun fibers with controllable drug release |
| CN102824641A (en) * | 2012-09-07 | 2012-12-19 | 东华大学 | Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof |
-
2017
- 2017-01-17 CN CN201710035464.XA patent/CN106860432A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336885A (en) * | 2008-08-08 | 2009-01-07 | 东华大学 | Preparation method of microelement nano fibrofelt |
| CN101736419A (en) * | 2009-12-07 | 2010-06-16 | 东华大学 | Method for preparing core sheath structure fiber by using electrospun coaxial spinning head |
| CN102251317A (en) * | 2011-05-18 | 2011-11-23 | 东华大学 | Preparation method of electrospun fibers with controllable drug release |
| CN102824641A (en) * | 2012-09-07 | 2012-12-19 | 东华大学 | Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof |
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