CN106855578A - A kind of coagulation function detection chip - Google Patents
A kind of coagulation function detection chip Download PDFInfo
- Publication number
- CN106855578A CN106855578A CN201710153891.8A CN201710153891A CN106855578A CN 106855578 A CN106855578 A CN 106855578A CN 201710153891 A CN201710153891 A CN 201710153891A CN 106855578 A CN106855578 A CN 106855578A
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- chamber
- reaction chamber
- blood
- taking needle
- detection chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N2011/006—Determining flow properties indirectly by measuring other parameters of the system
- G01N2011/0086—Determining flow properties indirectly by measuring other parameters of the system magnetic properties
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- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
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- Engineering & Computer Science (AREA)
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- Urology & Nephrology (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of coagulation function detection chip, including blood taking needle (2), carry medicine chamber and reaction chamber (6), magnetoelasticity iron core (5) is provided with the reaction chamber, load medicine core (4) is provided with the load medicine chamber, the blood taking needle is communicated when being under pressure with the load medicine core, the load medicine core is communicated with reaction chamber, the blood gathered by blood taking needle is mixed in being flowed into load medicine core with the detection reagent carried in medicine core, and mixed liquid is flowed into reaction chamber.The present invention is mixed automatically using tip blood sampling is disposably quantified with quantitative reagent, without venous blood collection compared with existing equipment, is added without other reagent, convenient and swift, reduces patient suffering.
Description
Technical field
It is specifically a kind of that there is coagulation function detection chip the present invention relates to a kind of field of measuring technique.
Background technology
Instant detection type Hemostasis examination technology, particularly the development root of bed side Hemostasis examination is due to solidifying based on inspection center
Blood measurement cannot meet growing instant detection demand, including anticoagulant therapy immediate feedback.This require in hospital or
Emergency to the timely adjustment after the adjustment of patient dose and patient discharge, either for patient satisfaction still to doctor
This is all critically important for benefit in itself for institute.In this field, coagulation function detection method and equipment are just with more excellent
Gesture, by taking thrombelastography as an example, TEG graphically dynamically, can be monitored intactly since blood coagulation to blood clot shape
Into and fibrinolysis overall process, can be to clotting factor, fibrinogen, platelet aggregation and plasmin
The aspects such as solution carry out complete detection and assessment.Recent studies have shown that, TEG can be with after monitoring, the wound of coagulation function in patient's art
The management of blood product, the therapeutic effect to wounded patient coagulation disorders is timely evaluated, and obtains good effect
Really.In traditional external source coagulation function experiment (such as PT, APTT) can only detect in the blood plasma under platelet-free participant status blood coagulation because
Sub- activity.It can not illustrate blood coagulation overall process, can only reflect a certain stage or certain blood coagulation product in coagulation process.And TEG energy
The activity of clotting factor, platelet function and fibrinolysis is monitored in the process of setting of blood, reflects physiological status
The complicated coagulation process overall picture that lower blood platelet is participated in.TEG has been successfully applied to the diagnosis of coagulation disorders and has monitored various hands
The curative effect of Coagulation Dysfunction and anticoagulant therapy during art.Compared to traditional coagulation function laboratory examination, TEG has higher
Accuracy, can more fully reflect whole blood coagulation.
The popularization of certain this kind of method and apparatus application clinically is still present certain problem, it is contemplated that POCT sets
The standby requirement at aspects such as miniaturization, portability and ease for use, particularly examines coagulation function now for developed countries
Look into and be generalized to the trend of one-level medical institutions of community as the anticoagulant treatment even demand of health screening, existing method and
Equipment, including thrombelastogram instrument is with the torque sensor structure for changing thrombelastogram instrument and using the rotation of optical detection
Formula elastic force figure instrument (Rotational thromboelastometry, ROTEM) etc., all be present similar.
The content of the invention
In consideration of it, it is an object of the invention to provide a kind of coagulation function detection chip.
The purpose of the present invention is achieved through the following technical solutions, a kind of coagulation function detection chip, including blood taking needle,
Medicine chamber and reaction chamber are carried, magnetoelasticity iron core is provided with the reaction chamber, load medicine core, institute are provided with the load medicine chamber
State blood taking needle to be communicated with the load medicine core when being under pressure, the load medicine core is communicated with reaction chamber, is gathered by blood taking needle
Blood be flowed into carry medicine core in carry medicine core in detection reagent mix, mixed liquid is flowed into reaction chamber.
Further, also including flexible board, blood taking needle is fixed on flexible board, is under pressure during blood sampling while core can be pierced through
The sealing of piece makes blood taking needle be communicated with medicine core is carried.
Further, the load medicine core is loose structure.
Further, the also waste chamber including being arranged at reaction chamber end and connect with reaction chamber.
Further, the load medicine chamber or/and reaction chamber are sealing structure, in vacuum negative pressure condition.
Further, the waste chamber is sealing structure, in vacuum negative pressure condition.
Further, also including seal casinghousing, the reaction chamber, load medicine chamber are arranged in seal casinghousing, blood taking needle
One end is extend into seal casinghousing.
Further, also including the protective cover for preventing blood taking needle to be contaminated.
By adopting the above-described technical solution, the present invention has the advantage that：
1. the present invention is mixed automatically using tip blood sampling is disposably quantified with quantitative reagent, need not compared with existing equipment
Venous blood collection, adds without other reagent, convenient and swift, reduces patient suffering；2. the present invention is used cooperatively with detecting instrument, with
, from viscosity angle monitor coagulation process, compared to currently a popular optics, mechanical detection method, structure is more for the method for magnetoelasticity detection
Plus it is simple, cost is lower, and it is possible to prevente effectively from the shortcoming that is easily influenceed by exceptional samples such as jaundice, highs fat of blood of optical means；
3. invention chip type design be more easy to it is integrated, detection flux it is higher.
Brief description of the drawings
In order that the object, technical solutions and advantages of the present invention are clearer, below in conjunction with accompanying drawing the present invention is made into
The detailed description of one step, wherein：
Fig. 1 is structure chart of the invention；
Fig. 2 is exploded view of the invention；
Fig. 3 is the original record of testing result, and abscissa is time course, and ordinate is the voltage change of record, with blood
Fluid viscosity change is in inverse correlation, can reflect the process of setting of blood；
Fig. 4 is by the result figure after calculating treatment；Abscissa is time shaft, and ordinate is the blood coagulation degree for calculating,
Result figure real time reaction coagulation process, and can therefrom obtain various clinical coagulation parameters, for diagnosis provides foundation.
Specific embodiment
Below with reference to accompanying drawing, the preferred embodiments of the present invention are described in detail；It should be appreciated that preferred embodiment
Only for the explanation present invention, rather than in order to limit the scope of the invention.
A kind of coagulation function detection chip, including blood taking needle 2, load medicine chamber and reaction chamber 6, set in the reaction chamber
Be equipped with magnetoelasticity iron core 5, be provided with load medicine core 4 in the load medicine chamber, the blood taking needle when being under pressure with the load medicine core
Communicate, it is described load medicine core communicated with reaction chamber, by blood taking needle gather blood be flowed into load medicine core in load medicine core in
Detection reagent mixes, and mixed liquid is flowed into reaction chamber.
In the present invention, carrying medicine core will detect that the reagent for needing is stored in loose structure in dry chemical form, porous knot
Structure design increases the contact area of reagent and blood sample, accelerates the mixing of reagent and blood sample.
In the present invention, magnetoelasticity iron core is placed in reaction chamber, with sample directly contact, monitors coagulation process.Reaction
Chamber design has supporting construction for loading magnetoelasticity iron core.
Also include flexible board 3 as the improvement to the present embodiment, blood taking needle is fixed on flexible board, is pressed during blood sampling
The sealing that power can pierce through chip simultaneously makes blood taking needle be communicated with medicine core is carried.
It is loose structure as the medicine core that carries of the improvement to the present embodiment.
As the improvement to the present embodiment, the also waste liquid chamber including being arranged at reaction chamber end and connect with reaction chamber
Room 7.Waste chamber is used to collect the bubble and unnecessary sample of residual in chip.
Used as the improvement to the present embodiment, the load medicine chamber or/and reaction chamber are sealing structure, in negative pressure of vacuum shape
State.
Used as the improvement to the present embodiment, the waste chamber is sealing structure, in vacuum negative pressure condition.
Used as the improvement to the present embodiment, also including seal casinghousing 8, the reaction chamber, load medicine chamber are arranged at sealing
In housing, one end of blood taking needle is extend into seal casinghousing.
As the improvement to the present embodiment, also including the protective cover 1 for preventing blood taking needle to be contaminated.
Use flow principle of the invention：Removal protective cover, finger tip blood sampling is carried out using blood taking needle；Blood taking needle quilt during blood sampling
The sealant for puncturing and carrying medicine chamber is pushed, path is formed, peripheral blood will flow into chip under suction function；Blood flows through load medicine
It is fully contacted with the detection reagent on loose structure surface during chamber and is mixed, starts coagulation process；Treat that blood quickly fills with reaction chamber
Room, you can chip is put into magnetoelasticity detection platform, starts to detect coagulation process.In coagulation process, blood sample
Can slowly be solidified in reaction chamber, sample viscosity constantly increases, and the sensor in reaction chamber can turn viscosity B coefficent
It is changed into signal amplitude, obtains measurement result.
Device will obtain blood sample viscosity (reaction condensation degree) versus time curve, complete to the real-time of coagulation process
Detection.It is analyzed by curve, it can be deduced that corresponding coagulation indexes, with Clinical significance of MG.
The preferred embodiments of the present invention are the foregoing is only, is not intended to limit the invention, it is clear that those skilled in the art
Member can carry out various changes and modification without departing from the spirit and scope of the present invention to the present invention.So, if of the invention
These modifications and modification belong within the scope of the claims in the present invention and its equivalent technologies, then the present invention is also intended to comprising these
Including change and modification.
Claims (8)
1. a kind of coagulation function detection chip, it is characterised in that：Including blood taking needle (2), carry medicine chamber and reaction chamber (6), institute
State and be provided with reaction chamber magnetoelasticity iron core (5), load medicine core (4) is provided with the load medicine chamber, the blood taking needle is being subject to
Communicated with the load medicine core during pressure, the load medicine core is communicated with reaction chamber, and the blood gathered by blood taking needle is flowed into load
Mix with the detection reagent carried in medicine core in medicine core, mixed liquid is flowed into reaction chamber.
2. a kind of coagulation function detection chip according to claim 1, it is characterised in that：Also include flexible board (3), blood sampling
Pin is fixed on flexible board, is under pressure during blood sampling while the sealing that can pierce through chip makes blood taking needle be communicated with medicine core is carried.
3. a kind of coagulation function detection chip according to claim 2, it is characterised in that：The load medicine core is porous knot
Structure.
4. a kind of coagulation function detection chip according to claim 1, it is characterised in that：Also include being arranged at reaction chamber
End and the waste chamber (7) connected with reaction chamber.
5. a kind of coagulation function detection chip according to claim 1, it is characterised in that：The load medicine chamber or/and anti-
Chamber is answered for sealing structure, in vacuum negative pressure condition.
6. a kind of coagulation function detection chip according to claim 4, it is characterised in that：The waste chamber is tied for sealing
Structure, in vacuum negative pressure condition.
7. a kind of coagulation function detection chip according to claim 1, it is characterised in that：Also include seal casinghousing (8), institute
State reaction chamber, load medicine chamber to be arranged in seal casinghousing, one end of blood taking needle is extend into seal casinghousing.
8. a kind of coagulation function detection chip according to claim 7, it is characterised in that：Also include for preventing blood taking needle
The protective cover (1) being contaminated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710153891.8A CN106855578A (en) | 2017-03-15 | 2017-03-15 | A kind of coagulation function detection chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710153891.8A CN106855578A (en) | 2017-03-15 | 2017-03-15 | A kind of coagulation function detection chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106855578A true CN106855578A (en) | 2017-06-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710153891.8A Pending CN106855578A (en) | 2017-03-15 | 2017-03-15 | A kind of coagulation function detection chip |
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| Country | Link |
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| CN (1) | CN106855578A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108398470A (en) * | 2018-04-13 | 2018-08-14 | 广州万孚生物技术股份有限公司 | Blood activated clotting time measures biosensor and preparation method thereof |
| CN113116348A (en) * | 2021-03-02 | 2021-07-16 | 天津大学 | Continuous arterial blood detection device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104049029A (en) * | 2014-07-02 | 2014-09-17 | 重庆大学 | Multi-channel magneto-elastic sensor detection chip |
| CN105326511A (en) * | 2015-12-09 | 2016-02-17 | 国家纳米科学中心 | Vacuum blood sampling device for immunity detection |
-
2017
- 2017-03-15 CN CN201710153891.8A patent/CN106855578A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104049029A (en) * | 2014-07-02 | 2014-09-17 | 重庆大学 | Multi-channel magneto-elastic sensor detection chip |
| CN105326511A (en) * | 2015-12-09 | 2016-02-17 | 国家纳米科学中心 | Vacuum blood sampling device for immunity detection |
Non-Patent Citations (1)
| Title |
|---|
| 周平山等: "床旁凝血测定仪在抗凝监测中的应用研究", 《实用心脑肺血管病杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108398470A (en) * | 2018-04-13 | 2018-08-14 | 广州万孚生物技术股份有限公司 | Blood activated clotting time measures biosensor and preparation method thereof |
| CN108398470B (en) * | 2018-04-13 | 2024-01-30 | 广州万孚生物技术股份有限公司 | Biosensor for measuring blood activation clotting time and manufacturing method thereof |
| CN113116348A (en) * | 2021-03-02 | 2021-07-16 | 天津大学 | Continuous arterial blood detection device |
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| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170616 |
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| RJ01 | Rejection of invention patent application after publication |