CN208621554U - Portable POCT detector for multi-parameter - Google Patents

Portable POCT detector for multi-parameter Download PDF

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Publication number
CN208621554U
CN208621554U CN201821081233.9U CN201821081233U CN208621554U CN 208621554 U CN208621554 U CN 208621554U CN 201821081233 U CN201821081233 U CN 201821081233U CN 208621554 U CN208621554 U CN 208621554U
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layer
electrode
parameter
rotating
sample
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梁波
叶学松
丁浩
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Shandong Industrial Technology Research Institute of ZJU
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Shandong Industrial Technology Research Institute of ZJU
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Abstract

The utility model discloses the portable POCT detectors for multi-parameter, including shell, shell is equipped with sampling apparatus, sampling apparatus includes detection module and rotating module, rotating module includes the rotating layer and fixing layer that can be rotated, rotating layer is located at the center of fixing layer, and rotating layer has a sample storage chamber of storage sample to be tested, fixing layer circumferentially multiple detection modules;When sampling, rotating layer rotation, detection module are corresponding with sample storage chamber position.The utility model can be not only used for the detection of multi-parameter and detection process is full-automatic, substantially increase detection efficiency.

Description

Portable POCT detector for multi-parameter
Technical field
The utility model relates to medical instruments fields, more specifically, it be related to it is a kind of for the portable of multi-parameter POCT detector.
Background technique
In-vitro diagnosis, i.e. IVD (In Vitro Diagnosis), refer to except human body, by human sample (blood Liquid, body fluid, tissue etc.) it is detected and obtains clinical diagnosis information, and then judge the products & services of disease or body function. In-vitro diagnosis can be divided into central laboratory by utilization object again and use and Point-of-Care Test(POCT).POCT refers in disease Clinical detection and the bedside detection (bedside testing) carried out beside people, is not necessarily clinical examination teacher usually to carry out. It is to be analyzed at once in sampling location, saves complex process program of the sample in laboratory inspection, quickly obtains examining knot A kind of new method of fruit.
Due to POCT be not necessarily to central laboratory, can directly be detected in victim, can quickly carry out diagnosis and treatment, nursing, Course of disease observation, and then quality of medical care is improved, therefore permeability steps up in ICU, operation, emergency treatment, clinic and patient family. The main purpose of POCT is exactly to obtain experimental result faster.The progress of diagnosis and ancillary technique, understanding to disease and is controlled The raising for the treatment of level is the main reason for POCT is gradually concerned by people (pressure of financial aspects is secondary cause).These progress make Some diseases diagnose other disease as early as possible and better healing close to eradicating.Easy to operate, being easy use is POCT Another feature.POCT has become a part of diagnostic system by its ease for use;POCT assume responsibility for the function in laboratory but It is not necessarily to traditional hospital laboratory equipment again.POCT can both be completed in the clinic of doctor or on the automobile started.POCT can Not limited by time, place, 24 hours it is comprehensive for service for patients.
Traditional POCT detector such as blood glucose meter, uric acid instrument etc. is mostly the detection of single parameter and detection method is more multiple It is miscellaneous.
Summary of the invention
The purpose of this utility model is to provide a kind of portable POCT detectors for multi-parameter, can be not only used for The detection of multi-parameter and detection process is full-automatic, substantially increases detection efficiency.
The technical scheme adopted by the utility model to solve the technical problem is as follows: the portable POCT for multi-parameter is detected Instrument, it is characterised in that: including shell, shell is equipped with sampling apparatus, and sampling apparatus includes detection module and rotating module, rotates mould Block includes the rotating layer and fixing layer that can be rotated, and rotating layer is located at the center of fixing layer, rotating layer have storage to The sample storage chamber of test sample sheet, fixing layer circumferentially multiple detection modules;When sampling, rotating layer rotation, detection module and sample This storage chamber position is corresponding.Preferably, rotating layer and fixing layer are plastics or metal material.
As a preferred option, rotating module further includes separating layer, and rotating layer is connected with fixing layer by separating layer.It is preferred that , separating layer is bearing.Preferably, rotating layer and fixing layer are circle.
As a preferred option, detection module is equally spaced.
As a preferred option, detection module includes siphon layer, working electrode and auxiliary electrode, and working electrode and auxiliary are electric Pole is respectively positioned on siphon layer.
As a preferred option, sample storage chamber has the opening of release sample to be tested, and siphon layer has siphon groove, siphon Slot one end has interface, and interface extends to rotating layer, and when sampling, opening is aligned and contacts with interface.Preferably, siphon groove U Type groove.Preferably, siphon rooved face is covered with hydrophilic film.Hydrophilic film can promote siphon groove siphon that sample to be tested is made to be evenly distributed, parent Moisture film is cellulose and its derivates.
As a preferred option, fixing layer is equipped with storage shell, driving motor and gear, and sample storage chamber is located at storage shell In, driving motor output shaft is fixed with gear, gear and storage shell engaged transmission.
As a preferred option, auxiliary electrode is between working electrode and interface, one end of working electrode and auxiliary electrode It is respectively positioned in siphon groove.Guarantee that sample to be tested is contacted with each electrode.
As a preferred option, detection module further includes reference electrode, and working electrode is located at reference electrode and auxiliary electrode Between;One end of working electrode, auxiliary electrode and reference electrode is respectively positioned in siphon groove.
As a preferred option, shell is equipped with electrode contacts module, and electrode contacts module includes auxiliary electrode contact, work Electrode contacts and reference electrode contact, electrode contacts module are circumferentially equally spaced, and electrode contacts module is corresponding with detection module; Alternatively, auxiliary electrode contact, working electrode contacts and reference electrode contact are laid with whole circumferential fashion, electrode contacts module and inspection Survey module contact when, working electrode is connect with working electrode contacts, and auxiliary electrode is connect with auxiliary electrode contact, reference electrode and The connection of reference electrode contact.Preferably, working electrode, auxiliary electrode and reference electrode are arranged in parallel, and are respectively positioned on siphon groove The same side.It can reduce the occupied space of electrode pair positioned at the same side.Preferably, working electrode contacts, auxiliary electrode contact and Reference electrode contact is metal clips.
As a preferred option, shell be equipped with motor, rotating layer have motor output shaft insertion connecting hole, connecting hole with Motor output shaft connection;It is interference fitted between connecting hole and motor output shaft.When sampling apparatus is installed on shell, apply one Fixed external force inserts in the hole motor output shaft.The interference fit realization sampling apparatus and shell of connecting hole and motor output shaft Detachable installation effect.Sampling apparatus is set as removably as disposable instrument, is convenient for changing sampling apparatus.
As a preferred option, fixing layer bottom end is equipped with mounting hole, and shell is equipped with fixing axle.When installation, fixing axle insertion In mounting hole, to fix fixing layer.
As a preferred option, sample storage chamber has sample holes.Add sample to be tested when, syringe by sample holes to Sample storage chamber injects sample to be tested.
As a preferred option, shell is additionally provided with processing display device, and processing display device includes micro-control unit, display Screen, key and power supply.Micro-control unit handles sampled value and obtains testing result.Display screen is liquid crystal display, is used for quilt Survey personnel's real time inspection testing result and detection time.Key includes key A and key B, and key A and key B are common plastics Key.Many kinds of parameters, including detection parameters, detection time can be arranged in key, for example, 1. working electrode is glucose oxidation to number Enzyme, then numbering 1. detection parameters is blood glucose.
As a preferred option, working electrode surface is covered with enzyme layer.Enzyme layer is different, and the parameter of detection is different, for example, enzyme layer When for glucose oxidation enzyme, then detection parameters are blood glucose, and when enzyme layer is uricase, then detection parameters are uric acid.
As a preferred option, shell is equipped with charging jacks.
As a preferred option, power supply is powered to the detector.
The course of work of the utility model: by key-press input parameter, such as 1. working electrode is glucose oxidation enzyme to number, then Number 1. detection parameters be blood glucose, behind number and so on, by sampling apparatus be inserted into shell in, will be to test sample by syringe Originally it is injected into sample storage chamber, micro-control unit controls sample storage chamber is rotated to the siphon groove interface of number 1. to be examined with sample Survey the opening alignment of chamber, storage shell is driven to move down for gear until opening and interface contact, number each electrode 1. with it is corresponding Electrode contacts contact, siphon layer carries out siphon, when micro-control unit detects enzyme layer on working electrode and sample to be tested When kinetic current, sample to be tested absorption is finished, and micro-control unit controls gear driving storage shell moves up, micro-control unit control Rotating layer rotation processed makes sample storage chamber be located at number 1. and number between 2., meanwhile, micro-control unit carries out sample to be tested Processing, processing result are shown by display screen, can inquire corresponding testing result by key A and B after detection.
Advantage is the utility model compared with prior art: 1, by setting rotating layer and fixing layer, setting on fixing layer Multiple detection modules are set, the detection of multi-parameter can be carried out;Detection process is full-automatic, substantially increases detection efficiency, reduces use The operation difficulty at family.
2, sampling apparatus and shell are detachably connected, and sampling apparatus is convenient for changing sampling apparatus as disposable instrument.
3, sample storage chamber is set on rotating layer, rotating layer is fixed with motor output shaft, is not necessarily to driving wheel, instrument is more Add simply, operates more convenient.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of 1 sampling apparatus of embodiment.
Fig. 2 is the sectional view of 1 sampling apparatus of embodiment.
Fig. 3 is the back view of shell.
Fig. 4 is the structural schematic diagram of detection module.
Fig. 5 is the front elevation of detector.
Fig. 6 is the structural schematic diagram of 2 sampling apparatus of embodiment.
Fig. 7 is to implement the 2 spaced back views of case electrode contact modules.
Fig. 8 is the back view for implementing the setting of 2 case electrode contact modules full circle weeks.
It is identified in figure: shell 1, detection module 31, rotating module 32, rotating layer 321, fixing layer 322, separating layer 323, sample This storage chamber 3222, storage shell 324, gear 325, siphon layer 311, working electrode 312, auxiliary electrode 313, reference electrode 314, Opening 3223, electrode fixed seat 14, electrode fixed seat jack 3221, siphon groove 3111, interface 3112, working electrode contacts 11, Auxiliary electrode contact 12, reference electrode contact 13, driving wheel 15, sample holes 16, charging jacks 17, display screen 2, key 3.
Specific embodiment
The present invention will be further described below with reference to the accompanying drawings and specific embodiments.
Sample to be tested and detection parameters
Sample to be tested is mostly physiological fluid, such as blood, urine, sweat, saliva, is felt wherein containing many clinical labororatories The detection parameters of interest, such as glucose, cholesterol, glycosylated hemoglobin, blood ketone in blood, the uric acid in urine, sweat In lactic acid etc..
Electrochemical analysis
Electrochemical analysis includes working electrode, reference electrode and auxiliary electrode.Reference electrode is used to pinpoint a zero point, electric current It flows through working electrode and reference electrode constitutes a system that is obstructed or being powered less substantially, utilize the stability of reference electrode current potential To measure the electrode potential of working electrode.Working electrode and auxiliary electrode constitute the system of an energization, for measuring work electricity The electric current that pole passes through.Using three electrode measurement systems, come the point of research work electrode and the relationship of electric current simultaneously.
Circuit theory
Using single-chip microcontroller as micro-control unit, the detection sample in sample storage chamber is passed through by each electrode by siphon layer It is connected in circuit, realizes that the reaction result to detection sample is adopted by source of stable pressure, across resistance operational amplifier circuit and 16 DAC Sample, sampled value handle through single-chip microcontroller and obtain final data.
POCT detector
Embodiment 1
A kind of portable POCT detector for multi-parameter, as shown in Figure 1 and Figure 5, including shell 1, shell 1 are equipped with place Display device is managed, processing display device includes micro-control unit, key 3, display screen 2 and power supply, and shell 1 is additionally provided with sampling cartridge It sets, sampling apparatus includes detection module 31 and rotating module 32, and rotating module 32 includes rotating layer 321 and fixing layer 322, rotation Layer 321 is hollow, and fixing layer 322 is located at the hollow position of rotating layer 321, and there is fixing layer 322 sample of storage sample to be tested to deposit Put chamber 3222, the circumferentially multiple detection modules 31 of rotating layer 321;When sampling, the rotation of rotating layer 321, detection module 31 and sample 3222 position of this storage chamber is corresponding.Micro-control unit controls detection module 31 and rotating module 32.
As shown in Figure 1, detection module 31 is equally spaced.
As shown in Fig. 2, rotating layer 321 and fixing layer 322 are connected by separating layer 323, separating layer 323 is bearing.As A kind of specific scheme, rotating layer 321, absciss layer 323 and fixing layer 322 are circle.Rotating layer 321, separating layer 323 and fixation Layer 322 constitutes driven wheel.As a kind of specific scheme, rotating layer 321 and fixing layer 322 are metal material.
As shown in figure 3, shell 1 is equipped with motor and driving wheel 15, driving wheel 15 connect with motor output shaft, driving wheel 15 and 321 engaged transmission of rotating layer.
It is located at as shown in Fig. 2, sampling module is equipped with storage shell 324, driving motor and gear 325, sample storage chamber 3222 It stores in shell 324, driving motor output shaft and gear 325 are fixed, 324 engaged transmission of gear 325 and storage shell.Fixing layer 322 When with the sample storage chamber 3222 for storing sample to be tested, storage shell 324, driving motor and gear 325 are located at fixing layer 322 On.Driving motor drives gear 325 to rotate, so that the driving storage shell 324 of gear 325 moves up and down.
Sampling apparatus is detachably connected with shell 1.As shown in figures 1 and 3, shell 1 is equipped with electrode fixed seat 14, fixed Layer 322 is equipped with electrode fixed seat jack 3221, is inserted into electrode fixed seat jack 3221 when installation, by electrode fixed seat 14.Electricity Pole fixing seat 14 and the cooperation of electrode fixed seat jack 3221 are applied not only to working electrode 312, auxiliary electrode 313 and reference electrode 314 fixation, and realize that the detachable installation of sampling apparatus and shell 1 acts on.Sampling apparatus is as disposable instrument, setting For removably, it is convenient for changing sampling apparatus.
As shown in Figure 1, sample storage chamber 3222 has sample holes 3224.Sample to be tested is added toward sample storage chamber 3222 When, syringe injects sample to be tested into sample storage chamber 3222 by sample holes 3224.
As shown in Figure 1 and Figure 4, detection module 31 includes siphon layer 311, working electrode 312 and auxiliary electrode 313.Such as Fig. 2 Shown, siphon layer 311 is located at 321 bottom end of rotating layer, and working electrode 312 and auxiliary electrode 313 are respectively positioned on siphon layer 311.Rainbow It inhales layer 311 and is located at sample 3222 lower section of chamber to be measured.
As depicted in figs. 1 and 2, sample storage chamber 3222 has the opening 3223 of release sample to be tested, and siphon layer 311 is equipped with Siphon groove 3111, siphon groove 3111 are U-type groove, and 3111 one end of siphon groove has interface 3112, and interface 3112 extends to fixing layer 322, when sampling, opening 3223 is aligned and contacts with interface 3112.3111 surface of siphon groove is covered with hydrophilic film.Hydrophilic film can promote 3111 siphon of siphon groove makes sample to be tested be evenly distributed, and hydrophilic film is cellulose and its derivates.
As shown in figure 4, auxiliary electrode 313, between working electrode 312 and interface 3112, working electrode 312 and auxiliary are electric One end of pole 313 is respectively positioned in siphon groove 3111, guarantees that sample to be tested is contacted with each electrode.
As shown in figure 4, detection module 31 further includes reference electrode 314, working electrode 312 is located at auxiliary electrode 313 and ginseng Than between electrode 314, one end of reference electrode 314 is located in siphon groove 3111.
As shown in figure 3, shell 1 is equipped with electrode contacts module, electrode contacts module includes working electrode contacts 11, auxiliary electricity Pole contact 12 and reference electrode contact 13, opening 3223 is when being aligned and contact with interface 3112, the other end of working electrode 312 and The connection of 11 one end of working electrode contacts, the other end of auxiliary electrode 313 are connect with 12 one end of auxiliary electrode contact, reference electrode 314 other end is connect with 13 one end of reference electrode contact, working electrode contacts 11, auxiliary electrode contact 12 and reference electrode touching The other end of point 13 is connect with micro-control unit respectively.Working electrode 312, auxiliary electrode 313 are parallel with reference electrode 314 to be set It sets, working electrode 312 is respectively positioned on the same side of siphon groove 3111 between reference electrode 314 and auxiliary electrode 313.Position It can reduce the occupied space of electrode in the same side.Working electrode contacts 11, auxiliary electrode contact 12 and reference electrode touch at 13 points It is metal clips.Auxiliary electrode 12 detects kinetic current for micro-control unit.
312 surface of working electrode has enzyme layer.Enzyme layer is different, and the parameter of detection is different, for example, enzyme layer is glucose oxidation enzyme When, then detection parameters are blood glucose, and when enzyme layer is uricase, then detection parameters are uric acid.Key 3 and display screen 2 respectively with it is micro- Control unit connection, as shown in figure 4, the display screen 2 is liquid crystal display.Display screen 2 is for showing testing result and time.
As shown in figure 4, it is common plastics key that key 3, which includes key A and key B, key A and key B,.Key 3 is used for Detection parameters, detection time etc. are set, for example, 1. working electrode is glucose oxidation enzyme to number, then numbering 1. detection parameters is blood Sugar, behind number and so on.
As shown in figure 4, shell 1 is equipped with charging jacks 17.Power supply is powered to entire detector.
In use, inputting parameter by key 3, such as 1. working electrode is glucose oxidation enzyme to number, then numbers 1. detection ginseng Number be blood glucose, behind number and so on, by sampling apparatus be inserted into shell 1 in, sample to be tested is injected by sample by syringe In this storage chamber 3222, the rotation of siphon groove interface 3112 of micro-control unit controls number 1. is opened to pattern detection chamber 3222 Mouthful alignment, storage shell 324 is driven to move down for gear 325 until opening 3223 is contacted with interface 3112, numbers each electrode 1. It is contacted with corresponding electrode contacts, siphon layer 311 carries out siphon, when micro-control unit detects the enzyme layer on working electrode 312 When with the kinetic current of sample to be tested, sample to be tested absorption is finished, the driving of micro-control unit controls gear 325 storage shell 324 to Upper movement, micro-control unit controls driving wheel 15 drive the rotation of rotating layer 321 that sample storage chamber 3222 is made to be located at number 1. and compile Number 2. between, meanwhile, micro-control unit handles sample to be tested, and processing result is shown by display screen 2, after detection Corresponding testing result can be inquired by key A and B.
Embodiment 2
Be in place of the present embodiment and the difference of embodiment 1: the rotating layer 321 in sampling apparatus has storage sample to be tested Sample storage chamber 3222, the circumferentially multiple detection modules 31 of fixing layer 322, fixing layer 322 is hollow, and rotating layer 321 is located at Hollow position, as shown in Figure 6.
As shown in fig. 7, shell 1 is equipped with electrode contacts module, electrode contacts module includes auxiliary electrode contact 12, work electricity Pole contact 11 and reference electrode contact 13, electrode contacts module are circumferentially equally spaced, electrode contacts module and detection module 31 It corresponds.Alternatively, auxiliary electrode contact 13, working electrode contacts 11 and reference electrode contact 13 are laid with whole circumferential fashion, As shown in Figure 8.
As shown in fig. 6, shell 1 is equipped with motor, rotating layer 321 has the connecting hole 3211 of motor output shaft insertion, connection Hole 3211 is connected with exporting axis.It is interference fitted between connecting hole 3211 and output shaft, when sampling apparatus is installed on shell 1, Apply certain external force output shaft is inserted into connecting hole 3211.The interference fit of connecting hole 3211 and output shaft realizes sampling cartridge Set the detachable installation effect with shell 1.When rotating layer 321 has the sample storage chamber 3222 of storage sample to be tested, shell is stored 324, driving motor and gear 325 are located on rotating layer 321.322 bottom end of fixing layer is equipped with mounting hole, and shell 1 is equipped with fixing axle. When installation, fixing axle is inserted into mounting hole, to fix fixing layer 322.
In use, such as 1. working electrode is glucose oxidation enzyme to number by key-press input parameter, then 1. detection parameters are numbered For blood glucose, behind number and so on, sampling apparatus is inserted into shell, sample to be tested is injected by sample by syringe and is deposited It puts in chamber, micro-control unit controls rotating layer is rotated to the opening of pattern detection chamber to be aligned with the siphon groove interface of number 1., tooth Wheel drive storage shell move down until opening and interface contact, each electrode numbered 1. contacted with corresponding electrode contacts, rainbow It inhales layer and carries out siphon, when micro-control unit detects the kinetic current of enzyme layer and sample to be tested on working electrode, to test sample This absorption finishes, and micro-control unit controls gear driving storage shell moves up, and the rotation of micro-control unit controls rotating layer makes sample 1. this storage chamber is located at number and numbers between 2., meanwhile, micro-control unit handles sample to be tested, and processing result passes through Display screen is shown, can inquire corresponding testing result by key A and B after detection.
Content described in this specification embodiment is only an enumeration of the implementation forms of the utility model concept, this is practical new The protection scope of type should not be construed as being limited to the specific forms stated in the embodiments, the protection scope of the utility model also and In those skilled in the art according to the utility model design it is conceivable that equivalent technologies mean.

Claims (10)

1. being used for the portable POCT detector of multi-parameter, it is characterised in that: including shell, shell is equipped with sampling apparatus, sampling Device includes detection module and rotating module, and rotating module includes the rotating layer and fixing layer that can be rotated, and rotating layer is located at The center of fixing layer, rotating layer have the sample storage chamber of storage sample to be tested, fixing layer circumferentially multiple detection moulds Block;When sampling, rotating layer rotation, detection module are corresponding with sample storage chamber position.
2. being used for the portable POCT detector of multi-parameter as described in claim 1, it is characterised in that: rotating module further includes Separating layer, rotating layer and fixing layer are connected by separating layer.
3. being used for the portable POCT detector of multi-parameter as described in claim 1, it is characterised in that: detection module is equidistant Arrangement.
4. being used for the portable POCT detector of multi-parameter as described in claim 1, it is characterised in that: detection module includes rainbow Layer, working electrode and auxiliary electrode, working electrode and auxiliary electrode is inhaled to be respectively positioned on siphon layer.
5. being used for the portable POCT detector of multi-parameter as claimed in claim 4, it is characterised in that: sample storage chamber has The opening of sample to be tested is discharged, siphon layer has siphon groove, and siphon groove one end has interface, and interface extends to rotating layer, samples When, opening is aligned and contacts with interface.
6. being used for the portable POCT detector of multi-parameter as claimed in claim 5, it is characterised in that: detection module further includes One end of reference electrode, working electrode, reference electrode and auxiliary electrode is respectively positioned in siphon groove.
7. being used for the portable POCT detector of multi-parameter as claimed in claim 6, it is characterised in that: shell is touched equipped with electrode Point module, electrode contacts module include auxiliary electrode contact, working electrode contacts and reference electrode contact, electrode contacts module week To being equally spaced, electrode contacts module is corresponding with detection module;Alternatively, auxiliary electrode contact, working electrode contacts and reference Electrode contacts are laid with whole circumferential fashion;When opening is aligned and contacts with interface, working electrode is connect with working electrode contacts, auxiliary Electrode is helped to connect with auxiliary electrode contact, reference electrode is connect with reference electrode contact.
8. being used for the portable POCT detector of multi-parameter as described in claim 1, it is characterised in that: shell is equipped with motor, Rotating layer has the connecting hole of motor output shaft insertion, and connecting hole is connect with motor output shaft;Connecting hole and motor output shaft it Between be interference fitted.
9. being used for the portable POCT detector of multi-parameter as described in claim 1, it is characterised in that: sample storage chamber has Sample holes.
10. being used for the portable POCT detector of multi-parameter as described in claim 1, it is characterised in that: shell is additionally provided with place Display device is managed, processing display device includes micro-control unit, display screen, key, power supply and charging jacks.
CN201821081233.9U 2018-07-09 2018-07-09 Portable POCT detector for multi-parameter Active CN208621554U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108593730A (en) * 2018-07-09 2018-09-28 浙江大学山东工业技术研究院 Portable POCT detectors for multi-parameter

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108593730A (en) * 2018-07-09 2018-09-28 浙江大学山东工业技术研究院 Portable POCT detectors for multi-parameter
CN108593730B (en) * 2018-07-09 2024-07-02 浙江大学山东工业技术研究院 Portable POCT detector for multiple parameters

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