CN106853211A - 一种治疗溃疡性结肠炎的中药组合物及其制备方法 - Google Patents
一种治疗溃疡性结肠炎的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种治疗溃疡性结肠炎的中药组合物。该中药组合物由白芨、马齿苋、党参、白术、扁豆、薏苡仁、砂仁、干地黄、山茱萸、山药、茯苓、枸杞子、白芍、地榆、仙鹤草、槐花水、牛角片、丹皮、生地、黑山栀和/或药学上可接受的载体制成。本发明还涉及了该中药组合物的制备方法。 本发明中药组合具有清肠化湿、滋肾养肝、理气活血、逐瘀止泻等作用,用于溃疡性结肠炎引起的腹痛、腹泻、里急后重、粘液脓血便等症。
Description
技术领域
本发明涉及一种中药组合物,具体的说,涉及一种治疗溃疡性结肠炎的中药组合物及其 制备方法。
背景技术
溃疡性结肠炎又名慢性非特异性溃疡性结肠炎,是以直、结肠的表浅性、非特异性炎症 病为主,伴有肠外多器官损害的疾病,目前认为本病与遗传因素有关,以自身免疫机制为根 本,感染、神经因素为诱因,病变主要在直肠、乙状结肠。首先是粘膜浅层的弥漫性炎症改 变。继之充血、水肿、肥厚和脆性增加,产生小溃疡,进而发展成大溃疡,晚期由于结肠组 织增生,肠壁变厚、变窄、肠管变短。轻型患者常有左下腹或全腹压痛伴肠鸣亢进。重型和 暴发型患者可有腹肌紧张、反跳痛,或可触及痉挛或肠壁增厚的乙状结肠和降结肠。直肠指 检常有压痛。
本病病情较为顽固,症状常持续存在或呈间歇发作期与缓解期交替的慢性病程。具体临 床表现有:
起病缓慢,多呈慢性、迁延性,反复发作性,少数突发起病,呈持续进展或暴发性过程。
消化系统表现:腹痛和腹泻最为常见,腹痛位于左下腹,隐痛、绞痛,便后缓解。腹泻以粘液脓血便最常见,每日数次至1 0次不等,常伴里急后重。尚有恶心、呕吐、食欲不振。
全身症状:贫血,消瘦,低蛋白血症,水电解质紊乱,精神焦虑。
肠外表现:常有关节炎,结节性红斑,慢性活动性肝炎,口腔溃疡等。
左下腹压痛,部分患者可触及条索状增厚或痉挛的肠管。
本病的预防应保持心情舒畅,注意饮食有节,起居有常、避免劳累。戒除烟酒,忌食辣 椒、冷冻、生冷食品,预防肠道感染。
中医认为溃疡性结肠炎属于“痢疾”、“泄泻”、“肠风”、“下利”等范畴,认为本病病位在肠,与肝、脾、胃、肠等脏腑有关。初起多因情志不畅,肝气郁结,犯及脾胃;或因饮食不节,过食肥甘,或因湿热之体复饮食生冷以致脾胃损伤,导致脾失健运,清浊不分;或因感受暑湿热毒之邪,从而湿热毒邪内蕴,下迫肠道,气血凝滞,壅而化脓;出血日久,亦必耗血伤阴。久病人络,可致瘀血内阻;病久脾肾阳虚,清阳不升而中气下陷,温运无力而胃关不固。
中医将此病分为六种类型:
脾虚湿热型:腹泻,次数不等,里急后重,或肛门灼热,粪便中挟黏液脓血样便,味腥臭,腹痛,小便短赤,乏力消瘦,发热,口苦纳呆。舌苔黄腻,脉细滑数。脾虚生湿,郁而发热,伤及肠道,传化失常,则有腹泻,次数不等;湿热熏蒸肠道,脉络受伤,气血瘀滞,化为脓血,故粪便中挟黏液脓血样便,味腥臭;湿热之邪壅滞肠中,气机不畅,则有腹痛、里急后重;湿热下注、肛门灼热、小便短赤;脾气虚弱,可见神疲乏力、纳呆消瘦;发热口苦、舌苔黄腻均为湿热内蕴之象;脾虚则脉细;脉滑数乃湿热之脉象。
肝旺脾弱型:腹痛即泻,泻后痛减,常因抑郁恼怒、情绪紧张或激动而发作,大便夹脓血,胸胁胀满,烦躁易怒,暧气纳呆,肠呜腹胀,头痛时作。舌淡红,脉弦细。七情所伤, 肝失条达,气机不畅,横逆犯脾,健运失司,导致腹痛即泻,泻后痛减,每因情志不调而作 汽滞血阻,壅而化脓,可有大便夹脓血;肝旺则胸胁胀满、烦躁易怒、头痛时作;气滞则嗳 气、肠鸣腹胀;脾虚则纳呆舌淡红,脉弦细是为肝旺脾虚之征。
瘀阻肠道型:腹部刺痛,按之痛甚,大便中常夹脓血或紫黑色血块,面色晦黯。舌黯红,有紫斑,脉细弦。瘀阻肠道,气机不畅,故有少腹剌痛,按之痛甚;气滞血瘀,壅而化 脓,故大便中常夹脓血或紫黑色血块;面色晦黯、舌黯红、有紫斑、脉细弦是为气滞血瘀之 象。
脾胃虚弱型:大便搪薄,可挟有黏液,或混有大量肠垢、脓血,甚则泄泻不止,饮食不当即有发作,乏力倦怠,食欲不振,面色苍白。舌淡苔白,脉濡细。脾胃虚弱,运化无权,水谷不化,清浊不分,故大便溏薄,或挟有黏液,或混有大量肠垢。脓血,甚则泄泻不止,饮食不当即有发作;脾胃虚弱,生化乏源,气血两亏,可见乏力倦怠、食欲不振、面色苍白;舌淡苔白,脉儒细为脾胃虚弱之征。
阴虚内热型:腹泻时作,腹中隐痛,便血鲜红黏稠,常伴有午后潮热,盗汗,心烦不寐。舌红少苦,脉细数。久泻不愈,伤及阴血,可有腹泻时作,腹中隐痛,便血鲜红黏稠;阴虚生内热,故有午后潮热,盗汗;虚热扰动心神,则心烦不寐;舌红少苦,脉细数是为阴虚内热之象。
脾肾阳虚型:黎明之前,肠鸣腹痛腹泻,泻后则安,大便为黏液血样,遇寒即发,形寒肢冷,口淡纳少,喜热饮,腰酸乏力,面色苍白。舌淡苔白,脉沉细无力。泄泻日久,肾 阳虚衰,不能温运脾阳,运化失常,黎明之前阳气未振,阴寒较盛,故有黎明之前腹痛腹泻, 又称为“五更泻”;泻后腑气通利,故泻后则安;阴寒凝滞,气血凝聚,伤及肠络,则大便 为黏液血样;阳虚生内寒,可见遇寒即发,形寒肢冷;肾阳不足,则腰酸乏力;脾阳虚亏测 口淡纳少,喜热饮;面色苍白;舌淡苔白,脉沉细无力均为脾肾阳虚之象。
4
中医釆用清肠化湿、滋肾养肝、理气活血、逐瘀止泻的方药治疗此病。
发明内容
本发明的目的是提供一种治疗溃疡性结肠炎的中药组合物。 本发明的目的还在于提供一种该中药组合物的制备方法。
为了实现本发明的目的,本发明提供了一种治疗溃疡性结肠炎的中药组合物,是由有效成分和药学上可接受的载体制成,所述的有效成分是由下列原料按重量份计制成的:
白芨10-20份 白术20-30份 砂仁10-15份 山药20-30份 白芍10-20份 槐花水10-20份生地20-30。
马齿苋5-10份 扁見5-10份 干地黄10-25份 茯苓15-25份 地榆15-25份 牛角片5-10份 黑山栀10-20。
党参15-20份 薏苡仁15-25份 山茱萸10-20份 枸祀子10-25份 仙鹤草10-15份丹皮15-20。
有效成分优选由下列原料按重量份计制成:
白芨16份 白术26份 砂仁13份 山药26份 白芍25份 槐花水16份 生地26份
黑山栀16份
本发明还提供了一种该中药组合物的制备方法,包括下述步骤:
党参、山药粉碎成极细粉备用;
砂仁、白芍、生地用60%乙醇回流二次,每次一小时,分次滤过,合并滤液,减压浓缩成相对密度为1.15 (60°C)的清膏;
白芨、马齿苋、白术、扁豆、薏苡仁、干地黄、山茱萸、茯苓、枸杞子、地榆、仙鹤草、槐花水、牛角片、丹皮、黑山栀加水煎煮二次,每次2小时,滤过,合并滤液,静置48小时,取上清液,减压浓缩成相对密度为1.20 (60°C)的稠膏,加入上述细粉及清膏,干燥,粉碎成细粉,与药学上可接受的载体制成颗粒、胶囊及片剂。
本发明的药物组合物可以与药学上可接收的载体,例如:填充剂如淀粉、微晶纤维素等;
粘合剂如维生素衍生物、淀粉等;通过颗粒剂、胶囊剂、片剂口服给药的方式使用。
本发明中药组合具有清肠化湿、滋肾养肝、理气活血、逐瘀止泻等作用,用于溃疡性结 肠炎引起的腹痛、腹泻、里急后重、粘液脓血便等症。
具体实施方式
以下实施例用于说明本发明,但不用来限制本发明的范围。 实施例1:本发明中药组合物颗粒剂党参180g、山药260g粉碎成极细粉备用;
砂仁130g、白芍250g、生地260g用60%乙醇回流二次,每次一小时,分次滤过, 合并滤液,减压浓缩成相对密度为1. 15 (60°C)的清膏;
白芨160g、马齿苋80g、白术260g、扁豆80g、薏苡仁210g、干地黄180g、山茱 萸160g、茯苓200g、枸杞子180g、地榆210g、仙鹤草130g、槐花水160g、牛角 片80g、丹皮180g、黑山栀160g加水煎煮二次,每次2小时,滤过,合并滤液, 静置48小时,取上清液,减压浓缩成相对密度为1.20 (60°C)的稠膏,加入上 述细粉及清膏,干燥,粉碎成细粉,加入糊精1000g、乳糖200g,混匀,以75% 乙醇湿法制粒,装袋即得。
实施例2:本发明中药组合物胶囊剂党参180g、山药260g粉碎成极细粉备用;
砂仁130g、白芍250g、生地260g用60%乙醇回流二次,每次一小时,分次滤过, 合并滤液,减压浓缩成相对密度为1. 15 (60°C)的清膏;
白芨160g、马齿苋80g、白术260g、扁豆80g、薏苡仁210g、干地黄180g、山茱 萸160g、茯苓200g、枸杞子180g、地榆210g、仙鹤草130g、槐花水160g、牛角 片80g、丹皮180g、黑山栀160g加水煎煮二次,每次2小时,滤过,合并滤液, 静置48小时,取上清液,减压浓缩成相对密度为1.20 (60°C)的稠膏,加入上 述细粉及清膏,干燥,粉碎成细粉,加入糊精650g,混匀,装入空胶囊内即得。
Claims (3)
1.一种治疗溃疡性结肠炎的中药组合物,是由有效成分和药学上可接受的载体制成,其特征在于:所述的有效成分是由下列原料按重量份计制成的。
2.如权利要求1-2任一所述的中药组合物,其特征在于所述中药组合可制成颗粒、胶囊及片 剂。
3.一种如权利要求1-3任一所述的中药组合物的制备方法,包括下述步骤党参、山药粉碎成极细粉备用:砂仁、白芍、生地用60%乙醇回流二次,每次一小时,分次滤过,合并滤液,减压浓缩成相对密度为1.15 (60°C)。
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