CN106852958A

CN106852958A - Combination and its preparation technology for preventing and treating atherosclerosis Chinese traditional medicine extract

Info

Publication number: CN106852958A
Application number: CN201510895411.6A
Authority: CN
Inventors: 韩丰河
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-08
Filing date: 2015-12-08
Publication date: 2017-06-16

Abstract

The present invention is used to prevent and treat combination and its preparation technology of atherosclerosis Chinese traditional medicine extract, belong to technical field of traditional Chinese medicines, it is characterized in that be related to it is a kind of the effects such as mainly have promoting blood circulation and removing blood stasis, clearing heat and detoxicating, by the combination by a certain percentage of salviamiltiorrhizabung, Andrographis Paniculata and its preparation technology.Contain that the esters such as the compounds such as the compounds such as various red sage root flavones, quinones and phenolic acid class, andrographolide, flavonoids are molten, water soluble ingredient in extract.Can be made into various formulations.It is mainly used in atherosclerosis and prevention and treatment of diseases associated therewith.

Description

Combination and its preparation technology for preventing and treating atherosclerosis Chinese traditional medicine extract

Technical field

It is more particularly to a kind of with promoting blood circulation and removing blood stasis the invention belongs to technical field of traditional Chinese medicines, it is clearing heat and detoxicating, it is cool

Blood is subsided a swelling effect, be mainly used in atherosclerosis and the disease relevant with atherosclerosis prevention and

The combination by a certain percentage of the Chinese medical extract for the treatment of and its preparation technology.

Background technology

Salviamiltiorrhizabung is the root and root of the Labiatae herbaceos perennial red sage root (Salvia miltiorrhiza Bge.)

Stem, first recorded in《Sheng Nong's herbal classic》, top grade is classified as, dry.Bitter, is slightly cold.The thoughts of returning home, Liver Channel.Have

Stasis-dispelling and pain-killing, invigorate blood circulation, relieving restlessness that clears away heart-fire effect, for irregular menstruation, Amenorrhea is stimulated the menstrual flow , lumps in the chest and abdomen,

Chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia, hepatosplenomegaly, angina pectoris etc..And have " one

The taste red sage root dissipate, the same Siwu Tang of work(" say.Modern study proves that the red sage root and its extract have suppression blood small

Plate function and antithrombus formation, suppress blood coagulation, activation fibrinolytic, improve microcirculation, resisting cardiovascular ischemic and

Infarct, antibacterial, anti-inflammatory and influence body immune system function, reducing blood lipid and antiatherosclerosis, protection

Visceral organ injury etc. is acted on.Existing clinic be commonly used to treatment coronary disease and angina pectoris, acute myocardial infarction AMI, cerebrovascular disease,

Pulmonary heart disease, liver, kidney, digestion, respiratory disorder, acute mastitis, retinopathy, prostatitis, inclined head

Bitterly, the non-cardiovascular and cerebrovascular disease such as scapulohumeral periarthritis, silver-colored shoulder disease and vertigo.

Herba Andrographitis is distributed in the ground such as India, Sri Lanka, Pakistan, Myanmar pastures, Thailand, Vietnam, Indonesia,

Africa and South America are also found.The Herba Andrographitis of China is among the people most early in Guangdong and south Fujian introducing and planting

Already as the key medicine for controlling dysentery and boil pyogenic infections.Taste bitter and cold, nontoxic, its Main Function is heat-clearing solution

Poison, cool blood detumescence.Modern times have more research to Herba Andrographitis, and experimental result confirms that Herba Andrographitis is to hook end spiral shell

Rotation body, pneumococcus, first streptococcus and micrococcus catarrhalis have certain inhibitory action.It is each that clinic is usually used in treatment

Plant infectious diseases, including trauma infection contamination, furuncle, carbuncle, erysipelas, the infection of the upper respiratory tract, acute and chronic tonsillotome

Inflammation, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infections, endometritis, pelvic infecton, tympanitis, periodontitis etc..Herba Andrographitis treatment leptospirosis, ileotyphus, acute icteric hepatitis, pneumonia, indigestion, bacillary dysentery, encephalitis B, leprosy, venomous snake bite, Buerger's disease, eczema etc., can obtain preferable effect.

The content of the invention

Salvia root P.E is shared with Andrographis Paniculata, clearing heat and detoxicating with promoting blood circulationization addiction, cool blood detumescence effect；Platelet aggregation rate and plasma fibrinogen content can be reduced, improve hemorheological properties, regulation vascular endothelial cell relaxes and contracts and secreting function, reduce the expression of inflammatory mediator and adhesion molecule in blood, the various pathological changes in Earlier period of inflammation reaction phase, fatty streaks phase, ripe patch phase, induction four phases of plaque rupture to atherogenesis process have intervention effect, reduce the generation of cardiovascular and cerebrovascular acute events；It is mainly used in atherosclerosis and the prevention and treatment of diseases relevant with atherosclerosis.This research is found and invented through experimental study for many years by China Academy Of Traditional Chinese Medicine Traditional Chinese Medicine Research Institute scientific research personnel.

Main active substances in Salvia root P.E have chemical composition to be divided into fat-soluble and water-soluble two major class：Liposoluble constituent：The red sage root it is fat-soluble be mostly, ketone compounds, it is orange-yellow and orange red with feature.Mainly there are following material, Tanshinone I (Tanshinone I), Tanshinone I I A (TanshinonellA), Tanshinone II B (Tanshinone IIB) Cryptotanshinone（Cryptotanshinone), different Cryptotanshinone (Fsocryptotanshinone) red sage root quinone A, (Tanshiquinone A), red sage root quinone B (TanshiquinoneB), the red sage root cruel (hlviol), different Cryptotanshinone（Isocryptotanshinone), light base Tanshinone I I A (Hydroxy tanshinone IIA) >Dioxy Tanshinone I (Tanshinone I) etc., with antibacterial, anti-inflammatory, treatment coronary heart disease the effects such as.

The water soluble ingredient of the red sage root:Predominantly cruel acid has red cruel acid A (Salvianolic acid A), red meal with wine acid B (Salvianolic acid B), red cruel acid C (Salvianolic acidC), red cruel acid D (Salvianolic acid D), pellet drink acid E (Salvianolic acid E), red acid acid F (Salvianolic acid F), red meal with wine acid H (Salvianolic acidH) danshensu (Danshensu), ursolic acid protocatechuic acid (Protocate

- chualdehyde), Rosmarinic acid (Rosmarinicacid), Rosmarinic acid first it is cruel (Methylrosmarinate)

Protocatechuic acid（Protocatechuic acid) etc. various cruel acid compounds etc..With improve microcirculation,

Suppress platelet aggregation, reduce myocardial damage and the effect such as anti-oxidant.Additionally, also containing flavonoids, triterpenes

With the composition such as sterol.

Main active substances in Andrographis Paniculata have：14- deoxidations -11, dehydrogenation andrographolide (the 14-deoxy-ll of 12- bis-, 12-oxoandrographolide), 14- deoxidations -11, dehydrogenation andrographolide (the 14-deoxy-ll of 12- bis-, 12-didehydroandrographolide) 0 still contains the glycoside materials such as sterol mound glycosides, carbohydrate , Difficult matter.Also chloride containing potassium, sodium chloride, alkaloid.Root alkyl containing 5- -7,8,2,3- tetramethoxy flavones (mono-0-methylwithin), 5- alkyl -7,8,2- trimethyl flavones (andrographin), 5,2- the second light industry bureau bases 7,8- dimethoxy flavones（Panicolin), dish element-7,4- dimethyl ether (apigenin-7,4-dimethylether), 0-Grains sterol and KH2P04 etc. are abandoned.Vinegar in leaf Herba Andrographitis containing deoxidation（Deoxyandrographalide), andrographolide（Andrographolide), cruel (neoandrograPho 1 in new Herba Andrographitis Ide), it is cruel in Herba Andrographitis high（) and Pan Ninei cruel (Panicolide) homoandrographolide.(andragraphan) still is burnt containing Herba Andrographitis, andrographon（), andrographon Herba Andrographitis sterol（Andrographosterin) and 0 _ Valley sterol-D-Glucose glycosides, qroxylin A (oroxylin-A), wogonin (wogonin), additionally, still having flavones, saturated aliphatic aldehyde, beta-unsaturated ketone etc..Separately from the Yu He Group Woven such as young tender each several part device pipe and plumular axis, plumule, andrographolide A, B, C (PaniculidesA, B, C) can be got.

Administration can mitigate the degree of AS lesions, delay AS processes.

Experimental study is proved, the red sage root is combined by a certain percentage with Andrographis Paniculata, the characteristics of effect to AS processes is intervened in too many levels, can by reduce AS rat blood serums T-CHOL, triglyceride levels and adjust body lipid-metabolism, by adjust TXA2/PGI2 balance, reduce NO pathologic increase and improve endothelium relax contracting and secreting function, by reduce plasma fibrinogen content, platelet aggregation rate, extension prothrombin time and improve AS hemorheology properties etc. multiple links intervene rat AS forming processes.

The red sage root is combined by a certain percentage with Andrographis Paniculata, and the various pathological changes in Earlier period of inflammation reaction phase, fatty streaks phase, ripe patch phase, induction four phases of plaque rupture to rabbit AS forming processes have different degrees of intervention effect.Pathology aspect, can obviously reduce Rabbit Thoracic Aortic AS plaque areas and fat line thickness, mitigates foley's tube and pulls local luminal stenosis degree caused by Rabbit Femoral Artery.The formation of lipidosis and foam cells in plaque can substantially be mitigated, also have certain inhibitory action to the infiltration of the inflammatory cells such as monocyte, lymphocyte, mast cell, and the breeder reaction of smooth muscle cell in model can be suppressed.There is inhibitory action to increasing for inflammatory mediator TNFa, CRP, LI-8 in AS rabbit anteserums, adhesivemoleculeICAM1, the expression of VCAM-1, CD18 in AS plaques can be reduced, the exception during AS such as chemotactic factor (CF) MCP-1, growth factor I GF-1 is increased also significant adjustment effect.Experiment in vitro shows that the vascular endothelial cell strain HUVEC and the adhesion effect of monocyte strain THP-1 induced TNF a and Hyperlipidemic Serum have obvious inhibitory action, and can mitigate intake abilities of the THP-1 to lipid.

Specific embodiment

Red rooted salvia is crushed and mixed, and adds 10 times of amount ethanol percolations, then with 10 times of 60% ethanol percolations of amount, merge ethanol percolation liquid twice, filtering.Merging filtrate, is concentrated into without alcohol taste, upper macroporous absorbent resin, and washing, then ethanol is washed, and concentrates ethanol eluate, and 80 °C of drying under reduced pressure obtain Salvia root P.E.

Herba Andrographitis pulverizing medicinal materials are mixed, and add 10 times of amount dilute alcohols, are soaked 8 hours while stirring, filtering.Medicinal material residue adds 8 times of dilute alcohols of amount, soaks 8 hours while stirring, filtering.Merging filtrate, is concentrated into without alcohol taste, adds ethanol solution to alcohol content to 40%, stirring while adding, stands overnight, concentrated supernatant to amylalcohol taste, upper macroporous absorbent resin, washes, then alcohol is washed, and concentrates ethanol eluate, and 80 °C of drying under reduced pressure obtain Andrographis Paniculata.

Andrographis Paniculata, Salvia root P.E, by 5:3 are used in mixed way.

Claims

1. a kind of for preventing and treating atherosclerosis Chinese traditional medicine extract, it is characterized in that by salviamiltiorrhizabung and punching

Lotus extract is combined by a certain percentage.

2., according to claim 1, the preparation technology of Salvia root P.E is characterised by that point two parts are carried out, its first

Divide and oozed with ethanol is cold, reclaim ethanol；Part II uses dilute alcohol cold soaking, reclaims ethanol, upper macroporous absorption

Resin, washing, alcohol is washed, and reclaims ethanol, the extract of gained after drying.