CN106829027A - The fast preparation method and device of a kind of hydrogen sterile liquid - Google Patents
The fast preparation method and device of a kind of hydrogen sterile liquid Download PDFInfo
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- CN106829027A CN106829027A CN201611256512.XA CN201611256512A CN106829027A CN 106829027 A CN106829027 A CN 106829027A CN 201611256512 A CN201611256512 A CN 201611256512A CN 106829027 A CN106829027 A CN 106829027A
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- hydrogen
- sterile liquid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/02—Filling, closing, or filling and closing, containers or wrappers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
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Abstract
The invention discloses the preparation method and device of a kind of hydrogen sterile liquid, belong to the preparation method technical field of hydrogeneous gas-liquid.The preparation method of hydrogen sterile liquid of the invention, comprises the following steps：（1）The plastic material packaging bag or Packaging Bottle that will be equipped with sterile liquid are put into hermetically sealed can；（2）After hermetically sealed can is sealed, hydrogen is passed through from hermetically sealed can top, while opening the air bleeding valve of sealing pot bottom；（3）When being full of hydrogen in tank to be sealed, the air bleeding valve of sealing pot bottom is closed；（4）Continue, to hydrogen is passed through in hermetically sealed can, when the relative pressure in tank to be sealed reaches 0.07 ~ 0.1MPa, to stop being passed through hydrogen to hermetically sealed can；（5）The air bleeding valve of sealing pot bottom is opened after a period of time, makes the relative pressure in hermetically sealed can be 0, take out sterile liquid packaging bag, hydrogen sterile liquid completes.The present invention need not open plastic material packaging bag or Packaging Bottle, can guarantee that the hydrogen liquid asepsis of final preparation, and preparation time is short, efficiency high.
Description
Technical field
The present invention relates to the fast preparation method and device of a kind of hydrogen sterile liquid, belong to hydrogeneous gas-liquid preparation side
Law technology field.
Background technology
At present, have numerous studies prove hydrogen can reduce all kinds of oxidative damages, the reaction that controls inflammation, reduction cell wither
Die, hydrogen bioactivity and its effect in various disease prevention and cure rapidly become study hotspot, therefore, in medicine technology field
Beginning largely prepares hydrogeneous gas-liquid, and by taking hydrogen physiological saline as an example, the preparation process of prior art is：At ambient pressure will be raw
Pure hydrogen constantly is passed through in reason bag of saline, hydrogen is dissolved in physiological saline, so as to prepare hydrogen physiological saline, finally
Hydrogen content can reach 1ppm in physiological saline.This method is carried out at ambient pressure, be passed through hydrogen for up to 24h very
To the longer time, there is a problem of preparation method time-consuming, waste time and energy, it is impossible to effectively solve quickly to be made in the case of some urgent needs
Standby requirement.And, normal saline bag anti-pressure ability is low in this method, and hydrogen is passed through for a long time can cause normal saline bag quick-fried
Split, cause hydrogen gas leakage, easily caused danger during Reusability.In addition, this method is in preparation process, it is impossible to ensure what is prepared
Hydrogen liquid asepsis.
The content of the invention
It is existing to solve it is an object of the invention to provide the fast preparation method and device of a kind of hydrogen sterile liquid
The hydrogeneous gas-liquid of technology has a preparation method, and time-consuming, the easily explosion of normal saline bag Reusability cause it is dangerous and it cannot be guaranteed that
The technical problem of hydrogen liquid asepsis.
The fast preparation method of hydrogen sterile liquid of the present invention is adopted the following technical scheme that：A kind of hydrogen sterile liquid
Preparation method, it is comprised the following steps：（1）The plastic material packaging bag or Packaging Bottle that will be equipped with sterile liquid are put into hermetically sealed can
In；（2）After hermetically sealed can is sealed, hydrogen is passed through from hermetically sealed can top, while opening the air bleeding valve of sealing pot bottom；（3）Treat close
When being full of hydrogen in sealed cans, the air bleeding valve of sealing pot bottom is closed；（4）Continue to being passed through hydrogen in hermetically sealed can, in tank to be sealed
Relative pressure when reaching 0.07 ~ 0.1MPa, stop being passed through hydrogen to hermetically sealed can；（5）Sealing pot bottom is opened after a period of time
Air bleeding valve, make relative pressure in hermetically sealed can be 0, take out sterile liquid packaging bag, hydrogen sterile liquid completes.
Preferably, step（4）In, when the pressure in hermetically sealed can reaches 0.12MPa, the air bleeding valve for sealing pot bottom is beaten automatically
Drive row pressure release into.
Preferably, step（5）In, the air bleeding valve of sealing pot bottom is opened after 1 to 2 hour.
Preferably, step（1）Extremely（5）The middle hermetically sealed can for using is metal sealing tank.
The quick preparation device of hydrogen sterile liquid of the present invention is adopted the following technical scheme that：A kind of hydrogen sterile liquid
Preparation facilities, including hermetically sealed can, hermetically sealed can includes tank body and cover, and the hermetically sealed can is cylindrical structure, on the cover
Inflation inlet is provided with, inflation inlet is provided with charge valve, and the tank base is provided with exhaust outlet, and exhaust outlet is provided with air bleeding valve, described
Cover is provided with pressure gauge, and the tank body and cover are made of metal.
Preferably, base is provided with the tank body, the upper surface of base is higher than exhaust outlet, and base is provided with support, described
Base and rack surface have metal-insulator lacquer coat.
Preferably, the cover is provided with handle, and handle is plastic material.
Preferably, the sealing ring for being provided with the cover and being coordinated along sealing on tank body, is connected with the cover outer rim
Seal buckle, the top of the tank body is provided with draw-in groove, and the lower end of the seal buckle has the connection sheet for being locked in draw-in groove.
Preferably, the material of the tank body and cover is aluminium or stainless steel.
Preferably, the wall thickness of the tank body and cover is all higher than 3mm.
The beneficial effects of the invention are as follows：The present invention is that sterile liquid is placed in hermetically sealed can together with packaging bag, then
To hydrogen is passed through in hermetically sealed can, due to hydrogen molecule very little, can pass through plastic material packaging bag or Packaging Bottle etc. and enter in it
Liquid, forms the sterile liquid of hydrogen, need not so open sterile liquid plastic packaging bag or Packaging Bottle etc., can guarantee that final
The hydrogen liquid asepsis of preparation.The present invention applies one in preparation process to sterile liquid plastic packaging bag or Packaging Bottle etc.
Fixed pressure, can increase speed and amount of the hydrogen through packaging bag, prepare the sterile liquid of hydrogeneous tolerance high, and strengthen right
The penetrability of plastic material, the aseptic eyedrops thicker for plastic material Packaging Bottle, it is also possible to which that realizes hydrogen penetrates dissolving,
Belong to pioneering.The present invention need not open plastic packaging bag or Packaging Bottle etc., can guarantee that the hydrogen liquid asepsis of final preparation.By
It is not that the sterile liquid in sterile liquid bag is directly pressurizeed in the present invention, and prior art is direct molten by pressurized with hydrogen
The process for entering physiological saline has essential distinction.The present invention uses cylindrical metal hermetically sealed can, and anti-pressure ability is strong, and hydrogen will not be worn
Saturating hermetically sealed can, preparation time is short, improves efficiency.The present invention can be used to prepare aseptic hydrogen physiological saline, hydrogen medicament for the eyes
The hydrogeneous gas-liquid such as water.
Further, base and support are set, sterile liquid packaging bag can be placed on support in manufacturing process, protect
Card packaging bag bottom and surrounding are ventilative, hydrogen is entered inside packaging bag from bottom and surrounding all directions.
Further, sealing Aluminium alloy for pots or stainless steel make, and thickness is in more than 3mm, it is ensured that pressurization repeatedly makes
Reliability.
Brief description of the drawings
Fig. 1 is the structural representation of the embodiment of the preparation facilities of the aseptic hydrogeneous gas-liquid of the present invention.
Specific embodiment
The present invention is described in detail with specific embodiment below in conjunction with the accompanying drawings.
The embodiment of the fast preparation method of hydrogen sterile liquid of the present invention is comprised the following steps：（1）Will be equipped with aseptic
The plastic material packaging bag of liquid or Packaging Bottle are put into hermetically sealed can；（2）After hermetically sealed can is sealed, hydrogen is passed through from hermetically sealed can top
Gas, while opening the air bleeding valve of sealing pot bottom；（3）When being full of hydrogen in tank to be sealed, the air bleeding valve of sealing pot bottom is closed；
（4）Continue, to hydrogen is passed through in hermetically sealed can, when the relative pressure in tank to be sealed reaches 0.07 ~ 0.1MPa, to stop to hermetically sealed can
It is passed through hydrogen；（5）The air bleeding valve of sealing pot bottom is opened after a period of time, makes the relative pressure in hermetically sealed can be 0, taken out aseptic
Pack for liquids, hydrogen sterile liquid completes.
Step（4）In, when the pressure in hermetically sealed can reaches 0.12MPa, the air bleeding valve of sealing pot bottom is automatically opened up and carried out
Pressure release.
Step（5）In, the air bleeding valve of sealing pot bottom is opened after 1 to 2 hour.
Step（1）Extremely（5）The middle hermetically sealed can for using is metal sealing tank.
As a example by quickly preparing aseptic hydrogen physiological saline, step（4）In, under 0.07MPa pressure, normal temperature condition, 1
Hydrogen content in the hydrogen physiological saline prepared after hour is 0.9ppm, is within 2 hours 1.2ppm；And in 0.1MPa pressure
Under, 1 hour hydrogen content, up to 1.2ppm, 2 hours is 1.5ppm.Therefore the pressure normal temperature of 0.1MPa is used lower 1 hour
The physiological saline that hydrogen content is 1.2ppm is prepared, preparation time is greatly shortened, efficiency is improve.
The hydrogen physiological saline prepared using this method directly local injection can be used to promote the diabetic mice surface of a wound to heal
Close.After inducing successfully diabetic mice wound model, it is divided into diabetic controls group and hydrogen saline therapy group, gives respectively
Give around the surface of a wound and inject 0.2ml physiological saline or hydrogen physiological saline daily at the surface of a wound, during epithelialization complete with the surface of a wound
Between be observation index.The complete epithelialization healing of the diabetic mice surface of a wound has been used 18.30 ± 0.82 days, and hydrogen physiological saline group is used
13.10 ± 0.97 days, diabetic wound healing can be obviously promoted.
The structure of the embodiment of the quick preparation device of hydrogen sterile liquid of the present invention is as shown in figure 1, the present embodiment
The preparation facilities of hydrogen physiological saline includes hermetically sealed can, and the hermetically sealed can is cylindrical structure, and hermetically sealed can includes tank body 1 and tank
The wall thickness of lid 2, the tank body 1 and cover is all higher than 3mm.The sealing ring for being provided with the cover 2 and being coordinated along sealing on tank body 1
71, seal buckle 72 is connected with the cover outer rim, the top of the tank body is provided with draw-in groove 73, the lower end tool of the seal buckle 72
There is the connection sheet for being locked in draw-in groove 73.The cover 2 is provided with inflation inlet 21, and inflation inlet 21 is provided with charge valve 22,
The bottom of the tank body 1 is provided with exhaust outlet 11, and exhaust outlet 11 is provided with air bleeding valve 12, and the cover 2 is provided with pressure gauge 3, this reality
Apply tank body 1 and cover 2 in example made of aluminum.Base 4 is provided with the tank body 1, the upper surface of base 4 is higher than exhaust outlet 11, bottom
Seat 4 is provided with support 5, and the base and rack surface have metal-insulator lacquer coat.The cover 2 is provided with handle 6, and handle is
Plastic material.
The present embodiment will be equipped with the plastic material packaging bag of sterile liquid when in use, first or Packaging Bottle is put into hermetically sealed can
In, then seal buckle is clamped on draw-in groove coordinates tank body and sealing of tank cover, is then passed through hydrogen to tank interior from inflation inlet,
The air bleeding valve on exhaust outlet being opened simultaneously, tank body top being accumulated in because the density of hydrogen is small, the air of tank body lower part will
Discharged by exhaust outlet, after a period of time in tank to be sealed full of hydrogen when, close air bleeding valve, continue to being passed through hydrogen in hermetically sealed can
Gas, when pressure gauge registration is in 0.07 ~ 0.1MPa, stops, to hydrogen is passed through in tank body, sealing pot bottom being opened after a period of time
Air bleeding valve, sterile liquid packaging bag is taken out when pressure gauge registration is 0, hydrogen sterile liquid completes.It is passed through hydrogen mistake
Cheng Zhong, when pressure is excessive in tank body, by safety relief valve releasing pressure automatically.
The present embodiment will be equipped with plastic material packaging bag or the Packaging Bottle of sterile liquid when hydrogen sterile liquid is made
It is placed on the support in hermetically sealed can, then to hydrogen is passed through in hermetically sealed can, due to hydrogen molecule very little, can pass through plastic material bag
Pack or Packaging Bottle enter in it, form the sterile liquid of hydrogen, need not so open pack for liquids or Packaging Bottle, can protect
The final hydrogen liquid asepsis for preparing of card.The present invention is applied in preparation process to sterile liquid plastic packaging bag or Packaging Bottle
Plus certain pressure, the liquid that hydrogen is dissolved into plastic material packaging bag or Packaging Bottle can be accelerated, hydrogen transmission can be increased
The speed and amount of plastic packaging bag, and increase the penetrability to plastic material, the aseptic eye thicker for plastic material Packaging Bottle
Liquid medicine, it is also possible to which that realizes hydrogen penetrates dissolving, belongs to of the invention pioneering.Because the present invention is not directly to plastic packaging bag
Or the liquid in Packaging Bottle is pressurizeed, and the process that pressurized with hydrogen dissolves in physiological saline is had substance by the direct of prior art
Difference.The present invention uses cylindrical metal hermetically sealed can, and anti-pressure ability is strong, and hydrogen will not penetrate hermetically sealed can, and preparation time is short, improves
Efficiency.
Above-described embodiment is a kind of preferred embodiment of the invention, in other embodiments of the invention, tank body and cover
Can also be made up of stainless steel or other metal materials.
Although being described in detail to embodiments of the present invention in the embodiment above, the invention is not restricted to
Above-mentioned implementation method, the scope of the present invention that appended claim is limited includes all equivalent replacements and change.
Claims (10)
1. a kind of fast preparation method of hydrogen sterile liquid, it is characterised in that：It is comprised the following steps：（1）Will be equipped with nothing
The plastic material packaging bag of bacteria liquid or Packaging Bottle are put into hermetically sealed can；（2）After hermetically sealed can is sealed, it is passed through from hermetically sealed can top
Hydrogen, while opening the air bleeding valve of sealing pot bottom；（3）When being full of hydrogen in tank to be sealed, the exhaust of sealing pot bottom is closed
Valve；（4）Continue, to hydrogen is passed through in hermetically sealed can, when the relative pressure in tank to be sealed reaches 0.07 ~ 0.1MPa, to stop to sealing
Tank is passed through hydrogen；（5）The air bleeding valve of sealing pot bottom is opened after a period of time, makes the relative pressure in hermetically sealed can be 0, take out nothing
Bacteria liquid packaging bag, hydrogen sterile liquid completes.
2. the fast preparation method of hydrogen sterile liquid according to claim 1, it is characterised in that：Step（4）In, it is close
When pressure in sealed cans reaches 0.12MPa, the air bleeding valve of sealing pot bottom is automatically opened up and carries out pressure release.
3. the fast preparation method of hydrogen sterile liquid according to claim 1, it is characterised in that：Step（5）In, 1
The air bleeding valve of sealing pot bottom is opened after to 2 hours.
4. the fast preparation method of the hydrogen sterile liquid according to claim 1 or 2 or 3, it is characterised in that：Step
（1）Extremely（5）The middle hermetically sealed can for using is metal sealing tank.
5. a kind of quick preparation device of hydrogen sterile liquid, including hermetically sealed can, hermetically sealed can includes tank body（1）And cover（2）,
It is characterized in that：The hermetically sealed can is cylindrical structure, the cover（2）It is provided with inflation inlet（21）, inflation inlet（21）On set
There is charge valve（22）, the tank body（1）Bottom is provided with exhaust outlet（11）, exhaust outlet（11）It is provided with air bleeding valve（12）, the tank
Lid（2）It is provided with pressure gauge（3）, the tank body（1）And cover（2）It is made of metal.
6. the quick preparation device of hydrogen sterile liquid according to claim 5, it is characterised in that：The tank body（1）
Inside it is provided with base（4）, base（4）Upper surface be higher than exhaust outlet（11）, base（4）It is provided with support（5）, the base（4）
And support（5）There is metal-insulator lacquer coat on surface.
7. the quick preparation device of hydrogen sterile liquid according to claim 5, it is characterised in that：The cover（2）
It is provided with handle（6）, handle（6）Material be plastics.
8. the quick preparation device of hydrogen sterile liquid according to claim 5, it is characterised in that：The cover（2）
Inside it is provided with and tank body（1）The upper sealing ring coordinated along sealing（71）, seal buckle is connected with the cover outer rim（72）, the tank
The top of body is provided with draw-in groove（73）, the seal buckle（72）Lower end have for being locked at draw-in groove（73）Interior connection sheet.
9. the quick preparation device of hydrogen sterile liquid according to claim 5, it is characterised in that：The tank body（1）
And cover（2）Material be aluminium or stainless steel.
10. the quick preparation device of hydrogen sterile liquid according to claim 5, it is characterised in that：The tank body（1）
And cover（2）Wall thickness be all higher than 3mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611256512.XA CN106829027A (en) | 2016-12-30 | 2016-12-30 | The fast preparation method and device of a kind of hydrogen sterile liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611256512.XA CN106829027A (en) | 2016-12-30 | 2016-12-30 | The fast preparation method and device of a kind of hydrogen sterile liquid |
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| Publication Number | Publication Date |
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| CN106829027A true CN106829027A (en) | 2017-06-13 |
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| CN201611256512.XA Pending CN106829027A (en) | 2016-12-30 | 2016-12-30 | The fast preparation method and device of a kind of hydrogen sterile liquid |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101932297A (en) * | 2009-03-13 | 2010-12-29 | 水株式会社 | Process and apparatus for producing hydrogen-containing biocompatible solution |
| CN104016470A (en) * | 2013-03-01 | 2014-09-03 | 百泉利康 | Method and apparatus to produce hydrogen-rich materials |
| CN104398475A (en) * | 2014-12-04 | 2015-03-11 | 上海纳诺巴伯纳米科技有限公司 | Device and method for filling medical infusion bag with hydrogen in non-contact manner |
| CN105246492A (en) * | 2014-03-13 | 2016-01-13 | 水株式会社 | Method for producing hydrogen-containing biological application solution, and exterior body therefor |
-
2016
- 2016-12-30 CN CN201611256512.XA patent/CN106829027A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101932297A (en) * | 2009-03-13 | 2010-12-29 | 水株式会社 | Process and apparatus for producing hydrogen-containing biocompatible solution |
| CN104016470A (en) * | 2013-03-01 | 2014-09-03 | 百泉利康 | Method and apparatus to produce hydrogen-rich materials |
| CN105246492A (en) * | 2014-03-13 | 2016-01-13 | 水株式会社 | Method for producing hydrogen-containing biological application solution, and exterior body therefor |
| CN104398475A (en) * | 2014-12-04 | 2015-03-11 | 上海纳诺巴伯纳米科技有限公司 | Device and method for filling medical infusion bag with hydrogen in non-contact manner |
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Application publication date: 20170613 |