CN100491213C - Production method of non-PVC multi-chamber large transfusion bag capable of avoiding water in solid medicine chamber after sterilization - Google Patents

Abstract

The production process of large non-PVC multiple chamber transfusion bag includes the steps of making bag, filling liquid medicine, sealing and sterilizing, cutting opening in the solid medicine chamber, filling solid medicine, and sealing. The present invention features that before sterilization, the solid medicine chamber is coated with composite aluminum-plastic film to avoid moisture to enter the inside. The said production process can prevent moisture from entering the solid medicine chamber through the non-PVC film of the solid medicine chamber.

Description

Production method of non-PVC multi-chamber large transfusion bag capable of avoiding water in solid medicine chamber after sterilization

technical field

The invention belongs to the field of medicine packaging, and in particular relates to a production method of a non-PVC multi-chamber bag infusion that can avoid water in a sterilized solid medicine chamber.

Background technique

The existing single-mouth tube single-chamber large transfusion bag has only one medicine charging chamber, and can only hold a kind of medicine liquid. During production, a single-chamber bag is first made by a bag-making machine, and the medicine is poured into the bag, and then the combined cover is welded. Since the large infusion is generally physiological saline or nutrient solution, it cannot be stored for a long time after being mixed with the therapeutic solid medicine, so the therapeutic solid medicine can be mixed with the large infusion only when in use. The liquid medicine is drawn out and injected into the container of solid medicine, and after it is completely dissolved, it is drawn out from the container of solid medicine and injected into the bag of large infusion solution. This kind of packaged infusion bag must also waste a disposable syringe and the man-hours of dispensing when used, which increases the cost of use; delaying the rescue time during emergency treatment may cause serious consequences; it is also easy to cause misuse for busy nurses The possibility of taking the medicine, or not knowing whether the medicine is dispensed correctly when waiting for the infusion after dispensing. In order to solve the above-mentioned technical problems, a plurality of drug-charging chambers which can be separated by separable weak welding seams and can hold liquid medicine and solid medicine at the same time can be arranged on the same infusion bag, that is, a non-PVC film large transfusion multi-chamber bag can be made. Liquid drugs in large infusions must be sterilized at high temperature after filling and sealing, while solid drugs (mainly sterile powders) cannot be sterilized at high temperature, that is, filling of solid drugs must be performed after liquid drugs are sterilized. Due to the poor water vapor resistance of non-PVC films at high temperatures, during the sterilization process, the concentration of water vapor outside the solid drug chamber is large, while the solid drug chamber is dry gas, so water vapor can easily pass through the non-PVC material that makes up the solid drug chamber. When the film enters the solid drug chamber, the water vapor condenses into water after sterilization and stays in the solid drug chamber. The shelf life of the solid drug after contact with water is very short, which affects the quality of the drug.

Contents of the invention

The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned prior art, and to provide a non-PVC film multi-chamber bag for large infusion after the liquid medicine is sterilized, and the water vapor will not pass through the non-PVC film that forms the solid medicine chamber. The non-PVC multi-chamber large infusion bag production method can avoid water in the solid medicine chamber after being sterilized into the solid medicine chamber, and the process is simple and practicable.

In order to solve the above technical problems, the present invention adopts the following technical solutions.

The production method of the non-PVC multi-chamber large infusion bag that can avoid water in the solid medicine chamber after sterilization of the present invention, its process steps include bag making, liquid medicine filling, sealing, sterilization, solid medicine chamber cutting, solid Medicine filling and sealing of the solid medicine chamber are characterized in that before sterilization, the solid medicine chamber is coated with an aluminum-plastic composite film that can prevent water vapor from entering the solid medicine chamber during sterilization.

As a further improvement of the present invention, the specific steps are: making bags, packing the solid medicine outside, and covering the aluminum-plastic composite film that can prevent water vapor from entering the solid medicine chamber during sterilization, liquid medicine filling, sealing the liquid medicine chamber, and sterilizing , cutting of the solid drug chamber, solid drug filling and sealing of the solid drug chamber.

The specific steps can also be: bag making, liquid medicine filling, sealing of the liquid medicine chamber, coating the aluminum-plastic composite film outside the solid medicine chamber to prevent water vapor from entering the solid medicine chamber during sterilization, sterilization, and solid medicine chamber Cutting, filling of solid medicine and sealing of solid medicine chamber.

The aluminum-plastic composite film is welded around the solid medicine chamber.

The beneficial effect of the present invention is that: the present invention is aimed at the non-PVC film multi-chamber bag large infusion solution that is provided with a plurality of charge chambers that can simultaneously hold liquid medicine and solid medicine on the same infusion bag, and there is water vapor condensation after sterilization in the production process. In order to solve the problem of water remaining in the solid medicine chamber, the aluminum-plastic composite film with high resistance to water vapor is used to seal the solid medicine chamber before sterilization to prevent water vapor from entering the solid medicine chamber during sterilization. The solid medicine is kept dry, and the quality and storage time of the medicine are improved.

Description of drawings

Fig. 1 is the structure schematic diagram before the large transfusion double-chamber bag that can hold liquid medicine and solid medicine is not filled with medicine;

Fig. 2 is a schematic diagram of the structure of the large infusion double-chamber bagged liquid medicine chamber after the medicine is filled and the aluminum-plastic composite film is welded;

Fig. 3 is a schematic structural view of the bagged solid medicine shown in Fig. 2 .

Fig. 4 is an enlarged cross-sectional view along line A-A of Fig. 3 .

Each label in the figure means:

1. High-strength weld seam 2. Liquid medicine chamber

3. Weak welding seam 4. Solid drug chamber

5. Drug filling port 6. Interface

7. Combination cover 8. Aluminum-plastic composite film

9. Cutting line

Detailed ways

The production method of the non-PVC multi-chamber large infusion bag that can avoid water in the solid medicine chamber after sterilization of the present invention, its process steps include bag making, liquid medicine filling, sealing, sterilization, solid medicine chamber cutting, solid Filling the medicine and sealing the solid medicine chamber, and wrapping the aluminum-plastic composite film outside the solid medicine chamber before sterilization can prevent water vapor from entering the solid medicine chamber during sterilization. The aluminum-plastic composite film is welded to the solid medicine chamber. around the room.

In the present invention, before filling the liquid medicine chamber, the aluminum-plastic composite film can be coated on the outside of the solid medicine chamber to prevent water vapor from entering the solid medicine chamber during sterilization. The specific process steps are as follows: bag making, solid medicine chamber Welding aluminum-plastic composite film around, filling liquid medicine, sealing liquid medicine chamber, sterilizing, cutting solid medicine chamber, filling solid medicine and sealing solid medicine chamber.

In the present invention, after filling the liquid medicine chamber, the aluminum-plastic composite film that can prevent water vapor from entering the solid medicine chamber during sterilization can be coated on the outside of the solid medicine chamber. The specific process steps are as follows: bag making, liquid medicine filling Packing and sealing of the liquid medicine chamber, welding aluminum-plastic composite film around the solid medicine chamber, sterilization, cutting of the solid medicine chamber, solid medicine filling and sealing of the solid medicine chamber. It can be determined according to the production equipment.

Below in conjunction with accompanying drawing, the following process is taken as an example to further describe the process step of the present invention in detail:

1) Bag making: first make the bag as shown in Figure 1 (take the double-chamber bag as an example), the periphery of the bag is sealed by high-strength welds 1, and the inner cavity of the bag is separated by separable weak welds 3 into packaging The liquid medicine chamber 2 and the solid medicine chamber 4, the liquid medicine chamber 2 is connected with an interface 6, and the solid medicine chamber 4 is connected with a reserved medicine filling port 5;

2) Liquid medicine filling: as shown in Figure 2, fill the liquid medicine chamber 2 with liquid medicine;

3) Sealing of the liquid medicine chamber: as shown in Figure 2, after the liquid medicine is filled, the interface 6 is sealed by the combination cover 7;

4) The outdoor coating of the solid medicine can prevent water vapor from entering the solid medicine chamber during sterilization: as shown in Figure 2, in order to prevent water vapor from entering the solid medicine chamber 4 during sterilization, the solid medicine The chamber 4 is coated with an aluminum-plastic composite film 8 that prevents water vapor from entering the solid medicine chamber 4 during sterilization, and the aluminum-plastic composite film 8 is welded around the solid medicine chamber 4;

5) Sterilization;

6) Cutting the solid drug chamber: cut the bag from the cutting line 9 shown in Figures 1 and 2, open the drug filling port 5 of the solid drug chamber 4,

7) Filling of solid medicine: put the powder (solid) medicine into the solid medicine chamber 4;

8) Sealing of the solid drug chamber: as shown in Figure 3, after the filling of the solid drug is completed, the drug filling port 5 is heat-sealed to obtain a liquid drug and a solid drug as shown in Figures 3 and 4. The outer coating of the medicine chamber 4 can prevent water vapor from entering the non-PVC film double-chamber bag infusion solution of the aluminum-plastic composite film 8 of the solid medicine chamber 4 during sterilization.

The above-mentioned aluminum-plastic composite film 8 has good water vapor resistance, good welding performance and good cooking resistance. It can be thermally welded together with the non-PVC film forming the solid drug chamber, and will not deform after high temperature sterilization. Invariance, when liquid medicine is sterilized, water vapor can be prevented from entering the solid medicine chamber 4 through the non-PVC film, so that the solid medicine chamber 4 is kept dry to improve the quality and storage time of the medicine.

Claims (4)

1. A non-PVC multi-chamber large infusion bag production method that can avoid water in the solid medicine chamber after sterilization, the process steps include bag making, liquid medicine filling, sealing, sterilization, solid medicine chamber cutting, The solid medicine filling and the sealing of the solid medicine chamber are characterized in that before sterilization, the solid medicine chamber is coated with an aluminum-plastic composite film that can prevent water vapor from entering the solid medicine chamber during sterilization. 2. The non-PVC multi-chamber large infusion bag production method capable of avoiding water in the solid medicine chamber after sterilization according to claim 1, characterized in that its specific steps are: bag making, solid medicine outdoor coating to prevent sterilization During sterilization, water vapor enters the aluminum-plastic composite film of the solid medicine chamber, liquid medicine filling, liquid medicine chamber sealing, sterilization, solid medicine chamber cutting, solid medicine filling and solid medicine chamber sealing. 3. The non-PVC multi-chamber large infusion bag production method capable of avoiding water in the solid medicine chamber after sterilization according to claim 1, characterized in that the specific steps are: bag making, liquid medicine filling, and liquid medicine chamber The aluminum-plastic composite film of the sealing and solid drug storage chamber can prevent water vapor from entering the solid drug storage room during sterilization, the sterilization, the solid drug storage room is cut, the solid drug filling and the solid drug storage room are sealed. 4. According to claim 1, 2 or 3, the production method of the non-PVC multi-chamber large infusion bag capable of avoiding water in the solid medicine chamber after sterilization is characterized in that the aluminum-plastic composite film is welded to the solid medicine chamber. around the room.

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