CN106822350A - It is a kind of to treat medicine of myocardial infarction and preparation method thereof - Google Patents

It is a kind of to treat medicine of myocardial infarction and preparation method thereof Download PDF

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Publication number
CN106822350A
CN106822350A CN201611164588.XA CN201611164588A CN106822350A CN 106822350 A CN106822350 A CN 106822350A CN 201611164588 A CN201611164588 A CN 201611164588A CN 106822350 A CN106822350 A CN 106822350A
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chinese medicine
radix
myocardial infarction
preparation
medicine preparation
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张君德
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia

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Abstract

Medicine of myocardial infarction and preparation method thereof is treated the invention discloses a kind of, is by weight to include following traditional Chinese medicine ingredients：Radix Angelicae Sinensis 6g, licorice 6g, Radix Angelicae Sinensis 13g, Ligusticum wallichii 13g, radix paeoniae rubrathe 13g, radix rehmanniae recen 13g, peach kernel 13g, safflower 13g, radix bupleuri 13g, Fructus Aurantii 13g, balloonflower root 13g, the Radix Astragali 30 60g, cassia twig 13g.The preparation and application of Chinese medicine composition of the present invention：It is decocted in water for oral dose：Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to the course for the treatment of of medication 26.

Description

It is a kind of to treat medicine of myocardial infarction and preparation method thereof
Technical field
It is to be related to a kind of Chinese medicine preparation for treating myocardial infarction specifically the invention belongs to Chinese medicine composition.
Background technology
Myocardial infarction is called miocardial infarction, and miocardial infarction is coronary occlusion, and blood flow is interrupted, and makes part cardiac muscle because serious Persistence ischemic and there is local necrosis.Clinically have acutely and more lasting retrosternal pain, heating, leukocytosis, Erythrocyte sedimentation rate (ESR) is accelerated, and serum cardiac enzyme activity increases and progressive ECG Change, and arrhythmia cordis, shock or the heart can occur Force failure.Myocardial infarction is mainly expanded by heart circle, and heart rate is fast, and apex decreased loudness of first sound may occur in which presystolic gallop rhythm, There is pericardiac friction sound at 2~3 days more.Apical region of heart may occur in which coarse systolic murmur or barlow syndrome, be two points Caused by valve dysfunction of papillary muscle or fracture, there can be various arrhythmia cordis.Blood pressure reduction.Can have and arrhythmia cordis, shock or the heart Other signs for the correlation that declines.The patient clinical that myocardial infarction occurs often has violent pectoralgia, and the duration is long, rests or buccal nitric acid Glycerine piece can not be allowed to alleviate, with fear, dying sense, sensation of asphyxia and sweat all over, the performance such as have the fidgets, can have not Gram, arrhythmia cordis and heart failure even die suddenly.Symptom being treated Western medicine, it is impossible to effectively treat the disease, and controlled using Chinese herbal medicine more Treat, with safe and effective advantage.
The present invention for treating the Chinese medicine preparation of myocardial infarction nursing, for myocardial infarction etiology and pathogenesis, with clearing heat and detoxicating, Clearing heat and promoting diuresis, cleaning heat and expelling wind, restore menstrual flow and invigorate blood circulation, promoting circulation of blood detumescence, promoting blood circulation to remove blood stasis, dissipating bind dredging collateral be the rules for the treatment of, reach cold dispelling Wen Yang, promote blood circulation Analgesic, treats effect of myocardial infarction.
The content of the invention
Present invention aim to address the problem in prior art, spy provide a kind of effect substantially, the course for the treatment of is shorter controls Treat the medicine of myocardial infarction.
In order to realize foregoing invention purpose, the present invention is made the raw material composition and its weight proportion of the effective ingredient For：Radix Angelicae Sinensis 6g, licorice 6g, Radix Angelicae Sinensis 13g, Ligusticum wallichii 13g, radix paeoniae rubrathe 13g, radix rehmanniae recen 13g, peach kernel 13g, safflower 13g, radix bupleuri 13g, Fructus Aurantii 13g, balloonflower root 13g, Radix Astragali 30-60g, cassia twig 13g.
The preparation and application of Chinese medicine composition of the present invention：It is decocted in water for oral dose：Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to medication The 2-6 courses for the treatment of.
The medicine for treating myocardial infarction is invented, natural drug is selected, for myocardial infarction etiology and pathogenesis, ingredients Respectively have its effect, coordinate mutually, Fructus Aurantii, balloonflower root, root of bidentate achyranthes qi-regulating are promoted blood circulation in side, and the cassia twig temperature heart activates yang.The Radix Astragali can benefiting qi and raising yang raising Cardiomyocyte viability.Above-mentioned all herbal medicines are shared, and mutually collaboration brings out the best in each other, and clearing heat and detoxicating, clearing heat and promoting diuresis, heat-clearing are played altogether and is dredged Wind, restore menstrual flow and invigorate blood circulation, promoting circulation of blood detumescence, promoting blood circulation to remove blood stasis, the effect of dissipating bind dredging collateral, reach cold dispelling Wen Yang, coronary circulation-promoting pain-relieving treats myocardial infarction Effect.
Specific embodiment
Embodiment 1：It is a kind of to treat medicine of myocardial infarction and preparation method thereof, by weight including following Chinese medicine into Point：Radix Angelicae Sinensis 6g, licorice 6g, Radix Angelicae Sinensis 13g, Ligusticum wallichii 13g, radix paeoniae rubrathe 13g, radix rehmanniae recen 13g, peach kernel 13g, safflower 13g, radix bupleuri 13g, Fructus Aurantii 13g, balloonflower root 13g, Radix Astragali 30-60g, cassia twig 13g.
Embodiment 2：If patient there are hyperlipidemic conditions, charred FRUCTUS CRATAEGI 15-18g, cassia seed 15-18g are added in said components.
Embodiment 3：If patient's had palpitation symptom, with American Ginseng 13g in said components.
Embodiment 4：If patient intentionally pain symptom, the corydalis tuber 10-16g in said components, leech 13g, Radix Notoginseng powder 3- 6g。
It is decocted in water for oral dose：Daily 1 dose, 7 doses be a course for the treatment of, it is necessary to the medication 2-6 courses for the treatment of.
The clinical treatment effect of the Chinese medicine preparation for myocardial infarction nursing of the present invention is illustrated below by way of practical example Really.
1st, clinical data
50 myocardial infarction patients, patient's average age 45 ± 20 years old (25~65 years old), meet "《Chinese medical disease diagnoses curative effect mark It is accurate》Myocardial infarction diagnosis standard in (State Administration of Traditional Chinese Medicine's promulgation) ", full diagnostics is myocardial infarction patient.
50 myocardial infarction patients all have the symptoms such as pectoralgia, cardiac arrhythmia, heart failure.
Criterion of therapeutical effect
Cure：Clinical symptom disappearance, cardiac muscle detection is normal；
It is effective：Clinical symptoms substantially mitigate, and patient's rhythm of the heart is neat, painless；
It is invalid：Clinical symptoms are without substantially mitigation, exacerbation of symptoms, and it is invalid to be judged to.
3rd, treatment results
After 50 myocardial infarction patients treat 3~4 courses for the treatment of, cure 38, treat effective 8, invalid 2.Treatment total effective rate It is 93%.
Typical case：
In certain, patient male 68 years old, examines because of acute gastroenteritis, previously has hypertension history, without history of coronary heart disease, Huan Zhean Put and rescued in rescue room, have an electro-cardiogram, as a result show：V1-V5 ST-Segments are substantially forced down, and T ripples are inverted, V1V2V3 leads Show preceding partition myocardial infarction, V3 ~ V5 leads show limitation Anterior wall myocardial infarction, V1 ~ V5 leads show extensive Anterior wall myocardial infarction, II, IIIth, avF leads show inferior wall myocardial infarction, I, avL leads show high lateral myocardial infarction, V7 ~ V8 leads show positive rear wall cardiac muscle stalk Extremely, II, III, avF leads are raised with particularly V4rST sections of Right chest lead, are acute myocardial infarction.Afterwards with treatment by Chinese herbs, take 6 doses of inventive formulation, is decocted in water for oral dose, daily 1 dose, daily 3 clothes.Second examines：Pain slightly feels mitigation, 12 doses of following the service, and three examine：Pain base This releasing, is after treatment effect afterwards, advises and continues to take 12 doses.Follow-up 1 year, all goes well.

Claims (4)

  1. It is 1. a kind of to treat medicine of myocardial infarction and preparation method thereof, it is characterised in that：The Chinese medicine preparation includes by weight Following traditional Chinese medicine ingredients：Radix Angelicae Sinensis 6g, licorice 6g, Radix Angelicae Sinensis 13g, Ligusticum wallichii 13g, radix paeoniae rubrathe 13g, radix rehmanniae recen 13g, peach kernel 13g, safflower 13g, radix bupleuri 13g, Fructus Aurantii 13g, balloonflower root 13g, Radix Astragali 30-60g, cassia twig 13g.
  2. 2. the Chinese medicine preparation of myocardial infarction is treated as claimed in claim 1, it is characterised in that：The Chinese medicine preparation also includes Jiaoshan Hill Short, bristly hair or beard 15-18g, cassia seed 15-18g.
  3. 3. the Chinese medicine preparation of myocardial infarction is treated as claimed in claim 1, it is characterised in that：The Chinese medicine preparation also includes the West Ginseng 13g.
  4. 4. the Chinese medicine preparation of myocardial infarction is treated as claimed in claim 1, it is characterised in that：The Chinese medicine preparation also includes prolonging recklessly Rope 10-16g, leech 13g, Radix Notoginseng powder 3-6g.
CN201611164588.XA 2016-12-16 2016-12-16 It is a kind of to treat medicine of myocardial infarction and preparation method thereof Withdrawn CN106822350A (en)

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Application publication date: 20170613