CN106822189A - A kind of propolis chromium yeast soft capsule and preparation method thereof - Google Patents
A kind of propolis chromium yeast soft capsule and preparation method thereof Download PDFInfo
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- CN106822189A CN106822189A CN201611095630.7A CN201611095630A CN106822189A CN 106822189 A CN106822189 A CN 106822189A CN 201611095630 A CN201611095630 A CN 201611095630A CN 106822189 A CN106822189 A CN 106822189A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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Abstract
The invention discloses a kind of propolis chromium yeast soft capsule and preparation method thereof, belong to health product technology field, in order to reduce blood sugar, in terms of 1000 propolis chromium yeast soft capsules, comprising raw material and auxiliary material, wherein raw material includes 300 320 grams of 120 130 grams of propolis, 18 24 grams of chromium yeast, 5 20 grams of vitamin e1,22 28 grams of glycerine and PEG400；The auxiliary material includes 210 230 grams of 210 230 grams of gelatin, 100 120 grams of glycerine and purified water.The present invention can be controlled and stabilizing blood sugar, effectively help diabetic's control blood sugar.
Description
Technical field
The invention belongs to health product technology field, and in particular to a kind of propolis chromium yeast soft capsule and preparation method thereof.
Background technology
Blood sugar refers to contained glucose in blood, and the level of normal person's fasting plasma glucose is 3.9~6.1mmol/L,
Full blood glucose level is 3.6~5.3mmol/L；0.5~1 hours blood glucose highest, is no more than 7.8mmol/ in 2 hours after the meal after the meal
L.With the development and the change of people life style of social economy, Chronic Non-Communicable Diseases seriously threatens human health,
Wherein, the health hazard especially with hypertension, high fat of blood, hyperglycaemia to people is the most serious.Hyperglycaemia can reduce the glutinous of granulocyte
Attached function, Chemotaxis Function and phagocytosis.Making the immunologic function of body reduces；Mitochondrial metabolic pathway is disturbed, increases super oxygen
The generation of compound and oxygen radical.Long-term hyperglycaemia can cause, induce various chronic diseases, it can be seen that hyperglycaemia is to the mankind
The influence of life is a long-term chronic process, but its extent of injury is enough to make the mankind forbidding to it.Therefore it is hypoglycemic
Have become the public health problem for receiving much concern.At home, as a whole, the average diabetic population ratio of China is
5% or so, crowd's ratio of some areas diabetes has reached 10%, and in rural area, its incidence has increased trend.International sugar
Niao Bing alliances (IDF) predict that China's diabetes and its complication crowd quantity will always occupy the whole world the 2nd in following 30 years
Position, and onset diabetes crowd is multiplied than regular meeting, far above the 40% of the U.S..Diabetes have turned into global health
Problem, has huge crowd in the whole world.Additionally, it is fat, high caloric diet or trophic structure are unreasonable, physical exertion is not enough and
Increasing age all accelerates the generation of hyperglycaemia, development.So needing control and stabilizing blood sugar.Propolis has activating cell, and reparation is received
The islet cells of damage, effective stimulus islet β cell insulin promotes exogenous glucose synthesis hepatic glycogen, and intensifier target is thin
Born of the same parents to the effect such as sensitiveness of insulin, so as to reduce blood sugar；Chromium yeast is the yeast rich in Organic Chromium, and supplement chromium improves
Glycometabolism, the effect of increase insulin active, correction carbohydrate metabolism disturbance are so as to stabilizing blood sugar.Vitamin E is a kind of excellent antioxygen
Agent, removes free radical, maintains healthy.
The content of the invention
According to above the deficiencies in the prior art, the technical problems to be solved by the invention are to propose that a kind of propolis chromium yeast is soft
Capsule and preparation method thereof, it is therefore an objective to be controlled to human body level.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：
A kind of propolis chromium yeast soft capsule, in terms of 1000 propolis chromium yeast soft capsules, comprising raw material and auxiliary material, its Central Plains
Material includes 120-130 grams of propolis, 18-24 grams of chromium yeast, 5-20 grams of vitamin e1,22-28 grams of glycerine and PEG400
300-320 grams；The auxiliary material includes 210-230 grams of 210-230 grams of gelatin, 100-120 grams of glycerine and purified water.
In terms of 1000 propolis chromium yeast soft capsules, comprising raw material and auxiliary material, wherein raw material includes 126 grams of propolis, chromium ferment
312 grams of female 20 grams, 7 grams of vitamin e1,25 grams of glycerine and PEG400；The auxiliary material includes 218 grams of gelatin, glycerine 109
Gram and 218 grams of purified water.
The preparation method of propolis chromium yeast soft capsule, the preparation method comprises the following steps,
Step one, prepares auxiliary material；Gelatin, glycerine and purified water are weighed respectively；
Step 2, gelatin is added by glycerine and purified water when changing and being heated to 60 DEG C in glue tank, is again heated to 80 DEG C of stirrings
2-3 hours；Stir；
Step 3, will change glue tank and vacuumizes, and deaeration then be carried out, then by products therefrom in 100 mesh sieve net filtrations, 60
DEG C temperature in be incubated, be made auxiliary material glue；
Step 4, preparing raw material weighs propolis, chromium yeast, vitamin E, glycerine and PEG400 respectively；
Step 5, propolis and chromium yeast is crushed respectively and is obtained to propolis fine powder and chromium yeast by 100 mesh sieve sieves
Fine powder；
Step 6, glue in-tank mixing is being changed by propolis fine powder, chromium yeast fine powder, vitamin E, glycerine and PEG400
Stir, and be heated to 80 DEG C and vacuumize 4-5 hours, and then deaeration, then cross 100 mesh sieve, obtain content feed liquid；
Step 7, by content feed liquid and auxiliary material glue in 18-22 DEG C of temperature, the environment of relative humidity 40% in pelleting
Pelleting is carried out on machine and obtains soft capsule, then placed in 18-22 DEG C of temperature, the environment of relative humidity 40% and determined for 4 hours
Type；
Step 8, the soft capsule after sizing is dried 8-12 hours in 20-25 DEG C of temperature, the environment of relative humidity 40%；
Step 9, carries out washing ball to dried soft capsule with 95% ethanol；
Step 10, dress is wrapped inside to washing the soft capsule after ball, allows rear external packing, finally inspection to be put in storage.
Present invention has the advantages that:Propolis has activating cell, repairs impaired islet cells, and β is thin for effective stimulus pancreas islet
Intracrine insulin, promotes exogenous glucose synthesis hepatic glycogen, enhancing target cell to the effect such as sensitiveness of insulin so that
Reduce blood sugar；Chromium yeast is the yeast rich in Organic Chromium, and supplement chromium improves glycometabolism, increases insulin active effect, entangles
Positive carbohydrate metabolism disturbance is so as to stabilizing blood sugar.Vitamin E is a kind of excellent antioxidant, removes free radical, is maintained healthy.
Therefore propolis, chromium and vitamin E are significantly reduced the effect of blood sugar with the use of tool.Three of the above raw material without incompatibility,
With the use of the function with preferable auxiliary hyperglycemic.
Specific embodiment
Below by the description to embodiment, the present invention is further detailed explanation, to help people in the art
Member has more complete, accurate and deep understanding to inventive concept of the invention, technical scheme.
Embodiment 1
A kind of propolis chromium yeast soft capsule, including auxiliary material and raw material, in terms of 1000 propolis chromium yeast soft capsules, the original
Material includes 312 grams of 126 grams of propolis, 20 grams of chromium yeast, 7 grams of vitamin e1,25 grams of glycerine and PEG400；The accessory package
Include 218 grams of 218 grams of gelatin, 109 grams of glycerine and purified water.
The preparation method of above-mentioned propolis chromium yeast soft capsule, comprises the following steps,
Step one, prepares auxiliary material；218 grams of 218 grams of gelatin, 109 grams of glycerine and purified water are weighed respectively；
109 grams of glycerine and 218 grams of purified waters are added 218 grams of gelatin when changing and being heated to 60 DEG C in glue tank by step 2, then
80 DEG C are heated to stir 2-3 hours；Stir；
Step 3, will change glue tank and vacuumizes, and deaeration then be carried out, then by products therefrom in 100 mesh sieve net filtrations, 60
DEG C temperature in be incubated, be made auxiliary material glue；
Step 4, preparing raw material weighs 126 grams of propolis, 20 grams of chromium yeast, 7 grams of vitamin e1,25 grams of glycerine and gathers respectively
400 312 grams of ethylene glycol；
Step 5,126 grams of propolis and 20 grams of chromium yeasts is crushed respectively and is obtained to propolis fine powder by 100 mesh sieve sieves
With chromium yeast fine powder；
Step 6, by 126 grams of propolis fine powders, 20 grams of chromium yeast fine powders, 17 grams of vitamin Es, 25 grams of glycerine and 312 grams of poly- second
Glycol 400 stirs changing glue in-tank mixing, and is heated to 80 DEG C and vacuumizes 4-5 hour, and then deaeration, then 100 mesh of mistake
Sieve, obtains content feed liquid；
Step 7, by content feed liquid and auxiliary material glue in 18-22 DEG C of temperature, the environment of relative humidity 40% in pelleting
Pelleting is carried out on machine and obtains soft capsule, then placed in 18-22 DEG C of temperature, the environment of relative humidity 40% and determined for 4 hours
Type；
Step 8, the soft capsule after sizing is dried 8-12 hours in 20-25 DEG C of temperature, the environment of relative humidity 40%；
Step 9, carries out washing ball to dried soft capsule with 95% ethanol；
Step 10, dress is wrapped inside to washing the soft capsule after ball, allows rear external packing, finally inspection to be put in storage.
Embodiment 2
A kind of propolis chromium yeast soft capsule, including auxiliary material and raw material, in terms of 1000 propolis chromium yeast soft capsules, the original
Material includes 300 grams of 120 grams of propolis, 18 grams of chromium yeast, 5 grams of vitamin e1,22 grams of glycerine and PEG400；The accessory package
Include 210 grams of 210 grams of gelatin, 100 grams of glycerine and purified water.
The preparation method of above-mentioned propolis chromium yeast soft capsule, comprises the following steps,
Step one, prepares auxiliary material；210 grams of 210 grams of gelatin, 100 grams of glycerine and purified water are weighed respectively；
100 grams of glycerine and 210 grams of purified waters are added 210 grams of gelatin when changing and being heated to 60 DEG C in glue tank by step 2, then
80 DEG C are heated to stir 2-3 hours；Stir；
Step 3, will change glue tank and vacuumizes, and deaeration then be carried out, then by products therefrom in 100 mesh sieve net filtrations, 60
DEG C temperature in be incubated, be made auxiliary material glue；
Step 4, preparing raw material weighs 120 grams of propolis, 18 grams of chromium yeast, 5 grams of vitamin e1,22 grams of glycerine and gathers respectively
400 300 grams of ethylene glycol；
Step 5,120 grams of propolis and 18 grams of chromium yeasts is crushed respectively and is obtained to propolis fine powder by 100 mesh sieve sieves
With chromium yeast fine powder；
Step 6, by 120 grams of propolis fine powders, 18 grams of chromium yeast fine powders, 15 grams of vitamin Es, 22 grams of glycerine and 300 grams of poly- second
Glycol 400 stirs changing glue in-tank mixing, and is heated to 80 DEG C and vacuumizes 4-5 hour, and then deaeration, then 100 mesh of mistake
Sieve, obtains content feed liquid；
Step 7, by content feed liquid and auxiliary material glue in 18-22 DEG C of temperature, the environment of relative humidity 40% in pelleting
The soft capsule that pelleting obtains 0.5 gram every is carried out on machine, then 4 is placed in 18-22 DEG C of temperature, the environment of relative humidity 40%
Hour is shaped；
Step 8, the soft capsule after sizing is dried 8-12 hours in 20-25 DEG C of temperature, the environment of relative humidity 40%；
Step 9, carries out washing ball to dried soft capsule with 95% ethanol；
Step 10, dress is wrapped inside to washing the soft capsule after ball, allows rear external packing, finally inspection to be put in storage.
Embodiment 3
A kind of propolis chromium yeast soft capsule, including auxiliary material and raw material, in terms of 1000 propolis chromium yeast soft capsules, the original
Material includes 320 grams of 130 grams of propolis, 24 grams of chromium yeast, 0 gram of vitamin E2,28 grams of glycerine and PEG400；The accessory package
Include 230 grams of 230 grams of gelatin, 120 grams of glycerine and purified water.
The preparation method of above-mentioned propolis chromium yeast soft capsule, comprises the following steps,
Step one, prepares auxiliary material；230 grams of 230 grams of gelatin, 120 grams of glycerine and purified water are weighed respectively；
120 grams of glycerine and 230 grams of purified waters are added 230 grams of gelatin when changing and being heated to 60 DEG C in glue tank by step 2, then
80 DEG C are heated to stir 2-3 hours；Stir；
Step 3, will change glue tank and vacuumizes, and deaeration then be carried out, then by products therefrom in 100 mesh sieve net filtrations, 60
DEG C temperature in be incubated, be made auxiliary material glue；
Step 4, preparing raw material weighs 130 grams of propolis, 24 grams of chromium yeast, 0 gram of vitamin E2,28 grams of glycerine and gathers respectively
400 320 grams of ethylene glycol；
Step 5,130 grams of propolis and 24 grams of chromium yeasts is crushed respectively and is obtained to propolis fine powder by 100 mesh sieve sieves
With chromium yeast fine powder；
Step 6, by 130 grams of propolis fine powders, 24 grams of chromium yeast fine powders, 20 grams of vitamin Es, 28 grams of glycerine and 320 grams of poly- second
Glycol 400 stirs changing glue in-tank mixing, and is heated to 80 DEG C and vacuumizes 4-5 hour, and then deaeration, then 100 mesh of mistake
Sieve, obtains content feed liquid；
Step 7, by content feed liquid and auxiliary material glue in 18-22 DEG C of temperature, the environment of relative humidity 40% in pelleting
The soft capsule that pelleting obtains 0.5 gram every is carried out on machine, then 4 is placed in 18-22 DEG C of temperature, the environment of relative humidity 40%
Hour is shaped；
Step 8, the soft capsule after sizing is dried 8-12 hours in 20-25 DEG C of temperature, the environment of relative humidity 40%；
Step 9, carries out washing ball to dried soft capsule with 95% ethanol；
Step 10, dress is wrapped inside to washing the soft capsule after ball, allows rear external packing, finally inspection to be put in storage.
The present invention is exemplarily described above, it is clear that the present invention is implemented and is not subject to the restrictions described above,
As long as employing the improvement of various unsubstantialities that method of the present invention design and technical scheme are carried out, or not improved this is sent out
Bright design and technical scheme directly applies to other occasions, within protection scope of the present invention.Protection of the invention
Scope should be determined by the scope of protection defined in the claims.
Claims (3)
1. a kind of propolis chromium yeast soft capsule, it is characterised in that：In terms of 1000 propolis chromium yeast soft capsules, comprising raw material and auxiliary
Material, wherein raw material include 120-130 grams of propolis, 18-24 grams of chromium yeast, 5-20 grams of vitamin e1,22-28 grams of glycerine and poly- second two
300-320 grams of alcohol 400；The auxiliary material includes 210-230 grams of 210-230 grams of gelatin, 100-120 grams of glycerine and purified water.
2. propolis chromium yeast soft capsule according to claim 1, it is characterised in that：With 1000 propolis chromium yeast soft capsules
Meter, comprising raw material and auxiliary material, wherein raw material includes 126 grams of propolis, 20 grams of chromium yeast, 7 grams of vitamin e1,25 grams of glycerine and poly- second
400 312 grams of glycol；The auxiliary material includes 218 grams of 218 grams of gelatin, 109 grams of glycerine and purified water.
3. the preparation method of propolis chromium yeast soft capsule according to claim 1, it is characterised in that the preparation method includes
Following steps,
Step one, prepares auxiliary material；Gelatin, glycerine and purified water are weighed respectively；
Step 2, gelatin is added by glycerine and purified water when changing and being heated to 60 DEG C in glue tank, is again heated to 80 DEG C of stirring 2-3 small
When；Stir；
Step 3, will change glue tank and vacuumizes, and deaeration then be carried out, then by products therefrom in 100 mesh sieve net filtrations, at 60 DEG C
It is incubated in temperature, is made auxiliary material glue；
Step 4, preparing raw material weighs propolis, chromium yeast, vitamin E, glycerine and PEG400 respectively；
Step 5, propolis and chromium yeast is crushed respectively and is obtained to propolis fine powder and chromium yeast fine powder by 100 mesh sieve sieves；
Step 6, the stirring of glue in-tank mixing is being changed by propolis fine powder, chromium yeast fine powder, vitamin E, glycerine and PEG400
Uniformly, and 80 DEG C are heated to vacuumize 4-5 hours, and then deaeration, then cross 100 mesh sieve, obtain content feed liquid；
Step 7, by content feed liquid and auxiliary material glue in 18-22 DEG C of temperature, the environment of relative humidity 40% on pellet press
Carry out pelleting and obtain soft capsule, then placed in 18-22 DEG C of temperature, the environment of relative humidity 40% and shaped for 4 hours；
Step 8, the soft capsule after sizing is dried 8-12 hours in 20-25 DEG C of temperature, the environment of relative humidity 40%；
Step 9, carries out washing ball to dried soft capsule with 95% ethanol；
Step 10, dress is wrapped inside to washing the soft capsule after ball, allows rear external packing, finally inspection to be put in storage.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611095630.7A CN106822189A (en) | 2016-12-02 | 2016-12-02 | A kind of propolis chromium yeast soft capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611095630.7A CN106822189A (en) | 2016-12-02 | 2016-12-02 | A kind of propolis chromium yeast soft capsule and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785557A (en) * | 2018-08-27 | 2018-11-13 | 烟台新时代健康产业有限公司 | A kind of Chinese medicine composition with auxiliary hyperglycemic function |
| CN113598367A (en) * | 2021-08-05 | 2021-11-05 | 江西汪氏蜜蜂园有限公司 | Fengyi soft capsule and preparation process thereof |
| CN116270806A (en) * | 2023-03-24 | 2023-06-23 | 芜湖市诺康生物科技有限公司 | Propolis chromium yeast soft capsule for assisting in reducing blood sugar and production process thereof |
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|---|---|---|---|---|
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
| CN101999668A (en) * | 2010-10-11 | 2011-04-06 | 孙羽蒙 | Formula for treating diabetes mellitus |
| CN102935094A (en) * | 2012-11-06 | 2013-02-20 | 芜湖市诺康生物科技有限公司 | Composite for diabetes |
| CN104920933A (en) * | 2015-06-09 | 2015-09-23 | 江苏日高蜂产品有限公司 | Propolis soft capsules and preparation method thereof |
| CN105962356A (en) * | 2016-05-03 | 2016-09-28 | 宣城柏维力生物工程有限公司 | Health-care propolis soft capsules and preparation method thereof |
-
2016
- 2016-12-02 CN CN201611095630.7A patent/CN106822189A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
| CN101999668A (en) * | 2010-10-11 | 2011-04-06 | 孙羽蒙 | Formula for treating diabetes mellitus |
| CN102935094A (en) * | 2012-11-06 | 2013-02-20 | 芜湖市诺康生物科技有限公司 | Composite for diabetes |
| CN104920933A (en) * | 2015-06-09 | 2015-09-23 | 江苏日高蜂产品有限公司 | Propolis soft capsules and preparation method thereof |
| CN105962356A (en) * | 2016-05-03 | 2016-09-28 | 宣城柏维力生物工程有限公司 | Health-care propolis soft capsules and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785557A (en) * | 2018-08-27 | 2018-11-13 | 烟台新时代健康产业有限公司 | A kind of Chinese medicine composition with auxiliary hyperglycemic function |
| CN113598367A (en) * | 2021-08-05 | 2021-11-05 | 江西汪氏蜜蜂园有限公司 | Fengyi soft capsule and preparation process thereof |
| CN116270806A (en) * | 2023-03-24 | 2023-06-23 | 芜湖市诺康生物科技有限公司 | Propolis chromium yeast soft capsule for assisting in reducing blood sugar and production process thereof |
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Application publication date: 20170613 |