CN106795561B - 用于对ezh2抑制剂的应答的生物标志物 - Google Patents

用于对ezh2抑制剂的应答的生物标志物 Download PDF

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Publication number
CN106795561B
CN106795561B CN201580044280.9A CN201580044280A CN106795561B CN 106795561 B CN106795561 B CN 106795561B CN 201580044280 A CN201580044280 A CN 201580044280A CN 106795561 B CN106795561 B CN 106795561B
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bap1
cancer
ezh2
biomarker
expression
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CN106795561A (zh
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R·莱维纳
L·拉费
O·阿卜杜勒-瓦哈卜
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Memorial Sloan Kettering Cancer Center
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580044280.9A 2014-06-19 2015-06-19 用于对ezh2抑制剂的应答的生物标志物 Expired - Fee Related CN106795561B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462014594P 2014-06-19 2014-06-19
US62/014,594 2014-06-19
PCT/US2015/036677 WO2015196064A1 (en) 2014-06-19 2015-06-19 Biomarkers for response to ezh2 inhibitors

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CN106795561A CN106795561A (zh) 2017-05-31
CN106795561B true CN106795561B (zh) 2021-04-16

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US (1) US20170138946A1 (OSRAM)
EP (1) EP3158086B1 (OSRAM)
JP (1) JP6684230B2 (OSRAM)
KR (1) KR20170020463A (OSRAM)
CN (1) CN106795561B (OSRAM)
AU (1) AU2015276899B2 (OSRAM)
BR (1) BR112016029911A2 (OSRAM)
CA (1) CA2952285A1 (OSRAM)
EA (1) EA036889B1 (OSRAM)
ES (1) ES2870096T3 (OSRAM)
IL (1) IL249443B (OSRAM)
MX (1) MX384423B (OSRAM)
SG (2) SG11201610610YA (OSRAM)
WO (1) WO2015196064A1 (OSRAM)
ZA (1) ZA201608555B (OSRAM)

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KR102021642B1 (ko) 2012-10-15 2019-09-16 에피자임, 인코포레이티드 암을 치료하는 방법
CN108025191A (zh) 2015-08-24 2018-05-11 Epizyme股份有限公司 治疗癌症的方法
TW201718598A (zh) 2015-08-27 2017-06-01 美國禮來大藥廠 Ｅｚｈ２抑制劑
JP7336193B2 (ja) * 2016-02-16 2023-08-31 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 原発性胃腺癌の体細胞プロモーター特性を明らかにするエピゲノムプロファイリング
GB201615842D0 (en) * 2016-09-16 2016-11-02 Ucl Business Plc Cell death biomarker
CN106963765B (zh) * 2017-03-28 2020-04-07 上海交通大学医学院附属第九人民医院 Ezh2抑制剂化合物在制备治疗眼部黑色素瘤的药物中的应用
WO2020247130A1 (en) * 2019-06-03 2020-12-10 Icahn School Of Medicine At Mount Sinai Compounds and methods for inhibiting cancers via rest inhibition
GB201919219D0 (en) 2019-12-23 2020-02-05 Otsuka Pharma Co Ltd Cancer biomarkers
CN118161615B (zh) * 2024-03-19 2025-08-12 山东大学齐鲁医院 Phf20抑制剂在制备抗皮肤癌药物中的应用

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BR112016029911A2 (pt) 2017-10-24
EP3158086A1 (en) 2017-04-26
SG10202007972SA (en) 2020-10-29
KR20170020463A (ko) 2017-02-22
AU2015276899B2 (en) 2021-08-12
SG11201610610YA (en) 2017-01-27
EP3158086A4 (en) 2018-01-10
CA2952285A1 (en) 2015-12-23
EP3158086B1 (en) 2021-03-24
JP2017525337A (ja) 2017-09-07
AU2015276899A1 (en) 2017-01-05
MX384423B (es) 2025-03-14
US20170138946A1 (en) 2017-05-18
ES2870096T3 (es) 2021-10-26
EA201692497A1 (ru) 2017-06-30
JP6684230B2 (ja) 2020-04-22
EA036889B1 (ru) 2021-01-12
CN106795561A (zh) 2017-05-31
IL249443A0 (en) 2017-02-28
MX2016017097A (es) 2017-05-01
ZA201608555B (en) 2022-05-25
WO2015196064A1 (en) 2015-12-23
IL249443B (en) 2022-05-01

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