CN106783508B - The method of transference tube and operation transference tube - Google Patents
The method of transference tube and operation transference tube Download PDFInfo
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- CN106783508B CN106783508B CN201611270479.6A CN201611270479A CN106783508B CN 106783508 B CN106783508 B CN 106783508B CN 201611270479 A CN201611270479 A CN 201611270479A CN 106783508 B CN106783508 B CN 106783508B
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
- H01J49/062—Ion guides
- H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
Abstract
The invention discloses a kind of transference tube and its operating methods.Transference tube includes the ion gate of inner space and internally positioned space；Inner space includes the ionized region and migration area with current potential absolute value V1.The ion gate being arranged between ionized region and migration area includes the first ion gate grid with current potential absolute value V2 and the second ion gate grid with current potential absolute value V3.Migration area includes at least the first migration area electrode with current potential absolute value V4 and the second migration area electrode with current potential absolute value V5.When the ion gate is opened, the potential well of ion is formed between the second ion gate grid and the first migration area electrode to compress to the cluster ion for entering migration area.
Description
Technical field
The present invention relates to transference tube technical fields, the in particular to side of transference tube and operation transference tube
Method.
Background technique
Ion mobility spectrometry (IMS) has become based on live trace detection technology more mature on molecular level.Ion transfer
Core component in spectrometer is transference tube.In migration tube, sample molecule is taken by force under the action of ionization source by proton
It takes, electron attachment, electron exchange etc. generate metastable product ion and can produce corresponding product ion.Product ion is logical
The control for crossing ion gate enters migration area in batch within the intimate same time and is migrated.These product ions are in atmosphere pressure ring
In the steady electric field in border, they macroscopically will appear as because the collision of acceleration and neutral fluxes gas molecule by electric field is slowed down
Obtain a constant average speed.Since different product ions its charge-mass ratio, geometric configuration and collision cross-section are different, because
And obtain average speed it is also different, so by one section of electric field after they just separated, successively reach detector thus
It completes to be detected.
Since ionic migration spectrometer has the advantages that high sensitivity, analysis speed is fast, price is low, structure is simple, portable etc.
And it is widely used in the fields such as explosive detection, drugs screening and chemical warfare agent early warning.But resolution capability is lower always
It is to perplex one of ion mobility spectrometry application and bottleneck of development.
Summary of the invention
According to an aspect of the present invention, a kind of transference tube, including inner space and internally positioned space are provided
The ion gate that can be opened and closed；Inner space includes the ionized region and migration area with current potential absolute value V1, and substance is by electricity
Enter transference tube from area one end, be ionized in ionized region, is driven later by electric field into migration area；
Wherein, the ion gate being arranged between ionized region and migration area includes the first ion gate grid with current potential absolute value V2
With the second ion gate grid with current potential absolute value V3, the first ion gate grid and the second ion gate grid are parallel to each other, pass through insulation
Piece is spaced apart and transference tube is divided into the ionized region and migration area；Migration area, which includes at least, has current potential absolute value V4
The first migration area electrode and the second migration area electrode with current potential absolute value V5, the second migration area electrode is than the first migration area
Electrode is far from the second ion gate grid；
Wherein, when the ion gate is opened, between the first ion gate grid and the first migration area electrode formed by from
The potential well of the ion of change is so as to the cluster ion compression to migration area is entered；
When the ion gate is opened, the current potential absolute value V2 of the first ion gate grid is greater than the electricity of the first migration area electrode
Position absolute value V4, the current potential absolute value V4 of the first migration area electrode are greater than the current potential absolute value V3 of the second ion gate grid, second from
The current potential absolute value V3 of cervical orifice of uterus grid is greater than or equal to the current potential absolute value V5 of the second migration area electrode；
Wherein, in the case where the ion gate remains turned-off, transference tube is arranged so that the current potential of ionized region is exhausted
It is greater than or equal to the current potential absolute value V3 of the second ion gate grid to value V1.
In one embodiment, when the ion gate is opened, keep the first ion gate grid current potential absolute value V2 and
The current potential absolute value V1 of ionized region is constant, applies reversed pulse potential to the second ion gate grid, so that the second ion gate grid electricity
Position absolute value V2 reduces a pulse potential absolute value.
In one embodiment, when the ion gate is opened, migration area includes the first migration area electrode and second
The current potential absolute value of the electrode of migration area electrode keeps identical in the case of closing with the ion gate.
In one embodiment, in the case where the ion gate remains turned-off, transference tube is arranged so that ionization
The current potential absolute value V2 > of current potential absolute value V3 > the first ion gate grid of the current potential absolute value ion gate grid of V1 >=second in area
The current potential absolute value V5 of the second migration area the current potential absolute value V4 > electrode of one migration area electrode.
In one embodiment, in the case where the ion gate remains turned-off, the current potential absolute value of the second ion gate grid
V3 than the first ion gate grid 7~30 volts of current potential absolute value V2 high, and the current potential absolute value V3 of the second ion gate grid and electricity
The difference of current potential absolute value V1 from area is not higher than 50 volts.
Another aspect of the present invention provides a kind of method for operating transference tube, and wherein transference tube includes internal empty
Between and internally positioned space the ion gate that can be opened and closed；Inner space includes the ionized region with current potential absolute value V1
And migration area, substance enter transference tube by ionized region one end, are ionized in ionized region, are driven later by electric field into migration
Area；
Wherein, the ion gate being arranged between ionized region and migration area has the first ion gate grid and tool of current potential absolute value V2
There are the second ion gate grid of current potential absolute value V3, the first ion gate grid and the second ion gate grid are parallel to each other, by between insulating trip
It separates and transference tube is divided into the ionized region and migration area；Migration area includes at least the with current potential absolute value V4
One migration area electrode and the second migration area electrode with current potential absolute value V5, the second migration area electrode is than the first migration area electrode
Far from the second ion gate grid；
Wherein, the method includes when the ion gate is opened, in the first ion gate grid and the first migration area electrode
Between formed the potential well for the ion being ionized so as to enter migration area cluster ion compress；
Wherein when the ion gate is opened, the current potential absolute value V2 of the first ion gate grid and the current potential of ionized region are kept
Absolute value V1 is constant, applies reversed pulse potential to the second ion gate grid, so that the second ion gate grid current potential absolute value V3 subtracts
A small pulse potential absolute value, so that the current potential absolute value V2 of the first ion gate grid is greater than the electricity of the first migration area electrode
Position absolute value V4, the current potential absolute value V4 of the first migration area electrode are greater than the current potential absolute value V3 of the second ion gate grid, second from
The current potential absolute value V3 of cervical orifice of uterus grid is greater than or equal to the current potential absolute value V5 of the second migration area electrode；
Wherein, in the case that the ion gate remains turned-off, transference tube is operated, so that the current potential absolute value of ionized region
V1 is greater than or equal to the current potential absolute value V3 of the second ion gate grid.
In one embodiment, when the ion gate is opened, keep migration area include the first migration area electrode and
The current potential absolute value of the electrode of second migration area electrode is identical in the case of closing with the ion gate.
In one embodiment, in the case where the ion gate remains turned-off, transference tube is operated, so that ionized region
The current potential absolute value ion gate grid of V1 >=second current potential absolute value V3 > the first ion gate grid current potential absolute value V2 > first
The current potential absolute value V5 of the second migration area the current potential absolute value V4 > electrode of migration area electrode.
In one embodiment, in the case where the ion gate remains turned-off, operation transference tube make second from
Current potential absolute value V2 high 7~30 volt of the current potential absolute value V3 of cervical orifice of uterus grid than the first ion gate grid, and the second ion gate grid
Current potential absolute value V3 and ionized region current potential absolute value V1 difference be not higher than 50 volts.
Detailed description of the invention
Fig. 1 is the schematic diagram of the transference tube of one embodiment of the invention；
Fig. 2 is using Simion software to legacy migration pipe model built figure；
Fig. 3 is runs 10000 example institutes to migration tube model is built using Simion software under normal working practices
The ion mobility spectrometry of acquisition；
Fig. 4 for using Simion software to build migration tube model transported under the operating mode of embodiment according to the present invention
10000 example ion mobility spectrometries obtained of row.
Specific embodiment
Although the present invention allows various modifications and interchangeable form, side that its specific embodiment passes through example
Formula is shown in the accompanying drawings, and will be described herein in detail.It should be appreciated, however, that attached drawing and the detailed description of accompanying
It is not to limit the invention to disclosed concrete form, but on the contrary, is to cover and fall by appended claims
All modifications, equivalent form and alternative forms in the spirit and scope of the present invention of restriction.Attached drawing is in order to illustrate, thus
It draws not to scale.
Conventional transference tube is mainly made of ionized region 11, migration area 30 and detector three parts, such as Fig. 1.Wherein,
Ionized region 11 is separated with migration area 30 using ion gate.Migration area 30 and detector are then separated using ion gate.Ion gate is usual
It is spaced apart using two or perhaps door grid in close proximity is formed, and separated between two door grid by insulating trip.Door grid
It can be the door grid of filament formation, add insulating trip between two door grid.
In Fig. 1, Vi is ionization area voltage, and Vg1 is the voltage of first gate electrode, and Vg2 is second ion gate grid electricity
The voltage of pole, while the voltage of second ion gate gate electrode is that (i.e. migration area 30 is most for the starting point voltage of migration area 30 again
High voltage), while each electrode voltage on migration area 30 is obtained by electric resistance partial pressure, tube body shell and collection extremely zero potential.In
In the case that ion gate is closed, the absolute value of each electrode voltage is respectively | Vi |=V1, | Vg1 |=V2, | Vg2 |=V3, | Vd1 |
=V4, | Vd2 | its height relationship of=V5 is as follows: V1 > V3 > V2 > V4 > V5, and wherein V4 and V5 pressure difference are in 75V or so.Obviously
When ion gate is closed, there is an electric field opposite with 30 direction of an electric field of migration area between two ion gate gate electrodes, ion can not
Pass through.
In conventional transference tube, in the moment that ion gate is opened, Vg1 will be applied one with original polarity of voltage
Identical pulse, amplitude are Δ V, at this time: (V2+ Δ V) > V3 > V4 > V5.Moment, two ion gate grid are opened in ion gate
Interelectrode reversed electric field is repaired, and ion is allowed through.
Under the operating mode of conventional transference tube, the cluster ion of migration area 30 is entered in ion gate opening time
The difference of the location of each ion and current potential is when as original state to obtain flight caused by different flying speeds
Time is different, finally will lead to the broadening of spectral peak halfwidth, to reduce ionic migration spectrometer resolution ratio.
In an embodiment according to the present invention, a kind of transference tube, including inner space and internally positioned sky are provided
Between the ion gate that can be opened and closed；Inner space includes the ionized region 11 and migration area 30 with current potential absolute value V1, object
Matter enters transference tube by 11 one end of ionized region, is ionized in ionized region 11, is driven later by electric field into migration area 30.Electricity
The first ion gate grid from the ion gate being arranged between area 11 and migration area 30 with current potential absolute value V2 and have current potential absolute
The second ion gate grid of value V3, the first ion gate grid and the second ion gate grid are parallel to each other, are spaced apart by insulating trip and will be from
Sub- migration tube is divided into the ionized region 11 and migration area 30；Migration area 30, which includes at least, has the first of current potential absolute value V4 to move
Move area's electrode 31 and the second migration area electrode 32 with current potential absolute value V5,32 to the first migration area of the second migration area electrode electricity
Pole 31 is far from the second ion gate grid.According to the present embodiment, when the ion gate is opened, moved in the first ion gate grid and first
It moves and forms the potential well for the ion being ionized between 30 electrode of area to compress to the cluster ion for entering migration area 30.
In the present embodiment, when the ion gate is opened, the current potential absolute value V2 > first of the first ion gate grid is moved
Move the current potential of the migration area current potential absolute value V3 >=second electrode 32 of current potential absolute value V4 > the second ion gate grid of area's electrode 31
Absolute value V5, i.e. V2 > V4 > V3 >=V5.Wherein, the reversed electricity between the voltage V3 of second grid and the voltage V2 of first grid
Voltage amplitude 7V~30V of field, and second grid is differed with 11 current potential of ionized region not higher than 50V.
Thus, it is possible to guarantee can there are enough ions to enter migration area 30 when ion gate is opened, to guarantee mobility spectrometer
Sensitivity；On the other hand, it can also be ensured that revealed at closing time without ion.Also, ion gate will be in the second ion when opening
Potential barrier is formed between door and the second migration electrode, takes the lead in be slowed down by potential barrier into the ion of migration area 30 to realize to cluster ion
Compression, ion gate close after migration electric field restore again to cluster ion accelerate.
According to an embodiment of the invention, initial position is close to ion gate in the limited opening time of the ion gate
The cluster ion of second grid (forward) takes the lead in entering migration area, and cluster ion will be by ion door system (i.e. first grid and second
Door grid) and preceding two-stage migration area electrode (the first and second migration area electrodes) between take the lead in slowing down in the potential well that is formed, and it is initial
Enter migration area after the cluster ion of position rearward, and deceleration time is short or do not subtract compared with taking the lead in entering migration area cluster ion in potential well
Speed to realize the compression to the total cluster ion in migration area is entered, and then improves the resolution ratio of migration tube.
According to the present embodiment, when the ion gate is opened, the current potential absolute value V2 of the first ion gate grid can be kept
It is constant with the current potential absolute value V1 of ionized region 11, reversed pulse potential is applied to the second ion gate grid, so that the second ion gate
Grid current potential absolute value V2 reduces a pulse potential absolute value.That is, the jump that the first ion fence gate Vg1 will be applied in the prior art
Dynamic voltage is applied to the second ion fence gate Vg2, and voltage pulse is reversed, at the same maintain the first ion fence gate voltage Vg1=V2 and
Ionization area voltage Vi=V1.
According to the present embodiment, in transference tube, in the case where the ion gate remains turned-off, transference tube is set
It is set to the electricity so that current potential absolute value V3 > the first ion gate grid of the current potential absolute value ion gate grid of V1 >=second of ionized region 11
The current potential absolute value V5 of the second migration area the current potential absolute value V4 > electrode 32 of position the first migration area absolute value V2 > electrode 31,
That is, V1 >=V3 > V2 > V4 > V5.According to the present embodiment, when the ion gate is opened, including the first migration area electrode 31
Keep identical in the case of closing with the ion gate with current potential absolute value V4, V5 of the electrode of the second migration area electrode 32.Migration
The current potential absolute value of other electrodes in area 30 can keep identical in the case of closing with the ion gate.Specifically, in a reality
It applies in example, in transference tube, in the case where the ion gate remains turned-off, the current potential absolute value V3 ratio of the second ion gate grid
7~30 volts of the current potential absolute value V2 high of first ion gate grid, and the current potential absolute value V3 and ionized region of the second ion gate grid
The difference of 11 current potential absolute value V1 is not higher than 50 volts.
Transference tube according to an embodiment of the present invention is moved compared to the transference tube of conventional structure in the prior art
The resolution ratio for moving pipe can improve 5~10% or so.
The embodiment of the present invention also provide it is a kind of operate transference tube method, wherein transference tube inner space with
And the ion gate that can be opened and closed in internally positioned space；Inner space includes 11 He of ionized region with current potential absolute value V1
Migration area 30, substance enter transference tube by 11 one end of ionized region, are ionized in ionized region 11, drive entrance by electric field later
Migration area 30；Wherein, the ion gate being arranged between ionized region 11 and migration area 30 has the first ion gate of current potential absolute value V2
Grid and the second ion gate grid with current potential absolute value V3, the first ion gate grid and the second ion gate grid are parallel to each other, by exhausted
Embolium is spaced apart and transference tube is divided into the ionized region 11 and migration area 30；Migration area 30, which includes at least, has current potential
The first migration area electrode 31 of absolute value V4 and the second migration area electrode 32 with current potential absolute value V5, the second migration area electrode
32 to the first migration area electrodes 31 are far from the second ion gate grid；Wherein, the method includes, when the ion gate is opened,
The potential well for the ion being ionized is formed between the first ion gate grid and the first migration area electrode 31 so as to entrance migration area 30
Cluster ion compression.
The method of embodiment according to the present invention keeps the current potential of the first ion gate grid when the ion gate is opened
The current potential absolute value V1 of absolute value V2 and ionized region 11 is constant, applies reversed pulse potential to the second ion gate grid, so that the
Two ion gate grid current potential absolute value V2 reduce a pulse potential absolute value, thus the current potential absolute value V2 > of the first ion gate grid
The migration area current potential absolute value V3 >=second electrode 32 of current potential absolute value V4 > the second ion gate grid of first migration area electrode 31
Current potential absolute value V5, i.e. V2 > V4 > V3 >=V5.Wherein, between the voltage V3 of second grid and the voltage V2 of first grid
Voltage amplitude 7V~30V of reversed electric field, and second grid is differed with 11 current potential of ionized region not higher than 50V.
According to the method for the present embodiment, when the ion gate is opened, keep migration area 30 includes the first migration area
The current potential absolute value of the electrode of electrode 31 and the second migration area electrode 32 is identical in the case of closing with the ion gate.
According to the method for the present embodiment, in the case where the ion gate remains turned-off, transference tube is operated, so that electric
The current potential absolute value V2 of current potential absolute value V3 > the first ion gate grid of the current potential absolute value ion gate grid of V1 >=second from area 11
The current potential absolute value V5 of the second migration area the current potential absolute value V4 > electrode 32 of the first migration area > electrode 31 is that is, V1 >=V3 > V2
> V4 > V5.
The specific example an of transference tube and its testing result of resolution ratio is given below.
Fig. 2 is to use such as Simion software model built according to the structure and size of conventional migration tube, wherein migrating
30 length of area is 88mm, and the voltage between two ion gate grid of ion gate is set as 20V, and spacing is set as 0.5mm, migration area
30 electric field strengths are set as 260V/cm.
Under the usual manner that ion gate is opened, when ion gate is closed, V3 > V2 has one between two ion gate gate electrodes
A electric field opposite with 30 direction of an electric field of migration area, ion can not pass through.In the moment that ion gate is opened, first gate electrode
Vg1 will be applied an identical pulse with original polarity of voltage, and amplitude is Δ V, at this time: (V2+ Δ V) > V3, two ions
Reversed electric field between door grid is changed, and ion is allowed through.Cluster ion is under the positive field effect of ion gate, into migration
Area 30, and ion gate grid are passed through under the opposite direction collisions of 30 weak electric field of migration area and migration air-flow, it reaches Faraday plate and is simultaneously received
Collection.
Fig. 3 be using Simion under conventional ion gate working condition, run the migration spectrum of 10000 examples acquisition
Figure, wherein set ion gate opening time as 200us, period 43ms.Acquisition migration spectrum half-peak breadth is 0.475ms, and peak position is
23.8ms, resolution ratio 50.075.
Under the premise of not changing Simion Suo Jian transference tube mechanism, Simion software service condition is adjusted, it will be original
The beat voltage for being applied to the first ion fence gate Vg1 is applied to the second ion fence gate Vg2, and voltage pulse is reversed, maintains simultaneously
First ion fence gate voltage Vg1=V2 and ionization area voltage Vi=V1.At closing time, have one between two ion gate gate electrodes of V2 < V3
A electric field opposite with 30 direction of an electric field of migration area, ion can not pass through；When ion gate is opened, V2 > V4 > V3 >=V5, ion
Reversed electric field between door is changed, and ion is allowed through, after ion reaches migration area 30, due to the second ion fence gate voltage V3
Less than the first migration electrode voltage V4, the cluster ion for reaching migration area 30 will be compressed under the action of reversed electric field.Ion
It after door is closed, migrates electric field and restores normal, cluster ion at the uniform velocity migrates and under the action of migrating electric field and migration air-flow by farad
Disk receives.Fig. 4 is that moving for 10000 examples acquisitions is run after changing ion gate unfolding mode by this programme using Simion
Spectrogram is moved, wherein set ion gate opening time as 200us, period 43ms.Acquisition migration spectrum half-peak breadth is 0.440ms, peak
Position is 23.8ms, resolution ratio 54.071.
Adjust the ion gate of legacy migration pipe under the premise of not changing migration tube structure according to this programme from the point of view of calculating
After unfolding mode, migration spectrum half-peak breadth is down to 0.440ms by 0.475ms.After adjustment ion gate unfolding mode to enter migration area
30 cluster ion has certain compression effectiveness, and migration tube resolution ratio improves 8% or so.(effect portion: 1. changes are small, real
It is now simple；2. compression, is not only potential barrier, but potential well)
Although some embodiments of this totality inventional idea have been shown and have illustrated, those of ordinary skill in the art will be managed
Solution can make a change these embodiments in the case where the principle and spirit without departing substantially from this totality inventional idea, of the invention
Range is limited with claim and their equivalent.
Claims (9)
1. a kind of transference tube, the openable and closable ion gate including inner space and internally positioned space；
Inner space includes the migration area for having the ionized region of current potential absolute value V1 and being separated with ionized region by ion gate, substance by
Ionized region one end enters transference tube, is ionized in ionized region, is driven later by electric field into migration area；
Wherein, the ion gate being arranged between ionized region and migration area includes the first ion gate grid and tool with current potential absolute value V2
There are the second ion gate grid of current potential absolute value V3, the first ion gate grid and the second ion gate grid are parallel to each other, by between insulating trip
It separates and transference tube is divided into the ionized region and migration area；Migration area includes at least the with current potential absolute value V4
One migration area electrode and the second migration area electrode with current potential absolute value V5, the second migration area electrode is than the first migration area electrode
Far from the second ion gate grid；
Wherein, when the ion gate is opened, formation is ionized between the first ion gate grid and the first migration area electrode
The potential well of ion is so as to the cluster ion compression to migration area is entered；
When the ion gate is opened, the current potential that the current potential absolute value V2 of the first ion gate grid is greater than the first migration area electrode is exhausted
The current potential absolute value V3 of second ion gate grid, the second ion gate are greater than to value V4, the current potential absolute value V4 of the first migration area electrode
The current potential absolute value V3 of grid is greater than or equal to the current potential absolute value V5 of the second migration area electrode；
Wherein, in the case where the ion gate remains turned-off, transference tube is arranged so that the current potential absolute value of ionized region
V1 is greater than or equal to the current potential absolute value V3 of the second ion gate grid.
2. transference tube as described in claim 1, wherein when the ion gate is opened, keep the first ion gate grid
Current potential absolute value V2 and ionized region current potential absolute value V1 it is constant, reversed pulse potential is applied to the second ion gate grid, is made
It obtains the second ion gate grid current potential absolute value V3 and reduces a pulse potential absolute value.
3. transference tube as described in claim 1, wherein when the ion gate is opened, migration area includes first
The current potential absolute value of the electrode of migration area electrode and the second migration area electrode keeps identical in the case of closing with the ion gate.
4. transference tube as described in claim 1, wherein in the case where the ion gate remains turned-off, Ion transfer
Pipe is arranged so that the current potential absolute value V3 of the second ion gate grid is greater than the current potential absolute value V2 of the first ion gate grid, the first ion
The current potential absolute value V2 of door grid is greater than the current potential absolute value V4 of the first migration area electrode, the current potential absolute value of the first migration area electrode
V4 is greater than the current potential absolute value V5 of the second migration area electrode.
5. transference tube as claimed in claim 4, wherein in the case where the ion gate remains turned-off, the second ion
Current potential absolute value V2 high 7~30 volt of the current potential absolute value V3 of door grid than the first ion gate grid, and the second ion gate grid
The difference of the current potential absolute value V1 of current potential absolute value V3 and ionized region is not higher than 50 volts.
6. a kind of method for operating transference tube, wherein transference tube include inner space and internally positioned space can
Opening and closable ion gate；Inner space includes the ionized region and migration area with current potential absolute value V1, and substance is by electricity
Enter transference tube from area one end, be ionized in ionized region, is driven later by electric field into migration area；
Wherein, first ion gate grid of the ion gate being arranged between ionized region and migration area with current potential absolute value V2 and there is electricity
The second ion gate grid of position absolute value V3, the first ion gate grid and the second ion gate grid are parallel to each other, are spaced apart by insulating trip
And transference tube is divided into the ionized region and migration area；Migration area, which includes at least, has the first of current potential absolute value V4 to move
It moves area's electrode and the second migration area electrode with current potential absolute value V5, the second migration area electrode is more separate than the first migration area electrode
Second ion gate grid；
Wherein, the method includes when the ion gate is opened, between the first ion gate grid and the first migration area electrode
The potential well for the ion being ionized is formed to compress to the cluster ion for entering migration area；
Wherein when the ion gate is opened, the current potential of the current potential absolute value V2 and ionized region that keep the first ion gate grid are absolute
Value V1 is constant, applies reversed pulse potential to the second ion gate grid, so that the second ion gate grid current potential absolute value V3 reduces one
A pulse potential absolute value, so that the current potential that the current potential absolute value V2 of the first ion gate grid is greater than the first migration area electrode is exhausted
The current potential absolute value V3 of second ion gate grid, the second ion gate are greater than to value V4, the current potential absolute value V4 of the first migration area electrode
The current potential absolute value V3 of grid is greater than or equal to the current potential absolute value V5 of the second migration area electrode；
Wherein, in the case that the ion gate remains turned-off, transference tube is operated, so that the current potential absolute value V1 of ionized region is big
In or equal to the second ion gate grid current potential absolute value V3.
7. keep migration area includes the first migration method as claimed in claim 6, wherein when the ion gate is opened
The current potential absolute value of the electrode of area's electrode and the second migration area electrode is identical in the case of closing with the ion gate.
8. transference tube is operated method as claimed in claim 6, wherein in the case where the ion gate remains turned-off,
So that the current potential absolute value V3 of the second ion gate grid is greater than the current potential absolute value V2 of the first ion gate grid, the electricity of the first ion gate grid
Position absolute value V2 is greater than the current potential absolute value V4 of the first migration area electrode, and the current potential absolute value V4 of the first migration area electrode is greater than the
The current potential absolute value V5 of two migration area electrodes.
9. method according to claim 8, wherein operation transference tube makes in the case where the ion gate remains turned-off
Obtain current potential absolute value V2 high 7~30 volt of the current potential absolute value V3 than the first ion gate grid of the second ion gate grid, and second
The difference of the current potential absolute value V1 of the current potential absolute value V3 and ionized region of ion gate grid is not higher than 50 volts.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611270479.6A CN106783508B (en) | 2016-12-29 | 2016-12-29 | The method of transference tube and operation transference tube |
| EP17211140.3A EP3343215B1 (en) | 2016-12-29 | 2017-12-29 | Ion migration tube for an ion mobility spectrometer and method of operating the same |
| US15/858,255 US10535509B2 (en) | 2016-12-29 | 2017-12-29 | Ion migration tube and method of operating the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611270479.6A CN106783508B (en) | 2016-12-29 | 2016-12-29 | The method of transference tube and operation transference tube |
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| CN110491765B (en) * | 2018-11-25 | 2020-06-19 | 中国科学院大连化学物理研究所 | Control method of ion gate in ion mobility spectrometry |
| CN112490109B (en) * | 2020-11-24 | 2024-04-16 | 中国科学院大连化学物理研究所 | Time domain enhanced ion migration tube |
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| CN102931046A (en) * | 2011-08-09 | 2013-02-13 | 中国科学院大连化学物理研究所 | Spatial focusing ion gate component and spatial focusing ion migration tube |
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| PL1971855T3 (en) * | 2006-01-10 | 2018-10-31 | Smiths Detection-Watford Limited | Ion selection apparatus and method |
| US7538320B2 (en) * | 2006-06-27 | 2009-05-26 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Ion detection device and method with compressing ion-beam shutter |
| US8872102B2 (en) * | 2008-01-17 | 2014-10-28 | Indian University Research and Technology Corporation | Ion mobility spectrometer and method of operating same |
| JP5094520B2 (en) * | 2008-04-14 | 2012-12-12 | 株式会社日立製作所 | Ion filter, mass spectrometry system and ion mobility spectrometer |
| CN101728208B (en) * | 2008-10-20 | 2012-09-26 | 同方威视技术股份有限公司 | Ion gate and method of bipolar ion mobility spectrometry |
| CN102313774B (en) * | 2010-06-30 | 2013-05-08 | 清华大学 | Ion gate structure and operation method of ionic migration spectrometer |
| CN104321127B (en) * | 2012-03-15 | 2018-02-02 | 株式会社岛津制作所 | Ionic migration spectrometer comprising deceleration ion gate |
| CN102903598B (en) * | 2012-10-24 | 2015-04-15 | 公安部第三研究所 | Method for improving traditional ion transference tube sensitivity |
| CN104752148B (en) * | 2013-12-30 | 2017-10-10 | 同方威视技术股份有限公司 | Corona discharge component, ionic migration spectrometer, the method using corona discharge component progress corona discharge |
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| CN106783508A (en) | 2017-05-31 |
| EP3343215B1 (en) | 2023-11-08 |
| US20180190482A1 (en) | 2018-07-05 |
| US10535509B2 (en) | 2020-01-14 |
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