CN103854948A - High magnetic field asymmetrical and suction compound ion migration spectrometer - Google Patents
High magnetic field asymmetrical and suction compound ion migration spectrometer Download PDFInfo
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- CN103854948A CN103854948A CN201210528213.2A CN201210528213A CN103854948A CN 103854948 A CN103854948 A CN 103854948A CN 201210528213 A CN201210528213 A CN 201210528213A CN 103854948 A CN103854948 A CN 103854948A
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Abstract
The invention discloses a high magnetic field asymmetrical and suction compound ion migration spectrometer. After a radio frequency voltage is exerted on a high magnetic field asymmetrical waveform ion migration spectrometer, an offset voltage is scanned within a certain range so that sample ions can be detected by passing through a migration area under the special offset voltage, the sample ions which are not matched with the offset voltage arrive at a detection electrode of a suction ion migration spectrometer under the combined action of an electric field of the suction ion migration spectrometer and an electric field of the high magnetic field asymmetrical ion migration spectrometer, and therefore sample ion information disappeared in the single high magnetic field asymmetrical ion migration spectrometer can be obtained. The ion information is not lost, and more comprehensive sample information is provided for actual application and scientific research.
Description
Technical field
The invention belongs to the two-dimension analysis technology of chemical analysis field ion mobility spectrometry, specifically asymmetric the and suction-type compound ion mobility spectrometer of High-Field.
Background technology
High-Field asymmetric waveform ion mobility spectrometry (High-field asymmetric waveform ionmobility spectrometry, FAIMS) is to utilize ionic mobility to carry out ion isolation in height difference after the match.Sample enters ionized region by carrier gas band, and the sample ions being then ionized enters migration area.Migration area is generally two parallel dull and stereotyped or coaxial cylindrical structures.On one flat plate therein, add the rf electric field of asymmetric waveform, another piece ground connection.In migration area, ion can do the motion of concussion up and down under the effect of high-frequency electric field in the direction vertical with carrier gas direction.Due to the mobility difference at height field ion, in each cycle of high-frequency electric field, ion all can produce a displacement in vertical direction, and final ion is got on pole plate and buried in oblivion.If apply the bucking voltage of a coupling on high-frequency electric field, offset the displacement that ion produces y direction under asymmetric field, make ion can pass through drift region, arrive and detect the utmost point.By within the specific limits bucking voltage being scanned, just can make different sample ions arrive and detect the utmost point by migration area under specific bucking voltage, realize the detection of sample.Reach the object of selectivity detection sample by applying specific bucking voltage.
Suction-type ion mobility spectrometry (aspiration ion mobility spectrometry, AIMS) is that sample enters ionized region by carrier gas band, and the sample ions being then ionized enters migration area.Migration area is two parallel slab constructions, and carrier gas is passed through between two flat boards, and the electric field on parallel-plate is vertical with airflow direction, and under the effect of transverse electric field, ion is complied with the size of its mobility in the motion that has a friction speed across airflow direction.It is very fast that the ion that mobility is large crosses the speed of air-flow, crosses that a bit of distance is rear just can be arrived on Detection electrode with air flow stream.The ion that mobility is little need to move the longer time between pole plate, namely just can strike the position of Detection electrode back along the mobile long segment distance of the direction continuation that enters migration area.The detector that is arranged with one group of electricity isolation on Detection electrode records respectively shock amount of ions in the above.The result of analyzing is to obtain one group of signal mode corresponding to the electric current producing on each detector.Suction-type ion mobility spectrometry is not because there is no ion fence gate, and the utilization ratio of ion is very high, and the ion of all mobilities is all got off by recording occurring continuously.
High-Field asymmetric waveform ion mobility spectrometry reaches the object of select target ion by applying specific bucking voltage, lost the ion information needing under other bucking voltages; And the ion information of all mobilities of suction-type ion mobility spectrometry recording occurring continuously has but lost the means of selecting specific ion to detect.
Given this, the present invention by High-Field asymmetric waveform Ion mobility spectrometry and suction-type Ion mobility spectrometry in conjunction with forming two-dimension analysis technology.Regioselective ion detects by High-Field Asymmetric Waveform Ion Mobility Spectrometer device, and all the other ions detect by suction-type ion mobility spectrometry instrument simultaneously.When selectivity obtains specific ion information, also obtain the information of all the other ions, do not lost ion information, for practical application and scientific research provide sample message more comprehensively.
Summary of the invention
The invention discloses a kind of High-Field asymmetric waveform Ion mobility spectrometry and suction-type Ion mobility spectrometry in conjunction with forming two-dimentional analytical technology.Regioselective ion detects by High-Field Asymmetric Waveform Ion Mobility Spectrometer device, and all the other ions detect by suction-type ion mobility spectrometry instrument simultaneously.
Asymmetric and the suction-type compound ion mobility spectrometer of High-Field, comprises ion migration area,
The tabular electrode of a pair of rectangle being arranged in parallel, as High-Field asymmetric electrode; The tabular electrode of a pair of rectangle being arranged in parallel, as suction-type symmetry electrode; Jointly surrounded the square cylinder of left and right two end openings as sidewall by four pole plates of High-Field asymmetric electrode and suction-type symmetry electrode, the pole plate of High-Field asymmetric electrode pole plate and suction-type symmetry electrode is perpendicular, and the inner space of square cylinder is ion migration area;
Left end in square cylinder is provided with ion source, is provided with successively bucking electrode and receiving pole in the right-hand member of square cylinder;
Receiving pole comprises that ion receiving plane is parallel to the SYMMETRICAL FIELD receiving pole of the pole plate of suction-type symmetry electrode towards the High-Field asymmetric field receiving pole of square cylinder openend and ion receiving plane.
Bucking electrode is a pair of plate electrode being arranged in parallel.
In between High-Field asymmetric electrode pole plate, in migration area, apply high-frequency electric field, and on high-frequency electric field, apply the bucking voltage of a coupling;
Between the pole plate of suction-type symmetry electrode, in migration area, apply a direct current uniform electric field;
High-Field direction of an electric field asymmetric and suction-type two-dimensional ionic migration spectrum is mutual vertical distribution.
Left end in square cylinder is provided with carrier gas inlet, is provided with carrier gas outlet in the right-hand member of square cylinder;
The asymmetric ion mobility spectrometry of High-Field and suction-type ion mobility spectrometry share a carrier gas, and airflow direction is all vertical with both directions of an electric field.
The electric field of the asymmetric ion mobility spectrometry of High-Field is non homogen field, and high-low pressure alternately occurs, and applies the scanning voltage of certain limit; The electric field of suction-type ion mobility spectrometry is uniform field.
Ionization source is radioactive ionization gauge source or light ionization source or discharge ionization source.
In the time that ionization source is light ionization source, in carrier gas, add dopant for generation of reactive ion; Dopant is acetone, ethanol or toluene.
Advantage of the present invention
The present invention is the asymmetric and suction-type compound ion mobility spectrometer of High-Field, when selectivity obtains specific ion information, has also obtained the information of all the other ions, does not lose ion information, for practical application and scientific research provide sample message more comprehensively.
Accompanying drawing explanation
Fig. 1 is the asymmetric and asymmetric ion mobility spectrometry schematic diagram of suction-type compound ion mobility spectrometer migration tube High-Field of High-Field;
Fig. 2 is the asymmetric and suction-type compound ion mobility spectrometer migration tube suction-type ion mobility spectrometry schematic diagram of High-Field;
Fig. 3 is the asymmetric and suction-type compound ion mobility spectrometer migration tube schematic appearance of High-Field.
Embodiment
The invention provides the asymmetric and suction-type compound ion mobility spectrometer of a kind of High-Field.
Asymmetric and the suction-type compound ion mobility spectrometer of High-Field, comprises ion migration area,
The tabular electrode of a pair of rectangle being arranged in parallel, as High-Field asymmetric electrode; The tabular electrode of a pair of rectangle being arranged in parallel, as suction-type symmetry electrode; Jointly surrounded the square cylinder of left and right two end openings as sidewall by four pole plates of High-Field asymmetric electrode and suction-type symmetry electrode, the pole plate of High-Field asymmetric electrode pole plate and suction-type symmetry electrode is perpendicular, and the inner space of square cylinder is ion migration area;
Left end in square cylinder is provided with ion source, is provided with successively bucking electrode and receiving pole in the right-hand member of square cylinder;
Receiving pole comprises that ion receiving plane is parallel to the SYMMETRICAL FIELD receiving pole of the pole plate of suction-type symmetry electrode towards the High-Field asymmetric field receiving pole of square cylinder openend and ion receiving plane.
Bucking electrode is a pair of plate electrode being arranged in parallel.
Asymmetric and principle suction-type compound ion mobility spectrometer of High-Field is that the asymmetric ion mobility spectrometry of High-Field and suction-type ion mobility spectrometry share a carrier gas, and airflow direction is all vertical with both directions of an electric field.Both directions of an electric field are mutual vertical distribution.The former electric field is non homogen field, and high-low pressure alternately occurs, and applies the scanning voltage of certain limit.The latter's electric field is uniform field.
Ionization source is radioactive ionization gauge source or light ionization source or discharge ionization source.
In the time that ionization source is light ionization source, in carrier gas, add dopant for generation of reactive ion.
Dopant is acetone, ethanol, toluene.
As shown in FIG. 1 to 3, wherein 1 is ionization source, 2 migration electrodes, 3 auxiliary electrodes, 4 is detecting electrode, 5 is suction-type ion mobility spectrometry detecting electrode, and 6 is sample air inlet, and 7 is carrier gas inlet, 8 is carrier gas outlet, 9 is radio-frequency voltage, and 10 is bucking voltage, and 11 is the asymmetric ion mobility spectrometry migration tube of High-Field bottom crown, 12 is the asymmetric ion mobility spectrometry migration tube of High-Field top crown, 13 is the uniform electric field in suction-type ion mobility spectrometry migration area, and 14 is the front pole plate of suction-type ion mobility spectrometry, and 15 is the rear pole plate of suction-type ion mobility spectrometry.
When measurement, sample is ionized at ionization source 1 place, then under carrier gas rolling action, enters the migration area that migration electrode 2 forms, above migration area inner high voltage asymmetric field electrode, be applied in an asymmetric radio-frequency voltage and a compensating direct current voltage, like this at this electrode and form peripherally a changing electric field between electrode, the sample ions that bucking voltage matches could be by migration area by the asymmetric ion mobility spectrometry Faraday plate of High-Field collector, the non-matching sample ions of bucking voltage is under the electric field of suction-type ion mobility spectrometry and the electric field acting in conjunction of the asymmetric ion mobility spectrometry of High-Field, strike suction-type ion mobility spectrometry Faraday plate collector, thereby can obtain the sample ions information dieing out in the asymmetric ion mobility spectrometry of single High-Field.Residual gas is discharged through gas vent.
Claims (7)
1. the asymmetric and suction-type compound ion mobility spectrometer of High-Field, comprises ion migration area, it is characterized in that:
The tabular electrode of a pair of rectangle being arranged in parallel, as High-Field asymmetric electrode; The tabular electrode of a pair of rectangle being arranged in parallel, as suction-type symmetry electrode; Jointly surrounded the square cylinder of left and right two end openings as sidewall by four pole plates of High-Field asymmetric electrode and suction-type symmetry electrode, the pole plate of High-Field asymmetric electrode pole plate and suction-type symmetry electrode is perpendicular, and the inner space of square cylinder is ion migration area;
Left end in square cylinder is provided with ion source, is provided with successively bucking electrode and receiving pole in the right-hand member of square cylinder;
Receiving pole comprises that ion receiving plane is parallel to the SYMMETRICAL FIELD receiving pole of the pole plate of suction-type symmetry electrode towards the High-Field asymmetric field receiving pole of square cylinder openend and ion receiving plane.
2. and suction-type compound ion mobility spectrometer asymmetric according to High-Field described in claim 1, is characterized in that: bucking electrode is a pair of plate electrode being arranged in parallel.
3. and suction-type compound ion mobility spectrometer asymmetric according to High-Field described in claim 1, is characterized in that:
In between High-Field asymmetric electrode pole plate, in migration area, apply high-frequency electric field, and on high-frequency electric field, apply the bucking voltage of a coupling;
Between the pole plate of suction-type symmetry electrode, in migration area, apply a direct current uniform electric field;
High-Field direction of an electric field asymmetric and suction-type two-dimensional ionic migration spectrum is mutual vertical distribution.
4. and suction-type compound ion mobility spectrometer asymmetric according to High-Field described in claim 1, is characterized in that:
Left end in square cylinder is provided with carrier gas inlet, is provided with carrier gas outlet in the right-hand member of square cylinder;
The asymmetric ion mobility spectrometry of High-Field and suction-type ion mobility spectrometry share a carrier gas, and airflow direction is all vertical with both directions of an electric field.
5. the asymmetric and suction-type compound ion mobility spectrometer of High-Field according to claim 3, is characterized in that: the electric field of the asymmetric ion mobility spectrometry of High-Field is non homogen field, and high-low pressure alternately occurs, and applies the scanning voltage of certain limit; The electric field of suction-type ion mobility spectrometry is uniform field.
6. and suction-type compound ion mobility spectrometer asymmetric according to High-Field described in claim 1, is characterized in that: ionization source is radioactive ionization gauge source or light ionization source or discharge ionization source.
7. and suction-type compound ion mobility spectrometer asymmetric according to High-Field described in claim 6, is characterized in that:
In the time that ionization source is light ionization source, in carrier gas, add dopant for generation of reactive ion; Dopant is acetone, ethanol or toluene.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105632874A (en) * | 2014-11-07 | 2016-06-01 | 中国科学院大连化学物理研究所 | DC non-uniform electric field ion migration tube |
| CN105702555A (en) * | 2014-11-27 | 2016-06-22 | 中国科学院大连化学物理研究所 | Method for improving ionization efficiency of differential ion mobility spectrometry |
| CN107026067A (en) * | 2017-04-10 | 2017-08-08 | 金华职业技术学院 | A kind of ionic migration spectrometer without ion shutter of use fast-pulse electron source |
| CN107393805A (en) * | 2017-08-02 | 2017-11-24 | 金华职业技术学院 | The device of photic separation is studied under a kind of low temperature |
| CN110312462A (en) * | 2017-02-06 | 2019-10-08 | 奥尔斯通医疗有限公司 | The improvement or relevant improvement that subject is prepared for medical treatment or veterinary inspection |
| CN112530783A (en) * | 2019-08-30 | 2021-03-19 | 株式会社岛津制作所 | Device for carrying out field asymmetric waveform ion mobility spectrometry |
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| CN102478542A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Flat-type fully differential ion mobility spectrometry |
| CN102478544A (en) * | 2010-11-30 | 2012-05-30 | 中国科学院大连化学物理研究所 | Novel method for identifying and detecting explosive |
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| US20060255264A1 (en) * | 2005-05-16 | 2006-11-16 | Belford Michael W | Enhanced ion desolvation for an ion mobility spectrometry device |
| CN101067616A (en) * | 2007-06-06 | 2007-11-07 | 中国科学院合肥物质科学研究院 | Longitudinal high-field asymmetrical wave form ion mobility spectrum device |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105632874A (en) * | 2014-11-07 | 2016-06-01 | 中国科学院大连化学物理研究所 | DC non-uniform electric field ion migration tube |
| CN105632874B (en) * | 2014-11-07 | 2017-09-26 | 中国科学院大连化学物理研究所 | A kind of direct current inhomogeneous field transference tube |
| CN105702555A (en) * | 2014-11-27 | 2016-06-22 | 中国科学院大连化学物理研究所 | Method for improving ionization efficiency of differential ion mobility spectrometry |
| CN110312462A (en) * | 2017-02-06 | 2019-10-08 | 奥尔斯通医疗有限公司 | The improvement or relevant improvement that subject is prepared for medical treatment or veterinary inspection |
| CN107026067A (en) * | 2017-04-10 | 2017-08-08 | 金华职业技术学院 | A kind of ionic migration spectrometer without ion shutter of use fast-pulse electron source |
| CN107026067B (en) * | 2017-04-10 | 2018-12-14 | 金华职业技术学院 | A kind of ionic migration spectrometer without ion shutter using fast-pulse electron source |
| CN107393805A (en) * | 2017-08-02 | 2017-11-24 | 金华职业技术学院 | The device of photic separation is studied under a kind of low temperature |
| CN112530783A (en) * | 2019-08-30 | 2021-03-19 | 株式会社岛津制作所 | Device for carrying out field asymmetric waveform ion mobility spectrometry |
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Application publication date: 20140611 |