CN106773120A - Contact lens material and contact lens - Google Patents
Contact lens material and contact lens Download PDFInfo
- Publication number
- CN106773120A CN106773120A CN201510828639.3A CN201510828639A CN106773120A CN 106773120 A CN106773120 A CN 106773120A CN 201510828639 A CN201510828639 A CN 201510828639A CN 106773120 A CN106773120 A CN 106773120A
- Authority
- CN
- China
- Prior art keywords
- contact lens
- polymer
- matrix
- steam generator
- hydrogenperoxide steam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Eyeglasses (AREA)
Abstract
A kind of contact lens, including matrix, the contact lens also include the polymer nanocapsules being mixed in the matrix, and the polymer nanocapsules can be by the release oxygen that chemically reacts, in case angle till film anoxic.The present invention also provides a kind of contact lens material for preparing above-mentioned contact lens.
Description
Technical field
The present invention relates to a kind of contact lens material, and prepared by the contact lens material
Contact lens.
Background technology
Contact lenses are substantially categorized as soft and hard type glasses.Wherein, soft contact lens are usual
It is divided into hydrogel contact lens and non-aqueous gel contact lenses.
Conventional soft hydrogel contact lenses are generally by hydrophilic monomer (such as methacrylic acid hydroxyl second
Ester, NVP etc.) copolymer composition, and can by lathe cutting method, rotation pour
Building method, injection molding forming method or its combination, afterwards by physiological saline and/or PBS
In carry out swelling treatment and be made with obtaining the glasses of water content 20%-80% (mass percent).
Contact lenses are comfortable when wearing and safety is important.For example, silicone hydrogel contact lens
Should be comfortable when wearing for using, wearing the mode overnight and/or for a long time continuously worn to wear daily
And safety.But.Present contact lenses wear device can by lens sticks to cornea, by
It is not high in the oxygen permeability of eyeglass so that cornea anoxic so as to cause wearer's glasses discomfort, corneal edema,
The problems such as eye-blurred.In addition, this kind of eyeglass is also easy to cause the problem of cornea swelling when wearing at night.
The content of the invention
In view of the foregoing, it is necessary to which providing a kind of can improve oxygen permeability and not be easily caused cornea swelling
Contact lens.
A kind of contact lens, including matrix, the contact lens also include being mixed in the matrix
In polymer nanocapsules, the polymer nanocapsules can by chemically react release oxygen, in case
Angle till film anoxic.
A kind of contact lens material, is used to prepare contact lens, the contact lens material
Including by polymer nanocapsules, hydrophilic monomer, hydrated polymer, light trigger and crosslinking agent group
Into mixture, under ultraviolet light, the hydrophilic monomer and hydrated polymer can be in light triggers
And matrix is formed after being copolymerized in the presence of crosslinking agent, the polymer nanocapsules are mixed in this
In matrix.
Compared with prior art, the polymer nanocapsules in above-mentioned contact lens can be in matrix
Oxygen is produced by chemically reacting, to improve the oxygen permeability of the contact lens, it is possible to be cornea etc.
Position provides necessary oxygen, prevents cornea from swelling and being damaged to eyes because of anoxic.
Specific embodiment
In following narration, various specific detail system is used to provide the overall understanding of the embodiment of the present invention.This
Invention will coordinate its preferred embodiment be specified in down, it should be understood that the present invention in all preferred embodiments only
It is used to illustrate, and is not used to the limitation present invention.Ripe this operator is it should also be understood that reality of the invention
Apply and be not necessary to one or more specific details, or other ad hoc approach.Present invention could apply to various contact lenses,
Hereinafter do an explanation.
A better embodiment of the invention is used to provide a kind of contact lens, the contact lens
Including matrix and the polymer nanocapsules being mixed in the matrix.Wherein, the polymer nanocapsules bag
Include hydrogen peroxide (H2O2) solution and it is used to wrap up the wall material of the hydrogenperoxide steam generator.The polymer nanocomposite
The wall material of capsule slowly can be decomposed and discharge the hydrogenperoxide steam generator in the matrix, the hydrogen peroxide
Oxygen and water are voluntarily decomposed and discharged, the oxygen permeability of the contact lenses is improved, and for the positions such as cornea carry
Oxygen and water, so as to prevent cornea because of anoxic the problems such as swelling.Further, the stealth is being used
During eyeglass, under the irradiation of visible ray, the decomposition rate of the hydrogen peroxide is accelerated, so as to accelerate oxygen
The rate of release of gas.Further, when using the contact lens, a small amount of peroxidating can be added
Hydrogen enzyme, so that promote hydrogen peroxide to decompose release oxygen, so as to further speed up the rate of release of oxygen.
Further, since hydrogen peroxide has sterilizing function in itself, so that for the contact lens provide sterilization work(
Can, prevent eyes from being infected by microorganism.
In the present embodiment, the shared quality percentage in contact lens of the polymer nanocapsules
Than being 0.01%-5%.
In the present embodiment, the polymer nanocapsules include hydrogenperoxide steam generator and are used to wrap up the mistake
The wall material of hydrogen peroxide solution.Wherein, the shared matter in the polymer nanocapsules of the hydrogenperoxide steam generator
Amount percentage is 0.05%-10%, and the concentration of hydrogen peroxide is 1%~35% (quality in the hydrogenperoxide steam generator
Percentage).The wall material is decomposable macromolecular material.Further, the decomposable macromolecular material
Comprising chitin, PLGA (PLGA), sodium alginate, gelatin or other are natural
Or the decomposability macromolecule of synthesis etc..
In the present embodiment, the contact lens can be hydrogel lenses or silicone hydrogel lenses.
When the contact lens are hydrogel lenses, the matrix is hydrogel；When the contact lens are
During silicone hydrogel lenses, the matrix is silicone-hydrogel.Wherein, the hydrogel and silicone-hydrogel are by parent
Aqueous monomers and hydrated polymer be copolymerized in the presence of light trigger and crosslinking agent after shape
Into.Wherein, the hydrated polymer is as hydrogel and the main chain of silicone-hydrogel, the hydrophilic monomer
As functional monomer in hydrogel and silicone-hydrogel increasing the performances such as its hydrophily and oxygen permeability.Enter
One step, the hydrophilic monomer and the shared quality percentage in the contact lens of hydrated polymer
Than being 94%-99.95%.The shared mass percent in the contact lens of the crosslinking agent is
0.001%~2%.The shared mass percent in the contact lens of the light trigger is
0.005%~1.5%.
More specifically, when the matrix is hydrogel, the hydrophilic monomer may be selected from N- vinyl pyrroles
Alkanone (NVP), GMA (GMA) and N, N- DMAA (DMAA)
In one of which, the hydrated polymer may include methyl methacrylate (MMA) and methyl-prop
Olefin(e) acid hydroxyl ethyl ester (HEMA).When the matrix is silicone-hydrogel, the hydrophilic monomer can be N- ethene
Base pyrrolidones (NVP), the hydrated polymer may include methyl methacrylate (MMA), methyl
Hydroxy-ethyl acrylate (HEMA), dimethyl silicone polymer (PDMS) and trishydroxymethylaminomethane
(TRIS).Wherein, the light trigger can use Irgacure-1173 (chemical industry standard model),
The crosslinking agent can use GDMA (EGDMA).
The present invention also provides a kind of contact lens material for preparing above-mentioned contact lens, its
Including by polymer nanocapsules, hydrophilic monomer, hydrated polymer, light trigger and crosslinking agent group
Into mixture.Wherein, under ultraviolet light, the hydrophilic monomer and hydrated polymer can be in light
Matrix is formed after being copolymerized in the presence of initiator and crosslinking agent, makes the polymer nanocapsules
It is mixed in the matrix.The polymer nanocapsules include hydrogenperoxide steam generator and are used to wrap up the peroxide
Change the wall material of hydrogen solution.
The hydrogen peroxide in polymer nanocapsules in contact lens of the present invention can be in light
According to oxygen and water is resolved under the conditions of grade, to improve the oxygen permeability of the contact lens, it is possible to be angle
The positions such as film provide necessary oxygen and water, prevent cornea from swelling and being damaged to eyes because of anoxic.
Further, the hydrogen peroxide can also provide sterilizing function for the contact lens, prevent eyes
Infected by nano biological.
Above content is to combine specific preferred embodiment further description made for the present invention,
The specific implementation of the invention is not to be limited to these illustrations.For the technical field of the invention
For those of ordinary skill, some equivalent substitutes or obvious are made without departing from the inventive concept of the premise
Modification, and performance or purposes are identical, should all be considered as belonging to claims by being submitted to of the invention
The scope of patent protection of determination.
Claims (10)
1. a kind of contact lens, including matrix, it is characterised in that：The contact lens are also wrapped
The polymer nanocapsules being mixed in the matrix are included, the polymer nanocapsules can be by chemical reaction
Release oxygen, in case angle till film anoxic.
2. contact lens as claimed in claim 1, it is characterised in that：The polymer nanocapsules bag
Include hydrogenperoxide steam generator and wrap up the wall material of the hydrogenperoxide steam generator.
3. contact lens as claimed in claim 1, it is characterised in that：The polymer nanocapsules exist
Shared mass percent is 0.01%-5% in the contact lens.
4. contact lens as claimed in claim 3, it is characterised in that：The hydrogenperoxide steam generator is at this
Shared mass percent is 0.05%-10%, peroxide in the hydrogenperoxide steam generator in polymer nanocapsules
The concentration for changing hydrogen is 1%~35% (mass percent).
5. contact lens as claimed in claim 2, it is characterised in that：The wall material is decomposable height
Molecular material.
6. contact lens as claimed in claim 5, it is characterised in that：The decomposable macromolecule material
Material is comprising chitin, PLGA, sodium alginate, gelatin or other are natural or synthetic
Decomposability macromolecule.
7. contact lens as described in claim 1, it is characterised in that：The matrix is hydrogel,
The hydrophilic monomer is selected from NVP, GMA and N, N-
The one of which of DMAA, the hydrated polymer includes methyl methacrylate and methyl
Hydroxy-ethyl acrylate.
8. contact lens as described in claim 1, it is characterised in that：The matrix is silicone-hydrogel,
The hydrophilic monomer be NVP, the hydrated polymer include methyl methacrylate,
Hydroxyethyl methacrylate, dimethyl silicone polymer and trishydroxymethylaminomethane.
9. a kind of contact lens material, is used to prepare contact lens, it is characterised in that：This is hidden
Shape spectacle lens materials are included by polymer nanocapsules, hydrophilic monomer, hydrated polymer, light-initiated
Agent and the mixture of crosslinking agent composition, under ultraviolet light, the hydrophilic monomer and hydrated polymer
Thing forms matrix after being copolymerized in the presence of light trigger and crosslinking agent, the polymer nano
Rice glue capsule is mixed in the matrix.
10. contact lens material as claimed in claim 9, it is characterised in that：The polymer nanocomposite
Capsule includes hydrogenperoxide steam generator and wraps up the wall material of the hydrogenperoxide steam generator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510828639.3A CN106773120A (en) | 2015-11-25 | 2015-11-25 | Contact lens material and contact lens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510828639.3A CN106773120A (en) | 2015-11-25 | 2015-11-25 | Contact lens material and contact lens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106773120A true CN106773120A (en) | 2017-05-31 |
Family
ID=58964402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510828639.3A Pending CN106773120A (en) | 2015-11-25 | 2015-11-25 | Contact lens material and contact lens |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106773120A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108641262A (en) * | 2018-05-02 | 2018-10-12 | 熊振 | A kind of contact lens material and its preparation |
| CN111965842A (en) * | 2020-08-12 | 2020-11-20 | 安徽信息工程学院 | Hydrophobic contact lens |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630128B1 (en) * | 1998-08-28 | 2003-10-07 | Destiny Pharma Limited | Porphyrin derivatives their use in photodynamic therapy and medical devices containing them |
| CN1893822A (en) * | 2003-11-17 | 2007-01-10 | 生物之门股份公司 | Antimicrobial composite material |
| CN101167002A (en) * | 2005-02-17 | 2008-04-23 | 奥西班德科技公司 | Method and apparatus for supplying gas to an area |
| CN101600348A (en) * | 2006-12-04 | 2009-12-09 | S.K.药物公司 | The Synergistic antimicrobial preparations that comprises chlorite and hydrogen peroxide |
| CN104936564A (en) * | 2012-10-05 | 2015-09-23 | 南加利福尼亚大学 | Implantable oxygenator with self-contained electrolyte |
| WO2015155171A1 (en) * | 2014-04-08 | 2015-10-15 | Novartis Ag | Ophthalmic lenses with oxygen-generating elements therein |
-
2015
- 2015-11-25 CN CN201510828639.3A patent/CN106773120A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6630128B1 (en) * | 1998-08-28 | 2003-10-07 | Destiny Pharma Limited | Porphyrin derivatives their use in photodynamic therapy and medical devices containing them |
| CN1893822A (en) * | 2003-11-17 | 2007-01-10 | 生物之门股份公司 | Antimicrobial composite material |
| CN101167002A (en) * | 2005-02-17 | 2008-04-23 | 奥西班德科技公司 | Method and apparatus for supplying gas to an area |
| CN101600348A (en) * | 2006-12-04 | 2009-12-09 | S.K.药物公司 | The Synergistic antimicrobial preparations that comprises chlorite and hydrogen peroxide |
| CN104936564A (en) * | 2012-10-05 | 2015-09-23 | 南加利福尼亚大学 | Implantable oxygenator with self-contained electrolyte |
| WO2015155171A1 (en) * | 2014-04-08 | 2015-10-15 | Novartis Ag | Ophthalmic lenses with oxygen-generating elements therein |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108641262A (en) * | 2018-05-02 | 2018-10-12 | 熊振 | A kind of contact lens material and its preparation |
| CN111965842A (en) * | 2020-08-12 | 2020-11-20 | 安徽信息工程学院 | Hydrophobic contact lens |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0611781B1 (en) | Ophthalmic lens polymer incorporating acyclic monomer | |
| JP4926970B2 (en) | Lactam polymer derivatives | |
| US6727336B1 (en) | Ocular lens materials and process for producing the same | |
| AU2007272558B2 (en) | Actinically crosslinkable copolymers for manufacturing contact lenses | |
| CN109563293A (en) | Polymer composition containing graft polymers network and it is used to prepare and uses their method | |
| JP2007289641A (en) | Method for forming contact lenses containing therapeutic agent | |
| TW201510603A (en) | Ionic silicone hydrogels having improved hydrolytic stability | |
| NZ600609A (en) | Silicone hydrogel contact lenses that gradually release a hydrophobic comfort agent to the wearer | |
| CN109790243A (en) | Three block prepolymer and its purposes in silicone hydrogels | |
| ATE433850T1 (en) | OPHTALMIC LENSES AND COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF | |
| CN102460222A (en) | Multi-armed macromonomers, polymeric materials and contact lenses comprising same | |
| CN106810640B (en) | Glue constituent and glue eyeglass | |
| CN106773120A (en) | Contact lens material and contact lens | |
| WO2015159942A1 (en) | Medical device including anionic drug | |
| TWI630436B (en) | Contact lens material and contact lens | |
| CN115710329B (en) | Flexible hydrophilic contact lens containing ectoin and preparation method thereof | |
| CN101959664A (en) | Methods and systems for processing silicone hydrogel ophthalmic lenses for improved lens transfer | |
| EP3363862B1 (en) | Photochromic soft contact lens composition and method for preparing same | |
| TWI671361B (en) | Hydrogel composition and hydrogel contact lenses made of the composition | |
| KR102600599B1 (en) | Manufacturing method of hydrogel contact lens having reactive oxigen species scavenging ability using reactive polypehnol | |
| CN103282053B (en) | Medical device for controlled release of drug | |
| CN108641262A (en) | A kind of contact lens material and its preparation | |
| US20030018123A1 (en) | Biocompatible optically transparent polymeric material | |
| JP2559292B2 (en) | Resin composition for producing soft contact lens, soft contact lens and method for producing the same | |
| TW201807458A (en) | Eye lens, intraocular lens and package having eye lens |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170531 |
|
| WD01 | Invention patent application deemed withdrawn after publication |