CN106756189B - A kind of preparation method and application of GaInO liquid alloys - Google Patents
A kind of preparation method and application of GaInO liquid alloys Download PDFInfo
- Publication number
- CN106756189B CN106756189B CN201611001759.7A CN201611001759A CN106756189B CN 106756189 B CN106756189 B CN 106756189B CN 201611001759 A CN201611001759 A CN 201611001759A CN 106756189 B CN106756189 B CN 106756189B
- Authority
- CN
- China
- Prior art keywords
- liquid
- metals
- gaino
- metal
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/10—Alloys containing non-metals
- C22C1/1036—Alloys containing non-metals starting from a melt
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C1/00—Making non-ferrous alloys
- C22C1/10—Alloys containing non-metals
- C22C1/1036—Alloys containing non-metals starting from a melt
- C22C1/1057—Reactive infiltration
- C22C1/1063—Gas reaction, e.g. lanxide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K11/00—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00
- G01K11/06—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using melting, freezing, or softening
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of preparation method and applications of GaInO liquid alloys.By high-purity In metals by molal quantity 0.17 ~ 0.28, high-purity Ga metals by molal quantity 0.83 ~ 0.72 are weighed and are put into beaker respectively, then beaker is placed on magnetic stirring apparatus.It will integrally be put into vacuum glove box, 50 DEG C ~ 80 DEG C are heated to beaker by magnetic stirring apparatus, and be stirred continuously after the metal into beaker becomes liquid, 2 ~ 6ml oxygen is slowly injected to liquid metal with syringe（Purity is 99.7%）And obtain GaInO liquid metals after continuing 30 ~ 60min of stirring.The liquid metals can accurately control different instruction temperature and viscosity, have excellent conduction, heat conduction and personalized forming ability, and prepare simple, easy to use, of low cost.
Description
Technical field
The present invention relates to a kind of preparation method and applications of GaInO liquid alloys, belong to biological species material preparation technology neck
Domain.
Background technology
Liquid metal, refers to the metalloid that fusing point is no more than 660.37 DEG C, they have high thermal conductivity, good ratio
Heat, low viscosity and stability are currently used for preparing the most promising a kind of material of novel power supply, electromagnetic device.
In recent years, with aging of population, in, the increase of young wound, the basis of new and high technology bio-medical material is ground
Study carefully work and also obtained global extensive attention, industry also obtains unprecedented high speed development.As medical living is horizontal
Raising, to the long-time stability after the human body implantation biocompatibility of bio-medical material, biological safety, implantation and
The requirement of patient comfort is higher and higher, and the biological and medicinal implant material that this just needs to research and develop is except with the same of complex function
When, should be able to also under the different body temperature environment of human body long term survival.The biological and medicinal implant material long period of soaking that will be developed
Bioactivity experiment is carried out in human body simulation fluid environment such as artificial blood, artificial bone-marrow liquid, artificial saliva, and is observed
Implant and the ion exchange in ambient body fluid and pre- osteogenic activity be implant material into before zoopery using most general
Time osteogenic activity appraisement system.However, the general difficulty that the appraisement system of this Bioactivity faces in practice exists
In：When implant material applies the bony site in human body not load-bearing, repair time is at least 6 weeks, and when implant material should
Used in the bony site of human bearing, repair time is at least 1 year, therefore, for a long time will be needed for basic research
Culture coexists with human body simulation body fluid in implant material.Since the temperature of partes corporis humani position changes in the range of 36.0 ~ 36.7 DEG C,
When there is outer material to be implanted into, extraneous bacterium, Virus entry often make the horizontal rises of IL-6, cause inflammatory reaction, cause people
Temperature is increased to nearly 41 DEG C or so, and here it is the fevers being commonly called as.But existing method is carrying out the experiment of human body simulation body fluid
During evaluation, temperature-control range be constant temperature at 36 DEG C or so, cannot reflect the actual change situation of human body temperature, therefore, for a long time
Experimentation need simulate different human body at a temperature of complex process.For the above situation, design can rapidly, significantly reflect
The detection material of human body temperature scope is just very necessary.
The content of the invention
There is high conductivity, the system for the GaInO liquid alloys that not hydrophilic, viscosity is good it is an object of the invention to provide a kind of
Preparation Method specifically includes following steps：It will be put into after pure In metals and pure Ga metal mixeds in container, vacuum item will be integrally placed at
Under part, 50 DEG C ~ 80 DEG C are heated to, and is stirred continuously to metal and becomes liquid, is then slowly introducing oxygen to liquid metal,
And obtain GaInO liquid metals after continuing 30 ~ 60min of stirring；Wherein, the molar percentage of In metals is 17 ~ 28%, Ga metals
Molar percentage 83 ~ 72%.
Preferably, the purity of In metals and Ga metals of the present invention is all higher than being equal to 99.99%.
Preferably, the intake of oxygen of the present invention is 0.3 ~ 0.5 times of Ga-In mixing molal quantitys.
Preferably, whole preparation process of the present invention carries out in vacuum glove box.
It is another object of the present invention to be used to GaInO liquid alloys for biomaterial monitor biomaterial and human mould
Intend the temperature variations of human body simulation body fluid during body fluid co-cultures.Specific method is：Good person's body simulated body fluid will be configured
It adjusts to 36 DEG C ± 1 DEG C of the human body initial temperature of health, is put into vacuum glove box or insulated cabinet, vacuumizes, completely cut off solution
With the heat exchange action of ambient enviroment, the GaInO liquid alloys of the different melting points prepared are instilled in solution, then will be commented
The biomaterial of valency is put into simulated body fluid, observes the state change process of the GaInO liquid alloys of different melting points.
The present invention prepares the CaIn alloys of different melting points, moreover, adding oxygen on this basis（O）Increasing as liquid alloy
Stick increases its surface tension and viscosity, is used as the instruction material of body temperature detecting system；When human body is due to introducing
Microscopic bacteria and temperature is caused to raise, which can rapidly change state.It is excellent that material is prepared with reference to the method for the invention
Good conduction, heat conduction and property not soluble in water, available for producing of low cost, easy to operate, personalized bionical human body
Hygrosensor.
Compared with prior art, the advantage of the invention is that：
（1）Step（2）Middle whipping process using oxygen as tackifier, can be adjusted effectively by the oxygen for adding in different content
The surface tension and viscosity of GaInO liquid alloys, can be such that it is connected with other device into intimate, and also personalizable is designed to not similar shape
Shape.
（2）The alloy is by the different-alloy ingredient of restriction than that can make shape under the different temperatures in the range of human body temperature
Into the random conversion of stable solid-liquid phase, and with excellent electric conductivity and non-hydrophily, when use, can directly be instilled body
Liquid can be also connected as thermoelectric sensor with temperature control system simultaneously.
（3）The preparation process of the method for the present invention is simple and convenient to operate, is of low cost very much, can prepare different instructions
The GaInO liquid metals of temperature are put into body fluid simultaneously to be used, and when use directly draws instillation with syringe, inserts refrigerator guarantor
It deposits, it is easy to accomplish industrialized production.
（4）GaInO liquid metals prepared by the method for the present invention change for monitoring human body simulation rehydration temperature, operation side
Just it is, of low cost.The liquid metal is nontoxic to human body, good biocompatibility, to test environment and test in the range of human body temperature
Material is pollution-free；By controlling liquid metal viscosity, temperature sensing ball not of different shapes that can be arbitrarily, when observing temperature change
It is easily distinguishable, and eliminate influence of the water bath with thermostatic control equipment to experiment authenticity in traditional immersion test.
Specific embodiment
The present invention is described in further detail With reference to embodiment, but protection scope of the present invention and unlimited
In the content.
Embodiment 1
A kind of preparation method of GaInO liquid alloys, specifically includes following steps described in the present embodiment：
（1）Obtain liquid alloy raw material：By high-purity In metals that purity is 99.99% and high-purity Ga that purity is 99.99%
Metal is weighed respectively, wherein, the molar percentage of In metals is 17%, Ga metal molars percentage 83%, and Ga-In mixing rubs
Your number is 1 mole.
（2）Obtain liquid alloy：By step（1）The obtained Ga metals of middle weighing are put into In metals in beaker, then will
Beaker is placed on magnetic stirring apparatus, and rotor is placed in beaker；It will integrally be put into vacuum glove box, pass through magnetic stirring apparatus
50 DEG C are heated to beaker, and is stirred continuously after the metal into beaker becomes liquid, is slowly noted to liquid metal with syringe
Penetrate 0.3 mole of oxygen（Purity is 99.7%）And continue to obtain the GaInO liquid gold that instruction temperature is 30 DEG C after stirring 30 min
Belong to.
By process conditions identical in this example, by step（2）After the metal in beaker becomes liquid, with syringe to liquid
State metal is slowly injected 0.4 mole and 0.5 mole of Medical grade oxygen and is continued respectively after stirring 35 min and 60 min respectively
The GaInO liquid metals that different viscosities or different forming ability fusing points are 30 DEG C can be obtained；
The viscosity of GaInO liquid alloys can be effectively adjusted by the oxygen for adding in different content, is measured by capillary tube method
And the viscosity of different oxygen content is calculated, it is as shown in the table.
Embodiment 2
A kind of preparation method of GaInO liquid alloys, specifically includes following steps described in the present embodiment：
（1）Obtain liquid alloy raw material：By high-purity In metals that purity is 99.99% and high-purity Ga that purity is 99.99%
Metal is weighed respectively, wherein, the molar percentage of In metals is 28%, Ga metal molars percentage 72%, and Ga-In mixing rubs
Your number is 1 mole.
（2）Obtain liquid alloy：By step（1）The obtained Ga metals of middle weighing are put into In metals in beaker, then will
Beaker is placed on magnetic stirring apparatus, and rotor is placed in beaker；It will integrally be put into vacuum glove box, pass through magnetic stirring apparatus
80 DEG C are heated to beaker, and is stirred continuously after the metal into beaker becomes liquid, is slowly noted to liquid metal with syringe
Penetrate 0.5 mole of oxygen（Purity is 99.7%）And continue to obtain the GaInO liquid metals that instruction temperature is 42 DEG C after stirring 60min.
Embodiment 3
A kind of preparation method of GaInO liquid alloys, specifically includes following steps described in the present embodiment：
（1）Obtain liquid alloy raw material：By high-purity In metals that purity is 99.99% and high-purity Ga that purity is 99.99%
Metal is weighed respectively, wherein, the molar percentage of In metals is 20%, Ga metal molars percentage 80%, and Ga-In mixing rubs
Your number is 1 mole.
（2）Obtain liquid alloy：By step（1）The obtained Ga metals of middle weighing are put into In metals in beaker, then will
Beaker is placed on magnetic stirring apparatus, and rotor is placed in beaker；It will integrally be put into vacuum glove box, pass through magnetic stirring apparatus
60 DEG C are heated to beaker, and is stirred continuously after the metal into beaker becomes liquid, is slowly noted to liquid metal with syringe
Penetrate 0.5 mole of oxygen（Purity is 99.7%）And continue to obtain the GaInO liquid metals that instruction temperature is 35 DEG C after stirring 60min.
Embodiment 4
A kind of preparation method of GaInO liquid alloys, specifically includes following steps described in the present embodiment：
（1）Obtain liquid alloy raw material：By high-purity In metals that purity is 99.99% and high-purity Ga that purity is 99.99%
Metal is weighed respectively, wherein, the molar percentage of In metals is 23%, Ga metal molars percentage 77%, and Ga-In mixing rubs
Your number is 1 mole.
（2）Obtain liquid alloy：By step（1）The obtained Ga metals of middle weighing are put into In metals in beaker, then will
Beaker is placed on magnetic stirring apparatus, and rotor is placed in beaker；It will integrally be put into vacuum glove box, pass through magnetic stirring apparatus
70 DEG C are heated to beaker, and is stirred continuously after the metal into beaker becomes liquid, is slowly noted to liquid metal with syringe
Penetrate 0.3 mole of oxygen（Purity is 99.7%）And continue to obtain the GaInO liquid metals that instruction temperature is 40 DEG C after stirring 50min.
Embodiment 5
A kind of preparation method of GaInO liquid alloys, specifically includes following steps described in the present embodiment：
（1）Obtain liquid alloy raw material：By high-purity In metals that purity is 99.99% and high-purity Ga that purity is 99.99%
Metal is weighed respectively, wherein, the molar percentage of In metals is 21%, Ga metal molars percentage 79%, and Ga-In mixing rubs
Your number is 1 mole.
（2）Obtain liquid alloy：By step（1）The obtained Ga metals of middle weighing are put into In metals in beaker, then will
Beaker is placed on magnetic stirring apparatus, and rotor is placed in beaker；It will integrally be put into vacuum glove box, pass through magnetic stirring apparatus
70 DEG C are heated to beaker, and is stirred continuously after the metal into beaker becomes liquid, is slowly noted to liquid metal with syringe
Penetrate 0.4 mole of oxygen（Purity is 99.7%）And continue to obtain the GaInO liquid metals that instruction temperature is 37 DEG C after stirring 40min.
GaInO liquid metals are used in the detection materials process of simulated body fluid human body temperature scope, specifically included following
Step is described in detail by taking the GaInO liquid alloys that embodiment 4 is prepared as an example below.
（1）The GaInO liquid alloy rubber heads dropper that fusing point is 40 DEG C will be prepared to suck, be put into drying box and keep 40
DEG C temperatures above, for use
（2）Will configure good person's body simulated body fluid be heated to health 36 DEG C ± 1 DEG C of human body initial temperature after, be put into vacuum
It in glove box or insulated cabinet, vacuumizes, completely cuts off the heat exchange action of solution and ambient enviroment,
（3）Step（1）The GaInO liquid alloys of middle 40 DEG C of fusing point are instilled in simulated body fluid, into after solution, liquid metal
Natural coagulation is into prill.
（4）The biomaterial to be evaluated is put into simulated body fluid again, is co-cultured with body fluid.If the biomaterial is in people
Bacterium is introduced in body simulated body fluid, body temperature temperature is caused to raise, then liquid alloy bead softens scattered, as bead keeps solid-like
State, then it represents that material sterilizing is complete, and biocompatibility is good, can carry out next step biological test observation.
Claims (4)
1. a kind of preparation method of GaInO liquid alloys, which is characterized in that specifically include following steps：By pure In metals and pure
Be put into container, will be integrally placed under vacuum condition after Ga metal mixeds, be heated to 50 DEG C ~ 80 DEG C, and be stirred continuously to
Metal becomes liquid, is then slowly introducing oxygen to liquid metal, and obtains GaInO liquid gold after continuing 30 ~ 60min of stirring
Belong to；Wherein, the molar percentage of In metals is 17 ~ 28%, Ga metal molars percentage 83 ~ 72%；
The intake of oxygen is 0.3 ~ 0.5 times of Ga-In mixing molal quantitys.
2. the preparation method of GaInO liquid alloys according to claim 1, it is characterised in that：In metals and Ga metals it is pure
Degree is all higher than being equal to 99.99%.
3. the preparation method of GaInO liquid alloys according to claim 1, it is characterised in that：Whole preparation process is in vacuum
It is carried out in glove box.
4. the GaInO liquid alloys that preparation method described in claim 1 ~ 3 any one is prepared are used to monitor biomaterial
The temperature variations of human body simulation body fluid during being co-cultured with human body simulation body fluid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611001759.7A CN106756189B (en) | 2016-11-15 | 2016-11-15 | A kind of preparation method and application of GaInO liquid alloys |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611001759.7A CN106756189B (en) | 2016-11-15 | 2016-11-15 | A kind of preparation method and application of GaInO liquid alloys |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106756189A CN106756189A (en) | 2017-05-31 |
| CN106756189B true CN106756189B (en) | 2018-05-25 |
Family
ID=58968073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611001759.7A Active CN106756189B (en) | 2016-11-15 | 2016-11-15 | A kind of preparation method and application of GaInO liquid alloys |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106756189B (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0173806B1 (en) * | 1984-09-07 | 1990-10-10 | Tokuriki Honten Company Limited | Gallium alloy for dental restorations |
| JP5753987B1 (en) * | 2014-06-06 | 2015-07-22 | 合同会社エネオン総合研究所 | Hydrogen generating alloy, method for producing hydrogen generating alloy, hydrogen generating cartridge, hydrogen producing apparatus, hydrogen producing method, and fuel cell system |
| CN104561721A (en) * | 2015-02-13 | 2015-04-29 | 杭州龙灿液态金属科技有限公司 | Room-temperature liquid alloy with low melting temperature, preparation process og alloy and thermometer |
| CN105088043B (en) * | 2015-09-17 | 2017-12-05 | 河北安耐哲新能源技术有限公司 | A kind of liquid alloy and its preparation method and application |
-
2016
- 2016-11-15 CN CN201611001759.7A patent/CN106756189B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN106756189A (en) | 2017-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | Biomaterial characteristics and application of silicone rubber and PVA hydrogels mimicked in organ groups for prostate brachytherapy | |
| CN102936671B (en) | Anti-infective medical titanium metal material | |
| CN102943190B (en) | Anti-infection medical titanium alloy | |
| CN102936670A (en) | Anti-infective medical titanium alloy | |
| CN107456601A (en) | A kind of Zn-Cu systems kirsite and preparation method and application | |
| Gil et al. | Microstructural, mechanical and citotoxicity evaluation of different NiTi and NiTiCu shape memory alloys | |
| CN106756189B (en) | A kind of preparation method and application of GaInO liquid alloys | |
| Chiulan et al. | Comprehensive characterization of silica-modified silicon rubbers | |
| Zhang et al. | Micro/nanostructured TiO2/ZnO coating enhances osteogenic activity of SaOS-2 cells | |
| Maschhoff et al. | An intelligent bioreactor system for the cultivation of a bioartificial vascular graft | |
| CN105203586B (en) | A kind of colloid brain parenchym preparation method and cranium brain physical model | |
| CN103865079A (en) | Antibacterial silk fibroin hydrogel and instantaneous preparation method thereof | |
| CN107177769B (en) | A kind of anti-infective stainless steel implantation material preparation method | |
| CN109456511A (en) | A kind of temperature-sensitive, conduction and the instant self-healing hydrogel of collagen-based for having super drawing | |
| CN105250235B (en) | A kind of carragheen soft capsule material and its application | |
| CN106085854A (en) | A kind of cell culture system based on hemodialyzer | |
| CN102660049A (en) | Method and device for preparing temperature-induced reversible color-changing bacterial cellulose composite membrane | |
| CN106770957A (en) | One tobacco articles oral cavity dissolving-out analog device | |
| Zhuo et al. | Medical gloves modified by a one-minute spraying process with blood-repellent, antibacterial and wound-healing abilities | |
| CN102564846A (en) | Constant temperature water bath circulation device simulating oral cavity environment and method for testing stress by utilizing same | |
| Jian-qiang et al. | Effect of sodium chloride on meltability of mozzarella cheese | |
| CN107287534B (en) | Base block amorphous state alloy of a kind of Co for biomaterial and preparation method thereof | |
| CN202092909U (en) | Water bath cup and device comprises same | |
| CN106148759A (en) | Have and facilitate bone and the medical titanium alloy of revascularization biological function and preparation thereof | |
| CN107957433A (en) | Textile thermal property test device and test method under a kind of low temperature environment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |