CN106749625A - Plasma protein and hemoglobin combined production device - Google Patents
Plasma protein and hemoglobin combined production device Download PDFInfo
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- CN106749625A CN106749625A CN201611190745.4A CN201611190745A CN106749625A CN 106749625 A CN106749625 A CN 106749625A CN 201611190745 A CN201611190745 A CN 201611190745A CN 106749625 A CN106749625 A CN 106749625A
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- 102000001554 Hemoglobins Human genes 0.000 title claims abstract description 90
- 108010054147 Hemoglobins Proteins 0.000 title claims abstract description 90
- 102000004506 Blood Proteins Human genes 0.000 title claims abstract description 88
- 108010017384 Blood Proteins Proteins 0.000 title claims abstract description 88
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 38
- 239000007788 liquid Substances 0.000 claims abstract description 64
- 238000003860 storage Methods 0.000 claims abstract description 54
- 210000002381 plasma Anatomy 0.000 claims abstract description 43
- 210000004369 blood Anatomy 0.000 claims abstract description 35
- 239000008280 blood Substances 0.000 claims abstract description 35
- 238000010612 desalination reaction Methods 0.000 claims abstract description 12
- 238000007599 discharging Methods 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 11
- 238000001694 spray drying Methods 0.000 claims abstract description 11
- 238000009434 installation Methods 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 239000000284 extract Substances 0.000 claims abstract description 4
- 238000000605 extraction Methods 0.000 claims abstract description 4
- 238000001728 nano-filtration Methods 0.000 claims description 20
- 210000000601 blood cell Anatomy 0.000 claims description 19
- 238000001914 filtration Methods 0.000 claims description 19
- 238000000108 ultra-filtration Methods 0.000 claims description 17
- 230000004913 activation Effects 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000000498 cooling water Substances 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 6
- 238000012545 processing Methods 0.000 abstract description 6
- 239000000047 product Substances 0.000 description 20
- 239000007787 solid Substances 0.000 description 7
- BXMVKQIIJSXIBU-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) diphenyl phosphate Chemical compound O=C1CCC(=O)N1OP(=O)(OC=1C=CC=CC=1)OC1=CC=CC=C1 BXMVKQIIJSXIBU-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000002956 ash Substances 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 244000144977 poultry Species 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 102000006395 Globulins Human genes 0.000 description 2
- 108010044091 Globulins Proteins 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000005996 Blood meal Substances 0.000 description 1
- 235000002918 Fraxinus excelsior Nutrition 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 235000020997 lean meat Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- 229940116540 protein supplement Drugs 0.000 description 1
- 235000005974 protein supplement Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- External Artificial Organs (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention discloses a kind of plasma protein and hemoglobin combined production device, including：Former blood storage tank；Filter, it is connected to former blood storage tank；First centrifuge, it is connected to filter；Plasma protein preparation facilities, it includes the plasma protein desalination enrichment facility, the 6th measuring pump, plasma protein spray-drying installation and the plasma protein classification material collecting device that are sequentially connected, and plasma protein desalination enrichment facility is connected to the light phase blood plasma liquid discharging opening of the first centrifuge by the first measuring pump；Hemoglobin preparation facilities, its hemoglobin for including being sequentially connected extracts enrichment facility, the 7th measuring pump, hemoglobin spray-drying installation and hemoglobin classification material collecting device, and hemoglobin extraction element is connected to the heavy phase haemocyte liquid discharging opening of the first centrifuge by the second measuring pump.The coproduction processing of the achievable plasma protein of the present invention and hemoglobin, improves the quality of plasma protein and hemoglobin, realizes homogeneity, the standardization of product.
Description
Technical field
The present invention relates to livestock and poultry blood technical field of comprehensive utilization, more particularly to a kind of plasma protein and hemoglobin coproduction
Device.
Background technology
Blood is one of Main By product for producing in slaughtering process, account for livestock and poultry live body weight 4%~
9.8%.Blood is rich in various nutriments and bioactive ingredients, with nutrition very high and function value, albumen in blood
Matter accounts for 17%~22%, and the protein content with lean meat is suitable, is otherwise known as " liquid meat ".Plasma protein is main in blood plasma
Solid constituent, its amino acid content enrich, be of high nutritive value, can be used as protein supplement, adhesive etc.；Hemoglobin is rich in
PORPHYRIN IRON is a kind of natural haematochrome and mends source of iron.At present, the annual livestock and poultry blood of China is more than 3,000,000 tons, but utilization rate is not
Foot 30%.For a long time, livestock and poultry blood is directly processed into blood meal, or after being centrifuged drying, is processed into SDPP
And globulin powder, product quality is poor, and its economic value added is not high.
The blood plasma liquid that blood anticoagulant centrifugation is obtained directly is dried and prepares SDPP, the product for obtaining has ash
The problems such as dividing content high, product colour depth, poorly water-soluble；Meanwhile, the blood cell liquid that centrifugal blood is obtained directly is dried, system
Standby globulin powder, the hemoglobin purity that obtains is low, poorly water-soluble, fat content high the problems such as.Therefore, to existing process skill
Art is innovated, and researches and develops plasma protein and hemoglobin co-production technology, obtain the good high-quality plasma protein of low ash content, color and
Active constituent content and purity hemoglobin product high, meet the requirement of food and medical industry, are conducive to blood protein to provide
Source makes full use of.
The content of the invention
For above-mentioned technical problem, the invention provides a kind of plasma protein and hemoglobin combined production device, it is by blood plasma
Albumen and hemoglobin processing are coupled, and realize that plasma protein is processed with the standardization of hemoglobin, improve plasma protein
With the quality of hemoglobin, homogeneity, the standardization of product are realized, improve energy utilization rate.
The present invention provide technical scheme be：
A kind of plasma protein and hemoglobin combined production device, including：
Former blood storage tank；
Filter, it is connected to the former blood storage tank；
First centrifuge, it is connected to the filter；
Plasma protein preparation facilities, it includes the plasma protein desalination enrichment facility, the 6th measuring pump, the blood plasma that are sequentially connected
Albumen spray-drying installation and plasma protein classification material collecting device, wherein, the plasma protein desalination enrichment facility is by the
One measuring pump is connected to the light phase blood plasma liquid discharging opening of first centrifuge；
Hemoglobin preparation facilities, it includes that hemoglobin for being sequentially connected extracts enrichment facility, the 7th measuring pump, blood red
Albumen spray-drying installation and hemoglobin classification material collecting device, wherein, the hemoglobin extraction element is by the second meter
Amount pump is connected to the heavy phase haemocyte liquid discharging opening of first centrifuge.
Preferably, in described plasma protein and hemoglobin combined production device, the plasma protein desalination enrichment facility
Including：
Blood plasma storage tank；
Blood plasma liquid blend tank, it passes through the 3rd measuring pump and is connected to the blood plasma storage tank, wherein, the blood plasma liquid allotment
Tank is provided with pH detecting elements, means for feeding acid and adder-subtractor；
Ultrafiltration nanofiltration device, it passes through the 5th measuring pump and is connected to the blood plasma liquid blend tank, wherein, the ultrafiltration nanofiltration
Device includes ultrafiltration membrance filter module and nanofiltration membrane module, in the ultrafiltration membrance filter module, the aperture of milipore filter for 5~
20kDa, in the nanofiltration membrane module, nanofiltration membrane aperture is 100~300Da；
Plasma protein liquid hold-up tank, it is connected to the ultrafiltration nanofiltration device.
Preferably, in described plasma protein and hemoglobin combined production device, the hemoglobin extracts enrichment facility
Including：
Blood cell liquid storage tank；
Ultrasonic disruption device, it passes through the 4th measuring pump and is connected to the blood cell liquid storage tank；
Second centrifuge, it is connected to the ultrasonic disruption device；
Film filter, its light phase discharging opening for being connected to second centrifuge；
Hemoglobin hold-up tank, it is connected to the film filter.
Preferably, in described plasma protein and hemoglobin combined production device, the ultrasonic disruption device includes anti-
Answer kettle, the bottom of the reactor is concave surface, the top of the reactor to extending out and bottom is inwardly received so that the reaction
The side wall of kettle is inclined relative to the axis of the reactor.
Preferably, in described plasma protein and hemoglobin combined production device, the side wall of the reactor is relative to institute
The angle of inclination for stating the axis of reactor is 75 °~85 °, and the radian of the concave surface is 30 °~90 °, is set inside the reactor
Be equipped with tool heads, a diameter of 5~8cm of the tool heads, length is 45~60cm, apart from the bottom 5 of the reactor~
10cm, apart from the 20~40cm of side wall of the reactor.
Preferably, in described plasma protein and hemoglobin combined production device, the side wall of the reactor is relative to institute
The angle of inclination for stating the axis of reactor is 85 °, and the radian of the concave surface is 60 °, a diameter of 8cm of the tool heads, length
It is 60cm, apart from the bottom 10cm of the reactor, apart from the side wall 20cm of the reactor.
Preferably, in described plasma protein and hemoglobin combined production device, the ultrasonic disruption device also includes
Ultrasonic activation part, driving power supply and numerical control system, wherein, the ultrasonic activation part includes ultrasonic wave transducer
Device, ultrasonic transformer and the tool heads, the driving power supply are supplied to the ultrasonic activation part and the numerical control system
Electricity, the numerical control system is connected to the ultrasonic activation part.
Preferably, in described plasma protein and hemoglobin combined production device, the former blood storage tank, blood plasma storage
Hide tank, the plasma protein liquid storage tank, the blood cell liquid storage tank and the hemoglobin storage tank and the reactor
Use cooling water circulation Sandwich pot.
Preferably, in described plasma protein and hemoglobin combined production device, the filter includes double medium filtration
Gauze, wherein, the aperture of the ground floor filtration gauze of the double medium filtration gauze is 2~6mm, and second layer screen pack aperture is
0.5~1mm, the spacing distance between two-layer filtration gauze is 5~20cm.
Preferably, described plasma protein and hemoglobin combined production device, also include：
Controller, it is connected to first measuring pump, second measuring pump, the 3rd measuring pump, the described 4th
Measuring pump, the 5th measuring pump, the 6th measuring pump and the 7th measuring pump.
Plasma protein of the present invention and hemoglobin combined production device have the advantages that：
First, the device can realize the coproduction processing of plasma protein and hemoglobin, realize plasma protein and hemoglobin
Standardization processing, improve the quality of plasma protein and hemoglobin, realize product homogeneity, standardization；
Secondly, device Central Plains blood storage tank, blood plasma storage tank, plasma protein liquid storage tank, blood cell liquid storage tank, blood red
Protein storage tank and reactor use cooling water circulation Sandwich pot, can be to the carrying out of raw material temperature control exactly, it is to avoid
Temperature raises the influence to raw material and product quality.
3rd, the device uses ultrasonic disruption device, and break process is carried out to the red blood cell in blood cell liquid, is free of
The hemoglobin product of cell membrane, improves the content and purity of hemoglobin.
4th, the device uses Multistage filtering device, the solid impurity in raw material is can remove, in reduction plasma protein products
Content of ashes, removal hemoglobin product in cell membrane component, improve product purity.
5th, the measuring pump is controlled using programmable logic controller (PLC) (i.e. controller), can be with each pipeline of real-time monitoring
The flow velocity of middle liquid, realizes the control to product quality；Ultrasonic disruption device is using programmable logic controller (PLC) (i.e. numeral control
System processed), can realize periodically quantitatively excluding smudge cells residue in the case of quantity-produced, it is also possible to broken ultrasound is stopped
Comprehensive deslagging is carried out when broken, there is high degree of automation, easy to adjust.
In sum, the present invention is provided a kind of plasma protein and hemoglobin combined production device, can process low ash content
SDPP and purity hemoglobin powder high, can be applied to large-scale production.
Brief description of the drawings
Fig. 1 is the structural representation of plasma protein of the present invention and hemoglobin combined production device.
Fig. 2 is the structural representation of ultrasonic disruption device of the present invention.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to specification text
Word can be implemented according to this.
As shown in figure 1, the present invention provides a kind of plasma protein and hemoglobin combined production device, including：Former blood storage tank 1；
Filter 2, it is connected to the former blood storage tank 1；First centrifuge 3, it is connected to the filter 2；Plasma protein
Preparation facilities, it includes the plasma protein desalination enrichment facility, the 6th measuring pump 18, the plasma protein spray drying dress that are sequentially connected
20 and plasma protein classification material collecting device 22 are put, wherein, the plasma protein desalination enrichment facility is connected by the first measuring pump 4
It is connected to the light phase blood plasma liquid discharging opening of first centrifuge 3；Hemoglobin preparation facilities, it includes the blood red egg being sequentially connected
It is white to extract enrichment facility, the 7th measuring pump 19, hemoglobin spray-drying installation 21 and hemoglobin classification material collecting device 23,
Wherein, the hemoglobin extraction element is gone out by the heavy phase haemocyte liquid that the second measuring pump 5 is connected to first centrifuge 3
Material mouth.
The blood storage for being gathered enters to filter 2 in former blood storage tank 1 by the outlet of former blood storage tank 1,
Through filter 2 filter after, into the first centrifuge 3, through centrifugation after, be divided into two-way, light phase blood plasma liquid enters to plasma protein
Preparation facilities, through the treatment that plasma protein desalination enrichment facility, plasma protein are spray-dried, forms SDPP, heavy phase blood
Cell liquid enters to hemoglobin preparation facilities, and enrichment facility and hemoglobin spray-drying installation 21 are extracted through hemoglobin
Treatment, forms hemoglobin powder.
The present invention realizes the coproduction processing for realizing plasma protein and hemoglobin, realizes plasma protein with hemoglobin
Standardization processing, improves the quality of plasma protein and hemoglobin, realizes homogeneity, the standardization of product.
In a preferred embodiment, in described plasma protein and hemoglobin combined production device, the plasma protein
Desalination enrichment facility includes：Blood plasma storage tank 6；Blood plasma blend tank 10, it passes through the 3rd measuring pump 8 and is connected to the blood plasma storage
Tank 6, wherein, the blood plasma blend tank 10 is provided with pH detecting elements, means for feeding acid and adder-subtractor；Ultrafiltration nanofiltration device 14,
It passes through the 5th measuring pump 12 and is connected to the blood plasma blend tank 10, wherein, the ultrafiltration nanofiltration device 14 includes milipore filter mistake
Filter module and nanofiltration membrane module, in the ultrafiltration membrance filter module, the aperture of milipore filter is 5~20kDa, the NF membrane
In filtering module, nanofiltration membrane aperture is 100~300Da；Plasma protein liquid storage tank 16, it is connected to the ultrafiltration nanofiltration device
14。
In a preferred embodiment, in described plasma protein and hemoglobin combined production device, the hemoglobin
Extracting enrichment facility includes：Blood cell liquid storage tank 7；Ultrasonic disruption device 11, it passes through the 4th measuring pump 9 and is connected to the blood
Ball liquid storage tank 7；Second centrifuge 13, it is connected to the ultrasonic disruption device 11；Film filter 15, it is connected to described
The light phase discharging opening of the second centrifuge 13；Haemoglobin liquid storage tank 17, it is connected to the film filter 15.
Specifically, can be with the former blood storage tank 11 of temperature control, it uses sandwich design, inside there is circulation the blood storage of collection
Condensed water, it is 4 DEG C~6 DEG C to keep temperature in tank, to ensure the quality of blood.Blood enters filtering through the outlet of former blood storage tank 11
Device 22, the filter 2 has double medium filtration gauze, and ground floor is used to filter the big solids such as hair, excrement, the second layer
For filtering the solids such as blood clot.By entering the first centrifuge 3 after filtering, (the first centrifuge 33 can be dish-style to blood
Centrifuge or tube centrifuge), after centrifugation, light phase blood plasma liquid enters the first measuring pump 4 to blood, and heavy phase haemocyte liquid enters the
Two measuring pumps 5.
Blood plasma liquid enters blood plasma storage tank 6 by the first measuring pump 4, and the blood plasma storage tank 6 uses sandwich design, inside follows
Ring condensed water, it is 4 DEG C~6 DEG C to keep temperature in tank, to ensure the quality of blood plasma liquid.Blood plasma liquid is logical through the outlet of blood plasma storage tank 6
Cross the 3rd measuring pump 8 and enter blood plasma blend tank 10, the blood plasma blend tank 10 is provided with pH meter (i.e. pH detecting elements), can measure in real time
The pH of blood plasma liquid, and by acid adding (acid adding is realized by means for feeding acid), plus alkali lye (by adder-subtractor come plus alkali) mode will
It is 10~11 that blood plasma liquid is formulated to most suitable ultrafiltration pH.Blood plasma liquid after allotment enters ultrafiltration nanofiltration device by the 5th measuring pump 12
14, the device purpose removes the salinity in blood plasma liquid, and the hole of ultrafiltration/nanofiltration pressure and film can be adjusted according to the requirement of product ash content
Footpath.Blood plasma liquid after ultrafiltration-nanofiltration enters plasma protein liquid storage tank 16, and its outlet is connected with the 6th measuring pump 18, most laggard
Enter plasma protein spray-drying installation 20, powdery product is obtained after blood plasma liquid is spray-dried, be stored in plasma protein classification
In material collecting device 22.
From the second measuring pump 5 out, into blood cell liquid storage tank 7, it uses sandwich design to heavy phase haemocyte liquid, inside follows
Ring condensed water, it is 4 DEG C~6 DEG C to keep temperature in tank, to ensure the quality of blood cell liquid.Blood cell liquid is exported from blood cell liquid storage tank 7,
By the 4th measuring pump 9, into ultrasonic disruption device 11, the device is added according to the volume for entering blood cell liquid in reactor
The water of equal volume, then carries out ultrasonic disruption to the blood cell liquid aqueous solution, in shattering process, can be by adjusting according to product needed
The temperature of reacting kettle jacketing layer interior circulation water is saved to regulate and control the temperature in reactor.Haemocyte solution after broken enters tubular type
Centrifuge 13 (i.e. the second centrifuge 13), after centrifugation, light phase enters film filter 15, it is therefore an objective to remove solid impurity.Filtering
The hemoglobin solutions for obtaining enter haemoglobin liquid hold-up tank 17, and its outlet is connected with the 7th measuring pump 19, finally enters blood
Lactoferrin spray-drying installation 21, powdery product is obtained after haemoglobin liquid is spray-dried, is stored in hemoglobin classification
In material collecting device 23.
The present embodiment can simultaneously obtain the SDPP and hemoglobin powder of high-quality.
As shown in Fig. 2 in a preferred embodiment, in described plasma protein and hemoglobin combined production device, institute
Stating ultrasonic disruption device 11 includes reactor 32, and the bottom 36 of the reactor 32 is concave surface, the top of the reactor 32
To extending out and bottom is inwardly received, so that the side wall 35 of the reactor 32 is inclined relative to the axis of the reactor.This sets
Excluded by discharging opening 29 in respect of the cell mixture helped after crushing.
In a preferred embodiment, in described plasma protein and hemoglobin combined production device, the reactor 32
The angle of inclination of axis of the side wall relative to the reactor 32 be 75 °~85 °, the radian of the concave surface is 30 °~90 °,
The reactor 32 is internally provided with tool heads 26, a diameter of 5~8cm of the tool heads 26, and length is 45~60cm, distance
5~the 10cm of bottom of the reactor 32, apart from the 20~40cm of side wall of the reactor 32.Above-mentioned design helps to improve broken
Broken effect, improves product quality.
In a preferred embodiment, in described plasma protein and hemoglobin combined production device, the reactor 32
The angle of inclination of axis of the side wall relative to the reactor 32 be 85 °, the radian of the concave surface is 60 °, the tool heads
26 a diameter of 8cm, length is 60cm, apart from the bottom 10cm of the reactor 32, apart from the side wall of the reactor 32
20cm。
In a preferred embodiment, in described plasma protein and hemoglobin combined production device, the ultrasonic wave breaks
Crushing device 11 also includes ultrasonic activation part, driving power supply and numerical control system, wherein, the ultrasonic activation part bag
Ultrasonic transducer 24, ultrasonic transformer 25 and the tool heads 26 are included, the driving power supply 30 is to the ultrasonic activation part
Powered with the numerical control system, the numerical control system 31 is connected to the ultrasonic activation part.The frequency of ultrasonic wave
Rate is controlled by numerical control system 31；The device can be crushed efficiently to haemocyte.Numerical control system can be from 10
~100kHz regulates and controls ultrasonic power.It is arranged on using programmable logic controller (PLC) (PLC) (i.e. numerical control system) described super
Sonication device 11, can realize periodically quantitatively excluding smudge cells residue, it is also possible to stopping in the case of quantity-produced
Comprehensive deslagging is only carried out during ultrasonication, there is high degree of automation, easy to adjust.
In a preferred embodiment, in described plasma protein and hemoglobin combined production device, the former blood storage
The storage of tank 1, the blood plasma storage tank 6, the plasma protein liquid storage tank, the blood cell liquid storage tank 7 and the haemoglobin liquid
Hide tank 17 and the reactor and use cooling water circulation Sandwich pot.
Specifically, by taking reactor 32 as an example, the structure of cooling water circulation Sandwich pot is：It is recirculated cooling water in chuck,
Chuck is provided with cooling water inlet 33, and top is provided with coolant outlet 34, and cooling water inlet 33 is connected by condensing unit, and cooling water goes out
Mouth flows back to condensing unit and recycles；Reactor is provided with raw material inlet 28 and liquid outlet 29, also with filler 27.The design
Help to realize to the precise control of blood cell liquid temperature degree in reactor, the favourite in controllable reactor at 0~50 DEG C, with full
The requirement of sufficient ultrasonic disruption effect and product quality.
In a preferred embodiment, in described plasma protein and hemoglobin combined production device, the filter 2
Including double medium filtration gauze, wherein, the aperture of the ground floor filtration gauze of the double medium filtration gauze is 2~6mm, second layer mistake
Aperture of filter screen is 0.5~1mm, and the spacing distance between two-layer filtration gauze is 5~20cm.Ground floor is used to filter hair, excrement
The big solids such as just, the second layer is used to filter the solids such as blood clot, helps fully to filter impurity, improves SDPP
With the quality of hemoglobin powder.
In a preferred embodiment, described plasma protein and hemoglobin combined production device, also include：Controller,
It is connected to first measuring pump 4, second measuring pump 5, the 3rd measuring pump 8, the 4th measuring pump 9, described
5th measuring pump, the 6th measuring pump 18 and the 7th measuring pump 19.Using programmable logic controller (PLC) (PLC) (i.e.
Controller) each measuring pump is controlled, the control to product quality can be realized with the flow velocity of liquid in each pipeline of real-time monitoring.
Although embodiment of the present invention is disclosed as above, it is not restricted to listed in specification and implementation method
With, it can be applied to various suitable the field of the invention completely, for those skilled in the art, can be easily
Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, the present invention is not limited
In specific details and shown here as the legend with description.
Claims (10)
1. a kind of plasma protein and hemoglobin combined production device, it is characterised in that including：
Former blood storage tank；
Filter, it is connected to the former blood storage tank；
First centrifuge, it is connected to the filter；
Plasma protein preparation facilities, it includes the plasma protein desalination enrichment facility, the 6th measuring pump, the plasma protein that are sequentially connected
Spray-drying installation and plasma protein classification material collecting device, wherein, the plasma protein desalination enrichment facility is by the first meter
Amount pump is connected to the light phase blood plasma liquid discharging opening of first centrifuge；
Hemoglobin preparation facilities, it includes that the hemoglobin being sequentially connected extracts enrichment facility, the 7th measuring pump, hemoglobin
Spray-drying installation and hemoglobin classification material collecting device, wherein, the hemoglobin extraction element passes through the second measuring pump
It is connected to the heavy phase haemocyte liquid discharging opening of first centrifuge.
2. plasma protein as claimed in claim 1 and hemoglobin combined production device, it is characterised in that the plasma protein desalination
Enrichment facility includes：
Blood plasma storage tank；
Blood plasma liquid blend tank, it passes through the 3rd measuring pump and is connected to the blood plasma storage tank, wherein, the blood plasma liquid blend tank sets
It is equipped with pH detecting elements, means for feeding acid and adder-subtractor；
Ultrafiltration nanofiltration device, it passes through the 5th measuring pump and is connected to the blood plasma liquid blend tank, wherein, the ultrafiltration nanofiltration device
Including ultrafiltration membrance filter module and nanofiltration membrane module, in the ultrafiltration membrance filter module, the aperture of milipore filter for 5~
20kDa, in the nanofiltration membrane module, nanofiltration membrane aperture is 100~300Da；
Plasma protein liquid hold-up tank, it is connected to the ultrafiltration nanofiltration device.
3. plasma protein as claimed in claim 2 and hemoglobin combined production device, it is characterised in that the hemoglobin is extracted
Enrichment facility includes：
Blood cell liquid storage tank；
Ultrasonic disruption device, it passes through the 4th measuring pump and is connected to the blood cell liquid storage tank；
Second centrifuge, it is connected to the ultrasonic disruption device；
Film filter, its light phase discharging opening for being connected to second centrifuge；
Hemoglobin hold-up tank, it is connected to the film filter.
4. plasma protein as claimed in claim 3 and hemoglobin combined production device, it is characterised in that the ultrasonic disruption dress
Put including reactor, the bottom of the reactor is concave surface, the top of the reactor to extending out and bottom is inwardly received so that
The side wall of the reactor is inclined relative to the axis of the reactor.
5. plasma protein as claimed in claim 4 and hemoglobin combined production device, it is characterised in that the side wall of the reactor
It it is 75 °~85 ° relative to the angle of inclination of the axis of the reactor, the radian of the concave surface is 30 °~90, the reactor
Tool heads are internally provided with, a diameter of 5~8cm of the tool heads, length is 45~60cm, apart from the bottom of the reactor
5~10cm, apart from the 20~40cm of side wall of the reactor.
6. plasma protein as claimed in claim 5 and hemoglobin combined production device, it is characterised in that the side wall of the reactor
Be 85 ° relative to the angle of inclination of the axis of the reactor, the radian of the concave surface is 60 °, the tool heads it is a diameter of
8cm, length is 60cm, apart from the bottom 10cm of the reactor, apart from the side wall 20cm of the reactor.
7. plasma protein and hemoglobin combined production device as described in claim 5 or 6, it is characterised in that the ultrasonic wave breaks
Crushing device also includes ultrasonic activation part, driving power supply and numerical control system, wherein, the ultrasonic activation part includes
Ultrasonic transducer, ultrasonic transformer and the tool heads, the driving power supply is to the ultrasonic activation part and the numeral
Control system is powered, and the numerical control system is connected to the ultrasonic activation part.
8. plasma protein and hemoglobin combined production device as described in claim 5 or 6, it is characterised in that the former blood storage
Tank, the blood plasma storage tank, the plasma protein liquid storage tank, the blood cell liquid storage tank and the hemoglobin storage tank with
And the reactor uses cooling water circulation Sandwich pot.
9. plasma protein as claimed in claim 1 and hemoglobin combined production device, it is characterised in that the filter includes
Double medium filtration gauze, wherein, the aperture of the ground floor filtration gauze of the double medium filtration gauze is 2~6mm, second layer screen pack
Aperture is 0.5~1mm, and the spacing distance between two-layer filtration gauze is 5~20cm.
10. plasma protein as claimed in claim 3 and hemoglobin combined production device, it is characterised in that also include：
Controller, it is connected to first measuring pump, second measuring pump, the 3rd measuring pump, the 4th metering
Pump, the 5th measuring pump, the 6th measuring pump and the 7th measuring pump.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611190745.4A CN106749625A (en) | 2016-12-20 | 2016-12-20 | Plasma protein and hemoglobin combined production device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611190745.4A CN106749625A (en) | 2016-12-20 | 2016-12-20 | Plasma protein and hemoglobin combined production device |
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| CN106749625A true CN106749625A (en) | 2017-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611190745.4A Pending CN106749625A (en) | 2016-12-20 | 2016-12-20 | Plasma protein and hemoglobin combined production device |
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| CN107136296A (en) * | 2017-06-02 | 2017-09-08 | 中国农业科学院农产品加工研究所 | High gelation SDPP and preparation method thereof |
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| CN107136296A (en) * | 2017-06-02 | 2017-09-08 | 中国农业科学院农产品加工研究所 | High gelation SDPP and preparation method thereof |
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