CN106748847B - A kind of extracting method of l-Alanine - Google Patents
A kind of extracting method of l-Alanine Download PDFInfo
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- CN106748847B CN106748847B CN201611020059.2A CN201611020059A CN106748847B CN 106748847 B CN106748847 B CN 106748847B CN 201611020059 A CN201611020059 A CN 201611020059A CN 106748847 B CN106748847 B CN 106748847B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
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Abstract
The invention discloses a kind of extracting methods of L alanine, this method includes that the first flocculant, the second flocculant and third flocculant are added into the L alanine zymotic fluid in order to flocculate, L alanine zymotic fluids after stirring, precipitation process, which are put into vacuum drum filter plant, to be detached, and flocculation clarified solution is obtained；The flocculation clarified solution is crystallized；By the drying of the crystalline solid of acquisition both the L alanine.Method provided by the present application is removed using flocculence precipitation and obtains the impurity such as thalline, protein, phosphate, residual sugar in zymotic fluid, it eliminates calcium precipitation in the prior art and crosses the processes such as film removal of impurities, extraction process is enormously simplified, reduces equipment investment, and improve product quality.It is come back in flocculation, decoloration, concentrate drying cycle using crystalline mother solution with brilliant residual water is washed.Loss of material is avoided, environmental protection pressure is reduced, improves yield, energy conservation and environmental protection.
Description
Technical field
The present invention relates to fermentation technical fields, more particularly to a kind of extracting method of l-Alanine.
Background technology
L-Alanine (L-Alanine) also known as L- α-alanines are a kind of important natural amino acids, are contained in blood
Most amino acid is measured, it is closely related with glycometabolism, it is main amino the Worker's Stadium in transamination reaction, there is important physiology work(
Energy.It is a kind of nutritional supplement, is the chief component of a variety of Hausmam Amin 20s, can also be made among medicine
Body is the primary raw material of vitamin B6.Food additives are alternatively arranged as, nutritive value of food is improved, improves artificial synthesized sweet tea
The sense of taste of taste agent.
With the continuous of l-Alanine is researched and developed and developed, the application in fields such as food and medicines constantly expands, and
There is growing trend.But l-Alanine must be developed it is later, the beginning of the eighties just Japanese industry metaplasia produce.China was in 80 years
There are small lot production, industrialized production just to start to walk for end.The production method of l-Alanine has proteolysis extraction method, chemistry
Synthetic method, fermentation method extraction and enzyme transforming process production.Since fermentation method production l-Alanine is at low cost, and meet green and healthy
Consumption concept has a vast market foreground.After fermentation method produces l-Alanine, generally carried using mostly subcrystalline method
Pure l-Alanine typically contains part l-Alanine in crystal waste, in addition (predominantly the third ammonia of L- of the organic matter in crystal waste
Acid, amino acid and polypeptide etc.) it is more, the direct emission of waste liquid can not only waste the unrecovered l-Alanine in part, while can be right
Environment pollutes.Therefore it develops a kind of to l-Alanine extraction process, to improve the recovery rate of l-Alanine, reduces environmental protection pressure
Power has important practical significance.
Invention content
The present invention provides a kind of extracting methods of l-Alanine.
The present invention provides following schemes：
A kind of extracting method of l-Alanine, this includes：
It takes and is heated to 53~57 DEG C of l-Alanine zymotic fluid, be added first into the l-Alanine zymotic fluid in order
Flocculant, the second flocculant and third flocculant flocculate, and 280 are added into the l-Alanine zymotic fluid after the flocculation
~310 milligrams of activated carbons carry out decoloration 27~32 minutes；
L-Alanine zymotic fluid after the decoloration is stirred, precipitation process, by described by stirring, precipitation process
L-Alanine zymotic fluid afterwards, which is put into vacuum drum filter plant, to be detached, and flocculation clarified solution is obtained；
Be concentrated at being 73~77 DEG C in temperature by the flocculation clarified solution dry matter content in clarified solution be 58%~
After 62%, cools the temperature to 20 DEG C and crystallized；Crystalline solid is detached with crystalline mother solution after crystallization；By the crystalline solid of acquisition
Temperature be 57~63 DEG C at dried both the l-Alanine.
Preferably：It is 10%~20% that l-Alanine content is obtained in the l-Alanine zymotic fluid.
Preferably：It is 14%~16% that l-Alanine content is obtained in the l-Alanine zymotic fluid.
Preferably：First flocculant is polymeric aluminum chlorides solution, and second flocculant is chitosan solution, described
Third flocculant is polyacrylamide solution.
Preferably：A concentration of the 9%~11% of aluminium polychloride, the chitosan solution in the polymeric aluminum chlorides solution
Middle chitosan concentration is 0.8%~1.1%, and concentration of polyacrylamide is 0.1~0.3% in the polyacrylamide solution.
Preferably：The first flocculant, the second flocculant and the third flocculation being added into the l-Alanine zymotic fluid
Agent and the mass ratio of the l-Alanine zymotic fluid are respectively：2：50000~3：50000、1：50000~2：50000 and 1：
50000~2：50000.
Preferably：The material of precoated shet is perlite and diatomite in the vacuum drum filter plant, and vacuum pressure is
0.04~0.05 megapascal；Feed pressure vacuum degree is 0.06~0.07 megapascal；Scraper feed distance for 0.075~0.085 centimetre/
Minute.
Preferably：The vacuum pressure is 0.04 megapascal；Feed pressure vacuum degree is 0.06 megapascal；Scraper feed distance is
0.078 cm per minute.
Preferably：Described take is heated to 53~57 DEG C of l-Alanine zymotic fluid, including：
It takes and is heated to 55 DEG C of l-Alanine zymotic fluid.
Preferably：It is described by the flocculation clarified solution temperature be 73~77 DEG C at be concentrated into dry matter content in clarified solution
After 58%~62%, cools the temperature to 20 DEG C and crystallized；Crystalline solid is detached with liquid after crystallization；By the knot of acquisition
Crystal temperature be 57~63 DEG C at dried both the l-Alanine, including：
It is concentrated at being 75 DEG C in temperature by the flocculation clarified solution after dry matter content in clarified solution is 60%, by temperature
20 DEG C are down to be crystallized；Crystalline solid is detached with liquid after crystallization；By the crystalline solid of acquisition temperature be 60 DEG C at into
Row drying both the l-Alanine.
According to specific embodiment provided by the invention, the invention discloses following technique effects：
By the invention it is possible to realize a kind of extracting method of l-Alanine, in an implementation mode, this includes：It takes
It is heated to 53~57 DEG C of l-Alanine zymotic fluid, the first flocculant, is added into the l-Alanine zymotic fluid in order
Two flocculants and third flocculant flocculate, and 280~310 milligrams are added into the l-Alanine zymotic fluid after the flocculation
Activated carbon carries out decoloration 27~32 minutes；L-Alanine zymotic fluid after the decoloration is stirred, precipitation process, it will be described
L-Alanine zymotic fluid after stirring, precipitation process, which is put into vacuum drum filter plant, to be detached, and it is clear to obtain flocculation
Clear liquid；It is 58%~62% to be concentrated into dry matter content in clarified solution at being 73~77 DEG C in temperature by the flocculation clarified solution
Afterwards, 20 DEG C are cooled the temperature to be crystallized；Crystalline solid is detached with crystalline mother solution after crystallization；By the crystalline solid of acquisition in temperature
Degree for dried at 57~63 DEG C both the l-Alanine.Method provided by the present application is using flocculence precipitation removal fermentation
The impurity such as thalline, protein, phosphate, residual sugar are obtained in liquid, eliminate calcium precipitation in the prior art and cross the processes such as film removal of impurities,
Extraction process is enormously simplified, reduces equipment investment, and improve product quality.Using crystalline mother solution and wash brilliant residual water again
It returns to flocculation, decoloration, be concentrated and dried in cycle.Loss of material is avoided, environmental protection pressure is reduced, improves yield, energy conservation and environmental protection.
Certainly, it implements any of the products of the present invention and does not necessarily require achieving all the advantages described above at the same time.
Specific implementation mode
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
The every other embodiment that art personnel are obtained, shall fall within the protection scope of the present invention.
An embodiment of the present invention provides a kind of extracting method of l-Alanine, this method includes：
It takes and is heated to 53~57 DEG C of l-Alanine zymotic fluid, be added first into the l-Alanine zymotic fluid in order
Flocculant, the second flocculant and third flocculant flocculate, and 280 are added into the l-Alanine zymotic fluid after the flocculation
~310 milligrams of activated carbons carry out decoloration 27~32 minutes；In practical applications, need to select the l-Alanine of suitable concentration to send out
Zymotic fluid, specifically, the embodiment of the present application can provide in the l-Alanine zymotic fluid l-Alanine content be 10%~
20%.Further, it is 14%~16% that l-Alanine content is obtained in the l-Alanine zymotic fluid.It is specifically chosen flocculant again
When, first flocculant is polymeric aluminum chlorides solution, and second flocculant is chitosan solution, and the third flocculant is
Polyacrylamide solution.Further, in the polymeric aluminum chlorides solution aluminium polychloride a concentration of 9%~11%, it is described
Chitosan concentration is 0.8%~1.1% in chitosan solution, and concentration of polyacrylamide is 0.1 in the polyacrylamide solution
~0.3%.Further, the first flocculant, the second flocculant and the third being added into the l-Alanine zymotic fluid
The mass ratio of flocculant and the l-Alanine zymotic fluid is respectively：2：50000~3：50000、1：50000~2：50000 with
And 1：50000~2：50000.It should be noted that when sequentially adding above-mentioned flocculant, need to carry out when flocculant is added
Stirring.
L-Alanine zymotic fluid after the decoloration is stirred, precipitation process, by described by stirring, precipitation process
L-Alanine zymotic fluid afterwards, which is put into vacuum drum filter plant, to be detached, and flocculation clarified solution is obtained；This is specifically chosen again
When vacuum drum filter plant, the material of precoated shet is perlite and diatomite, vacuum pressure in the vacuum drum filter plant
Power is 0.04~0.05 megapascal；Feed pressure vacuum degree is 0.06~0.07 megapascal；Scraper feed distance is 0.075~0.085
Cm per minute.
Be concentrated at being 73~77 DEG C in temperature by the flocculation clarified solution dry matter content in clarified solution be 58%~
After 62%, cools the temperature to 20 DEG C and crystallized；Crystalline solid is detached with liquid after crystallization；By the crystalline solid of acquisition in temperature
Degree for dried at 57~63 DEG C both the l-Alanine.When specific operation, can by remaining liquid after concentration with
And crystallization Liquid Residue weight continues flocculation decoloration and re-starts concentration.The rate of recovery can be greatly improved in this way.
Method provided by the present application is removed using flocculence precipitation and obtains thalline, protein, phosphate, residual sugar etc. in zymotic fluid
Impurity eliminates calcium precipitation in the prior art and crosses the processes such as film removal of impurities, enormously simplifies extraction process, reduce equipment and throw
Enter, and improves product quality.It is come back in flocculation, decoloration, concentrate drying cycle using crystalline mother solution with brilliant residual water is washed.
Loss of material is avoided, environmental protection pressure is reduced, improves yield, energy conservation and environmental protection.
It describes in detail below by the method that specific embodiment provides application
Embodiment 1
Take the l-Alanine zymotic fluid that the l-Alanine content that 500mlL is heated to 53 DEG C is 10% in totally dry burning
In cup, 20 milligrams a concentration of 9% of polymeric aluminum chlorides solution is added into the l-Alanine zymotic fluid and is added while stirring, adds
Enter to finish the chitosan solution for stirring 10 milligrams a concentration of 0.8% of addition after five minutes to be added while stirring, addition finishes stirring 5
10 milligrams a concentration of 0.1% of polyacrylamide solution is added after minute, addition finishes stirring 5 minutes and stands 10 minutes.To
300 milligrams of activated carbons are added in l-Alanine zymotic fluid after the flocculation and carry out decoloration 30 minutes；
L-Alanine zymotic fluid after the decoloration is stirred, precipitation process, by described by stirring, precipitation process
L-Alanine zymotic fluid afterwards, which is put into vacuum drum filter plant, to be detached, and flocculation clarified solution is obtained；The vacuum drum
The material of precoated shet is perlite and diatomite in filter plant, and vacuum pressure is 0.04 megapascal；Feed pressure vacuum degree is
0.06 megapascal；Scraper feed distance is 0.078 cm per minute.490ml flocculation clarified solutions are obtained, wherein thallus removing rate is
99.28%, protein removal rate is 83.82%, and residual sugar removal rate is 39.60%, light transmittance 86%, and l-Alanine loss late is
1.88%；
It is concentrated at being 75 DEG C in temperature by the flocculation clarified solution after dry matter content in clarified solution is 58%, by temperature
20 DEG C are down to be crystallized；Crystalline solid is detached with liquid after crystallization；Deionized water is added to carry out washing crystalline substance, by the knot of acquisition
Crystal temperature be 57 DEG C at dried both the l-Alanine.By l-Alanine crystalline mother solution and brilliant residual can also be washed
Water reenters flocculation, precipitation, activated carbon decolorizing, is concentrated and dried in cycle, improves the rate of recovery.Embodiment 1 is obtained at quality
Amount is 72.6 grams, and yield 97%, product quality meets national standard.
Embodiment 2
Take the l-Alanine zymotic fluid that the l-Alanine content that 500mlL is heated to 55 DEG C is 15% in totally dry burning
In cup, 20 milligrams a concentration of 10% of polymeric aluminum chlorides solution is added into the l-Alanine zymotic fluid and is added while stirring,
It is added to finish stirring 10 milligrams a concentration of 0.1% of chitosan solution is added after five minutes and be added while stirring, addition finishes stirring
10 milligrams a concentration of 0.1% of polyacrylamide solution is added after five minutes, addition finishes stirring 5 minutes and stands 10 minutes.To
300 milligrams of activated carbons are added in l-Alanine zymotic fluid after the flocculation and carry out decoloration 30 minutes；
L-Alanine zymotic fluid after the decoloration is stirred, precipitation process, by described by stirring, precipitation process
L-Alanine zymotic fluid afterwards, which is put into vacuum drum filter plant, to be detached, and flocculation clarified solution is obtained；The vacuum drum
The material of precoated shet is perlite and diatomite in filter plant, and vacuum pressure is 0.04 megapascal；Feed pressure vacuum degree is
0.06 megapascal；Scraper feed distance is 0.075 cm per minute.490ml flocculation clarified solutions are obtained, wherein thallus removing rate is
99.48%, protein removal rate is 84.42%, and residual sugar removal rate is 39.80%, light transmittance 86%, and l-Alanine loss late is
1.88%；
It is concentrated at being 75 DEG C in temperature by the flocculation clarified solution after dry matter content in clarified solution is 60%, by temperature
20 DEG C are down to be crystallized；Crystalline solid is detached with liquid after crystallization；Deionized water is added to carry out washing crystalline substance, by the knot of acquisition
Crystal temperature be 60 DEG C at dried both the l-Alanine.By l-Alanine crystalline mother solution and brilliant residual can also be washed
Water reenters flocculation, precipitation, activated carbon decolorizing, is concentrated and dried in cycle, improves the rate of recovery.Embodiment 2 is obtained at quality
73.6 grams of amount, yield 98%, product quality meets national standard.
Embodiment 3
Take the l-Alanine zymotic fluid that the l-Alanine content that 500mlL is heated to 57 DEG C is 20% in totally dry burning
In cup, 25 milligrams a concentration of 11% of polymeric aluminum chlorides solution is added into the l-Alanine zymotic fluid and is added while stirring,
It is added to finish stirring 10 milligrams a concentration of 1.1% of chitosan solution is added after five minutes and be added while stirring, addition finishes stirring
10 milligrams a concentration of 0.1% of polyacrylamide solution is added after five minutes, addition finishes stirring 5 minutes and stands 10 minutes.To
300 milligrams of activated carbons are added in l-Alanine zymotic fluid after the flocculation and carry out decoloration 30 minutes；
L-Alanine zymotic fluid after the decoloration is stirred, precipitation process, by described by stirring, precipitation process
L-Alanine zymotic fluid afterwards, which is put into vacuum drum filter plant, to be detached, and flocculation clarified solution is obtained；The vacuum drum
The material of precoated shet is perlite and diatomite in filter plant, and vacuum pressure is 0.05 megapascal；Feed pressure vacuum degree is
0.07 megapascal；Scraper feed distance is 0.085 cm per minute.475ml flocculation clarified solutions are obtained, wherein thallus removing rate is
97.48%, protein removal rate is 83.52%, and residual sugar removal rate is 38.90%, light transmittance 84%, and l-Alanine loss late is
1.98%；
It is concentrated at being 77 DEG C in temperature by the flocculation clarified solution after dry matter content in clarified solution is 62%, by temperature
20 DEG C are down to be crystallized；Crystalline solid is detached with liquid after crystallization；Deionized water is added to carry out washing crystalline substance, by the knot of acquisition
Crystal temperature be 63 DEG C at dried both the l-Alanine.By l-Alanine crystalline mother solution and brilliant residual can also be washed
Water reenters flocculation, precipitation, activated carbon decolorizing, is concentrated and dried in cycle, improves the rate of recovery.Embodiment 3 is obtained at quality
71.6 grams of amount, yield 95.8%, product quality meets national standard.
It should be noted that herein, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also include other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that
There is also other identical elements in process, method, article or equipment including the element.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the scope of the present invention.It is all
Any modification, equivalent replacement, improvement and so within the spirit and principles in the present invention, are all contained in protection scope of the present invention
It is interior.
Claims (8)
1. a kind of extracting method of l-Alanine, which is characterized in that the method includes：
It takes and is heated to 53~57 DEG C of l-Alanine zymotic fluid, polyaluminium is added into the l-Alanine zymotic fluid in order
Aluminum solutions, chitosan solution and polyacrylamide solution flocculate, and add into the l-Alanine zymotic fluid after the flocculation
Enter 280~310 milligrams of activated carbons and carries out decoloration 27~32 minutes；
L-Alanine zymotic fluid after the decoloration is stirred, precipitation process, by described after stirring, precipitation process
L-Alanine zymotic fluid is put into vacuum drum filter plant and is detached, and obtains flocculation clarified solution；The vacuum drum filtering
The material of precoated shet is perlite and diatomite in equipment, and vacuum pressure is 0.04~0.05 megapascal；Feed pressure vacuum degree is
0.06~0.07 megapascal；Scraper feed distance is 0.075~0.085 cm per minute；
It is concentrated at being 73~77 DEG C in temperature by the flocculation clarified solution after dry matter content in clarified solution is 58%~62%,
20 DEG C are cooled the temperature to be crystallized；Crystalline solid is detached with crystalline mother solution after crystallization；By the crystalline solid of acquisition in temperature
Be dried at 57~63 DEG C both the l-Alanine.
2. according to the method described in claim 1, it is characterized in that, in the l-Alanine zymotic fluid l-Alanine content be
10%~20%.
3. according to the method described in claim 2, it is characterized in that, in the l-Alanine zymotic fluid l-Alanine content be
14%~16%.
4. according to the method described in claim 1, it is characterized in that, in the polymeric aluminum chlorides solution aluminium polychloride concentration
It is 9%~11%, chitosan concentration is 0.8%~1.1% in the chitosan solution, poly- third in the polyacrylamide solution
Acrylamide a concentration of 0.1~0.3%.
5. according to the method described in claim 4, it is characterized in that, the first flocculation being added into the l-Alanine zymotic fluid
Agent, the second flocculant and third flocculant and the mass ratio of the l-Alanine zymotic fluid are respectively：2：50000~3：
50000、1：50000~2：50000 and 1：50000~2：50000.
6. according to the method described in claim 1, it is characterized in that, the vacuum pressure is 0.04 megapascal；Feed pressure vacuum
Degree is 0.06 megapascal；Scraper feed distance is 0.078 cm per minute.
7. method according to any one of claims 1 to 6, which is characterized in that described take is heated to 53~57 DEG C of L- third
Propylhomoserin zymotic fluid, including：
It takes and is heated to 55 DEG C of l-Alanine zymotic fluid.
8. method according to any one of claims 1 to 6, which is characterized in that
It is concentrated into after dry matter content in clarified solution is 60%, cools the temperature at being 75 DEG C in temperature by the flocculation clarified solution
20 DEG C are crystallized；Crystalline solid is detached with liquid after crystallization；It is dried at being 60 DEG C in temperature by the crystalline solid of acquisition
It is dry both the l-Alanine.
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| CN109776344B (en) * | 2017-11-13 | 2022-01-18 | 秦皇岛华恒生物工程有限公司 | Method for separating L-alanine and lactic acid by electrodialysis |
| CN108484423B (en) * | 2018-07-05 | 2021-02-09 | 秦皇岛华恒生物工程有限公司 | Method for separating and purifying L-alanine from L-alanine fermentation liquor |
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| CN101798273B (en) * | 2009-10-19 | 2013-05-01 | 广东肇庆星湖生物科技股份有限公司 | Valine purification method |
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