CN106729931A - Preparation method of silver-loaded chitosan medical dressing - Google Patents
Preparation method of silver-loaded chitosan medical dressing Download PDFInfo
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- CN106729931A CN106729931A CN201611046562.5A CN201611046562A CN106729931A CN 106729931 A CN106729931 A CN 106729931A CN 201611046562 A CN201611046562 A CN 201611046562A CN 106729931 A CN106729931 A CN 106729931A
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 49
- 239000004332 silver Substances 0.000 title claims abstract description 14
- 229910052709 silver Inorganic materials 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims description 17
- 241001092070 Eriobotrya Species 0.000 claims abstract description 40
- 235000009008 Eriobotrya japonica Nutrition 0.000 claims abstract description 40
- 239000000243 solution Substances 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 31
- 239000000835 fiber Substances 0.000 claims abstract description 24
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000284 extract Substances 0.000 claims abstract description 22
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 11
- 238000005406 washing Methods 0.000 claims abstract description 7
- 239000007864 aqueous solution Substances 0.000 claims abstract description 6
- 239000004744 fabric Substances 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 238000009941 weaving Methods 0.000 claims description 19
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 4
- 238000005470 impregnation Methods 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
- 238000007598 dipping method Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 14
- 238000000605 extraction Methods 0.000 abstract description 3
- 239000004745 nonwoven fabric Substances 0.000 abstract 2
- 230000002045 lasting effect Effects 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 206010052428 Wound Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 239000000419 plant extract Substances 0.000 description 5
- 239000003638 chemical reducing agent Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000012876 topography Methods 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000006722 reduction reaction Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920000742 Cotton Polymers 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000219146 Gossypium Species 0.000 description 2
- 238000004847 absorption spectroscopy Methods 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241001464837 Viridiplantae Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003378 silver Chemical class 0.000 description 1
- 229940083025 silver preparation Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000009988 textile finishing Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
- D06M11/83—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with metals; with metal-generating compounds, e.g. metal carbonyls; Reduction of metal compounds on textiles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Textile Engineering (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a method for preparing silver-loaded chitosan medical dressing by utilizing loquat leaf or loquat nucleus extract. Firstly, extracting the effective components of loquat leaves or loquat seeds by an extraction method to obtain an extracting solution; reducing silver nitrate with the extracting solution to prepare a nano-silver aqueous solution; finally, the chitosan fiber non-woven fabric is dipped by the obtained nano silver aqueous solution, and the silver-loaded chitosan medical dressing with excellent antibacterial effect is obtained. The method has the characteristics of simple process, ecological friendliness, rapidness, high efficiency, safety, no toxicity and the like; the chitosan fiber non-woven fabric is treated by the nano silver prepared by the method, and the prepared silver-loaded chitosan medical dressing has excellent broad-spectrum antibacterial property and lasting antibacterial effect, and the antibacterial rate can be kept above 98% even after multiple times of washing.
Description
Technical field
The invention belongs to textile finishing technical field, and in particular to one kind is prepared using loguat leaf or loquat seed extract solution
The method for carrying silver-colored chitosan medical dressing.
Background technology
Medical dressing is as a kind of medical material for covering sore, wound or other damaging parts in Wound healing
During can replace the damaged skin to there is collarium border to keep apart and play protection wound, reduce infection wound with extraneous
Effect, while wound exudate can also effectively be absorbed, and keeps certain humiture to provide the suitable ring needed for wound healing
Border, promotes wound healing.Current increasing with aging population and chronic ulcer wound, demand of the China to medical dressing
It is increasing, while requirement to medical dressing also more and more higher.At present, medical dressing is just towards high performance, functionalization, height
The direction of additional value is developed, and is real so as to assign its certain feature by some nano materials and the compound of medical dressing
One of effective way of existing this target.
Nano Silver has widely been added in medical dressing to assign at present due to the antibacterial characteristics with high-efficiency broad spectrum
Give the antibacterial functions that dressing is excellent.However, up to the present, the approach for preparing of Nano Silver mainly still relies on the method bag for reducing
Include two kinds of physics reducing process and chemical reduction method.They have that production cost is higher, efficiency is low and has greater environmental impacts etc. and ask
Topic.The nanometer silver products obtained especially by chemical reduction method are also possible to remain some harmful chemical compositions, instead
And limit its application in medicine and hygiene fieldses.A kind of new method for preparing Nano Silver is occurred in that in recent years, i.e. plant carries
Take thing reducing process.Plant extracts reducing process is mainly in the case of without other chemical reagent, is carried using green plants
Take thing and obtain Nano Silver reducing silver ion.Compared with other methods, plant extracts reducing process has unique advantage.It is first
First, China's vegetation resources enriches, and the available plant resources for utilizing enriches；Secondly, plant extracts reduction method for preparing nanometer
Silver have reaction it is gentle, it is ecological it is friendly, rapidly and efficiently, safety non-toxic the features such as, meet the requirement of sustainable development；Finally, examine
Consider the application of actual production, plant extracts reducing process is more easy to accomplish scale production compared to other methods.
Chitosan fiber non-weaving cloth as this cyclopean family of non-weaving cloth a member, because its own is except with biography
Unite outside some general characters of non-weaving cloth, also with some unique performances, such as excellent moisture-absorption water-retention, good biological group
The characteristic such as compatibility and biological degradability and certain sterilization, anti-inflammatory, hemostasis, analgesia accelerating wound healing is knitted, therefore is to use
Make the ideal material of medical dressing.
It is combined with Nano Silver obtained in plant extracts and chitosan fiber non-weaving cloth, the silver containing chitosan fiber for obtaining
Non-weaving cloth, both with the Biomedical function of chitosan fiber itself uniqueness, and the excellent antibacterial performance with Nano Silver.This
Outward, this silver containing chitosan fiber non-weaving cloth, because its preparing raw material derives from nature, and does not have in preparation process
Any other chemical addition agent of addition, therefore environmental protection, safety non-toxic, are highly suitable as medical antibacterial dressing.It is existing
The preparation of silver-colored chitosan medical dressing is carried, using inorganic and organic reducing agent class chemical products electronation gained Nano Silver, is deposited
Production cost it is higher, efficiency is low, chemical reducing agent residual harmful have impact on it in medicine and hygiene fieldses application
Problem.
The content of the invention
In order to solve the above technical problems, it is an object of the invention to provide a kind of preparation side for carrying silver-colored chitosan medical dressing
Method, the method is that a kind of utilization loguat leaf and/or loquat seed extract prepare Nano Silver and using the aqueous solution of gained Nano Silver
The chitosan medical dressing that impregnation process obtains efficient durability antibacterial functions is carried out to chitosan fiber non-weaving cloth.
A kind of preparation method for carrying silver-colored chitosan medical dressing of the invention, comprises the following steps：
(1) extraction of Loquat Leaf or loquat seed powder active ingredient：By Loquat Leaf or loquat seed powder with go
(in mixed liquor, loguat leaf concentration is calculated as 20-80g/L, loquat nuclear concentration with dry powder with dry powder after ionized water mixes by a certain percentage
Be calculated as 30-90g/L), in 80-95 DEG C of heating leaching for a period of time after, by filter centrifugation remove loguat leaf or loquat seed powder
Residue, obtains loquat leaf extract or loquat seed extract solution.
(2) preparation of nano-silver water solution：Take the appropriate loquat leaf extract obtained by step (1) or loquat seed extraction
Liquid mixes by a certain percentage with the silver nitrate aqueous solution of ion water dissolves, and in mixed liquor, silver nitrate concentration is 0.2-2mmol/
L, loquat-leaf extract concentration is calculated as 0.5-3g/L with its dry powder or loquat seed extract concentration is calculated as 2-10g/L with its dry powder,
After well mixed, the pH value of solution is adjusted to 3-10,45-80min is reacted at a temperature of 30-90 DEG C, obtain nano-silver water solution.
(3) the Nano Silver treatment of chitosan fiber non-weaving cloth：The pH value of the nano-silver water solution that step (2) is obtained is adjusted
Save to 4-8, by bath raio 1:20-50 (nonwoven sheet weight is to the ratio between volume of solution) input chitosan fiber non-weaving cloth, in
Impregnation process 20-60min at a temperature of 20-80 DEG C, then takes out non-weaving cloth, washing, drying, and the chitosan for obtaining carrying silver is medical
Dressing.
Further, in step (2), loquat-leaf extract concentration is calculated as 0.8-1.5g/L, silver nitrate consumption with its dry powder
It is 0.6-1.2mmol/L, solution ph is 5-7, and reaction temperature is 75-85 DEG C.
Further, in step (2), loquat seed extract concentration is calculated as 4-6g/L with its dry powder, and silver nitrate consumption is
0.6-1.2mmol/L, solution ph is 8-9, and reaction temperature is 55-65 DEG C.
Further, in step (3), Nano silver solution pH value is adjusted to 5-6, and dipping temperature is 25-65 DEG C.
By such scheme, the present invention at least has advantages below：
1st, Nano Silver preparation method is to reduce silver nitrate using loguat leaf and/or loquat seed extract solution in the present invention, should
Method process is simple, it is ecological friendly, rapidly and efficiently, safety non-toxic；
2nd, nano silver particles are loaded on chitosan fiber non-weaving cloth under mildly acidic conditions by infusion process, is obtained
Silver-colored chitosan medical dressing is carried, the adsorbance of Nano Silver is big, and silver-colored utilization rate is high, will not produce waste；And Nano Silver and fiber
Set firmly, is not easily runed off, and the chitosan fiber non-weaving cloth processing method is simple, it is easy to implement；
3rd, with silver-colored chitosan medical dressing is carried obtained in the inventive method, imitated with excellent broad spectrum antibacterial, and antibacterial
Insist on long, even if through repeatedly washing, bacteriostasis rate can also be maintained at more than 98%.
Described above is only the general introduction of technical solution of the present invention, in order to better understand technological means of the invention,
And can be practiced according to the content of specification, below with presently preferred embodiments of the present invention and coordinate accompanying drawing describe in detail as after.
Brief description of the drawings
Fig. 1 is the ultraviolet-visible absorption spectroscopy figure of the nano-silver water solution of preparation in example of the invention 1；
Fig. 2 is the transmission electron microscope picture of the nano-silver water solution of preparation in example of the invention 1；
Fig. 3 is the SEM figures of the silver-colored chitosan medical dressing surface topography of load of preparation in example of the invention 1；
Fig. 4 be the load silver chitosan medical dressing prepared in example of the invention 1 to Escherichia coli antibacterial effect comparison diagram,
A control sample standard cottons, b is the silver-colored chitosan medical dressing of load；
Fig. 5 is the load silver chitosan medical dressing of preparation in example of the invention 1 to staphylococcus aureus antibacterial effect
Comparison diagram, a is control sample standard cotton, and b is the silver-colored chitosan medical dressing of load；
Fig. 6 is that the present invention is the load silver chitosan medical dressing surface topography SEM figures prepared in example 2, and a is without nanometer
Silver arranges sample, and b is to arrange sample through Nano Silver.
Specific embodiment
With reference to the accompanying drawings and examples, specific embodiment of the invention is described in further detail.Hereinafter implement
Example is not limited to the scope of the present invention for illustrating the present invention.
Embodiment 1
Nano-silver water solution is prepared using loguat leaf, is comprised the following steps：
(1) Loquat Leaf for weigh 5g dryings, crushing is added thereto to 150mL deionized waters in 250mL conical flasks
And be well mixed, 90min is leached at a temperature of 80 DEG C, then filter, removal Loquat Leaf residue is centrifuged, obtain loguat leaf and carry
Take liquid；
(2) to 2mL loquat leaf extracts are added in the 1mmol/L silver nitrate solutiones of 50mL, after being well mixed, pH value is adjusted
It is 6, in 60min is reacted at 80 DEG C, obtains nano-silver water solution.
The ultraviolet-visible absorption spectroscopy of Nano Silver obtained in the present embodiment as shown in Figure 1, as seen from Figure 1, at 435nm
Occur in that typical Nano Silver absworption peak, it was demonstrated that nano-Ag particles are generated in the aqueous solution；Nanometer obtained in the present embodiment method
As shown in Figure 2, Fig. 2 shows silver-colored transmission electron microscope picture, and Nano Silver is spheric granules as obtained in loquat leaf extract, and particle diameter exists
20nm or so.
Prepared using Nano Silver manufactured in the present embodiment and carry silver-colored chitosan medical dressing, comprised the following steps：
(1) it is pre-adjusted nano-silver water solution pH value manufactured in the present embodiment extremely with the acetum of 0.1mol/L first
5.2, then by 1g chitosan fibers non-weaving cloth according to bath raio 1:50 are immersed in the nano-silver water solution of above-mentioned preparation, in 60
At DEG C persistent oscillation for a period of time, after solution from brown color become it is colourless after take out chitosan fiber non-weaving cloth, use a large amount of water
Dried after flushing, obtain carrying silver-colored chitosan medical dressing.
The present embodiment method is obtained to carry silver-colored chitosan medical dressing surface topography SEM figures as shown in Figure 3, can by Fig. 3
See, chitosan fiber adsorption there are a large amount of Argent grains after arrangement, and Argent grain is evenly distributed.
According to standard GB/T/T 20944.3-2008, chitosan fiber obtained in the present embodiment method is determined non-woven
Cloth medical dressing to Gram-negative bacteria Escherichia coli and the bacteriostasis property of gram-positive bacteria staphylococcus aureus, as a result such as
Shown in accompanying drawing 4 and Fig. 5, from Fig. 4 and Fig. 5, through the chitosan fiber non-weaving cloth medical dressing of Nano Silver arrangement to large intestine
Bacillus and staphylococcus aureus have and show excellent anti-microbial property.
Embodiment 2
Nano Silver is prepared using loquat seed, is comprised the following steps：
(1) the loquat seed powder for weigh 5g dryings, crushing is added thereto to 100mL deionizations in 250ml conical flasks
Water, it is well mixed that 90min is leached at a temperature of 90 DEG C, then filter, removal loquat seed powder residue is centrifuged, obtain loquat seed
Extract solution.
(2) to 5mL loquat seed extract solutions are added in the 1mmol/L silver nitrate solutiones of 50mL, after being well mixed, pH value is adjusted
It is 8-9,60min is reacted at being subsequently placed in 60 DEG C, obtains nano-silver water solution.
Prepared using nano-silver water solution manufactured in the present embodiment and carry silver-colored chitosan medical dressing, comprised the following steps：
(1) it is pre-adjusted nano-silver water solution pH value manufactured in the present embodiment extremely with the acetum of 0.1mol/L first
5.6, then by 1g chitosan fibers non-weaving cloth according to bath raio 1:50 are immersed, 25 points of persistent oscillation at a temperature of 30 DEG C
Clock, takes out chitosan fiber non-weaving cloth, is washed with massive laundering and dried, and obtains carrying silver-colored chitosan medical dressing.
The present embodiment method is obtained to carry silver-colored chitosan medical dressing surface topography SEM figures as shown in Figure 6, can by Fig. 6
See, fiber surface is adsorbed with a large amount of Argent grains after arrangement, and Argent grain is evenly distributed.
According to standard GB/T/T 20944.3-2008, the first arranged with Nano Silver obtained in the present embodiment method is determined
Shell amine fiber non-woven medical dressing to the bacteriostasis property of gram-positive bacteria staphylococcus aureus, as a result table 1 below
It is shown：
Table 1 carries the antibacterial washing fastness test result of silver-colored chitosan medical dressing
| Washing times | Bacteriostasis rate (%) |
| 0 | 99.88 |
| 5 | 99.66 |
| 10 | 98.64 |
| 20 | 98.14 |
As shown in Table 1, the chitosan fiber non-weaving cloth for being arranged through Nano Silver shows excellent to staphylococcus aureus
Different anti-microbial property, and by after repeatedly washing, bacteriostasis rate remains at more than 98%.
The above is only the preferred embodiment of the present invention, is not intended to limit the invention, it is noted that for this skill
For the those of ordinary skill in art field, on the premise of the technology of the present invention principle is not departed from, can also make it is some improvement and
Modification, these are improved and modification also should be regarded as protection scope of the present invention.
Claims (4)
1. a kind of preparation method for carrying silver-colored chitosan medical dressing, it is characterised in that comprise the following steps：
(1) Loquat Leaf or loquat seed powder are mixed with water, in mixed liquor loguat leaf concentration with dry powder be calculated as 20-80g/L,
Loquat nuclear concentration is calculated as 30-90g/L with dry powder, and is leached at a temperature of 80-95 DEG C, by filtering, centrifugation removal loguat leaf powder
End or loquat seed powder residue, obtain loquat leaf extract or loquat seed extract solution；
(2) the loquat leaf extract or loquat seed extract solution for obtaining step (1) mix with silver nitrate aqueous solution, in mixed liquor,
Silver nitrate concentration is 0.2-2mmol/L, and loquat-leaf extract concentration is calculated as 0.5-3g/L with loquat leaf dried powder or loquat seed is extracted
Thing concentration is calculated as 2-10g/L with loquat seed dry powder, after being well mixed, the pH value of solution is adjusted to 3-10, at a temperature of 30-90 DEG C
Reaction 45-80min, obtains nano-silver water solution；
(3) pH value of the nano-silver water solution for obtaining step (2) is adjusted to 4-8, by bath raio 1:20-50 puts into chitosan fiber
Non-weaving cloth, the impregnation process 20-60min at a temperature of 20-80 DEG C then takes out washing, drying, obtains carrying the chitosan doctor of silver
Use dressing.
2. preparation method according to claim 1, it is characterised in that：In step (2), loquat-leaf extract concentration is with Pi
Rake leaf dried powder is calculated as 0.8-1.5g/L, and silver nitrate concentration is 0.6-1.2mmol/L, and solution ph is 5-7, and reaction temperature is 75-
85℃。
3. preparation method according to claim 1, it is characterised in that：In step (2), loquat seed extract concentration is with Pi
Rake core dry powder is calculated as 4-6g/L, and silver nitrate concentration is 0.6-1.2mmol/L, and solution ph is 8-9, and reaction temperature is 55-65 DEG C.
4. preparation method according to claim 1, it is characterised in that：In step (3), Nano silver solution pH value adjust to
5-6, dipping temperature is 25-65 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611046562.5A CN106729931A (en) | 2016-11-23 | 2016-11-23 | Preparation method of silver-loaded chitosan medical dressing |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611046562.5A CN106729931A (en) | 2016-11-23 | 2016-11-23 | Preparation method of silver-loaded chitosan medical dressing |
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| CN106729931A true CN106729931A (en) | 2017-05-31 |
Family
ID=58975453
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| CN201611046562.5A Pending CN106729931A (en) | 2016-11-23 | 2016-11-23 | Preparation method of silver-loaded chitosan medical dressing |
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