CN107115553A - One kind prevents adhesion medical acid-sensitive antibacterial gauze of moisture absorption and preparation method thereof - Google Patents
One kind prevents adhesion medical acid-sensitive antibacterial gauze of moisture absorption and preparation method thereof Download PDFInfo
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
Prevented adhesion medical acid-sensitive antibacterial gauze of moisture absorption and preparation method thereof the invention discloses one kind, belong to hospital gauze and preparation method thereof field.The gauze is made up of hospital gauze base material and the gel layer sticked on hospital gauze base material, gel layer is prepared by mixed soaking solution, mixed soaking solution includes antibacterial Chinese medicine extract solution, sodium alginate, citric acid, glycerine and water, and antibacterial Chinese medicine extract solution is the built agent extract of folium isatidis and cordate houttuynia.The present invention after boiling, filter, concentrating by obtaining antibacterial Chinese medicine extract solution, then antibacterial Chinese medicine extract solution, citric acid, glycerine and sodium alginate soln are mixed to get mixed liquor, common hospital gauze is immersed in mixed liquor again, fully after infiltration, take out, be placed in oven drying, preparation method is simple, prepare and possess the hygroscopic effect that prevents adhesion, acid-sensitive, and possess the hospital gauze of antibacterial action.
Description
Technical field
The present invention relates to hospital gauze and preparation method thereof field, prevented adhesion the medical acid-sensitive of moisture absorption more particularly to one kind
Antibacterial gauze and preparation method thereof.
Background technology
Hospital gauze is mainly used in wrapping up the surface of a wound in hygiene medical treatment field, plays a part of protection protection wound.However,
During Clinical practice, there is many technical problems in hospital gauze, be mainly reflected in the following aspects：1st, gauze hygroscopicity
Difference, it is impossible to effective absorbing wound exudate, causes diffusate to solidify at wound, influences the healing of wound；2nd, gauze is anti-sticking
Even effect is poor so that new granulation tissue is easily grown into the mesh of gauze, and not only the surface of a wound can be caused when causing to change gauze
Secondary damage, and be unfavorable for wound healing larger pain is also brought to patient；3rd, the antiseptic release behavior of gauze load
Do not possess response to environment of bacteria growth, cause being excessively used for antibiotic, add toxic side effect and to have aggravated bacterium resistance to
The generation of the property of medicine, meanwhile, research shows, the microenvironment of bacterial growth,
Faintly acid is presented because of the tachymetabolism behavior of bacterium and anoxic fermentation, therefore, preparing has the moisture absorption that prevents adhesion
Function, and the antibacterial gauze of acid labile becomes the new approaches of preventing and treating bacterial disease.
The content of the invention
In order to solve the above technical problems, being prevented adhesion the medical acid-sensitive antibacterial gauze of moisture absorption and its system the invention provides one kind
Preparation Method.The preparation method of the present invention is simple, and obtained gauze not only has the moisture absorption effect of preventing adhesion, and creation is conducive to wound to be cured
The local environment of conjunction, and because gel layer has obvious sensitivity to acid, it is capable of the microenvironment quick release of directed toward bacteria growth
Antiseptic, improves antiseptic effective rate of utilization, and experimental result is also demonstrated is better than antibiotic using the antibacterial effect of Chinese medicine antibacterial agent
Vancomycin, has application prospect in hospital gauze field.
To achieve the above object, prevented adhesion the medical acid-sensitive antibacterial gauze of moisture absorption the invention discloses one kind, it is described medical
Antibacterial gauze is made up of hospital gauze base material and the gel layer sticked on hospital gauze base material, and the gel layer is soaked by mixing
Liquid is prepared, and the mixed soaking solution includes antibacterial Chinese medicine extract solution, sodium alginate, citric acid, glycerine and water, described anti-
Bacterium Chinese medicine extract is the built agent extract of folium isatidis and cordate houttuynia.
Further, the hospital gauze base material and the mass ratio of mixed soaking solution are 1：4~6.
Yet further, the mass ratio of each component is in the mixed soaking solution, antibacterial Chinese medicine extract solution：Sodium alginate：
Citric acid：Glycerine：Water=80~130：2~3.5：2.5~4：5~9：100~180.
Further, the mass ratio of folium isatidis and cordate houttuynia is 1 in the antibacterial Chinese medicine extract solution:1~3.
The invention also discloses a kind of preparation method of the medical acid-sensitive antibacterial gauze of moisture absorption that prevents adhesion, including following step
Suddenly：
1) antibacterial Chinese medicine extract solution is prepared：Folium isatidis and cordate houttuynia are mixed, boiling is heated to after adding water, continues to decoct
Filtered to decoction liquor, then by decoction liquor, obtain no slag decoction, will be concentrated under reduced pressure without slag decoction, and obtain antibacterial Chinese medicine extract solution；
2) mixed soaking solution is prepared：By citric acid, glycerine and step 1) prepare antibacterial Chinese medicine extract solution be dissolved into water
In, it is sufficiently stirred for obtaining well mixed mixture, then into gained mixture add alginic acid under rapid stirring
Sodium, obtains sticky gluey mixed soaking solution；
3) the moisture absorption medical antibacterial gauze that prevents adhesion is prepared：By fully activated through concentrated sodium hydroxide and it is pre-sterilized after medical yarn
Cloth base material is immersed in the step 2) prepare mixed soaking solution in, fully infiltration after, take out, be placed in drying box dry, system
The standby moisture absorption medical antibacterial gauze that prevents adhesion for obtaining being stained with gel layer on hospital gauze base material.
Further, the step 1) in, it is 1 by mass ratio:1~3 folium isatidis and cordate houttuynia are mixed to get in mixing
Medicine, adds water of the quality for 3~6 times of traditional Chinese medicine quality of mixing, is heated to boiling, continues decoction and obtains decoction liquor.
Yet further, the step 2) in, mass ratio is, citric acid：Glycerine：Antibacterial Chinese medicine extract solution：Alginic acid
Sodium=2.5~4：5~9：80~130：2~3.5.
Further, the step 3) in, in drying box carry out gradient increased temperature drying, i.e., gradually by room temperature extremely
30~45min is kept after 70~80 DEG C, then proceedes to be warming up to 15~25min of holding after 105~110 DEG C, stops heating, make temperature
Degree nature is reduced to room temperature.
The selection principle of each constituent of the present invention and corresponding proportion：
Sodium alginate is quick under the conditions of sour environment to form gel, realizes that quick absorbing wound exudate keeps wound
Relatively dry, creates the local environment for being conducive to wound healing；
The esterification of citric acid and glycerine, further plays a part of reinforcing to the gel layer of sodium alginate formation, prevents
Only the improper of gel layer comes off, meanwhile, there are the dynamic non-covalent key based on hydrogen bond, acid bar between citric acid and sodium alginate
The hydrogen bond crosslinks can be destroyed under part, so as to show the antiseptic release behavior of acid-sensitive；
Chinese medical extract selects the compound of folium isatidis and cordate houttuynia, by folium isatidis and cordate houttuynia in antibacterial Chinese medicine extract solution
Mass ratio control be 1:Between 1~3, it can reach and preferably suppress staphylococcus aureus, bacillus, P. aeruginosa
The strain such as bacillus and Escherichia coli.
The operation principle of antibacterial gauze prepared by the present invention is：
In hydrogel in addition to the ester bond that the esterification of citric acid and glycerine is constituted, between citric acid and sodium alginate also
There is interaction of hydrogen bond, the hydrogen bond crosslinks can be destroyed in acid condition, so that the structure of hydrogel becomes more to dredge
Pine, and then the release process of antiseptic is accelerated, hydrogel is presented the antiseptic release behavior of acid-sensitive, be finally presented as
Hydrogel has excellent antibacterial ability under the similar acid condition of bacterium infection, and in the nonacid bar of similar bacterium infection
Under part, less discharges antibiotic, so as to reduce the usage amount of antibiotic, suppresses the generation of bacterial drug resistance.
Beneficial effect：
1st, gauze prepared by the present invention possesses preferable soaking effect, and the quick absorbing wound exudate of energy keeps the phase of wound
To drying, the local environment for being conducive to wound healing is created, while playing a part of isolation cambium and gauze, gauze is prevented
Adhesion between cambium.
2nd, gauze prepared by the present invention, the energy quick release Chinese medicine antibacterial agent under sour environment, and show better than antibiosis
The antibacterial effect of element.
3rd, preparation method of the invention is simple, it is easy to accomplish industrialized production.
Brief description of the drawings
Fig. 1 is the scanning electron microscope (SEM) photograph of gauze surface gel layer prepared by the embodiment of the present invention；
Fig. 2 is influence of the citric acid content to water absorption rate in Fig. 1 gel layer；
Fig. 3 is influence of the sodium alginate content to water absorption rate in Fig. 1 gel layer；
Fig. 4 in Fig. 1 gel layer under difference pH environment antiseptic cumulative release situation；
Fig. 5 is antibacterial ability of Fig. 1 gel layer under different pH environment；
Fig. 6 is that the embodiment of the present invention carries Chinese medicine antibacterial agent and the antibacterial ability contrast of carried with antibiotics.
Embodiment
In order to preferably explain the present invention, what below in conjunction with specific embodiment and Figure of description, the present invention is furture elucidated
Main contents, but present disclosure is not limited solely to following examples.
Embodiment 1
It is 1 by mass ratio：1 folium isatidis and cordate houttuynia mixing, add the water of 4 times of quality, are heated to continuing to decoct after boiling
1h is boiled, the decoction liquor containing filtrate and filter residue is obtained, filtration treatment obtains filtrate, then filtrate progress low-temperature reduced-pressure is concentrated into
The a quarter of former filtrate volume, that is, prepare Chinese medicine extract, gives over to standby；It is 80 to weigh mass ratio：2：2.5：5：100
Chinese medicine extract, sodium alginate, citric acid, glycerine and water, wherein, specific operation process be by citric acid, glycerine and
Chinese medicine extract is dissolved into water (the preferred ultra-pure water of the present embodiment), is sufficiently stirred for obtaining well mixed mixture, then fast
Sodium alginate is added into mixture under conditions of speed stirring, is stirred, the gluey mixing leaching for possessing certain viscosity is obtained
Steep liquid；
Take one piece of common hospital gauze, the hospital gauze in advance by concentrated sodium hydroxide fully activate and aseptic process after,
In the mixed soaking solution that the hospital gauze is immersed in above-mentioned preparation, and hospital gauze and the mass ratio of mixed soaking solution are 1：5,
Keep fully infiltration, it is ensured that hospital gauze tow sides are loaded with mixed soaking solution, take out, mixed soaking solution will be loaded with
Hospital gauze, which is placed in drying box, carries out gradient increased temperature, and programming rate is controlled in 5 DEG C/min or so, is first warming up to after 75 DEG C and is incubated
30min or so, is then further continued for being warming up to 105 DEG C, and is incubated after 20min, stops heating, then temperature is reduced to room naturally
Temperature, i.e. mixed soaking solution prepare the moisture absorption that prevents adhesion of the invention medical in the tow sides formation gel layer of hospital gauze
Acid-sensitive antibacterial gauze.
Embodiment 2
It is 1 by mass ratio：2 folium isatidis and cordate houttuynia mixing, add the water of 4 times of quality, are heated to continuing to decoct after boiling
1h is boiled, the decoction liquor containing filtrate and filter residue is obtained, filtration treatment obtains filtrate, then filtrate progress low-temperature reduced-pressure is concentrated into
The a quarter of former filtrate volume, that is, prepare Chinese medicine extract, gives over to standby；It is 80 to weigh mass ratio：3.5：4：9：180
Chinese medicine extract, sodium alginate, citric acid, glycerine and water, wherein, specific operation process be by citric acid, glycerine and
Chinese medicine extract is dissolved into water (the preferred ultra-pure water of the present embodiment), is sufficiently stirred for obtaining well mixed mixture, then fast
Sodium alginate is added into mixture under conditions of speed stirring, is stirred, the gluey mixing leaching for possessing certain viscosity is obtained
Steep liquid；
Take one piece of common hospital gauze, the hospital gauze in advance by concentrated sodium hydroxide fully activate and aseptic process after,
In the mixed soaking solution that the hospital gauze is immersed in above-mentioned preparation, and hospital gauze and the mass ratio of mixed soaking solution are 1：6,
Keep fully infiltration, it is ensured that hospital gauze tow sides are loaded with mixed soaking solution, take out, mixed soaking solution will be loaded with
Hospital gauze, which is placed in drying box, carries out gradient increased temperature, and programming rate is controlled in 5 DEG C/min or so, is first warming up to after 75 DEG C and is incubated
40min or so, is then further continued for being warming up to 108 DEG C, and is incubated after 20min, stops heating, then temperature is reduced to room naturally
Temperature, i.e. mixed soaking solution prepare the moisture absorption that prevents adhesion of the invention medical in the tow sides formation gel layer of hospital gauze
Acid-sensitive antibacterial gauze.
Embodiment 3
It is 1 by mass ratio：1 folium isatidis and cordate houttuynia mixing, add the water of 4 times of quality, are heated to continuing to decoct after boiling
1h is boiled, the decoction liquor containing filtrate and filter residue is obtained, filtration treatment obtains filtrate, then filtrate progress low-temperature reduced-pressure is concentrated into
The a quarter of former filtrate volume, that is, prepare Chinese medicine extract, gives over to standby；It is 130 to weigh mass ratio：2：2.5：5：
100 Chinese medicine extract, sodium alginate, citric acid, glycerine and water, wherein specific operation process are by citric acid, glycerine
It is dissolved into Chinese medicine extract in water, is sufficiently stirred for obtaining well mixed mixture, then under rapid stirring to mixed
Sodium alginate is added in compound, is stirred, the gluey mixed soaking solution for possessing certain viscosity is obtained；
Take one piece of common hospital gauze, the hospital gauze in advance by concentrated sodium hydroxide fully activate and aseptic process after,
In the mixed soaking solution that the hospital gauze is immersed in above-mentioned preparation, and hospital gauze and the mass ratio of mixed soaking solution are 1：5,
Keep fully infiltration, it is ensured that hospital gauze tow sides are loaded with mixed soaking solution, take out, mixed soaking solution will be loaded with
Hospital gauze, which is placed in drying box, carries out gradient increased temperature, and programming rate is controlled in 5 DEG C/min or so, is first warming up to after 75 DEG C and is incubated
30min or so, is then further continued for being warming up to 105 DEG C, and is incubated after 20min, stops heating, then temperature is reduced to room naturally
Temperature, i.e. mixed soaking solution prepare the moisture absorption that prevents adhesion of the invention medical in the tow sides formation gel layer of hospital gauze
Acid-sensitive antibacterial gauze.
Embodiment 4
It is 1 by mass ratio：1 folium isatidis and cordate houttuynia mixing, add the water of 4 times of quality, are heated to continuing to decoct after boiling
1h is boiled, the decoction liquor containing filtrate and filter residue is obtained, filtration treatment obtains filtrate, then filtrate progress low-temperature reduced-pressure is concentrated into
The a quarter of former filtrate volume, that is, prepare Chinese medicine extract, gives over to standby；It is 130 to weigh mass ratio：3.5：4：9：
180 Chinese medicine extract, sodium alginate, citric acid, glycerine and water, wherein specific operation process are by citric acid, glycerine
It is dissolved into Chinese medicine extract in water, is sufficiently stirred for obtaining well mixed mixture, then adds into mixture sodium alginate,
Stir, obtain the gluey mixed soaking solution for possessing certain viscosity；
One piece of common hospital gauze is taken, the hospital gauze, will in advance by soda lye activation and aseptic process
The hospital gauze is immersed in the mixed soaking solution of above-mentioned preparation, and hospital gauze and the mass ratio of mixed soaking solution are 1：6, protect
Hold abundant infiltration, it is ensured that hospital gauze tow sides are loaded with mixed soaking solution, take out, the doctor of mixed soaking solution will be loaded with
It is placed in gauze in drying box and carries out gradient increased temperature, programming rate is controlled in 5 DEG C/min or so, is warming up to after 75 DEG C and is incubated
30min or so, is then further continued for being warming up to 110 DEG C, and is incubated after 20min, stops heating, temperature is reduced to room temperature naturally,
I.e. mixed soaking solution prepares the moisture absorption medical antibacterial that prevents adhesion of the present invention in the tow sides formation gel layer of hospital gauze
Gauze.
Understood with reference to Fig. 1, being rich in the gel layer of gauze surface prepared by the embodiment of the present invention 4 has substantial amounts of porous knot
Structure, in order to further simulate the influence of citric acid content and sodium alginate content to water absorption rate in gel layer, has respectively obtained figure
2nd, the test result figure shown in Fig. 3, therefore the preferably mass ratio of each component, antibacterial Chinese medicine extract solution：Sodium alginate：Citric acid：
Glycerine：Water=80~130：2~3.5：2.5~4：5~9：When 100~180, the water absorbing capacity of the gel layer prepared compared with
By force, therefore also just can quick absorbing wound exudate, the relatively dry of wound is kept, while can also play the newborn group of isolation
Knit, prevent the effect of gauze and cambium adhesion.
Understood with reference to Fig. 4, cumulative release of the gel layer for loading Chinese medicine antibacterial agent prepared by the present invention under sour environment
Rate will be significantly larger than neutral or alkaline environment, further verify antibacterial energy of the antiseptic under different pH environment in gel layer
Power, it is the gel layer of unsupported Chinese medicine antibacterial agent respectively in faintly acid A1, neutrality to have made A groups in two groups of check experiments, such as Fig. 5
Anti-bacteria test result figure under A2 and alkalescence A3 environment, B groups be load the gel layer of Chinese medicine antibacterial agent respectively faintly acid B1, in
Property B2 and alkalescence B3 environment under anti-bacteria test result figure, as can be seen from Figure 5, load Chinese medicine antibacterial agent gel layer in weak acid
Property environment under antibacterial ability be it is most strong, this be probably because gel layer in citric acid and sodium alginate between have based on hydrogen bond
Dynamic non-covalent key crosslinking, acid condition can destroy the hydrogen bond crosslinks, discharge antiseptic, so that gel layer is shown
The antiseptic release behavior of acid-sensitive.
Further the antiseptic for loading Chinese medicine antibacterial agent and carried with antibiotics is contrasted, C groups in Fig. 6, Fig. 6 have been obtained
Antibacterial test figure of the gel layer for unsupported antiseptic under weak acid environment is tested, the experiment of D groups is implemented for the load present invention
Antibacterial test figure of the gel layer of load Chinese medicine antibacterial agent prepared by example under weak acid environment, E groups experiment is mould through the ages to load
Antibacterial test figure of the gel layer of element under weak acid environment, it follows that load Chinese medicine antibacterial prepared by the embodiment of the present invention
The antibacterial ability of the gel layer of agent is greater than the gel layer of load vancomycin.
Antibacterial test further is carried out to gauze prepared by the embodiment of the present invention 4, the antibacterial test shown in table 1 has been obtained
List.
The class bacterium of table 1 four acts on the sterilizing rate after 5h with gauze
| Bacterial species | Staphylococcus aureus | Bacillus | Pseudomonas aeruginosa | Escherichia coli |
| Sterilizing rate | 99% | 98% | 95% | 97% |
Meanwhile, in order to test the antibacterial resistance of gauze prepared by the present invention, respectively with staphylococcus aureus, gemma bar
Bacterium, pseudomonas aeruginosa, Escherichia coli are model bacterium, using common broad-spectrum topical antibiotic erythromycin as model drug, are commented
This is loaded with the hospital gauze of Chinese medicine antibacterial gel layer to valency, and the antibacterial gauze of load erythromycin is distinguishing phase interaction with bacterium
With to the drug resistance of erythromycin, having obtained table 2 after 30 days.
The drug resistance test result list of table 2
Understood with reference to Tables 1 and 2, gauze prepared by the present invention possesses preferable antibacterial activity, to common golden yellow Portugal
Grape coccus, bacillus, the bacteriostasis rate of pseudomonas aeruginosa and Escherichia coli reached more than 95%, and prepared by the present invention
Gauze respectively with after above-mentioned four kinds of bacterial interactions 30 days, minimal inhibitory concentration to bacterium is simultaneously not apparent from increase, and loads
Have the hospital gauze of erythromycin respectively with after above-mentioned four kinds of bacterial interactions 30 days, to the minimal inhibitory concentration change of bacterium compared with
Greatly；Therefore, gauze of the invention also suppresses what bacterial drug resistance was produced while good antibiotic property is ensured with obvious
Ability.
Above example is only optimal citing, and is not the restriction to embodiments of the present invention.Except above-described embodiment
Outside, the present invention also has other embodiment.All use equivalent substitutions or the technical scheme of equivalent transformation formation, all fall within the present invention
It is required that protection domain.
Claims (8)
- The medical acid-sensitive antibacterial gauze of moisture absorption 1. one kind prevents adhesion, the medical antibacterial gauze is by hospital gauze base material and sticks to Gel layer composition on hospital gauze base material, it is characterised in that：The gel layer is prepared by mixed soaking solution, the mixing Soak includes antibacterial Chinese medicine extract solution, sodium alginate, citric acid, glycerine and water, and the antibacterial Chinese medicine extract solution is smalt Leaf and the built agent extract of cordate houttuynia.
- 2. the medical acid-sensitive antibacterial gauze of the moisture absorption that prevents adhesion according to claim 1, it is characterised in that：The hospital gauze Base material and the mass ratio of mixed soaking solution are 1：4~6.
- 3. the medical acid-sensitive antibacterial gauze of the moisture absorption that prevents adhesion according to claim 1, it is characterised in that：The mixing immersion The mass ratio of each component is in liquid, antibacterial Chinese medicine extract solution：Sodium alginate：Citric acid：Glycerine：Water=80~130：2~ 3.5：2.5~4：5~9：100~180.
- 4. the medical acid-sensitive antibacterial gauze of the moisture absorption that prevents adhesion according to claim 1, it is characterised in that：The antibacterial Chinese medicine The mass ratio of folium isatidis and cordate houttuynia is 1 in extract solution:1~3.
- 5. a kind of preparation method of the medical acid-sensitive antibacterial gauze of the moisture absorption that prevents adhesion described in claim 1, it is characterised in that：Bag Include following steps：1) antibacterial Chinese medicine extract solution is prepared：Folium isatidis and cordate houttuynia are mixed, boiling is heated to after adding water, continues decoction and is decocted Boil liquid, then decoction liquor is filtered, no slag decoction is obtained, the 20%~30% of institute's amount of water will be concentrated under reduced pressure into without slag decoction, obtained To antibacterial Chinese medicine extract solution；2) mixed soaking solution is prepared：By citric acid, glycerine and step 1) prepare antibacterial Chinese medicine extract solution be dissolved into water, fill Point stirring obtains well mixed mixture, then into gained mixture adds sodium alginate under rapid stirring, obtains To sticky gluey mixed soaking solution；3) the moisture absorption medical antibacterial gauze that prevents adhesion is prepared：By fully activated through concentrated sodium hydroxide and it is pre-sterilized after hospital gauze base Material is immersed in the step 2) prepare mixed soaking solution in, fully infiltration after, take out, be placed in drying box dry, be prepared into The moisture absorption medical antibacterial gauze that prevents adhesion of gel layer is stained with to hospital gauze base material.
- 6. the preparation method of the medical acid-sensitive antibacterial gauze of the moisture absorption that prevents adhesion according to claim 5, it is characterised in that：Institute State step 1) in, it is 1 by mass ratio:1~3 folium isatidis and cordate houttuynia are mixed to get mixing Chinese medicine, and it is mixing to add quality The water that 3~6 times of traditional Chinese medicine quality, is heated to boiling, continues decoction 1h and obtains decoction liquor.
- 7. the preparation method of the medical acid-sensitive antibacterial gauze of the moisture absorption that prevents adhesion according to claim 5, it is characterised in that：Institute State step 2) in, mass ratio is, citric acid：Glycerine：Antibacterial Chinese medicine extract solution：Sodium alginate=2.5~4：5~9：80~ 130：2~3.5.
- 8. the preparation method of the medical acid-sensitive antibacterial gauze of the moisture absorption that prevents adhesion according to claim 5, it is characterised in that：Institute State step 3) in, gradient increased temperature drying is carried out in drying box, i.e., gradually by room temperature to holding 30 after 70~80 DEG C~ 45min, then proceedes to be warming up to 15~25min of holding after 105~110 DEG C, stops heating, temperature is reduced to room temperature naturally.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107670093A (en) * | 2017-11-18 | 2018-02-09 | 安徽玉然经编科技有限公司 | A kind of anti-sticky type antibacterial medical bandage |
| CN109267358A (en) * | 2018-09-20 | 2019-01-25 | 合肥巧织纺织科技有限公司 | A kind of durable antibiotic absorbent cotton |
| CN111514364A (en) * | 2020-03-19 | 2020-08-11 | 中国人民解放军陆军军医大学第二附属医院 | Dressing for perianal infection of patient with malignant hemopathy and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269255A (en) * | 2008-05-14 | 2008-09-24 | 天津大学 | Therapy electrode tablet clamping self-pasting medicament film and preparation method thereof |
| CN102808321A (en) * | 2011-05-31 | 2012-12-05 | 如皋市芳崛工艺编织有限公司 | Antibacterial fabric containing traditional Chinese drug component |
| CN104906620A (en) * | 2015-05-15 | 2015-09-16 | 南阳市汇博生物技术有限公司 | Hydrogel antibacterial gauze dressing and preparation method therefor |
-
2017
- 2017-05-15 CN CN201710337591.5A patent/CN107115553B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269255A (en) * | 2008-05-14 | 2008-09-24 | 天津大学 | Therapy electrode tablet clamping self-pasting medicament film and preparation method thereof |
| CN102808321A (en) * | 2011-05-31 | 2012-12-05 | 如皋市芳崛工艺编织有限公司 | Antibacterial fabric containing traditional Chinese drug component |
| CN104906620A (en) * | 2015-05-15 | 2015-09-16 | 南阳市汇博生物技术有限公司 | Hydrogel antibacterial gauze dressing and preparation method therefor |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107670093A (en) * | 2017-11-18 | 2018-02-09 | 安徽玉然经编科技有限公司 | A kind of anti-sticky type antibacterial medical bandage |
| CN109267358A (en) * | 2018-09-20 | 2019-01-25 | 合肥巧织纺织科技有限公司 | A kind of durable antibiotic absorbent cotton |
| CN111514364A (en) * | 2020-03-19 | 2020-08-11 | 中国人民解放军陆军军医大学第二附属医院 | Dressing for perianal infection of patient with malignant hemopathy and preparation method thereof |
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