CN106729776B - A kind of solid-state medical supersonic coupled patch and preparation method thereof - Google Patents
A kind of solid-state medical supersonic coupled patch and preparation method thereof Download PDFInfo
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- CN106729776B CN106729776B CN201611182255.XA CN201611182255A CN106729776B CN 106729776 B CN106729776 B CN 106729776B CN 201611182255 A CN201611182255 A CN 201611182255A CN 106729776 B CN106729776 B CN 106729776B
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- solid
- state medical
- coupled patch
- medical supersonic
- sesbania gum
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- 238000002360 preparation method Methods 0.000 title claims abstract description 36
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims abstract description 22
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims abstract description 22
- 239000008367 deionised water Substances 0.000 claims abstract description 15
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 15
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- 241000219782 Sesbania Species 0.000 claims description 63
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 24
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 21
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- 239000012530 fluid Substances 0.000 claims description 10
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims description 8
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
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- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 claims description 3
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 239000011630 iodine Substances 0.000 claims description 2
- KRPAJLYSLFNDOA-UHFFFAOYSA-N mephenesin carbamate Chemical compound CC1=CC=CC=C1OCC(O)COC(N)=O KRPAJLYSLFNDOA-UHFFFAOYSA-N 0.000 claims description 2
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- QHZLMUACJMDIAE-UHFFFAOYSA-N Palmitic acid monoglyceride Natural products CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 claims 1
- YAVVGPBYBUYPSR-UHFFFAOYSA-N benzene;oxygen Chemical compound [O].C1=CC=CC=C1 YAVVGPBYBUYPSR-UHFFFAOYSA-N 0.000 claims 1
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- 230000007850 degeneration Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
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- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 3
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- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
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- 241000206575 Chondrus crispus Species 0.000 description 2
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- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 2
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- 229940070765 laurate Drugs 0.000 description 2
- CPTNXTSDQJQEFA-ZKOWQLKRSA-N mastoparan-A Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)=CNC2=C1 CPTNXTSDQJQEFA-ZKOWQLKRSA-N 0.000 description 2
- NSFBOCKFBVQQKB-CQWNSWRRSA-N mastoparan-B Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)=CNC2=C1 NSFBOCKFBVQQKB-CQWNSWRRSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
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- 210000003491 skin Anatomy 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical compound C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- FHYNZKLNCPUNEU-UHFFFAOYSA-N 4-[(3,4-dihydroxyphenyl)methyl]-3-[(4-hydroxyphenyl)methyl]oxolan-2-one Chemical compound C1=CC(O)=CC=C1CC1C(=O)OCC1CC1=CC=C(O)C(O)=C1 FHYNZKLNCPUNEU-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
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- 241000894006 Bacteria Species 0.000 description 1
- WXQDFOGZIYLEGP-UHFFFAOYSA-N C(C(C)C)#N.C(C(C)C)#N.[N] Chemical compound C(C(C)C)#N.C(C(C)C)#N.[N] WXQDFOGZIYLEGP-UHFFFAOYSA-N 0.000 description 1
- 241001478240 Coccus Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229930194542 Keto Natural products 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- BPOZNMOEPOHHSC-UHFFFAOYSA-N butyl prop-2-enoate;prop-2-enoic acid Chemical compound OC(=O)C=C.CCCCOC(=O)C=C BPOZNMOEPOHHSC-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 229920001038 ethylene copolymer Polymers 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 150000003235 pyrrolidines Chemical class 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sustainable Development (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of solid-state medical supersonic coupled patch and preparation method thereof.Described solid-state medical supersonic coupled patch is made up of the component of following percentage by weight meter：Waterborne polymeric gel 20~40%, propylene glycol alginate 2~6%, aliphatic acid trihydroxylic alcohol monoesters 2~8%, NMF 6~12%, preservative 0.01~0.05%, surplus are deionized water, wherein, waterborne polymeric gel by water-soluble acrylic copolymer and is modified sesbania gum with (0.5~1):The weight of (2~4) is than composition.Solid-state medical supersonic coupled patch provided by the invention is stable to light, heat, has the acoustical behavior closest with human body soft tissue, the accuracy height of Ultrasonic Diagnosis, and there is excellent biocompatibility, it is non-toxic to Skin Cell, it is no sensitization, non-stimulated, it is safe.
Description
Technical field
The present invention relates to a kind of coupled patch, and in particular to a kind of solid-state medical supersonic coupled patch and preparation method thereof.
Background technology
Medical ultrasonic coupling agent is the essential medical material of clinical ultrasound diagnosis, and it is to improving ultrasonic diagnostic technique
Definition and resolution ratio play extremely important effect.Medical ultrasonic coupling agent can drive away ultrasonic probe and tissue it
Between air, so as to establish efficiently, the transonic passage of fidelity, preferable couplant, which should possess, leads that acoustic performance is good, image is clear
It is clear, resolving power is high；It is nontoxic to people non-stimulated, with skin and mucosa good biocompatibility；Ultrasonic probe is not damaged, not pollution clothes etc.
Feature.
Traditional ultrasonic coupling agent is mostly liquid, the application in a manner of smearing, but is had some limitations.When using super
During sonic therapy, when the medicine that is absorbed by the skin is used together with fluid couplant, medicine and liquid coupling as therapeutic purposes
Closing piece will mix, it is most likely that produce unpredictable chemical reaction, and can not be applied to human body crooked position or be unsuitable for
The position of contact damage.In addition, being needed to use after, water is cleaned or toilet paper is directly wiped to remove residual coupling agent, this
Sample operation was both inconvenient or unhygienic.
The defects of solid ultrasonic couplant of rising in recent years can overcome liquid ultrasonic couplant above-mentioned, available for body table
Any part in face.Solid ultrasonic couplant is more using aqueous high molecular material as main component in the prior art, and addition is certain
NMF, preservative, the material such as colouring agent, it is cured to be made, such as：The A of Publication No. CN 105536005 Chinese patent Shen
Please disclose a kind of solid-state medical supersonic coupled patch and preparation method thereof, the ultrasonic coupling paster, by mass percentage by with
Lower composition composition：Sodium alginate polymer 1.0%-6.0%, carragheen 1.0%-5.0%, xanthans 0.03%-0.05%, hydroxyl
Methylcellulose 0.1%-0.8%, propane diols 2.0%-15%, glycerine 2.0%-15%, preservative 0.01%-0.12%, it is remaining
Measure as deionized water.But the gel chance light that the carragheen in the patent is formed is degradable, easily loses viscosity, liquefies.
Therefore, it is necessary to develop it is a kind of safely, effectively and stable solid-state medical supersonic coupled patch, to meet market need
Ask.
The content of the invention
To solve the problems, such as that prior art is present, safely, effectively and stable consolidate it is an object of the invention to provide a kind of
State medical supersonic coupled patch and preparation method thereof.
Technical scheme provided by the invention is as follows：
A kind of solid-state medical supersonic coupled patch is made up of the component of following percentage by weight meter：Waterborne polymeric gel 20
~40%, propylene glycol alginate 2~6%, aliphatic acid trihydroxylic alcohol monoesters 2~8%, NMF 6~12%, preservative 0.01~
0.05%th, surplus is deionized water.
Preferably, described solid-state medical supersonic coupled patch is made up of the component of following percentage by weight meter：It is water-based poly-
It is compound gel 30%, propylene glycol alginate 4%, aliphatic acid trihydroxylic alcohol monoesters 6%, NMF 8%, preservative 0.02%, remaining
Measure as deionized water.
Above-mentioned waterborne polymeric gel is by water-soluble acrylic copolymer and modified sesbania gum with (0.5~1):(2~4)
Weight than composition.
Preferably, described waterborne polymeric gel by water-soluble acrylic copolymer and is modified sesbania gum with 0.5:2
Weight is than composition.
Further, described water-soluble acrylic copolymer is acrylic acid-acrylic acid butyl ester-styrol copolymer, is in
Solid-like, compared with other propylene liguid acid copolymers, active ingredient is high and stability is good, described water-soluble acrylic copolymer's
Preparation method is solution polymerization process commonly used in the art, is：
(1) polymerized monomer acrylic acid, butyl acrylate and the styrene after depressurizing and refining are weighed respectively, are mixed, institute
Acrylic acid, butyl acrylate, the weight ratio of styrene stated are 3.2:4.4:0.9, the initiator for then adding 2~3wt% is even
Nitrogen bis-isobutyronitrile (AIBN), mix, add appropriate n-butanol, be configured to the mixed solution that solid content is 10%, it is standby；
(2) take 50mL n-butanols to be placed in reactor, be heated to solvent reflux temperature, slowly dripped in the case where at the uniform velocity stirring
The mixed solution for adding step (1) to be prepared, the volume ratio of the mixed solution and n-butanol is 2:1, rate of addition is
0.8mL/min, in 80~120 DEG C of 4~6h of back flow reaction, after reaction terminates, 60 DEG C are cooled to, ammoniacal liquor is added dropwise under agitation, extremely
The pH value of system discharges to 8~9 and produces copolymer solution, be subsequently placed in 105 DEG C of dryings to constant, produce copolymer.
The preparation method of above-mentioned modification sesbania gum comprises the following steps：
(1) take a certain amount of sesbania gum powder to be scattered in cold water, the glue that mass fraction is 0.4% is made, in stirring shape
1mol/L hydrochloric acid solution modulation pH to 5~6 is added dropwise under state, then toward vinyl pyrrolidone is slowly added dropwise in glue, continues
20min is stirred, glue is then subjected to ultrasonic vibration 10min, and is passed through nitrogen, obtains mixture, it is standby；
(2) mixture that step (1) processing obtains is subjected to gamma-radiation 10~15min of radiation treatment, then takes out placement
2~3h, the absolute ethyl alcohol of 2~3 times of volumes is slowly added dropwise under agitation, continues to stir 5min, 2000r/min centrifugation 15min, take
Precipitation plus water stirring and dissolving, are slowly added dropwise the absolute ethyl alcohols of 2~3 times of volumes again, 4000r/min centrifugation 10min, will precipitate into
Row drying, obtains crude extract；
(3) the obtained crude extract of step (2) processing is placed in apparatus,Soxhlet's, adds absolute ethyl alcohol extracting 24h, with except
The polyvinylpyrrolidone of dereaction generation, is then dried in vacuo under the conditions of 50 DEG C, produces the modification sesbania gum of purifying.
Further, the sesbania gum powder and vinyl pyrrolidone in the preparation method step (1) of the modified sesbania gum
Mass ratio be 1:4.
Further, the gamma-radiation dose of radiation in the preparation method step (2) of the modified sesbania gum be 3~
20kGy。
Further, described aliphatic acid trihydroxylic alcohol monoesters is Glyceryl Monolaurate, glycerol stearate monoesters, palmitic acid
At least one of monoglyceride, cardamom monoglyceride.
Further, described NMF is polyalcohols, polysaccharide, natural SP, NMF-50, saualane and pyrrolidines
At least one of keto carboxylic acid sodium.
Further, described preservative is dimethyl OIT, in imidazolidinyl urea, dihydroxymethyl dimethyl second
At least one of uride, Phenoxyethanol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDMH.
In addition, the present invention also provides a kind of preparation method of described solid-state medical supersonic coupled patch, it includes following
Step：
(1) toward water is added in water-soluble acrylic copolymer, stir to being completely dissolved, then a small amount of add is modified several times
Sesbania gum, vibration 30~60min of dissolving, obtains mixture；
(2) propylene glycol alginate, aliphatic acid trihydroxylic alcohol monoesters are added in the mixture obtained toward step (1), is warming up to
50~60 DEG C, insulation continues 25~30min of stirring, then adds NMF, is uniformly mixed；
(3) treat that the material that step (2) obtains is cooled to room temperature, add preservative, and stir, finished fluid is made；
(4) finished fluid is vacuumized into 6~10min of defoaming, then injects mould under vacuum, it is cured, it is stripped, bag
Dress, produces solid-state medical supersonic coupled patch.
The use of B ultrasound equipment can be made according to the needs of clinical practice in solid-state medical supersonic coupled patch of the present invention
Stock size, shape, including but not limited to MP-A types, irregular shape specification MP-B types.
Described MP-A type circle specifications, diameter × thickness：90×8mm、90×10mm、90×15mm、90×20mm、
100×10mm、100×15mm、100×20mm、90×25mm、20×2mm、25×2mm、20×5mm。
Described irregular shape specification MP-B types：B1、B2、B3、B4、B5、B6、B7、B8、B9.
Solid-state medical supersonic coupled patch outward appearance of the present invention is translucent or transparent shape, and can be corresponding by adding
Colouring agent be made with coloured coupled patch.
Above-mentioned modification sesbania gum is sesbania gum and vinyl pyrrolidone graft copolymer, has good bio-compatible
Property and biodegradability, pass through the hydroxyl on the main chain of sesbania gum molecule, side chain, carboxyl isoreactivity group introduce vinyl
Pyrrolidones, light, the heat endurance of sesbania gum are remarkably improved, and there is certain adjustment effect to the viscosity of sesbania gum, dropped
The viscosity of low sesbania gum, the gel strength of sesbania gum is improved, the gel mechanical property formed it into is close with tissue.Work as field
Mountain valley with clumps of trees and bamboo glue is with vinyl pyrrolidone using mass ratio as 1:The ratio of (3~6) is reacted, and grafting rate is with vinyl pyrrolidone
Dosage increase and increase, but vinyl pyrrolidone self-polymerization degree is also increasing simultaneously, causes vinyl pyrrolidone
The conversion ratio of monomer reduces, when sesbania gum with vinyl pyrrolidone using mass ratio as 1:4 ratio is reacted, vinylpyridine
The conversion ratio of pyrrolidone monomer reaches optimal, and up to 43.85%, and grafting rate is up to 108.16%.
The present invention is coupled as solid ultrasonic and pasted using acrylic acid-acrylic acid butyl ester-styrol copolymer and modified sesbania gum
The waterborne polymeric gel of piece, is combined with natural gum material and high polymer material, and two kinds of components complement each other, described propylene
Acid-n butyl acrylate styrene can make up toughness deficiency, low intensity and the tissue load ability of modified sesbania gum gel
The defects of poor, while the excellent cohesive of modified sesbania gum, thickening property, film forming can be given full play to.In addition, described propylene
Acid-n butyl acrylate styrene can also effectively prevent waterborne polymeric gel from aging phenomenon occurs.
Described propylene glycol alginate is advantageous to improve modified sesbania gum salt-resistance, prevent from being modified sesbania gum and metal from
Son crosslinks, and forms the high viscoplasticity frozen glue of the network structure with certain water-resistance.Described aliphatic acid trihydroxylic alcohol monoesters
The monoesters to be formed is reacted for the aliphatic acid such as stearic acid, laurate, palmitic acid, myristic acid, oleic acid and glycerine, property is gentle, can
Effectively suppress solid ultrasonic coupled patch and foaming is formed in preparation process, there is manufactured solid ultrasonic coupled patch good
Sound conductive performance.
Compared with prior art, advantage of the invention is that：
(1) solid-state medical supersonic coupled patch of the invention is flexible and high resilience, any surface finish are colorless and transparent, and
Bubble-free, without insoluble foreign matter, there is the acoustical behavior closest with human body soft tissue, its velocity of sound, acoustic characteristic impedance rate harmony
Attenuation coefficient slope meets《People's Republic of China's pharmaceuticals industry standard》On medical ultrasonic coupling agent in YY0299-2008
Standard, have higher Ultrasonic Diagnosis accuracy.
(2) solid-state medical supersonic coupled patch provided by the invention has excellent biocompatibility, to Skin Cell without
Toxicity, it is no sensitization, non-stimulated, safe and stable to light, heat, placed 180 days at 37 DEG C or place 90 at 50 DEG C
My god, its smooth in appearance, without liquefaction phenomenon on surface, and do not occur going mouldy or peculiar smell, stability are good.
(3) solid-state medical supersonic coupled patch provided by the invention is solid-state, thus transport, storage and easy to use and warp
Ji.
Embodiment
The present invention is further described below by way of embodiment, but the present invention is not limited only to following examples.
Embodiment 1 is modified sesbania gum preparation and performance detection
The preparing raw material of the modified sesbania gum of A-D groups see the table below：
| Group | A groups | B groups | C groups | D groups |
| Sesbania gum powder:Vinyl pyrrolidone (mass ratio) | 1:3 | 1:4 | 1:5 | 1:6 |
Preparation method：
(1) take a certain amount of sesbania gum powder to be scattered in cold water, the glue that mass fraction is 0.4% is made, in stirring shape
1mol/L hydrochloric acid solution modulation pH to 6 is added dropwise under state, then toward vinyl pyrrolidone is slowly added dropwise in glue, continues to stir
20min, glue is then subjected to ultrasonic vibration 10min, and is passed through nitrogen, obtain mixture, it is standby；
(2) the obtained mixture of step (1) processing being subjected to gamma-radiation radiation treatment 12min, dose of radiation is 3~
20kGy, then take out and place 3h, the absolute ethyl alcohol of 2 times of volumes is slowly added dropwise under agitation, continue to stir 5min, 2000r/min
15min is centrifuged, takes precipitation plus water stirring and dissolving, the absolute ethyl alcohol of 2 times of volumes, 4000r/min centrifugations are slowly added dropwise again
10min, precipitation is dried, obtains crude extract；
(3) the obtained crude extract of step (2) processing is placed in apparatus,Soxhlet's, adds absolute ethyl alcohol extracting 24h, with except
The polyvinylpyrrolidone of dereaction generation, is then dried in vacuo under the conditions of 50 DEG C, produces the modification sesbania gum of purifying.
Modified sesbania gum performance detection：
Grafting rate %=(W2-W1)/W1× 100, monomer conversion %=(W2-W1)/W3× 100, wherein, W1For sesbania gum
The quality of powder, W2For the quality of modified sesbania gum, W3For the quality of vinyl pyrrolidone.
As a result it see the table below 1.
Table 1 is modified sesbania gum grafting rate and vinylpyrrolidone monomer conversion ratio
| Group | A groups | B groups | C groups | D groups |
| Grafting rate (%) | 105.73 | 108.16 | 112.35 | 115.04 |
| Monomer conversion (%) | 42.28 | 43.85 | 39.54 | 34.72 |
As a result show, sesbania gum is with vinyl pyrrolidone using mass ratio as 1:The ratio of (3~6) is reacted, grafting
Rate is as the dosage of vinyl pyrrolidone increases and increases, but vinyl pyrrolidone self-polymerization degree is also increasing simultaneously
Add, cause the conversion ratio of vinylpyrrolidone monomer to reduce, when sesbania gum with vinyl pyrrolidone using mass ratio as 1:4
Ratio is reacted, and the conversion ratio of vinylpyrrolidone monomer reaches optimal, and up to 43.85%, and grafting rate is up to 108.16%
(B groups).
The preparation of sterile medical supersonic coupled patch is used as raw material using modified sesbania gum made from B groups below.
The preparation of the solid-state medical supersonic coupled patch of embodiment 2
The solid-state medical supersonic coupled patch of the embodiment of the present invention 2 is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 30%, propylene glycol alginate 4%, Glyceryl Monolaurate 6%, polyethylene glycol 8%, imidazolidinyl urea
0.02%th, surplus is deionized water, and wherein waterborne polymeric gel by acrylic acid-acrylic acid butyl ester-styrol copolymer and changes
Property sesbania gum is with 0.5:2 weight is than composition.
Preparation method：
(1) toward water is added in acrylic acid-acrylic acid butyl ester-styrol copolymer, stir to being completely dissolved, then several times
It is a small amount of to add modified sesbania gum, vibration dissolving 50min, obtain mixture；
(2) propylene glycol alginate, Glyceryl Monolaurate are added in the mixture obtained toward step (1), is warming up to 55
DEG C, insulation continues to stir 30min, then adds polyethylene glycol, is uniformly mixed；
(3) treat that the material that step (2) obtains is cooled to room temperature, add imidazolidinyl urea, and stir, finished product is made
Liquid；
(4) finished fluid is vacuumized into defoaming 8min, then injects mould under vacuum, it is cured, it is stripped, packaging,
Produce solid-state medical supersonic coupled patch.
The preparation of the solid-state medical supersonic coupled patch of embodiment 3
The solid-state medical supersonic coupled patch of the embodiment of the present invention 3 is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 35%, propylene glycol alginate 3%, Glyceryl Monolaurate 4%, polyethylene glycol 6%, dimethyl OIT
0.03%th, surplus is deionized water, and wherein waterborne polymeric gel by acrylic acid-acrylic acid butyl ester-styrol copolymer and changes
Property sesbania gum is with 0.5:2 weight is than composition.
Preparation method reference implementation example 2.
The preparation of the solid-state medical supersonic coupled patch of embodiment 4
The solid-state medical supersonic coupled patch of the embodiment of the present invention 4 is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 22%, propylene glycol alginate 6%, Glyceryl Monolaurate 8%, polyethylene glycol 12%, Phenoxyethanol 0.05%,
Surplus is deionized water, and wherein waterborne polymeric gel is by acrylic acid-acrylic acid butyl ester-styrol copolymer and modified sesbania gum
With 0.5:2 weight is than composition.
Preparation method reference implementation example 2.
The preparation of the solid-state medical supersonic coupled patch of embodiment 5
The solid-state medical supersonic coupled patch of the embodiment of the present invention 5 is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 30%, propylene glycol alginate 4%, glycerol stearate monoesters 6%, pyrrolidone sodium carboxylate 8%, acyl in DMDM second
Urea 0.04%, surplus are deionized water, wherein waterborne polymeric gel by acrylic acid-acrylic acid butyl ester-styrol copolymer and
Modified sesbania gum is with 1:2 weight is than composition.
Preparation method reference implementation example 2.
The preparation of the solid-state medical supersonic coupled patch of embodiment 6
The solid-state medical supersonic coupled patch of the embodiment of the present invention 6 is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 30%, propylene glycol alginate 4%, cardamom monoglyceride 6%, NMF-50 8%, dihydroxymethyl dimethyl second
Interior uride 0.02%, surplus are deionized water, and wherein waterborne polymeric gel is by acrylic acid-acrylic acid butyl ester-styrene copolymerized
Thing and modified sesbania gum are with 1:4 weight is than composition.
Preparation method reference implementation example 2.
The preparation of the solid-state medical supersonic coupled patch of comparative example 1
The solid-state medical supersonic coupled patch of comparative example 1 of the present invention is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 30%, propylene glycol alginate 4%, Glyceryl Monolaurate 6%, polyethylene glycol 8%, imidazolidinyl urea
0.02%th, surplus is deionized water, and wherein waterborne polymeric gel is only made up of modified sesbania gum.
Preparation method reference implementation example 2, the difference of this comparative example and embodiment 2 is, described waterborne polymeric gel
Lack acrylic acid-acrylic acid butyl ester-styrol copolymer, be only made up of modified sesbania gum.
The preparation of the solid-state medical supersonic coupled patch of comparative example 2
The solid-state medical supersonic coupled patch of comparative example 2 of the present invention is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 30%, propylene glycol alginate 4%, Glyceryl Monolaurate 6%, polyethylene glycol 8%, imidazolidinyl urea
0.02%th, surplus is deionized water, and wherein waterborne polymeric gel waterborne polymeric gel is by acrylic acid-acrylic acid butyl ester-benzene
Ethylene copolymer and sesbania gum are with 0.5:2 weight is than composition.
Preparation method reference implementation example 2, the difference of this comparative example and embodiment 2 is, described waterborne polymeric gel
In modification sesbania gum replace with sesbania gum.
The preparation of the solid-state medical supersonic coupled patch of comparative example 3
The solid-state medical supersonic coupled patch of comparative example 3 of the present invention is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 30%, Glyceryl Monolaurate 6%, polyethylene glycol 12%, imidazolidinyl urea 0.02%, surplus are deionized water,
Wherein waterborne polymeric gel waterborne polymeric gel is by acrylic acid-acrylic acid butyl ester-styrol copolymer and modified sesbania gum
With 0.5:2 weight is than composition.
Preparation method reference implementation example 2, the difference of this comparative example and embodiment 2 is, does not add propylene glycol alginate,
And accordingly increase the dosage of NMF polyethylene glycol.
The preparation of the solid-state medical supersonic coupled patch of comparative example 4
The solid-state medical supersonic coupled patch of comparative example 4 of the present invention is made up of the component of following percentage by weight meter：It is water-based poly-
Compound gel 30%, propylene glycol alginate 6%, polyethylene glycol 12%, imidazolidinyl urea 0.02%, surplus are deionized water,
Wherein waterborne polymeric gel waterborne polymeric gel is by acrylic acid-acrylic acid butyl ester-styrol copolymer and modified sesbania gum
With 0.5:2 weight is than composition.
Preparation method reference implementation example 2, the difference of this comparative example and embodiment 2 is, does not add Glyceryl Monolaurate,
And accordingly increase the dosage of propylene glycol alginate and NMF polyethylene glycol.
Test example one, the detection of solid-state medical supersonic coupled patch physicochemical property
According to《Pharmacopoeia of People's Republic of China》Version, GB/T15261-2008, GB/T16886.5-2003, GB/ in 2010
2.1.11.3.1 items in T16886.10-2005, Ministry of Public Health's disinfection technology standard (version in 2002), the present invention is implemented respectively
Outward appearance, pH value, density and the acoustical behavior of solid-state medical supersonic coupled patch are detected made from example 2-6 and comparative example 1-4,
As a result 2 be see the table below.
The testing result of the outward appearance of the solid-state medical supersonic coupled patch of the present invention of table 2, pH value and density
The acoustical behavior testing result of the solid-state medical supersonic coupled patch of the present invention of table 3
| Group | The velocity of sound (m/s) | Acoustic characteristic impedance rate (Pa.s/m) | Acoustic attenuation coefficient slope (dB/cm.MHz) |
| Embodiment 2 | 1584 | 1.63×106 | 0.036 |
| Embodiment 3 | 1592 | 1.65×106 | 0.041 |
| Embodiment 4 | 1568 | 1.61×106 | 0.030 |
| Embodiment 5 | 1590 | 1.65×106 | 0.038 |
| Embodiment 6 | 1598 | 1.66×106 | 0.039 |
| Comparative example 1 | 1655 | 1.75×106 | 0.056 |
| Comparative example 2 | 1642 | 1.73×106 | 0.053 |
| Comparative example 3 | 1632 | 1.70×106 | 0.050 |
| Comparative example 4 | 1620 | 1.68×106 | 0.045 |
From upper table 2, solid-state medical supersonic coupled patch made from 2-6 of the embodiment of the present invention is colorless and transparent, and
Bubble-free, without insoluble foreign matter, density is 1.027~1.042g/cm3, pH value is 6.94~7.10, is met《The Chinese people are total to
With state's medicine professional standard》Standard in YY0299-2008 on medical ultrasonic coupling agent.And the shortage laurate of comparative example 4 is sweet
There is a small amount of bubble in oily monoesters, obtained ultrasonic coupling paster.
From upper table 3, the velocity of sound of solid-state medical supersonic coupled patch made from 2-6 of the embodiment of the present invention be 1568~
1605m/s, acoustic characteristic impedance rate are 1.61 × 106~1.67 × 106Pa.s/m, acoustic attenuation coefficient slope be 0.030~
0.041dB/cm.MHz, meet《People's Republic of China's pharmaceuticals industry standard》On the ultrasonic coupling of medicine in YY0299-2008
(velocity of sound is 1520~1620m/s to the standard of mixture, acoustic characteristic impedance rate is 1.5 × 106~1.7 × 106Pa.s/m, acoustic attenuation system
Number slope≤0.05dB/cm.MHz), there is excellent acoustical behavior, and with ultrasonic coupling paster and human body made from embodiment 2
The bulk sound velocity 1540m/s of soft tissue, acoustic characteristic impedance rate are 1.59 × 106Pa.s/m is closest, and acoustic attenuation coefficient slope is most
Small, acoustical behavior is optimal.And the waterborne polymeric gel shortage acrylic acid-acrylic acid butyl ester described in comparative example 1-styrene copolymerized
Thing, only it is made up of modified sesbania gum, or modified sesbania gum is replaced with sesbania gum in comparative example 2, both obtained ultrasonic coupling patches
The velocity of sound, acoustic characteristic impedance rate and the acoustic attenuation coefficient slope of piece are beyond standard；Comparative example 3 and comparative example 4 lack sea respectively
Propylene glycol alginate and Glyceryl Monolaurate, the velocity of sound, acoustic characteristic impedance rate and the acoustic attenuation system of obtained ultrasonic coupling paster
Number slope increased.
Result above shows, is made up of acrylic acid-acrylic acid butyl ester-styrol copolymer and modified sesbania gum water-based poly-
Compound gel is that solid-state medical supersonic coupled patch made of primary raw material has an excellent acoustical behavior, and ultrasonic conducting effect is good
It is good, and propylene glycol alginate and Glyceryl Monolaurate are to keeping acoustical behavior to play an important roll.
Test example two, solid-state medical supersonic coupled patch limit test of microbe
According to GB/T15979-2002《The evaluation criterion of amenities》Regulation, respectively to 2-6 of the embodiment of the present invention and right
Solid-state medical supersonic coupled patch carries out limit test of microbe in ratio 1-4, as a result see the table below 4.
The microbial limit testing result of the solid-state medical supersonic coupled patch of the present invention of table 4
From upper table 4, solid-state medical supersonic coupled patch made from 2-6 of the embodiment of the present invention and comparative example 1-4, detection
Total number of bacteria≤200cfu/g, total number of fungi≤100cfu/g, and do not detect coliform, Pseudomonas aeruginosa and golden yellow grape
The pathogenic bacteria such as coccus, meet《The evaluation criterion of amenities》In standard on microbial limit.
The biocompatibility test of test example three, solid-state medical supersonic coupled patch
According to GB/T16886.5-2003 and GB/T16886.10-2005 respectively to the embodiment of the present invention 2,5,6 and contrast
Finished fluid in example 2 before the solidification of solid-state medical supersonic coupled patch carries out cell toxicity test, stimulation and sensitization and tested, as a result
It see the table below 5 and 6.
Toxicity test result of the ultrasonic coupling paster finished fluid of the present invention of table 5 to L-929 l cells
| Group | Phenomenon | Conclusion |
| Embodiment 2 | Intensive regular, the triangular in shape or fusiformis of cell arrangement, have no cell degeneration or necrosis | It is non-toxic |
| Embodiment 5 | Intensive regular, the triangular in shape or fusiformis of cell arrangement, have no cell degeneration or necrosis | It is non-toxic |
| Embodiment 6 | Intensive regular, the triangular in shape or fusiformis of cell arrangement, have no cell degeneration or necrosis | It is non-toxic |
| Comparative example 2 | Intensive regular, the triangular in shape or fusiformis of cell arrangement, have no cell degeneration or necrosis | It is non-toxic |
Acute skin irritation and sensitization result of the test of the ultrasonic coupling paster finished fluid of the present invention of table 6 to cavy
| Group | Stimulate phenomenon | Conclusion |
| Embodiment 2 | Without erythema, without oedema | It is non-stimulated, without sensitization |
| Embodiment 5 | Without erythema, without oedema | It is non-stimulated, without sensitization |
| Embodiment 6 | Without erythema, without oedema | It is non-stimulated, without sensitization |
| Comparative example 2 | Without erythema, without oedema | It is non-stimulated, without sensitization |
From upper table 5 and 6, the ultrasonic coupling paster finished fluid of the embodiment of the present invention 2,5,6 and comparative example 2 is to L-929
The no any influence of growth of l cell, and cavy will not be caused the excitants such as erythema, oedema or anaphylaxis occur
Symptom, show that solid-state medical supersonic coupled patch provided by the invention is safe, there is excellent biocompatibility.
Test example four, solid-state medical supersonic coupled patch stability inspection
Take solid-state medical supersonic coupled patch made from the comparative example 1-4 of 3 batch embodiment 2,5,6 to pack respectively to be placed in
37 DEG C of preservation 180d, 50 DEG C of preservation 90d, lucifuge, does not observe the change of ultrasonic coupling paster, as a result see the table below 7.
The stability test result of the solid-state medical supersonic coupled patch of the present invention of table 7
| Group | 37 DEG C, 180d | 50 DEG C, 90d |
| Embodiment 2 | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell |
| Embodiment 5 | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell |
| Embodiment 6 | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell |
| Comparative example 1 | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell | Smooth in appearance, without liquefaction but occur tacky, metaboly |
| Comparative example 2 | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell | Smooth in appearance, there is a small amount of drop, occur going mouldy and peculiar smell |
| Comparative example 3 | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell |
| Comparative example 4 | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell | Smooth in appearance, without liquefaction, without going mouldy or peculiar smell |
From embodiment 2,5,6, sesbania gum after modified has preferable light, heat endurance, under the conditions of 50 DEG C
Place 90 days, obtained ultrasonic coupling paster smooth in appearance, without liquefaction, without going mouldy or peculiar smell, and with sesbania gum directly as original
Ultrasonic coupling paster made from material is placed 90 days under the conditions of 50 DEG C, a small amount of drop is occurred, is gone mouldy or phenomena such as peculiar smell, sees contrast
Example 2.In addition, the only modified sesbania gum composition of waterborne polymeric gel, acrylic acid-acrylic acid butyl ester-styrene copolymerized is not added
Thing, there are the aging phenomena such as tacky, deformation in appearance after obtained ultrasonic coupling paster is placed 90 days under the conditions of 50 DEG C, sees contrast
Example 1；Propylene glycol alginate or aliphatic acid trihydroxylic alcohol monoesters are not added, does not influence the stability of ultrasonic coupling paster, are seen pair
Ratio 3,4.Result above shows that addition acrylic acid-acrylic acid butyl ester-styrol copolymer is advantageous to raising waterborne polymeric and coagulated
The ageing resistance of glue, sesbania gum after modified are advantageous to the light of raising waterborne polymeric gel, heat endurance.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (7)
1. a kind of solid-state medical supersonic coupled patch, it is characterised in that described solid-state medical supersonic coupled patch is by following heavy
Measure the component composition of percentages：Waterborne polymeric gel 20 ~ 40%, propylene glycol alginate 2 ~ 6%, aliphatic acid trihydroxylic alcohol
Monoesters 2 ~ 8%, NMF 6 ~ 12%, preservative 0.01 ~ 0.05%, surplus are deionized water；
Wherein, described waterborne polymeric gel by water-soluble acrylic copolymer and is modified sesbania gum with (0.5 ~ 1):(2~4)
Weight than composition；
Described water-soluble acrylic copolymer is acrylic acid-acrylic acid butyl ester-styrol copolymer；
The preparation method of the modified sesbania gum comprises the following steps：
（1）Take a certain amount of sesbania gum powder to be scattered in cold water, the glue that mass fraction is 0.4% is made, is dripped under stirring
Add 1mol/L hydrochloric acid solution to modulate pH to 5 ~ 6, then toward vinyl pyrrolidone is slowly added dropwise in glue, continue to stir
20min, glue is then subjected to ultrasonic vibration 10min, and is passed through nitrogen, obtain mixture, it is standby；
（2）By step（1）Handle obtained mixture and carry out gamma-radiation 10 ~ 15min of radiation treatment, then take out 2 ~ 3h of placement,
The absolute ethyl alcohol of 2 ~ 3 times of volumes is slowly added dropwise under agitation, continues to stir 5min, 2000r/min centrifugation 15min, takes precipitation to add
Water stirring and dissolving, the absolute ethyl alcohol of 2 ~ 3 times of volumes is slowly added dropwise again, 4000r/min centrifugation 10min, precipitation is dried,
Obtain crude extract；
（3）By step（2）Handle obtained crude extract to be placed in apparatus,Soxhlet's, absolute ethyl alcohol extracting 24h is added, to remove instead
The polyvinylpyrrolidone that should be generated, then it is dried in vacuo under the conditions of 50 DEG C, produces the modification sesbania gum of purifying.
2. solid-state medical supersonic coupled patch according to claim 1, it is characterised in that described solid-state medical supersonic coupling
Paster is closed to be made up of the component of following percentage by weight meter：Waterborne polymeric gel 30%, propylene glycol alginate 4%, aliphatic acid
Trihydroxylic alcohol monoesters 6%, NMF 8%, preservative 0.02%, surplus are deionized water.
3. solid-state medical supersonic coupled patch according to claim 1, it is characterised in that described waterborne polymeric gel
By water-soluble acrylic copolymer and modified sesbania gum with 0.5:2 weight is than composition.
4. solid-state medical supersonic coupled patch according to claim 1, it is characterised in that the preparation of the modified sesbania gum
Method and step（1）In sesbania gum powder and vinyl pyrrolidone mass ratio be 1:4.
5. solid-state medical supersonic coupled patch according to claim 1, it is characterised in that the preparation of the modified sesbania gum
Method and step（2）In gamma-radiation dose of radiation be 3 ~ 20kGy.
6. solid-state medical supersonic coupled patch according to claim 1 or 2, it is characterised in that described aliphatic acid ternary
Alcohol monoesters is at least one in Glyceryl Monolaurate, glycerol stearate monoesters, palmitic acid monoglyceride, cardamom monoglyceride
Kind；
Described NMF is at least one in polyethylene glycol, natural SP, NMF-50, saualane and pyrrolidone sodium carboxylate
Kind；
Described preservative is dimethyl OIT, imidazolidinyl urea, dimethyloldimethylhydantoin, benzene oxygen second
At least one of alcohol, iodine propilolic alcohol butyl mephenesin Carbamate, DMDMH.
A kind of 7. method for preparing the solid-state medical supersonic coupled patch as described in claim 1-6 is any, it is characterised in that bag
Include following steps：
（1）Water is added into water-soluble acrylic copolymer, is stirred to being completely dissolved, it is then a small amount of several times to add the modified field mountain valley with clumps of trees and bamboo
Glue, vibration 30 ~ 60min of dissolving, obtains mixture；
（2）Toward step（1）Propylene glycol alginate, aliphatic acid trihydroxylic alcohol monoesters are added in obtained mixture, is warming up to 50 ~ 60
DEG C, insulation continues 25 ~ 30min of stirring, then adds NMF, is uniformly mixed；
（3）Treat step（2）Obtained material is cooled to room temperature, adds preservative, and stirs, and finished fluid is made；
（4）Finished fluid is vacuumized into 6 ~ 10min of defoaming, then injects mould under vacuum, it is cured, it is stripped, packaging, i.e.,
Obtain solid-state medical supersonic coupled patch.
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