CN106729600A - A kind of Western medicine compound for obesity - Google Patents

A kind of Western medicine compound for obesity Download PDF

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CN106729600A
CN106729600A CN201611102259.2A CN201611102259A CN106729600A CN 106729600 A CN106729600 A CN 106729600A CN 201611102259 A CN201611102259 A CN 201611102259A CN 106729600 A CN106729600 A CN 106729600A
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parts
vitamin
acid
mortar
western medicine
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不公告发明人
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Zhengzhou Chenghe Information Technology Co Ltd
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Abstract

The invention discloses a kind of Western medicine compound for obesity, including following weight fraction raw material：10 15 parts of soyabean protein powder, 5 15 parts of olive oil, 15 parts of acetylsalicylic acid, 5 10 parts of linoleic acid, 35 parts of citric acid, 0.01 0.1 parts of vitamin A, 0.01 0.1 parts of bata-carotene, 0.01 0.1 parts of vitamin D, 0.01 0.1 parts of vitamin B1,0.01 0.1 parts of vitamin B2,0.01 0.1 parts of nicotinic acid, 0.01 0.1 parts of vitamin C, 25 parts of xylitol, 58 parts of tartaric acid, 25 parts of promethazine hydrochloride piece.The Western medicine compound can obviously reduce body weight and food ration, reduce blood plasma HbA1c, LDL and TG level, suppress blood glucose rise, suppresses adipose tissue HMGB1 expression and declines, raising HDL levels；Also have the advantages that preparation method is simple, curative effect is short, instant effect, toxic and side effect it is small.

Description

A kind of Western medicine compound for obesity
Technical field
The present invention relates to a kind of technical field of western medicines, specifically a kind of Western medicine compound for obesity.
Background technology
Obesity is a kind of chronic metabolic disease caused by many factors, with the volume and cell of body fat cell The percentage that number increases cause body fat percentage of liveweight increases and with the characteristics of some local excessive deposition fat extremely.Simple obesity is suffered from Person's TBF is distributed than more uniform, does not have endocrine disturbance phenomenon, and also without dysbolism disease, often there is obesity in its family Medical history.
The treatment of current obesity patient generally uses following methods：1）It is appropriate to lower meals heat.Intake heat is less than Consumption of calorie, body fat is progressively decomposed during negative balance, and body weight progressively declines；2）Replace high heat food with low calorie foods, use poultry Meat, lean meat replace fat meat.Replace the dessert that sugar is more, oil is big with egg, milk, bean product.Chocolate, cream ice cream, candy Should not eat；3）Increase vegetables, beans, bean product etc. while the food that sugar is more, oil is big, calorific value is high is reduced；Stem class vegetables are such as Celery, rape, pakchoi；Melon vegetables such as wax gourd, cucurbita pepo etc.；4）Pay the utmost attention to cut down staple food.Staple food is eaten as fat meat Obtaining excessively can all cause simple obesity；5）Gradually reduce the food that sugar is more, oil is big, nutritive value is not high, such as dessert, fried Snack, western fast food, sweet drink etc.；6）Supplement various vitamins.Do not eaten when TV is seen.No drinking；7）Exercising with oxygen, Such as walking, jog, aerobic behaviour, dancing, cycling, swimming, rope skipping, stair climbing；8）Healthy lifestyles are set up, rationally Nutrition, actively takes exercise, sufficient sleep, is good at adjusting psychological pressure, keeps setting the mind at rest；Non-smoking, do not take drugs, do not indulge in excessive drinking.
But not only curative effect is long for above-mentioned treatment method, slowly effect, and Most patients can not adhere to getting off, and delay The state of an illness, therefore, the present invention provides a kind of compound Western medicine preparation that can effectively treat obesity, and not only curative effect is short, instant effect, It is safe and toxic and side effect is small.
The content of the invention
It is an object of the invention to provide a kind of Western medicine compound for obesity, to solve to be carried in above-mentioned background technology The problem for going out.
To achieve the above object, the present invention provides following technical scheme：
A kind of Western medicine compound for obesity, including following weight fraction raw material：Soyabean protein powder 10-15 parts, olive Oily 5-15 parts, acetylsalicylic acid 1-5 parts, linoleic acid 5-10 parts, citric acid 3-5 parts, vitamin A 0.01-0.1 parts, beta carotene 0.01-0.1 parts, vitamin D 0.01-0.1 parts, vitamin B1 0.01-0.1 parts, vitamin B2 0.01-0.1 parts, vitamin PP 0.01-0.1 parts, vitamin C 0.01-0.1 parts, xylitol 2-5 parts, tartaric acid 5-8 parts, 2-5 parts of promethazine hydrochloride piece.
As further scheme of the invention：Raw material including following weight fraction：12 parts of soyabean protein powder, olive oil 8 Part, 2 parts of acetylsalicylic acid, 6 parts of linoleic acid, 4 parts of citric acid, 0.05 part of vitamin A, 0.03 part of beta carotene, vitamin D 0.02 Part, 0.02 part of vitamin B1,0.03 part of vitamin B2,0.02 part of nicotinic acid, 0.02 part of vitamin C, xylitol 4.3 Part, 6.2 parts of tartaric acid, 3.5 parts of promethazine hydrochloride piece.
A kind of preparation method of Western medicine compound for obesity, concretely comprises the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 10-15 minutes in being added to nonmetallic mortar, and closed black out is saved backup；
（2）In desinfection chamber, take during linoleic acid, citric acid are added to above-mentioned nonmetallic mortar and grind well 1-3 minutes, closed black out is protected Deposit standby；
（3）In desinfection chamber, take tartaric acid and grind well 1-3 minutes during acetylsalicylic acid is added to above-mentioned nonmetallic mortar, closed black out Save backup；
（4）In desinfection chamber, promethazine hydrochloride piece is put into after frying 1-2min in olive oil and taken out, cooling is standby；
（5）Promethazine hydrochloride piece after will be fried is put into above-mentioned nonmetallic mortar and is ground well 1-3 minutes, and closed black out preserves standby With；
（6）In desinfection chamber, take during soyabean protein powder, xylitol are added to above-mentioned nonmetallic mortar and mix, and be pressed into 0.1-1 Gram piece, grain, ball, get product.
Compared with prior art, the beneficial effects of the invention are as follows：
First, the Western medicine compound has preferable therapeutic effect in terms of obesity is treated, and can obviously reduce body weight and food ration, Blood plasma HbA1c, LDL and TG level is reduced, suppresses blood glucose rise, suppressed adipose tissue HMGB1 expression and decline, raising HDL levels, It is a kind of medicine for safely and effectively treating obesity；
2nd, raw material is easy to get, and cost of material is low, and preparation method is simple, is conducive to marketing；
3rd, application method is simple, and user need not move and go on a diet, it is easier to adhere to, and curative effect is short, instant effect, and Toxic and side effect is small, safe.
Specific embodiment
The technical scheme of this patent is described in more detail with reference to specific embodiment.
Embodiment 1
A kind of Western medicine compound for obesity, including following weight fraction raw material：10 parts of soyabean protein powder, olive oil 5 Part, 1 part of acetylsalicylic acid, 5 parts of linoleic acid, 3 parts of citric acid, 0.01 part of vitamin A, 0.01 part of beta carotene, vitamin D 0.01 Part, 0.01 part of vitamin B1,0.01 part of vitamin B2,0.01 part of nicotinic acid, 0.01 part of vitamin C, 2 parts of xylitol, 5 parts of tartaric acid, 2 parts of promethazine hydrochloride piece.
A kind of preparation method of Western medicine compound for obesity, concretely comprises the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 10 minutes in being added to nonmetallic mortar, and closed black out is saved backup；（2）In desinfection chamber, linoleic acid, lemon are taken Acid is ground well 1 minute in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（3）In desinfection chamber, tartaric acid and vinegar are taken Salicylic acid is ground well 1 minute in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（4）In desinfection chamber, by hydrochloric acid isopropyl Piperazine piece fries taking-up after 1min in being put into olive oil, and cooling is standby；（5）Promethazine hydrochloride piece after will be fried is put into above-mentioned non- Ground well in metal mortar 1 minute, closed black out is saved backup；（6）In desinfection chamber, take soyabean protein powder, xylitol and be added to Mixing in above-mentioned nonmetallic mortar, and 0.1 gram of piece, grain, ball are pressed into, get product.
Embodiment 2
A kind of Western medicine compound for obesity, including following weight fraction raw material：15 parts of soyabean protein powder, olive oil 15 Part, 5 parts of acetylsalicylic acid, 10 parts of linoleic acid, 5 parts of citric acid, 0.1 part of vitamin A, 0.1 part of beta carotene, 0.1 part of vitamin D, 0.1 part of vitamin B1,0.1 part of vitamin B2,0.1 part of nicotinic acid, 0.1 part of vitamin C, 5 parts of xylitol, tartaric acid 8 Part, 5 parts of promethazine hydrochloride piece.
A kind of preparation method of Western medicine compound for obesity, concretely comprises the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 15 minutes in being added to nonmetallic mortar, and closed black out is saved backup；（2）In desinfection chamber, linoleic acid, lemon are taken Acid is ground well 3 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（3）In desinfection chamber, tartaric acid and vinegar are taken Salicylic acid is ground well 3 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（4）In desinfection chamber, by hydrochloric acid isopropyl Piperazine piece fries taking-up after 2min in being put into olive oil, and cooling is standby；（5）Promethazine hydrochloride piece after will be fried is put into above-mentioned non- Ground well in metal mortar 3 minutes, closed black out is saved backup；（6）In desinfection chamber, take soyabean protein powder, xylitol and be added to Mixing in above-mentioned nonmetallic mortar, and 1 gram of piece, grain, ball are pressed into, get product.
Embodiment 3
A kind of Western medicine compound for obesity, including following weight fraction raw material：12 parts of soyabean protein powder, olive oil 8 Part, 2 parts of acetylsalicylic acid, 6 parts of linoleic acid, 4 parts of citric acid, 0.05 part of vitamin A, 0.03 part of beta carotene, vitamin D 0.02 Part, 0.02 part of vitamin B1,0.03 part of vitamin B2,0.02 part of nicotinic acid, 0.02 part of vitamin C, xylitol 4.3 Part, 6.2 parts of tartaric acid, 3.5 parts of promethazine hydrochloride piece.
A kind of preparation method of Western medicine compound for obesity, concretely comprises the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 12 minutes in being added to nonmetallic mortar, and closed black out is saved backup；（2）In desinfection chamber, linoleic acid, lemon are taken Acid is ground well 2 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（3）In desinfection chamber, tartaric acid and vinegar are taken Salicylic acid is ground well 2 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（4）In desinfection chamber, by hydrochloric acid isopropyl Piperazine piece fries taking-up after 1.5min in being put into olive oil, and cooling is standby；（5）Promethazine hydrochloride piece after will be fried is put into above-mentioned Ground well in nonmetallic mortar 2 minutes, closed black out is saved backup；（6）In desinfection chamber, take soyabean protein powder, xylitol and add The mixing in above-mentioned nonmetallic mortar, and 0.6 gram of piece, grain, ball are pressed into, get product.
Embodiment 4
A kind of Western medicine compound for obesity, including following weight fraction raw material：14 parts of soyabean protein powder, olive oil 10 Part, 4 parts of acetylsalicylic acid, 8 parts of linoleic acid, 4 parts of citric acid, 0.5 part of vitamin A, 0.6 part of beta carotene, 0.5 part of vitamin D, 0.5 part of vitamin B1,0.5 part of vitamin B2,05 part of nicotinic acid, 0.5 part of vitamin C, 4 parts of xylitol, tartaric acid 7 Part, 4 parts of promethazine hydrochloride piece.
A kind of preparation method of Western medicine compound for obesity, concretely comprises the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 14 minutes in being added to nonmetallic mortar, and closed black out is saved backup；（2）In desinfection chamber, linoleic acid, lemon are taken Acid is ground well 2.5 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（3）In desinfection chamber, take tartaric acid and Acetylsalicylic acid is ground well 2.5 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（4）In desinfection chamber, by hydrochloric acid Fenazil piece fries taking-up after 1.9min in being put into olive oil, and cooling is standby；（5）Promethazine hydrochloride piece after will be fried is put into Ground well in above-mentioned nonmetallic mortar 2.5 minutes, closed black out is saved backup；（6）In desinfection chamber, soyabean protein powder, xylose are taken Alcohol is mixed in being added to above-mentioned nonmetallic mortar, and is pressed into 0.8 gram of piece, grain, ball, is got product.
Comparative example 1
A kind of Western medicine compound for obesity, including following weight fraction raw material：12 parts of soyabean protein powder, olive oil 8 Part, 2 parts of acetylsalicylic acid, 6 parts of linoleic acid, 4 parts of citric acid, 0.05 part of vitamin A, 0.03 part of beta carotene, vitamin D 0.02 Part, 0.02 part of vitamin B1,0.03 part of vitamin B2,0.02 part of nicotinic acid, 0.02 part of vitamin C, xylitol 4.3 Part, 6.2 parts of tartaric acid, 1.5 parts of promethazine hydrochloride piece.
A kind of preparation method of Western medicine compound for obesity, concretely comprises the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 12 minutes in being added to nonmetallic mortar, and closed black out is saved backup；（2）In desinfection chamber, linoleic acid, lemon are taken Acid is ground well 2 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（3）In desinfection chamber, tartaric acid and vinegar are taken Salicylic acid is ground well 2 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（4）In desinfection chamber, by hydrochloric acid isopropyl Piperazine piece fries taking-up after 1.5min in being put into olive oil, and cooling is standby；（5）Promethazine hydrochloride piece after will be fried is put into above-mentioned Ground well in nonmetallic mortar 2 minutes, closed black out is saved backup；（6）In desinfection chamber, take soyabean protein powder, xylitol and add The mixing in above-mentioned nonmetallic mortar, and 0.6 gram of piece, grain, ball are pressed into, get product.
Comparative example 2
A kind of Western medicine compound for obesity, including following weight fraction raw material：12 parts of soyabean protein powder, olive oil 8 Part, 2 parts of acetylsalicylic acid, 6 parts of linoleic acid, 4 parts of citric acid, 0.05 part of vitamin A, 0.03 part of beta carotene, vitamin D 0.02 Part, 0.02 part of vitamin B1,0.03 part of vitamin B2,0.02 part of nicotinic acid, 0.02 part of vitamin C, xylitol 4.3 Part, 6.2 parts of tartaric acid, 0.5 part of promethazine hydrochloride piece.
A kind of preparation method of Western medicine compound for obesity, concretely comprises the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 12 minutes in being added to nonmetallic mortar, and closed black out is saved backup；（2）In desinfection chamber, linoleic acid, lemon are taken Acid is ground well 2 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（3）In desinfection chamber, tartaric acid and vinegar are taken Salicylic acid is ground well 2 minutes in being added to above-mentioned nonmetallic mortar, and closed black out is saved backup；（4）In desinfection chamber, by hydrochloric acid isopropyl Piperazine piece fries taking-up after 1.5min in being put into olive oil, and cooling is standby；（5）Promethazine hydrochloride piece after will be fried is put into above-mentioned Ground well in nonmetallic mortar 2 minutes, closed black out is saved backup；（6）In desinfection chamber, take soyabean protein powder, xylitol and add The mixing in above-mentioned nonmetallic mortar, and 0.6 gram of piece, grain, ball are pressed into, get product.
The influence of experimental example 1 Western medicine compound to obesity mice
1.1 experiment materials
Experimental facilities：Glycosylated hemoglobin determines kit；HDL (HDL) kit, low-density lipoprotein (LDL) Kit and cruel (TG) kit of glycerine three；
Experimental animal：Ob/ob mouse, male 50,10 week old, body weight 55-60g.
1.2 experimental techniques
50 ob/ob mouse are randomly divided into 4 groups, i.e. model group, 3 groups of embodiment, 1 group of comparative example, 2 groups of comparative example, are taken in addition 10 normal ob/ob mouse are as a control group.Model group gives physiological saline gavage；3 groups of embodiment gives the preparation of embodiment 3 Western medicine compound gavage；1 group of comparative example gives the Western medicine compound gavage of the preparation of comparative example 1；2 groups of comparative example gives comparative example 2 The Western medicine compound gavage of preparation, successive administration 5 weeks.
After 5 weeks, food ration is weighed and calculated to each group mouse, determined glycosylated hemoglobin (HbAlc), blood sugar, height Density lipoprotein (HDL), low-density lipoprotein (LDL) and glycerine three are cruel (TG).Take adipose tissue, homogenate, the examination of BCA protein determinations After agent box determines protein concentration, taking 50ug sample proteins carries out 10% dodecyl sodium sulfate polypropylene phthalein amine (SDS-PAGE) Gel denaturing electrophoretic and then polyvinylidene fluoride (PVDF) film is gone to, add HMGB1 primary antibodies, p-actin to make internal reference, Western Blot detects the expression of adipose tissue HMGB1 albumen.Comparing carries out T inspections between the difference of each administration group and model group, group.
The Western medicine compound administration influence (n=10) to ob/ob mouse in 4 weeks of table 1
Group Promethazine hydrochloride tablet amounts（Part） Food ration Body weight HMGB1 is expressed（%）
Control group - 4.2±0.5 29.6±0.6 101±15
Model group - 6.8±0.2 59.5±0.5 584±54
2 groups of comparative example 0.5 5.8±0.3 57.7±1.5 401±35
1 group of comparative example 1.5 4.6±0.2 50.1±3.5 302±26
3 groups of embodiment 3.5 4.3±0.3 49.8±1.2 298±15
The 4 weeks blood biochemistry index on ob/ob mouse of Western medicine compound administration of table 2 influence (n=10)
Table 1,3 groups of embodiment of the result of table 2 display, 2 groups of comparative example, 1 group of comparative example substantially lose weight and food ration, reduce blood plasma HbA1c, LDL and TG level, suppress blood glucose rise, suppress adipose tissue HMGB1 expression and decline, raising HDL levels.Embodiment 3 Group than 2 groups of comparative example, the therapeutic effect of 1 group of comparative example substantially, with the increase of promethazine hydrochloride tablet amounts, get over by therapeutic effect It is good, therefore, the Western medicine compound is a kind of medicine for safely and effectively treating obesity.
The Western medicine compound has advantages below：
First, the Western medicine compound has preferable therapeutic effect in terms of obesity is treated, and can obviously reduce body weight and food ration, Blood plasma HbA1c, LDL and TG level is reduced, suppresses blood glucose rise, suppressed adipose tissue HMGB1 expression and decline, raising HDL levels, It is a kind of medicine for safely and effectively treating obesity；
2nd, raw material is easy to get, and cost of material is low, and preparation method is simple, is conducive to marketing；
3rd, application method is simple, and user need not move and go on a diet, it is easier to adhere to, and curative effect is short, instant effect, and Toxic and side effect is small, safe.
The better embodiment to this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party Formula, in the ken that one skilled in the relevant art possesses, can also be on the premise of this patent objective not be departed from Make a variety of changes.

Claims (3)

1. a kind of Western medicine compound for obesity, it is characterised in that the raw material including following weight fraction：Soyabean protein powder 10-15 parts, olive oil 5-15 parts, acetylsalicylic acid 1-5 parts, linoleic acid 5-10 parts, citric acid 3-5 parts, vitamin A 0.01-0.1 parts, Beta carotene 0.01-0.1 parts, vitamin D 0.01-0.1 parts, vitamin B1 0.01-0.1 parts, vitamin B2 0.01-0.1 Part, nicotinic acid 0.01-0.1 parts, vitamin C 0.01-0.1 parts, xylitol 2-5 parts, tartaric acid 5-8 parts, promethazine hydrochloride Piece 2-5 parts.
2. the Western medicine compound for obesity according to claim 1, it is characterised in that including following weight fraction Raw material：12 parts of soyabean protein powder, 8 parts of olive oil, 2 parts of acetylsalicylic acid, 6 parts of linoleic acid, 4 parts of citric acid, 0.05 part of vitamin A, β- 0.03 part of carrotene, 0.02 part of vitamin D, 0.02 part of vitamin B1,0.03 part of vitamin B2,0.02 part of nicotinic acid, 0.02 part of vitamin C, 4.3 parts of xylitol, 6.2 parts of tartaric acid, 3.5 parts of promethazine hydrochloride piece.
3. the preparation method of a kind of Western medicine compound for obesity as described in claim 1-2 is any, it is characterised in that Concretely comprise the following steps：
（1）Vitamin A, beta carotene, vitamin D, vitamin B1, vitamin B2, nicotinic acid, dimension life are taken in desinfection chamber Plain C is ground well 10-15 minutes in being added to nonmetallic mortar, and closed black out is saved backup；
（2）In desinfection chamber, take during linoleic acid, citric acid are added to above-mentioned nonmetallic mortar and grind well 1-3 minutes, closed black out is protected Deposit standby；
（3）In desinfection chamber, take tartaric acid and grind well 1-3 minutes during acetylsalicylic acid is added to above-mentioned nonmetallic mortar, closed black out Save backup；
（4）In desinfection chamber, promethazine hydrochloride piece is put into after frying 1-2min in olive oil and taken out, cooling is standby；
（5）Promethazine hydrochloride piece after will be fried is put into above-mentioned nonmetallic mortar and is ground well 1-3 minutes, and closed black out preserves standby With；
（6）In desinfection chamber, take during soyabean protein powder, xylitol are added to above-mentioned nonmetallic mortar and mix, and be pressed into 0.1-1 Gram piece, grain, ball, get product.
CN201611102259.2A 2016-12-05 2016-12-05 A kind of Western medicine compound for obesity Pending CN106729600A (en)

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Application publication date: 20170531