CN106729179A - A kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease - Google Patents

A kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease Download PDF

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CN106729179A
CN106729179A CN201611180497.5A CN201611180497A CN106729179A CN 106729179 A CN106729179 A CN 106729179A CN 201611180497 A CN201611180497 A CN 201611180497A CN 106729179 A CN106729179 A CN 106729179A
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mycotoxin
medicine
mould
preparation
relevant disease
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杨晓军
陈彦龙
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Animal Husbandry And Pharmaceutical Co Ltd Shijiazhuang And Good Animal
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Animal Husbandry And Pharmaceutical Co Ltd Shijiazhuang And Good Animal
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

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Abstract

The present invention discloses a kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease, and raw material includes following component and parts by weight, is combined aluminium hydroxide sodium-calcium-silicate, 65 ~ 75；Esterification Portugal's mannose, 26 ~ 33；Herba Andrographitis, 73 ~ 77；Polygonum flaccidum, 62 ~ 67；Folium isatidis, 57 ~ 74；Desmodium triquetrum, 45 ~ 53；Golden cypress, 47 ~ 53；Medicated Leaven, 27 ~ 34；Malt 26 ~ 34；Probiotics, 35 ~ 45.The present invention can either prevent and treat mould, mycotoxin, while feed intake can be quickly improved again, the illness such as treatment proventriculitis, ventriculitis, diarrhoea.

Description

A kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease
Technical field
The present invention relates to a kind of preparation method for preventing and treating mould, the medicine of mycotoxin relevant disease, for domestic animals The symptoms such as proventriculitis, ventriculitis, diarrhoea that mould, mycotoxin cause.
Background technology
Mycotoxin is the toxic metabolic products that mould produces in its food for being polluted, and they can be by feed or food Product enter in humans and animals body, cause the acute or chronic toxicity of humans and animals, damage the liver of body, kidney, nerve fiber, Hematopoietic tissue and skin histology etc..Mycotoxin species is very more.Toxin produced by various moulds is different, the danger for causing Evil degree is also differed.Wherein, zearalenone, vomitoxin, ochracin, volt bar verticillium toxin and T2 toxin cause gland Gastritis, ventriculitis, diarrhoea etc.
Mould and mycotoxin species are various, and the infringement of different types of mould and toxin to body has differences, to each System, tissue, the pathogenic situation of organ are also not quite similar.The form of expression differs after causing clinical onset, pathological change after cut open inspection Widely different, this brings great difficulty to the diagnosis of clinical veterinarian personnel and disposing task.
Most people thinks that de- mould dose of addition just can thoroughly prevent feed mold, or pig to eat addition and take off mould in feed Be not in exception after the feed that goes mouldy of agent.In fact, de- mould dose can only slough a part of mould, to mycotoxin and a big portion Mould is divided not remove and removing effect.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of preventing and treating mould, the preparation of the medicine of mycotoxin relevant disease Method, can either prevent and treat mould, mycotoxin, while feed intake can be quickly improved again, treatment proventriculitis, ventriculitis, diarrhoea Etc. illness.
In order to solve the above technical problems, the technical solution used in the present invention is：
A kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease, raw material include following component and parts by weight,
Compound aluminium hydroxide sodium-calcium-silicate, 65 ~ 75；Esterification Portugal's mannose, 26 ~ 33；Herba Andrographitis, 73 ~ 77；Polygonum flaccidum, 62 ~ 67； Folium isatidis, 57 ~ 74；Desmodium triquetrum, 45 ~ 53；Golden cypress, 47 ~ 53；Medicated Leaven, 27 ~ 34；Malt 26 ~ 34；Probiotics, 35 ~ 45.
Further improvement of the present invention is：Raw material includes following component and parts by weight, is combined aluminium hydroxide sodium calcium silicon Hydrochlorate, 68 ~ 71；Esterification Portugal's mannose, 28 ~ 32；Herba Andrographitis, 74 ~ 76；Polygonum flaccidum, 63 ~ 67；Folium isatidis, 58 ~ 72；Desmodium triquetrum, 49 ~ 52；Golden cypress, 49 ~ 51；Medicated Leaven, 28 ~ 33；Malt 28 ~ 33；Probiotics, 36 ~ 44.
Further improvement of the present invention is：The probiotics includes following species and parts by weight,
Bulgarian bacterium, 9 ~ 11；Lactobacillus paracasei, 9 ~ 11；Streptococcus fecalis, 9 ~ 11；Lactic acid bacteria, 9 ~ 11.
Further improvement of the present invention is：Comprise the following steps, proportionally choose raw material, crushed respectively after drying , then be well mixed for each component raw material by 70~100 mesh sieves.
Due to using above-mentioned technical proposal, the beneficial effect produced by the present invention to be：
A kind of preventing and treating mould of the invention, the preparation method of the medicine of mycotoxin relevant disease, can either prevent and treat mould, mould Toxin, while feed intake can be quickly improved again, the illness such as treatment proventriculitis, ventriculitis, diarrhoea.
Herba Andrographitis of the invention is clearing heat and detoxicating, swelling and pain relieving；Folium isatidis is clearing heat and detoxicating, palace blood ecchymose removing；Desmodium triquetrum heat-clearing solution Heat, disperse accumulations dampness removing, desinsection；Polygonum flaccidum eliminating dampness to stop diarrhea, scattered silt analgesic, wind dispelling insecticide；Golden cypress, heat-clearing, eliminating dampness；Medicated Leaven is used for dyspepsia Do not change, do not feel like eating, increased borborygmus and diarrhea etc.；Malt promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, dyspepsia, abdominal distention, spleen eating less.It is all Medicine is shared, and plays clearing heat and detoxicating altogether, except humidifying is stagnant, the lower gas that helps digestion, middle benefit gas stomach invigorating, the work(of appetizing intestines wide.
Probiotics of the invention, including Bulgarian bacterium, Lactobacillus paracasei, streptococcus fecalis, lactic acid bacteria pass through adhesin and intestines Mucosa cells are combined closely, and occupy-place, the main constituents as physiologic barrier, so as to reach recovery are colonized on intestinal mucosa surface Host resistance, repairs gut flora barrier, cures the effect of intestines problem；In addition drug and nutriment can also be promoted The absorption of matter, generation B family vitamin.
Specific embodiment
The present invention is described in further details with reference to embodiment：
A kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease, raw material include following component and parts by weight, Compound aluminium hydroxide sodium-calcium-silicate, 65 ~ 75；Esterification Portugal's mannose, 26 ~ 33；Herba Andrographitis, 73 ~ 77；Polygonum flaccidum, 62 ~ 67；Smalt Leaf, 57 ~ 74；Desmodium triquetrum, 45 ~ 53；Golden cypress, 47 ~ 53；Medicated Leaven, 27 ~ 34；Malt 26 ~ 34；Probiotics, 35 ~ 45.
The preferred scheme of raw material components and parts by weight is：Compound aluminium hydroxide sodium-calcium-silicate, 68 ~ 71；Esterification Portugal is sweet Dew sugar, 28 ~ 32；Herba Andrographitis, 74 ~ 76；Polygonum flaccidum, 63 ~ 67；Folium isatidis, 58 ~ 72；Desmodium triquetrum, 49 ~ 52；Golden cypress, 49 ~ 51；Six god Song, 28 ~ 33；Malt 28 ~ 33；Probiotics, 36 ~ 44.
Probiotics includes following species and parts by weight, Bulgarian bacterium, 9 ~ 11；Lactobacillus paracasei, 9 ~ 11；Excrement hammer Bacterium, 9 ~ 11；Lactic acid bacteria, 9 ~ 11.
Raw material is proportionally chosen, 70~100 mesh sieves were crushed respectively after drying, each component raw material is then mixed equal It is even.
Embodiment 1
Compound aluminium hydroxide sodium-calcium-silicate, 65 grams；Esterification Portugal's mannose, 26 grams；Herba Andrographitis, 73 grams；Polygonum flaccidum, 62 grams；Smalt Leaf, 57 grams；Desmodium triquetrum, 45 grams；Golden cypress, 47 grams；Medicated Leaven, 27 grams；26 grams of malt；Bulgarian bacterium, 9 grams；Lactobacillus paracasei, 9 Gram；Streptococcus fecalis, 9 grams；Lactic acid bacteria, 9 grams.
Raw material is proportionally chosen, 80 mesh sieves were crushed respectively after drying, be then well mixed each component raw material, obtained Medicine.
In adding drug to feed, wherein shared by medicine 1/500.It is continuous to feed 5~7, livestock is treated, obtain Rehabilitation.
Embodiment 2
Compound aluminium hydroxide sodium-calcium-silicate, 75 grams；Esterification Portugal's mannose, 33 grams；Herba Andrographitis, 77 grams；Polygonum flaccidum, 67 grams；Smalt Leaf, 74 grams；Desmodium triquetrum, 53 grams；Golden cypress, 53 grams；Medicated Leaven, 34 grams；34 grams of malt；Bulgarian bacterium, 11 grams；Lactobacillus paracasei, 11 grams；Streptococcus fecalis, 11 grams；Lactic acid bacteria, 11 grams.
Raw material is proportionally chosen, 70 mesh sieves were crushed respectively after drying, be then well mixed each component raw material, obtained Medicine.
In adding drug to feed, wherein shared by medicine 1/500.It is continuous to feed 5~7, livestock is treated, obtain Rehabilitation.
Embodiment 3
Compound aluminium hydroxide sodium-calcium-silicate, 68；Esterification Portugal's mannose, 28；Herba Andrographitis, 74；Polygonum flaccidum, 63；Folium isatidis, 58；Calabash Reed tea, 49；Golden cypress, 49；Medicated Leaven, 28；Malt 28；Bulgarian bacterium, 9；Lactobacillus paracasei, 11；Streptococcus fecalis, 9；Lactic acid bacteria, 10。
Raw material is proportionally chosen, 100 mesh sieves were crushed respectively after drying, be then well mixed each component raw material, obtained To medicine.
In adding drug to feed, wherein shared by medicine 1/500.It is continuous to feed 5~7, livestock is treated, obtain Rehabilitation.
Embodiment 4
Compound aluminium hydroxide sodium-calcium-silicate, 71；Esterification Portugal's mannose, 32；Herba Andrographitis, 76；Polygonum flaccidum, 67；Folium isatidis, 72；Calabash Reed tea, 52；Golden cypress, 51；Medicated Leaven, 33；Malt, 33；Bulgarian bacterium, 10；Lactobacillus paracasei, 9；Streptococcus fecalis, 11；Lactic acid Bacterium, 10.
Raw material is proportionally chosen, 90 mesh sieves were crushed respectively after drying, be then well mixed each component raw material, obtained Medicine.
In adding drug to feed, wherein shared by medicine 1/500.It is continuous to feed 5~7, livestock is treated, obtain Rehabilitation.
Embodiment 5
Compound aluminium hydroxide sodium-calcium-silicate, 70；Esterification Portugal's mannose, 30；Herba Andrographitis, 75；Polygonum flaccidum, 65；Folium isatidis, 70；Calabash Reed tea, 50；Golden cypress, 50；Medicated Leaven, 30；Malt, 30；Bulgarian bacterium, 10；Lactobacillus paracasei, 10；Streptococcus fecalis, 10；Lactic acid Bacterium, 10.
Raw material is proportionally chosen, 80 mesh sieves were crushed respectively after drying, be then well mixed each component raw material, obtained Medicine.
In adding drug to feed, wherein shared by medicine 1/500.It is continuous to feed 5~7, livestock is treated, obtain Rehabilitation.
It is of the invention it is a kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease, can either prevent and treat mould, Mycotoxin, while feed intake can be quickly improved again, the illness such as treatment proventriculitis, ventriculitis, diarrhoea.

Claims (4)

  1. It is 1. a kind of to prevent and treat mould, the preparation method of the medicine of mycotoxin relevant disease, it is characterised in that：Raw material include it is following into Divide and parts by weight,
    Compound aluminium hydroxide sodium-calcium-silicate, 65 ~ 75；Esterification Portugal's mannose, 26 ~ 33；Herba Andrographitis, 73 ~ 77；Polygonum flaccidum, 62 ~ 67； Folium isatidis, 57 ~ 74；Desmodium triquetrum, 45 ~ 53；Golden cypress, 47 ~ 53；Medicated Leaven, 27 ~ 34；Malt 26 ~ 34；Probiotics, 35 ~ 45.
  2. 2. it is according to claim 1 it is a kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease, its feature It is：Raw material includes following component and parts by weight, is combined aluminium hydroxide sodium-calcium-silicate, 68 ~ 71；Esterification Portugal's mannose, 28 ~ 32；Herba Andrographitis, 74 ~ 76；Polygonum flaccidum, 63 ~ 67；Folium isatidis, 58 ~ 72；Desmodium triquetrum, 49 ~ 52；Golden cypress, 49 ~ 51；Medicated Leaven, 28 ~ 33； Malt 28 ~ 33；Probiotics, 36 ~ 44.
  3. 3. it is according to claim 1 and 2 it is a kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease, its It is characterised by：The probiotics includes following species and parts by weight,
    Bulgarian bacterium, 9 ~ 11；Lactobacillus paracasei, 9 ~ 11；Streptococcus fecalis, 9 ~ 11；Lactic acid bacteria, 9 ~ 11.
  4. 4. it is according to claim 3 it is a kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease, its feature It is：Comprise the following steps, proportionally choose raw material, 70~100 mesh sieves were crushed respectively after drying, it is then that each component is former Material is well mixed.
CN201611180497.5A 2016-12-20 2016-12-20 A kind of preventing and treating mould, the preparation method of the medicine of mycotoxin relevant disease Pending CN106729179A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109452490A (en) * 2018-11-15 2019-03-12 山西大学 A kind of prevention and treatment the chicken ventriculitis as caused by mycotoxicosis, the feed addictive of proventriculitis and its application
CN110464777A (en) * 2019-05-19 2019-11-19 河南工业大学 A kind of preparation method for the probiotics for protecting stomach and releasing vomitoxin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
北京圣格锐 百卫中国: "霉菌毒素的危害及其解决方案", 《HTTPS://MP.WEIXIN.QQ.COM/S/5J1KTEI34VOMH3JXWTSZJW》 *
柴瑞震: "《吃对食物，养好肠胃》", 30 September 2014, 中国轻工业出版社 *
石家庄和牧佳动物药业有限公司: "牡佳益康—主治家畜呕吐、厌食、胃肠胀气", 《HTTP://WWW.1866.TV/PRO/422184.HTML》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109452490A (en) * 2018-11-15 2019-03-12 山西大学 A kind of prevention and treatment the chicken ventriculitis as caused by mycotoxicosis, the feed addictive of proventriculitis and its application
CN110464777A (en) * 2019-05-19 2019-11-19 河南工业大学 A kind of preparation method for the probiotics for protecting stomach and releasing vomitoxin

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